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Biochemical Journal

  1. Characterization of VPS34-IN1, a selective inhibitor of Vps34, reveals that the phosphatidylinositol 3-phosphate-binding SGK3 protein kinase is a downstream target of class III phosphoinositide 3-kinase

    Bago, R., Malik, N., Munson, M. J., Prescott, A. R., Davies, P., Sommer, E., Shpiro, N., Ward, R., Cross, D., Ganley, I. G. & Alessi, D. R. Nov 2014 In : Biochemical Journal. 463, 3, p. 413-427 15 p.

    Research output: Contribution to journalArticle

  2. Conserved structure and domain organization among bacterial Slc26 transporters

    Compton, E. L. R., Page, K., Findlay, H. E., Haertlein, M., Moulin, M., Zachariae, U., Norman, D. G., Gabel, F. & Javelle, A. 15 Oct 2014 In : Biochemical Journal. 463, 2, p. 297-307 11 p.

    Research output: Contribution to journalArticle

  3. Chromatin and oxygen sensing in the context of JmjC histone demethylases

    Shmakova, A., Batie, M., Druker, J. & Rocha, S. 15 Sep 2014 In : Biochemical Journal. 462, 3, p. 385-395 11 p.

    Research output: Contribution to journalArticle

  4. Structures of bacterial kynurenine formamidase reveal a crowded binuclear zinc catalytic site primed to generate a potent nucleophile

    Díaz-Sáez, L., Srikannathasan, V., Zoltner, M. & Hunter, W. N. 15 Sep 2014 In : Biochemical Journal. 462, 3, p. 581-589 9 p.

    Research output: Contribution to journalArticle

  5. An unexpected twist to the activation of IKKβ: TAK1 primes IKKβ for activation by autophosphorylation

    Zhang, J., Clark, K., Lawrence, T., Peggie, M. W. & Cohen, P. 1 Aug 2014 In : Biochemical Journal. 461, 3, p. 531-537 7 p.

    Research output: Contribution to journalArticle

  6. Biochemical and genetic characterization of Trypanosoma cruzi N-myristoyltransferase

    Roberts, A. J., Torrie, L. S., Wyllie, S. & Fairlamb, A. H. 15 Apr 2014 In : Biochemical Journal. 459, 2, p. 323-332 10 p.

    Research output: Contribution to journalArticle

  7. Phosphorylation by Akt within the ST loop of AMPK-α1 down-regulates its activation in tumour cells

    Hawley, S. A., Ross, F. A., Gowans, G. J., Tibarewal, P., Leslie, N. R. & Hardie, D. G. 15 Apr 2014 In : Biochemical Journal. 459, 2, p. 275-287 13 p.

    Research output: Contribution to journalArticle

  8. How the structure of the large subunit controls function in an oxygen-tolerant [NiFe]-hydrogenase

    Bowman, L., Flanagan, L., Fyfe, P. K., Parkin, A., Hunter, W. N. & Sargent, F. 15 Mar 2014 In : Biochemical Journal. 458, 3, p. 449-458 10 p.

    Research output: Contribution to journalArticle

  9. Transcriptionally correlated subcellular dynamics of MBNL1 during lens development and their implication for the molecular pathology of myotonic dystrophy type 1

    Coleman, S. M., Prescott, A. R. & Sleeman, J. E. Mar 2014 In : Biochemical Journal. 458, 2, p. 267-280 14 p.

    Research output: Contribution to journalArticle

  10. Investigation of LKB1 Ser431 phosphorylation and Cys433 farnesylation using mouse knockin analysis reveals an unexpected role of prenylation in regulating AMPK activity

    Houde, V. P., Ritorto, M. S., Gourlay, R., Davies, P., Shpiro, N., Sakamoto, K. & Alessi, D. R. 15 Feb 2014 In : Biochemical Journal. 458, 1, p. 41-56 16 p.

    Research output: Contribution to journalArticle

  11. Bisubstrate UDP-peptide conjugates as human O-GlcNAc transferase inhibitors

    Borodkin, V. S., Schimpl, M., Gundogdu, M., Rafie, K., Dorfmueller, H. C., Robinson, D. A. & van Aalten, D. M. F. 1 Feb 2014 In : Biochemical Journal. 457, 3, p. 497-502 6 p.

    Research output: Contribution to journalArticle

  12. Nrf2 affects the efficiency of mitochondrial fatty acid oxidation

    Ludtmann, M. H. R., Angelova, P. R., Zhang, Y., Abramov, A. Y. & Dinkova-Kostova, A. T. 1 Feb 2014 In : Biochemical Journal. 457, 3, p. 415-424 10 p.

    Research output: Contribution to journalArticle

  13. RAM function is dependent on Kapβ2-mediated nuclear entry

    Gonatopoulos-Pournatzis, T. & Cowling, V. H. 1 Feb 2014 In : Biochemical Journal. 457, 3, p. 473-484 12 p.

