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  1. The anti-inflammatory drug BAY 11-7082 suppresses the MyD88-dependent signalling network by targeting the ubiquitin system

    Strickson, S., Campbell, D. G., Emmerich, C. H., Knebel, A., Plater, L., Ritorto, M. S., Shpiro, N. & Cohen, P. 1-May-2013 In : Biochemical Journal. 451, 3, p. 427-437, 11 p.

    Research output: Contribution to journal › Article

  2. The P-body component USP52/PAN2 is a novel regulator of HIF1A mRNA stability

    Bett, J. S., Ibrahim, A. F. M., Garg, A. K., Kelly, V., Pedrioli, P., Rocha, S. & Hay, R. T. 15-Apr-2013 In : Biochemical Journal. 451, 2, p. 185-194, 10 p., BJ20130026

    Research output: Contribution to journal › Article

  3. The CUL3-KLHL3 E3 ligase complex mutated in Gordon's hypertension syndrome interacts with and ubiquitylates WNK isoforms: disease-causing mutations in KLHL3 and WNK4 disrupt interaction

    Ohta, A., Schumacher, F-R., Mehellou, Y., Johnson, C., Knebel, A., Macartney, T. J., Wood, N. T., Alessi, D. R. & Kurz, T. 1-Apr-2013 In : Biochemical Journal. 451, 1, p. 111-122, 12 p.

    Research output: Contribution to journal › Article

  4. Characterisation of a pre-export enzyme-chaperone complex on the twin-arginine transport pathway

    Dow, J. M., Gabel, F., Sargent, F. & Palmer, T. 1-Mar-2013 In : Biochemical Journal.

    Research output: Contribution to journal › Article

  5. DNA-binding regulates site-specific ubiquitination of IRF-1

    Landré, V., Pion, E., Narayan, V., Xirodimas, D. P. & Ball, K. L. 1-Feb-2013 In : Biochemical Journal. 449, 3, p. 707-717, 11 p.

    Research output: Contribution to journal › Article

  6. AS160 deficiency causes whole-body insulin resistance via composite effects in multiple tissues.

    Chen, H-Y., Ducommun, S., Quan, C., Xie, B., Li, M., Wasserman, D. H., Sakamoto, K., MacKintosh, C. & Chen, S. 15-Jan-2013 In : Biochemical Journal. 449, 2, p. 479-489, 11 p.

    Research output: Contribution to journal › Article

  7. Characterization of Staphylococcus aureus EssB, an integral membrane component of the Type VII secretion system: atomic resolution crystal structure of the cytoplasmic segment

    Zoltner, M., Fyfe, P. K., Palmer, T. & Hunter, W. N. 15-Jan-2013 In : Biochemical Journal. 449, 2, p. 469-477, 9 p.

    Research output: Contribution to journal › Article

  8. CFTR mutations altering CFTR fragmentation

    Tosoni, K., Stobbart, M., Cassidy, D. M., Venerando, A., Pagano, M. A., Luz, S., Amaral, M. D., Kunzelmann, K., Pinna, L. A., Farinha, C. M. & Mehta, A. 2013 In : Biochemical Journal. 449, 1, p. 295-305, 11 p.

    Research output: Contribution to journal › Article

  9. TfR1 interacts with the IKK complex and is involved in IKK-NF-kappaB signalling

    Kenneth, N. S., Mudie, S., Naron, S. & Rocha, S. 2013 In : Biochemical Journal. 449, p. 275-284

    Research output: Contribution to journal › Article

  10. 2-APB-potentiated channels amplify CatSper-induced Ca signals in human sperm

    Lefièvre, L., Nash, K., Mansell, S., Costello, S., Punt, E., Correia, J., Morris, J., Kirkman-Brown, J., Wilson, S. M., Barratt, C. L. R. & Publicover, S. Dec-2012 In : Biochemical Journal. 448, 2, p. 189-200, 12 p.

    Research output: Contribution to journal › Article

  11. Akt is efficiently activated by PIF-pocket- and PtdIns(3,4,5)P-3-dependent mechanisms leading to resistance to PDK1 inhibitors

    Najafov, A., Shpiro, N. & Alessi, D. R. Dec-2012 In : Biochemical Journal. 448, 2, p. 285-295, 11 p.

    Research output: Contribution to journal › Article

  12. AMP-activated protein kinase phosphorylates and inactivates liver glycogen synthase

    Bultot, L., Guigas, B., Von Wilamowitz-Moellendorff, A., Maisin, L., Vertommen, D., Hussain, N., Beullens, M., Guinovart, J. J., Foretz, M., Viollet, B., Sakamoto, K., Hue, L. & Rider, M. H. 1-Apr-2012 In : Biochemical Journal. 443, p. 193-203, 11 p.

    Research output: Contribution to journal › Article

  13. The anti-neurodegenerative agent clioquinol regulates the transcription factor FOXO1a

    Cameron, A. R., Wallace, K., Logie, L., Prescott, A. R., Unterman, T. G., Harthill, J. & Rena, G. 1-Apr-2012 In : Biochemical Journal. 443, p. 57-64, 8 p.

    Research output: Contribution to journal › Article

  14. Protein kinase D2 has a restricted but critical role in T-cell antigen receptor signalling in mature T-cells

    Navarro, M. N., Sinclair, L. V., Feijoo-Carnero, C., Clarke, R., Matthews, S. A. & Cantrell, D. A. 15-Mar-2012 In : Biochemical Journal. 442, 3, p. 649-659, 11 p.

    Research output: Contribution to journal › Article

  15. Both p110 alpha and p110 beta isoforms of PI3K can modulate the impact of loss-of-function of the PTEN tumour suppressor

    Berenjeno, I. M., Guillermet-Guibert, J., Pearce, W., Gray, A., Fleming, S. & Vanhaesebroeck, B. 15-Feb-2012 In : Biochemical Journal. 442, p. 151-159, 9 p.

    Research output: Contribution to journal › Article

  16. Changes in the ratio of free NEDD8 to ubiquitin triggers NEDDylation by ubiquitin enzymes

    Hjerpe, R., Thomas, Y., Chen, J., Zemla, A., Curran, S., Shpiro, N., Dick, L. R. & Kurz, T. 1-Feb-2012 In : Biochemical Journal. 441, p. 927-936, 10 p.

    Research output: Contribution to journal › Article

  17. Characterization of the cellular action of the MSK inhibitor SB-747651A

    Naqvi, S., Macdonald, A., McCoy, C. E., Darragh, J., Reith, A. D. & Arthur, J. S. C. 1-Jan-2012 In : Biochemical Journal. 441, p. 347-357, 11 p.

    Research output: Contribution to journal › Article

  18. Identification of the protein kinases that activate the E3 ubiquitin ligase Pellino 1 in the innate immune system

    Goh, E. T. H., Arthur, J. S. C., Cheung, P. C. F., Akira, S., Toth, R. & Cohen, P. 1-Jan-2012 In : Biochemical Journal. 441, p. 339-346, 8 p.

    Research output: Contribution to journal › Article

  19. Reduction in BACE1 decreases body weight, protects against diet-induced obesity and enhances insulin sensitivity in mice

    Meakin, P. J., Harper, A. J., Hamilton, D. L., Gallagher, J., McNeilly, A. D., Burgess, L. A., Vaanholt, L. M., Bannon, K. A., Latcham, J., Hussain, I., Speakman, J. R., Howlett, D. R. & Ashford, M. L. J. 1-Jan-2012 In : Biochemical Journal. 441, p. 285-296, 12 p.

    Research output: Contribution to journal › Article

  20. SPAK/OSR1 regulate NKCC1 and WNK activity: analysis of WNK isoform interactions and activation by T-loop trans-autophosphorylation

    Thastrup, J. O., Rafiqi, F. H., Vitari, A. C., Pozo-Guisado, E., Deak, M., Mehellou, Y. & Alessi, D. R. 1-Jan-2012 In : Biochemical Journal. 441, p. 325-337, 13 p.