    Research output: Contribution to journalArticle

  14. Cap-binding complex (CBC)

    Gonatopoulos-Pournatzis, T. & Cowling, V. H. 15 Jan 2014 In : Biochemical Journal. 457, 2, p. 231-242 12 p.

    Research output: Contribution to journalScientific review

  15. Characterization of WZ4003 and HTH-01-015 as selective inhibitors of the LKB1-tumour-suppressor-activated NUAK kinases

    Banerjee, S., Buhrlage, S. J., Huang, H-T., Deng, X., Zhou, W., Wang, J., Traynor, R., Prescott, A. R., Alessi, D. R. & Gray, N. S. 1 Jan 2014 In : Biochemical Journal. 457, 1, p. 215-225 11 p.

    Research output: Contribution to journalArticle

  16. Alternative substrates reveal catalytic cycle and key binding events in the reaction catalysed by anthranilate phosphoribosyltransferase from Mycobacterium tuberculosis

    Cookson, T. V. M., Castell, A., Bulloch, E. M. M., Evans, G. L., Short, F. L., Baker, E. N., Lott, J. S. & Parker, E. J. 2014 In : Biochemical Journal. 461, 1, p. 87-98 12 p.

    Research output: Contribution to journalArticle

  17. Biochemical analysis of TssK, a core component of the bacterial Type VI secretion system, reveals distinct oligomeric states of TssK and identifies a TssK-TssFG sub-complex

    English, G., Byron, O., Cianfanelli, F. R., Prescott, A. R. & Coulthurst, S. J. 2014 In : Biochemical Journal. 461, 2, p. 291-304 14 p.

    Research output: Contribution to journalArticle

  18. Interplay between Polo kinase, LKB1-activated NUAK1 kinase, PP1βMYPT1 phosphatase complex and the SCFβTrCP E3 ubiquitin ligase

    Banerjee, S., Zagorska, A., Deak, M., Campbell, D. G., Prescott, A. R. & Alessi, D. R. 2014 In : Biochemical Journal. 461, 2, p. 233-245 13 p.

    Research output: Contribution to journalArticle

  19. Kinase and channel activity of TRPM6 are co-ordinated by a dimerization motif and pocket interaction

    van der Wijst, J., Blanchard, M. G., Woodroof, H. I., Macartney, T. J., Gourlay, R., Hoenderop, J. G., Bindels, R. J. & Alessi, D. R. 2014 In : Biochemical Journal. 460, 2, p. 165-175 11 p.

    Research output: Contribution to journalArticle

  20. Parkin is activated by PINK1-dependent phosphorylation of ubiquitin at Serine65

    Kazlauskaite, A., Kondapalli, C., Gourlay, R., Campbell, D. G., Ritorto, M. S., Hofmann, K., Alessi, D. R., Knebel, A., Trost, M. & Muqit, M. M. K. 2014 In : Biochemical Journal. 460, 1, p. 127-139 13 p.

    Research output: Contribution to journalArticle

  21. Structural and biochemical characterization of the KLHL3-WNK kinase interaction important in blood pressure regulation

    Schumacher, F-R., Sorrell, F. J., Alessi, D. R., Bullock, A. N. & Kurz, T. 2014 In : Biochemical Journal. 460, 2, p. 237-246 10 p.

    Research output: Contribution to journalArticle

  22. Chemical tools to probe cellular O-GlcNAc signalling

    Ostrowski, A. & van Aalten, D. M. F. 15 Nov 2013 In : Biochemical Journal. 456, 1, p. 1-12 12 p.

    Research output: Contribution to journalArticle

  23. Human cap methyltransferase (RNMT) N-terminal non-catalytic domain mediates recruitment to transcription initiation sites

    Aregger, M. & Cowling, V. H. 18 Jul 2013 In : Biochemical Journal. 455, 1, p. 67-73 7 p.

    Research output: Contribution to journalArticle

  24. Comprehensive characterization and optimization of anti-LRRK2 (leucine-rich repeat kinase 2) monoclonal antibodies

    Davies, P., Hinkle, K. M., Sukar, N. N., Sepulveda, B., Mesias, R., Serrano, G., Alessi, D. R., Beach, T. G., Benson, D. L., White, C. L., Cowell, R. M., Das, S. S., West, A. B. & Melrose, H. L. 1 Jul 2013 In : Biochemical Journal. 453, 1, p. 101-113 13 p.

    Research output: Contribution to journalArticle

  25. Elevated SGK1 predicts resistance of breast cancer cells to Akt inhibitors

    Sommer, E. M., Dry, H., Cross, D., Guichard, S., Davies, B. R. & Alessi, D. R. 15 Jun 2013 In : Biochemical Journal. 452, 3, p. 499-508 10 p.