    Research output: Contribution to journal › Article

  21. Human YKL-39 is a pseudo-chitinase with retained chitooligosaccharide- binding properties

    Schimpl, M., Rush, C. L., Betou, M., Eggleston, I. M., Recklies, A. D. & van Aalten, D. M. F. 2012 In : Biochemical Journal. 446, 1, p. 149-157, 9 p.

    Research output: Contribution to journal › Article

  22. The AMPK-related kinase SIK2 is regulated by cAMP via phosphorylation at Ser in adipocytes

    Henriksson, E., Jones, H. A., Patel, K., Peggie, M., Morrice, N., Sakamoto, K. & Göransson, O. 2012 In : Biochemical Journal. 444, 3, p. 503-514, 12 p.

    Research output: Contribution to journal › Article

  23. mTORC2 targets AGC kinases through Sin1-dependent recruitment

    Cameron, A. J. M., Linch, M. D., Saurin, A. T., Escribano, C. & Parker, P. J. 15-Oct-2011 In : Biochemical Journal. 439, p. 287-297, 11 p.

    Research output: Contribution to journal › Article

  24. Exo70, a subunit of the exocyst complex, interacts with SNEVhPrp19/hPso4 and is involved in pre-mRNA splicing

    Dellago, H., Loescher, M., Ajuh, P., Ryder, U., Kaisermayer, C., Grillari-Voglauer, R., Fortschegger, K., Gross, S., Gstraunthaler, A., Borth, N., Eisenhaber, F., Lamond, A. I. & Grillari, J. 15-Aug-2011 In : Biochemical Journal. 438, p. 81-91, 11 p.

    Research output: Contribution to journal › Article

  25. TTBK2 kinase substrate specificity and the impact of spinocerebellar-ataxia-causing mutations on expression, activity, localization and development

    Bouskila, M., Esoof, N., Gay, L., Fang, E. H., Deak, M., Begley, M. J., Cantley, L. C., Prescott, A., Storey, K. G. & Alessi, D. R. 1-Jul-2011 In : Biochemical Journal. 437, p. 157-167, 11 p.

    Research output: Contribution to journal › Article

  26. Structural investigation of inhibitor designs targeting 3-dehydroquinate dehydratase from the shikimate pathway of Mycobacterium tuberculosis

    Dias, M. V. B., Snee, W. C., Bromfield, K. M., Payne, R. J., Palaninathan, S. K., Ciulli, A., Howard, N. I., Abell, C., Sacchettini, J. C. & Blundell, T. L. 15-Jun-2011 In : Biochemical Journal. 436, 3, p. 729-739, 11 p.

    Research output: Contribution to journal › Article

  27. Protor-1 is required for efficient mTORC2-mediated activation of SGK1 in the kidney

    Pearce, L. R., Sommer, E. M., Sakamoto, K., Wullschleger, S. & Alessi, D. R. 15-May-2011 In : Biochemical Journal. 436, p. 169-179, 11 p.

    Research output: Contribution to journal › Article

  28. Phosphorylation of cAMP-specific PDE4A5 (phosphodiesterase-4A5) by MK2 (MAPKAPK2) attenuates its activation through protein kinase A phosphorylation

    MacKenzie, K. F., Wallace, D. A., Hill, E. V., Anthony, D. F., Henderson, D. J. P., Houslay, D. M., Arthur, J. S. C., Baillie, G. S. & Houslay, M. D. 1-May-2011 In : Biochemical Journal. 435, p. 755-769, 15 p.

    Research output: Contribution to journal › Article

  29. Counter-modulation of fatty acid-induced pro-inflammatory nuclear factor kappa B signalling in rat skeletal muscle cells by AMP-activated protein kinase

    Green, C. J., Macrae, K., Fogarty, S., Hardie, D. G., Sakamoto, K. & Hundal, H. S. 15-Apr-2011 In : Biochemical Journal. 435, p. 463-474, 12 p.

    Research output: Contribution to journal › Article

  30. Identification and characterization of AtI-2, an Arabidopsis homologue of an ancient protein phosphatase 1 (PP1) regulatory subunit

    Templeton, G. W., Nimick, M., Morrice, N., Campbell, D., Goudreault, M., Gingras, A-C., Takemiya, A., Shimazaki, K. & Moorhead, G. B. G. 1-Apr-2011 In : Biochemical Journal. 435, p. 73-83, 11 p.

    Research output: Contribution to journal › Article

  31. The role of TBK1 and IKK epsilon in the expression and activation of Pellino 1

    Smith, H., Liu, X-Y., Da, L., Goh, E. T. H., Chan, A-T., Xi, J., Seh, C-C., Qureshi, I. A., Lescar, J., Ruedl, C., Gourlay, R., Morton, S., Hough, J., McIver, E. G., Cohen, P. & Cheung, P. C. F. 15-Mar-2011 In : Biochemical Journal. 434, p. 537-548, 12 p.

    Research output: Contribution to journal › Article

  32. Functional interactions between ubiquitin E2 enzymes and TRIM proteins

    Napolitano, L. M., Jaffray, E. G., Hay, R. T. & Meroni, G. 1-Mar-2011 In : Biochemical Journal. 434, p. 309-319, 11 p.

    Research output: Contribution to journal › Article

  33. Role of TAPP1 and TAPP2 adaptor binding to PtdIns(3,4)P-2 in regulating insulin sensitivity defined by knock-in analysis

    Wullschleger, S., Wasserman, D. H., Gray, A., Sakamoto, K. & Alessi, D. R. 1-Mar-2011 In : Biochemical Journal. 434, p. 265-274, 10 p.

    Research output: Contribution to journal › Article

  34. Novel cross-talk within the IKK family controls innate immunity

    Clark, K., Peggie, M., Plater, L., Sorcek, R. J., Young, E. R. R., Madwed, J. B., Hough, J., McIver, E. G. & Cohen, P. 15-Feb-2011 In : Biochemical Journal. 434, p. 93-104, 12 p.

    Research output: Contribution to journal › Article

  35. ERK/p90(RSK)/14-3-3 signalling has an impact on expression of PEA3 Ets transcription factors via the transcriptional repressor capicua

    Dissanayake, K., Toth, R., Blakey, J., Olsson, O., Campbell, D. G., Prescott, A. R. & MacKintosh, C. 1-Feb-2011 In : Biochemical Journal. 433, p. 515-525, 11 p.

    Research output: Contribution to journal › Article

  36. Characterization of GSK2334470, a novel and highly specific inhibitor of PDK1

    Najafov, A., Sommer, E. M., Axten, J. M., DeYoung, M. P. & Alessi, D. R. 15-Jan-2011 In : Biochemical Journal. 433, p. 357-369, 13 p.

    Research output: Contribution to journal › Article

  37. Human OGA binds substrates in a conserved peptide recognition groove

    Schimpl, M., Schuettelkopf, A. W., Borodkin, V. S. & van Aalten, D. M. F. 15-Nov-2010 In : Biochemical Journal. 432, p. 1-7, 7 p.

    Research output: Contribution to journal › Article

  38. Unique functions for protein kinase D1 and protein kinase D2 in mammalian cells

    Matthews, S. A., Navarro, M. N., Sinclair, L. V., Emslie, E., Feijoo-Carnero, C. & Cantrell, D. A. 15-Nov-2010 In : Biochemical Journal. 432, p. 153-163, 11 p.

    Research output: Contribution to journal › Article

  39. Characterization of PF-4708671, a novel and highly specific inhibitor of p70 ribosomal S6 kinase (S6K1)

    Pearce, L. R., Alton, G. R., Richter, D. T., Kath, J. C., Lingardo, L., Chapman, J., Hwang, C. & Alessi, D. R. 15-Oct-2010 In : Biochemical Journal. 431, p. 245-255, 11 p.