    Research output: Contribution to journalArticle

  26. Characterisation of a pre-export enzyme-chaperone complex on the twin-arginine transport pathway

    Dow, J. M., Gabel, F., Sargent, F. & Palmer, T. 15 May 2013 In : Biochemical Journal. 452, 1, p. 57-66 10 p.

    Research output: Contribution to journalArticle

  27. The anti-inflammatory drug BAY 11-7082 suppresses the MyD88-dependent signalling network by targeting the ubiquitin system

    Strickson, S., Campbell, D. G., Emmerich, C. H., Knebel, A., Plater, L., Ritorto, M. S., Shpiro, N. & Cohen, P. 1 May 2013 In : Biochemical Journal. 451, 3, p. 427-437 11 p.

    Research output: Contribution to journalArticle

  28. The P-body component USP52/PAN2 is a novel regulator of HIF1A mRNA stability

    Bett, J. S., Ibrahim, A. F. M., Garg, A. K., Kelly, V., Pedrioli, P., Rocha, S. & Hay, R. T. 15 Apr 2013 In : Biochemical Journal. 451, 2, p. 185-194 10 p.BJ20130026

    Research output: Contribution to journalArticle

  29. The CUL3-KLHL3 E3 ligase complex mutated in Gordon's hypertension syndrome interacts with and ubiquitylates WNK isoforms: disease-causing mutations in KLHL3 and WNK4 disrupt interaction

    Ohta, A., Schumacher, F-R., Mehellou, Y., Johnson, C., Knebel, A., Macartney, T. J., Wood, N. T., Alessi, D. R. & Kurz, T. 1 Apr 2013 In : Biochemical Journal. 451, 1, p. 111-122 12 p.

    Research output: Contribution to journalArticle

  30. DNA-binding regulates site-specific ubiquitination of IRF-1

    Landré, V., Pion, E., Narayan, V., Xirodimas, D. P. & Ball, K. L. 1 Feb 2013 In : Biochemical Journal. 449, 3, p. 707-717 11 p.

    Research output: Contribution to journalArticle

  31. AS160 deficiency causes whole-body insulin resistance via composite effects in multiple tissues.

    Chen, H-Y., Ducommun, S., Quan, C., Xie, B., Li, M., Wasserman, D. H., Sakamoto, K., MacKintosh, C. & Chen, S. 15 Jan 2013 In : Biochemical Journal. 449, 2, p. 479-489 11 p.

    Research output: Contribution to journalArticle

  32. Characterization of Staphylococcus aureus EssB, an integral membrane component of the Type VII secretion system: atomic resolution crystal structure of the cytoplasmic segment

    Zoltner, M., Fyfe, P. K., Palmer, T. & Hunter, W. N. 15 Jan 2013 In : Biochemical Journal. 449, 2, p. 469-477 9 p.

    Research output: Contribution to journalArticle

  33. CFTR mutations altering CFTR fragmentation

    Tosoni, K., Stobbart, M., Cassidy, D. M., Venerando, A., Pagano, M. A., Luz, S., Amaral, M. D., Kunzelmann, K., Pinna, L. A., Farinha, C. M. & Mehta, A. 2013 In : Biochemical Journal. 449, 1, p. 295-305 11 p.

    Research output: Contribution to journalArticle

  34. TfR1 interacts with the IKK complex and is involved in IKK-NF-kappaB signalling

    Kenneth, N. S., Mudie, S., Naron, S. & Rocha, S. 2013 In : Biochemical Journal. 449, p. 275-284

    Research output: Contribution to journalArticle

  35. Ube2W conjugates ubiquitin to α-amino groups of protein N-termini

    Tatham, M. H., Plechanovova, A., Jaffray, E. G., Salmen, H. & Hay, R. T. 2013 In : Biochemical Journal. 453, 1, p. 137-145 9 p.

    Research output: Contribution to journalArticle

  36. 2-APB-potentiated channels amplify CatSper-induced Ca signals in human sperm

    Lefièvre, L., Nash, K., Mansell, S., Costello, S., Punt, E., Correia, J., Morris, J., Kirkman-Brown, J., Wilson, S. M., Barratt, C. L. R. & Publicover, S. Dec 2012 In : Biochemical Journal. 448, 2, p. 189-200 12 p.

    Research output: Contribution to journalArticle

  37. Akt is efficiently activated by PIF-pocket- and PtdIns(3,4,5)P-3-dependent mechanisms leading to resistance to PDK1 inhibitors

    Najafov, A., Shpiro, N. & Alessi, D. R. Dec 2012 In : Biochemical Journal. 448, 2, p. 285-295 11 p.

    Research output: Contribution to journalArticle

  38. AMP-activated protein kinase phosphorylates and inactivates liver glycogen synthase

    Bultot, L., Guigas, B., Von Wilamowitz-Moellendorff, A., Maisin, L., Vertommen, D., Hussain, N., Beullens, M., Guinovart, J. J., Foretz, M., Viollet, B., Sakamoto, K., Hue, L. & Rider, M. H. 1 Apr 2012 In : Biochemical Journal. 443, p. 193-203 11 p.

    Research output: Contribution to journalArticle

  39. The anti-neurodegenerative agent clioquinol regulates the transcription factor FOXO1a

    Cameron, A. R., Wallace, K., Logie, L., Prescott, A. R., Unterman, T. G., Harthill, J. & Rena, G. 1 Apr 2012 In : Biochemical Journal. 443, 1, p. 57-64 8 p.

    Research output: Contribution to journalArticle

  40. Protein kinase D2 has a restricted but critical role in T-cell antigen receptor signalling in mature T-cells

    Navarro, M. N., Sinclair, L. V., Feijoo-Carnero, C., Clarke, R., Matthews, S. A. & Cantrell, D. A. 15 Mar 2012 In : Biochemical Journal. 442, 3, p. 649-659 11 p.

    Research output: Contribution to journalArticle

  41. Both p110 alpha and p110 beta isoforms of PI3K can modulate the impact of loss-of-function of the PTEN tumour suppressor

    Berenjeno, I. M., Guillermet-Guibert, J., Pearce, W., Gray, A., Fleming, S. & Vanhaesebroeck, B. 15 Feb 2012 In : Biochemical Journal. 442, p. 151-159 9 p.

    Research output: Contribution to journalArticle

  42. Changes in the ratio of free NEDD8 to ubiquitin triggers NEDDylation by ubiquitin enzymes

    Hjerpe, R., Thomas, Y., Chen, J., Zemla, A., Curran, S., Shpiro, N., Dick, L. R. & Kurz, T. 1 Feb 2012 In : Biochemical Journal. 441, 3, p. 927-936 10 p.

    Research output: Contribution to journalArticle

  43. Characterization of the cellular action of the MSK inhibitor SB-747651A

    Naqvi, S., Macdonald, A., McCoy, C. E., Darragh, J., Reith, A. D. & Arthur, J. S. C. 1 Jan 2012 In : Biochemical Journal. 441, p. 347-357 11 p.

    Research output: Contribution to journalArticle

  44. Identification of the protein kinases that activate the E3 ubiquitin ligase Pellino 1 in the innate immune system

    Goh, E. T. H., Arthur, J. S. C., Cheung, P. C. F., Akira, S., Toth, R. & Cohen, P. 1 Jan 2012 In : Biochemical Journal. 441, p. 339-346 8 p.

    Research output: Contribution to journalArticle

  45. Reduction in BACE1 decreases body weight, protects against diet-induced obesity and enhances insulin sensitivity in mice

    Meakin, P. J., Harper, A. J., Hamilton, D. L., Gallagher, J., McNeilly, A. D., Burgess, L. A., Vaanholt, L. M., Bannon, K. A., Latcham, J., Hussain, I., Speakman, J. R., Howlett, D. R. & Ashford, M. L. J. 1 Jan 2012 In : Biochemical Journal. 441, 1, p. 285-296 12 p.

    Research output: Contribution to journalArticle

  46. SPAK/OSR1 regulate NKCC1 and WNK activity: analysis of WNK isoform interactions and activation by T-loop trans-autophosphorylation

    Thastrup, J. O., Rafiqi, F. H., Vitari, A. C., Pozo-Guisado, E., Deak, M., Mehellou, Y. & Alessi, D. R. 1 Jan 2012 In : Biochemical Journal. 441, p. 325-337 13 p.

    Research output: Contribution to journalArticle

  47. Human YKL-39 is a pseudo-chitinase with retained chitooligosaccharide- binding properties

    Schimpl, M., Rush, C. L., Betou, M., Eggleston, I. M., Recklies, A. D. & van Aalten, D. M. F. 2012 In : Biochemical Journal. 446, 1, p. 149-157 9 p.

    Research output: Contribution to journalArticle

  48. The AMPK-related kinase SIK2 is regulated by cAMP via phosphorylation at Ser in adipocytes

    Henriksson, E., Jones, H. A., Patel, K., Peggie, M., Morrice, N., Sakamoto, K. & Göransson, O. 2012 In : Biochemical Journal. 444, 3, p. 503-514 12 p.

    Research output: Contribution to journalArticle

  49. The serine/threonine kinase ULK1 is a target of multiple phosphorylation events

    Bach, M., Larance, M., James, D. E. & Ramm, G. 1 Dec 2011 In : Biochemical Journal. 440, 2, p. 283-291 9 p.

    Research output: Contribution to journalArticle

  50. mTORC2 targets AGC kinases through Sin1-dependent recruitment

    Cameron, A. J. M., Linch, M. D., Saurin, A. T., Escribano, C. & Parker, P. J. 15 Oct 2011 In : Biochemical Journal. 439, p. 287-297 11 p.