    Research output: Contribution to journal › Article

  40. 14-3-3 binding to LRRK2 is disrupted by multiple Parkinson's disease-associated mutations and regulates cytoplasmic localization

    Nichols, R. J., Dzamko, N., Morrice, N. A., Campbell, D. G., Deak, M., Ordureau, A., Macartney, T., Tong, Y., Shen, J., Prescott, A. R. & Alessi, D. R. 15-Sep-2010 In : Biochemical Journal. 430, p. 393-404, 12 p.

    Research output: Contribution to journal › Article

  41. Identification of topological determinants in the N-terminal domain of transcription factor Nrf1 that control its orientation in the endoplasmic reticulum membrane

    Zhang, Y. & Hayes, J. D. 15-Sep-2010 In : Biochemical Journal. 430, p. 497-510, 14 p.

    Research output: Contribution to journal › Article

  42. Inhibition of LRRK2 kinase activity leads to dephosphorylation of Ser(910)/Ser(935), disruption of 14-3-3 binding and altered cytoplasmic localization

    Dzamko, N., Deak, M., Hentati, F., Reith, A. D., Prescott, A. R., Alessi, D. R. & Nichols, R. J. 15-Sep-2010 In : Biochemical Journal. 430, p. 405-413, 9 p.

    Research output: Contribution to journal › Article

  43. Loss of AMP-activated protein kinase alpha 2 subunit in mouse beta-cells impairs glucose-stimulated insulin secretion and inhibits their sensitivity to hypoglycaemia

    Beall, C., Piipari, K., Al-Qassab, H., Smith, M. A., Parker, N., Carling, D., Viollet, B., Withers, D. J. & Ashford, M. L. J. 15-Jul-2010 In : Biochemical Journal. 429, p. 323-333, 11 p.

    Research output: Contribution to journal › Article

  44. Structural basis for the efficient phosphorylation of AZT-MP (3 '-azido-3 '-deoxythymidine monophosphate) and dGMP by Plasmodium falciparum type I thymidylate kinase

    Whittingham, J. L., Carrero-Lerida, J., Brannigan, J. A., Ruiz-Perez, L. M., Silva, A. P. G., Fogg, M. J., Wilkinson, A. J., Gilbert, I. H., Wilson, K. S. & Gonzalez-Pacanowska, D. 15-Jun-2010 In : Biochemical Journal. 428, p. 499-509, 11 p.

    Research output: Contribution to journal › Article

  45. Regulation of the miR-212/132 locus by MSK1 and CREB in response to neurotrophins

    Remenyi, J., Hunter, C. J., Cole, C., Ando, H., Impey, S., Monk, C. E., Martin, K. J., Barton, G. J., Hutvagner, G. & Arthur, J. S. C. 1-Jun-2010 In : Biochemical Journal. 428, p. 281-291, 11 p.

    Research output: Contribution to journal › Article

  46. Selective SUMO modification of cAMP-specific phosphodiesterase-4D5 (PDE4D5) regulates the functional consequences of phosphorylation by PKA and ERK

    Li, X., Vadrevu, S., Dunlop, A., Day, J., Advant, N., Troeger, J., Klussmann, E., Jaffray, E., Hay, R. T., Adams, D. R., Houslay, M. D. & Baillie, G. S. 15-May-2010 In : Biochemical Journal. 428, p. 55-65, 11 p.

    Research output: Contribution to journal › Article

  47. Bioinformatic and experimental survey of 14-3-3-binding sites

    Johnson, C., Crowther, S., Stafford, M. J., Campbell, D. G., Toth, R. & MacKintosh, C. 1-Apr-2010 In : Biochemical Journal. 427, p. 69-78, 10 p.

    Research output: Contribution to journal › Article

  48. Molecular mechanism of elongation factor 1A inhibition by a Legionella pneumophila glycosyltransferase

    Hurtado-Guerrero, R., Zusman, T., Pathak, S., Ibrahim, A. F. M., Shepherd, S., Prescott, A., Segal, G. & van Aalten, D. M. F. 15-Mar-2010 In : Biochemical Journal. 426, p. 281-292, 12 p.