    Research output: Contribution to journalArticle

  51. Exo70, a subunit of the exocyst complex, interacts with SNEVhPrp19/hPso4 and is involved in pre-mRNA splicing

    Dellago, H., Löscher , M., Ajuh, P., Ryder, U., Kaisermayer, C., Grillari-Voglauer, R., Fortschegger, K., Gross, S., Gstraunthaler, A., Borth, N., Eisenhaber, F., Lamond, A. I. & Grillari, J. 15 Aug 2011 In : Biochemical Journal. 438, p. 81-91 11 p.

    Research output: Contribution to journalArticle

  52. Protor-1 is required for efficient mTORC2-mediated activation of SGK1 in the kidney

    Pearce, L. R., Sommer, E. M., Sakamoto, K., Wullschleger, S. & Alessi, D. R. 15 May 2011 In : Biochemical Journal. 436, p. 169-179 11 p.

    Research output: Contribution to journalArticle

  53. Phosphorylation of cAMP-specific PDE4A5 (phosphodiesterase-4A5) by MK2 (MAPKAPK2) attenuates its activation through protein kinase A phosphorylation

    MacKenzie, K. F., Wallace, D. A., Hill, E. V., Anthony, D. F., Henderson, D. J. P., Houslay, D. M., Arthur, J. S. C., Baillie, G. S. & Houslay, M. D. 1 May 2011 In : Biochemical Journal. 435, p. 755-769 15 p.

    Research output: Contribution to journalArticle

  54. Counter-modulation of fatty acid-induced pro-inflammatory nuclear factor kappa B signalling in rat skeletal muscle cells by AMP-activated protein kinase

    Green, C. J., Macrae, K., Fogarty, S., Hardie, D. G., Sakamoto, K. & Hundal, H. S. 15 Apr 2011 In : Biochemical Journal. 435, 2, p. 463-474 12 p.

    Research output: Contribution to journalArticle

  55. Identification and characterization of AtI-2, an Arabidopsis homologue of an ancient protein phosphatase 1 (PP1) regulatory subunit

    Templeton, G. W., Nimick, M., Morrice, N., Campbell, D., Goudreault, M., Gingras, A-C., Takemiya, A., Shimazaki, K. & Moorhead, G. B. G. 1 Apr 2011 In : Biochemical Journal. 435, p. 73-83 11 p.

    Research output: Contribution to journalArticle

  56. The role of TBK1 and IKK epsilon in the expression and activation of Pellino 1

    Smith, H., Liu, X-Y., Da, L., Goh, E. T. H., Chan, A-T., Xi, J., Seh, C-C., Qureshi, I. A., Lescar, J., Ruedl, C., Gourlay, R., Morton, S., Hough, J., McIver, E. G., Cohen, P. & Cheung, P. C. F. 15 Mar 2011 In : Biochemical Journal. 434, p. 537-548 12 p.

    Research output: Contribution to journalArticle

  57. Functional interactions between ubiquitin E2 enzymes and TRIM proteins

    Napolitano, L. M., Jaffray, E. G., Hay, R. T. & Meroni, G. 1 Mar 2011 In : Biochemical Journal. 434, p. 309-319 11 p.

    Research output: Contribution to journalArticle

  58. Role of TAPP1 and TAPP2 adaptor binding to PtdIns(3,4)P-2 in regulating insulin sensitivity defined by knock-in analysis

    Wullschleger, S., Wasserman, D. H., Gray, A., Sakamoto, K. & Alessi, D. R. 1 Mar 2011 In : Biochemical Journal. 434, p. 265-274 10 p.

    Research output: Contribution to journalArticle

  59. Novel cross-talk within the IKK family controls innate immunity

    Clark, K., Peggie, M., Plater, L., Sorcek, R. J., Young, E. R. R., Madwed, J. B., Hough, J., McIver, E. G. & Cohen, P. 15 Feb 2011 In : Biochemical Journal. 434, p. 93-104 12 p.

    Research output: Contribution to journalArticle

  60. ERK/p90(RSK)/14-3-3 signalling has an impact on expression of PEA3 Ets transcription factors via the transcriptional repressor capicua

    Dissanayake, K., Toth, R., Blakey, J., Olsson, O., Campbell, D. G., Prescott, A. R. & MacKintosh, C. 1 Feb 2011 In : Biochemical Journal. 433, p. 515-525 11 p.

    Research output: Contribution to journalArticle

  61. Characterization of GSK2334470, a novel and highly specific inhibitor of PDK1

    Najafov, A., Sommer, E. M., Axten, J. M., DeYoung, M. P. & Alessi, D. R. 15 Jan 2011 In : Biochemical Journal. 433, p. 357-369 13 p.

    Research output: Contribution to journalArticle

  62. Structural investigation of inhibitor designs targeting 3-dehydroquinate dehydratase from the shikimate pathway of Mycobacterium tuberculosis

    Dias, M. V. B., Snee, W. C., Bromfield, K. M., Payne, R. J., Palaninathan, S. K., Ciulli, A., Howard, N. I., Abell, C., Sacchettini, J. C. & Blundell, T. L. 2011 In : Biochemical Journal. 436, 3, p. 729-739 11 p.

    Research output: Contribution to journalArticle

  63. TTBK2 kinase substrate specificity and the impact of spinocerebellar-ataxia-causing mutations on expression, activity, localization and development

    Bouskila, M., Esoof, N., Gay, L., Fang, E. H., Deak, M., Begley, M. J., Cantley, L. C., Prescott, A., Storey, K. G. & Alessi, D. R. 2011 In : Biochemical Journal. 437, p. 157-167 11 p.

    Research output: Contribution to journalArticle

  64. Human OGA binds substrates in a conserved peptide recognition groove

    Schimpl, M., Schuettelkopf, A. W., Borodkin, V. S. & van Aalten, D. M. F. 15 Nov 2010 In : Biochemical Journal. 432, p. 1-7 7 p.

    Research output: Contribution to journalArticle

  65. Unique functions for protein kinase D1 and protein kinase D2 in mammalian cells

    Matthews, S. A., Navarro, M. N., Sinclair, L. V., Emslie, E., Feijoo-Carnero, C. & Cantrell, D. A. 15 Nov 2010 In : Biochemical Journal. 432, p. 153-163 11 p.

    Research output: Contribution to journalArticle

  66. Characterization of PF-4708671, a novel and highly specific inhibitor of p70 ribosomal S6 kinase (S6K1)

    Pearce, L. R., Alton, G. R., Richter, D. T., Kath, J. C., Lingardo, L., Chapman, J., Hwang, C. & Alessi, D. R. 15 Oct 2010 In : Biochemical Journal. 431, p. 245-255 11 p.

    Research output: Contribution to journalArticle

  67. 14-3-3 binding to LRRK2 is disrupted by multiple Parkinson's disease-associated mutations and regulates cytoplasmic localization

    Nichols, R. J., Dzamko, N., Morrice, N. A., Campbell, D. G., Deak, M., Ordureau, A., Macartney, T., Tong, Y., Shen, J., Prescott, A. R. & Alessi, D. R. 15 Sep 2010 In : Biochemical Journal. 430, p. 393-404 12 p.

    Research output: Contribution to journalArticle

  68. Inhibition of LRRK2 kinase activity leads to dephosphorylation of Ser(910)/Ser(935), disruption of 14-3-3 binding and altered cytoplasmic localization

    Dzamko, N., Deak, M., Hentati, F., Reith, A. D., Prescott, A. R., Alessi, D. R. & Nichols, R. J. 15 Sep 2010 In : Biochemical Journal. 430, p. 405-413 9 p.

    Research output: Contribution to journalArticle

  69. Loss of AMP-activated protein kinase alpha 2 subunit in mouse beta-cells impairs glucose-stimulated insulin secretion and inhibits their sensitivity to hypoglycaemia

    Beall, C., Piipari, K., Al-Qassab, H., Smith, M. A., Parker, N., Carling, D., Viollet, B., Withers, D. J. & Ashford, M. L. J. 15 Jul 2010 In : Biochemical Journal. 429, 2, p. 323-333 11 p.

    Research output: Contribution to journalArticle

  70. Structural basis for the efficient phosphorylation of AZT-MP (3 '-azido-3 '-deoxythymidine monophosphate) and dGMP by Plasmodium falciparum type I thymidylate kinase

    Whittingham, J. L., Carrero-Lerida, J., Brannigan, J. A., Ruiz-Perez, L. M., Silva, A. P. G., Fogg, M. J., Wilkinson, A. J., Gilbert, I. H., Wilson, K. S. & Gonzalez-Pacanowska, D. 15 Jun 2010 In : Biochemical Journal. 428, p. 499-509 11 p.

    Research output: Contribution to journalArticle

  71. Regulation of the miR-212/132 locus by MSK1 and CREB in response to neurotrophins

    Remenyi, J., Hunter, C. J., Cole, C., Ando, H., Impey, S., Monk, C. E., Martin, K. J., Barton, G. J., Hutvagner, G. & Arthur, J. S. C. 1 Jun 2010 In : Biochemical Journal. 428, 2, p. 281-291 11 p.

    Research output: Contribution to journalArticle

  72. Selective SUMO modification of cAMP-specific phosphodiesterase-4D5 (PDE4D5) regulates the functional consequences of phosphorylation by PKA and ERK

    Li, X., Vadrevu, S., Dunlop, A., Day, J., Advant, N., Troeger, J., Klussmann, E., Jaffray, E., Hay, R. T., Adams, D. R., Houslay, M. D. & Baillie, G. S. 15 May 2010 In : Biochemical Journal. 428, p. 55-65 11 p.