    Research output: Contribution to journal › Article

  49. Calmodulin-dependent protein kinase kinase-beta activates AMPK without forming a stable complex: synergistic effects of Ca2+ and AMP

    Fogarty, S., Hawley, S. A., Green, K. A., Saner, N., Mustard, K. J. & Hardie, D. G. 15-Feb-2010 In : Biochemical Journal. 426, p. 109-118, 10 p.

    Research output: Contribution to journal › Article

  50. Cystic fibrosis transmembrane regulator fragments with the Phe(508) deletion exert a dual allosteric control over the master kinase CK2

    Pagano, M. A., Marin, O., Cozza, G., Sarno, S., Meggio, F., Treharne, K. J., Mehta, A. & Pinna, L. A. 15-Feb-2010 In : Biochemical Journal. 426, p. 19-29, 11 p.

    Research output: Contribution to journal › Article

  51. Insulin-stimulated phosphorylation of endothelial nitric oxide synthase at serine-615 contributes to nitric oxide synthesis

    Ritchie, S. A., Kohlhaas, C. F., Boyd, A. R., Yalla, K. C., Walsh, K., Connell, J. M. C. & Salt, I. P. 15-Feb-2010 In : Biochemical Journal. 426, p. 85-90, 6 p.

    Research output: Contribution to journal › Article

  52. MSK1 regulates the transcription of IL-1ra in response to TLR activation in macrophages

    Darragh, J., Ananieva, O., Courtney, A., Elcombe, S. & Arthur, J. S. C. 1-Feb-2010 In : Biochemical Journal. 425, p. 595-602, 8 p.

    Research output: Contribution to journal › Article

  53. Regulation of mRNA cap methylation

    Cowling, V. H. 15-Jan-2010 In : Biochemical Journal. 425, p. 295-302, 8 p.

    Research output: Contribution to journal › Scientific review

  54. Guidelines for the effective use of chemical inhibitors of protein function to understand their roles in cell regulation

    Cohen, P. 1-Jan-2010 In : Biochemical Journal. 425, p. 53-54, 2 p.

    Research output: Contribution to journal › Scientific review

  55. IRAK1-independent pathways required for the interleukin-1-stimulated activation of the Tpl2 catalytic subunit and its dissociation from ABIN2

    Handoyo, H., Stafford, M. J., McManus, E., Baltzis, D., Peggie, M. & Cohen, P. 15-Nov-2009 In : Biochemical Journal. 424, p. 109-118, 10 p.

    Research output: Contribution to journal › Article

  56. Substrate specificity and inhibitors of LRRK2, a protein kinase mutated in Parkinson's disease

    Nichols, R. J., Dzamko, N., Hutti, J. E., Cantley, L. C., Deak, M., Moran, J., Bamborough, P., Reith, A. D. & Alessi, D. R. 15-Nov-2009 In : Biochemical Journal. 424, p. 47-60, 14 p.

    Research output: Contribution to journal › Article

  57. Glucocorticoids can activate the alpha-EnaC gene promoter independently of SGK1

    McTavish, N., Getty, J., Burchell, A. & Wilson, S. M. 15-Oct-2009 In : Biochemical Journal. 423, p. 189-197, 9 p.

    Research output: Contribution to journal › Article

  58. Characterization of SENP7, a SUMO-2/3-specific isopeptidase

    Shen, L. N., Geoffroy, M-C., Jaffray, E. G. & Hay, R. T. 15-Jul-2009 In : Biochemical Journal. 421, p. 223-230, 8 p.

    Research output: Contribution to journal › Article

  59. Ku-0063794 is a specific inhibitor of the mammalian target of rapamycin (mTOR)

    Garcia-Martinez, J. M., Moran, J., Clarke, R. G., Gray, A., Cosulich, S. C., Chresta, C. M. & Alessi, D. R. 1-Jul-2009 In : Biochemical Journal. 421, p. 29-42, 14 p.

    Research output: Contribution to journal › Article

  60. GIcNAcstatins are nanomolar inhibitors of human O-GIcNAcase inducing cellular hyper-O-GIcNAcylation

    Dorfmueller, H. C., Borodkin, V. S., Schimpl, M. & van Aalten, D. M. F. 1-Jun-2009 In : Biochemical Journal. 420, p. 221-227, 7 p.