    Research output: Contribution to journalArticle

  73. Bioinformatic and experimental survey of 14-3-3-binding sites

    Johnson, C., Crowther, S., Stafford, M. J., Campbell, D. G., Toth, R. & MacKintosh, C. 1 Apr 2010 In : Biochemical Journal. 427, 1, p. 69-78 10 p.

    Research output: Contribution to journalArticle

  74. Molecular mechanism of elongation factor 1A inhibition by a Legionella pneumophila glycosyltransferase

    Hurtado-Guerrero, R., Zusman, T., Pathak, S., Ibrahim, A. F. M., Shepherd, S., Prescott, A., Segal, G. & van Aalten, D. M. F. 15 Mar 2010 In : Biochemical Journal. 426, p. 281-292 12 p.

    Research output: Contribution to journalArticle

  75. Calmodulin-dependent protein kinase kinase-beta activates AMPK without forming a stable complex: synergistic effects of Ca2+ and AMP

    Fogarty, S., Hawley, S. A., Green, K. A., Saner, N., Mustard, K. J. & Hardie, D. G. 15 Feb 2010 In : Biochemical Journal. 426, p. 109-118 10 p.

    Research output: Contribution to journalArticle

  76. Cystic fibrosis transmembrane regulator fragments with the Phe(508) deletion exert a dual allosteric control over the master kinase CK2

    Pagano, M. A., Marin, O., Cozza, G., Sarno, S., Meggio, F., Treharne, K. J., Mehta, A. & Pinna, L. A. 15 Feb 2010 In : Biochemical Journal. 426, 1, p. 19-29 11 p.

    Research output: Contribution to journalArticle

  77. Insulin-stimulated phosphorylation of endothelial nitric oxide synthase at serine-615 contributes to nitric oxide synthesis

    Ritchie, S. A., Kohlhaas, C. F., Boyd, A. R., Yalla, K. C., Walsh, K., Connell, J. M. C. & Salt, I. P. 15 Feb 2010 In : Biochemical Journal. 426, p. 85-90 6 p.

    Research output: Contribution to journalArticle

  78. MSK1 regulates the transcription of IL-1ra in response to TLR activation in macrophages

    Darragh, J., Ananieva, O., Courtney, A., Elcombe, S. & Arthur, J. S. C. 1 Feb 2010 In : Biochemical Journal. 425, p. 595-602 8 p.

    Research output: Contribution to journalArticle

  79. Regulation of mRNA cap methylation

    Cowling, V. H. 15 Jan 2010 In : Biochemical Journal. 425, p. 295-302 8 p.

    Research output: Contribution to journalScientific review

  80. Guidelines for the effective use of chemical inhibitors of protein function to understand their roles in cell regulation

    Cohen, P. 1 Jan 2010 In : Biochemical Journal. 425, p. 53-54 2 p.

    Research output: Contribution to journalScientific review

  81. IRAK1-independent pathways required for the interleukin-1-stimulated activation of the Tpl2 catalytic subunit and its dissociation from ABIN2

    Handoyo, H., Stafford, M. J., McManus, E., Baltzis, D., Peggie, M. & Cohen, P. 15 Nov 2009 In : Biochemical Journal. 424, p. 109-118 10 p.

    Research output: Contribution to journalArticle

  82. Substrate specificity and inhibitors of LRRK2, a protein kinase mutated in Parkinson's disease

    Nichols, R. J., Dzamko, N., Hutti, J. E., Cantley, L. C., Deak, M., Moran, J., Bamborough, P., Reith, A. D. & Alessi, D. R. 15 Nov 2009 In : Biochemical Journal. 424, p. 47-60 14 p.

    Research output: Contribution to journalArticle

  83. Glucocorticoids can activate the alpha-EnaC gene promoter independently of SGK1

    McTavish, N., Getty, J., Burchell, A. & Wilson, S. M. 15 Oct 2009 In : Biochemical Journal. 423, p. 189-197 9 p.

    Research output: Contribution to journalArticle

  84. Characterization of SENP7, a SUMO-2/3-specific isopeptidase

    Shen, L. N., Geoffroy, M-C., Jaffray, E. G. & Hay, R. T. 15 Jul 2009 In : Biochemical Journal. 421, p. 223-230 8 p.

    Research output: Contribution to journalArticle

  85. Ku-0063794 is a specific inhibitor of the mammalian target of rapamycin (mTOR)

    Garcia-Martinez, J. M., Moran, J., Clarke, R. G., Gray, A., Cosulich, S. C., Chresta, C. M. & Alessi, D. R. 1 Jul 2009 In : Biochemical Journal. 421, p. 29-42 14 p.

    Research output: Contribution to journalArticle

  86. GIcNAcstatins are nanomolar inhibitors of human O-GIcNAcase inducing cellular hyper-O-GIcNAcylation

    Dorfmueller, H. C., Borodkin, V. S., Schimpl, M. & van Aalten, D. M. F. 1 Jun 2009 In : Biochemical Journal. 420, p. 221-227 7 p.

    Research output: Contribution to journalArticle

  87. Insulin resistance in polycystic ovary syndrome is associated with defective regulation of ERK1/2 by insulin in skeletal muscle in vivo

    Rajkhowa, M., Brett, S., Cuthbertson, D. J., Lipina, C., Ruiz-Alcaraz, A. J., Thomas, G. E., Logie, L., Petrie, J. R. & Sutherland, C. 15 Mar 2009 In : Biochemical Journal. 418, p. 665-671 7 p.

    Research output: Contribution to journalArticle

  88. Phosphorylation of Ewing's sarcoma protein (EWS) and EWS-Fli1 in response to DNA damage

    Klevernic, I. V., Morton, S., Davis, R. J. & Cohen, P. 15 Mar 2009 In : Biochemical Journal. 418, p. 625-634 10 p.

    Research output: Contribution to journalArticle

  89. Modulating serine palmitoyl transferase (SPT) expression and activity unveils a crucial role in lipid-induced insulin resistance in rat skeletal muscle cells

    Watson, M. L., Coghlan, M. & Hundal, H. S. 1 Feb 2009 In : Biochemical Journal. 417, 1, p. 791-801 11 p.

    Research output: Contribution to journalArticle

  90. Unsaturated fatty acid regulation of cytochrome P450 expression via a CAR-dependent pathway

    Finn, R. D., Henderson, C. J., Scott, C. L. & Wolf, C. R. 1 Jan 2009 In : Biochemical Journal. 417, 1, p. 43-54 12 p.

    Research output: Contribution to journalArticle

  91. mTOR complex 2 (mTORC2) controls hydrophobic motif phosphorylation and activation of serum- and glucocorticoid-induced protein kinase 1 (SGK1)

    Garcia-Martinez, J. M. & Alessi, D. R. 15 Dec 2008 In : Biochemical Journal. 416, 3, p. 375-385 11 p.

    Research output: Contribution to journalArticle

  92. A novel short splice variant of the tumour suppressor LKB1 is required for spermiogenesis

    Towler, M. C., Fogarty, S., Hawley, S. A., Pan, D. A., Martin, D. M. A., Morrice, N. A., McCarthy, A., Galardo, M. N., Meroni, S. B., Cigorraga, S. B., Ashworth, A., Sakamoto, K. & Hardie, D. G. 15 Nov 2008 In : Biochemical Journal. 416, 1, p. 1-14 14 p.

    Research output: Contribution to journalArticle

  93. Identification and characterization of FUS/TLS as a new target of ATM

    Gardiner, M., Toth, R., Vandermoere, F., Morrice, N. A. & Rouse, J. 15 Oct 2008 In : Biochemical Journal. 415, p. 297-307 11 p.

    Research output: Contribution to journalArticle

  94. Structural and kinetic differences between human and Aspergillus fumigatus D-glucosamine-6-phosphate N-acetyltransferase

    Hurtado-Guerrero, R., Raimi, O. G., Min, J., Zeng, H., Vallius, L., Shepherd, S., Ibrahim, A. F. M., Wu, H., Plotnikov, A. N. & van Aalten, D. M. F. 15 Oct 2008 In : Biochemical Journal. 415, p. 217-223 7 p.

    Research output: Contribution to journalArticle

  95. Structural and mechanistic insights into type II trypanosomatid tryparedoxin-dependent peroxidases

    Alphey, M. S., Konig, J. & Fairlamb, A. H. 15 Sep 2008 In : Biochemical Journal. 414, 3, p. 375-381 7 p.

    Research output: Contribution to journalArticle

  96. Regulation of gene expression by hypoxia

    Kenneth, N. S. & Rocha, S. 15 Aug 2008 In : Biochemical Journal. 414, 1, p. 19-29 11 p.

    Research output: Contribution to journalScientific review

  97. Regulation of hypoxia-inducible factor-1 alpha by NF-kappa B

    van Uden, P., Kenneth, N. S. & Rocha, S. 15 Jun 2008 In : Biochemical Journal. 412, 3, p. 477-484 8 p.

    Research output: Contribution to journalArticle

  98. Important role of the LKB1-AMPK pathway in suppressing tumorigenesis in PTEN-deficient mice

    Huang, X., Wullschleger, S., Shpiro, N., McGuire, V. A., Sakamoto, K., Woods, Y. L., McBurnie, W., Fleming, S. & Alessi, D. R. 1 Jun 2008 In : Biochemical Journal. 412, p. 211-221 11 p.

    Research output: Contribution to journalArticle

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