    Research output: Contribution to journal › Article

  61. Insulin resistance in polycystic ovary syndrome is associated with defective regulation of ERK1/2 by insulin in skeletal muscle in vivo

    Rajkhowa, M., Brett, S., Cuthbertson, D. J., Lipina, C., Ruiz-Alcaraz, A. J., Thomas, G. E., Logie, L., Petrie, J. R. & Sutherland, C. 15-Mar-2009 In : Biochemical Journal. 418, p. 665-671, 7 p.

    Research output: Contribution to journal › Article

  62. Phosphorylation of Ewing's sarcoma protein (EWS) and EWS-Fli1 in response to DNA damage

    Klevernic, I. V., Morton, S., Davis, R. J. & Cohen, P. 15-Mar-2009 In : Biochemical Journal. 418, p. 625-634, 10 p.

    Research output: Contribution to journal › Article

  63. The Nrf1 CNC/bZIP protein is a nuclear envelope-bound transcription factor that is activated by t-butyl hydroquinone but not by endoplasmic reticulum stressors

    Zhang, Y., Lucocq, J. M. & Hayes, J. D. 1-Mar-2009 In : Biochemical Journal. 418, p. 293-310, 18 p.

    Research output: Contribution to journal › Article

  64. Modulating serine palmitoyl transferase (SPT) expression and activity unveils a crucial role in lipid-induced insulin resistance in rat skeletal muscle cells

    Watson, M. L., Coghlan, M. & Hundal, H. S. 1-Feb-2009 In : Biochemical Journal. 417, p. 791-801, 11 p.

    Research output: Contribution to journal › Article

  65. Unsaturated fatty acid regulation of cytochrome P450 expression via a CAR-dependent pathway

    Finn, R. D., Henderson, C. J., Scott, C. L. & Wolf, C. R. 1-Jan-2009 In : Biochemical Journal. 417, p. 43-54, 12 p.

    Research output: Contribution to journal › Article

  66. mTOR complex 2 (mTORC2) controls hydrophobic motif phosphorylation and activation of serum- and glucocorticoid-induced protein kinase 1 (SGK1)

    Garcia-Martinez, J. M. & Alessi, D. R. 15-Dec-2008 In : Biochemical Journal. 416, p. 375-385, 11 p.

    Research output: Contribution to journal › Article

  67. A novel short splice variant of the tumour suppressor LKB1 is required for spermiogenesis

    Towler, M. C., Fogarty, S., Hawley, S. A., Pan, D. A., Martin, D. M. A., Morrice, N. A., McCarthy, A., Galardo, M. N., Meroni, S. B., Cigorraga, S. B., Ashworth, A., Sakamoto, K. & Hardie, D. G. 15-Nov-2008 In : Biochemical Journal. 416, p. 114, 14 p.

    Research output: Contribution to journal › Article

  68. Identification and characterization of FUS/TLS as a new target of ATM

    Gardiner, M., Toth, R., Vandermoere, F., Morrice, N. A. & Rouse, J. 15-Oct-2008 In : Biochemical Journal. 415, p. 297-307, 11 p.

    Research output: Contribution to journal › Article

  69. Structural and kinetic differences between human and Aspergillus fumigatus D-glucosamine-6-phosphate N-acetyltransferase

    Hurtado-Guerrero, R., Raimi, O. G., Min, J., Zeng, H., Vallius, L., Shepherd, S., Ibrahim, A. F. M., Wu, H., Plotnikov, A. N. & van Aalten, D. M. F. 15-Oct-2008 In : Biochemical Journal. 415, p. 217-223, 7 p.

    Research output: Contribution to journal › Article

  70. Biochemical characterization of the initial steps of the Kennedy pathway in Trypanosoma brucei: the ethanolamine and choline kinases

    Gibellini, F., Hunter, W. N. & Smith, T. K. 1-Oct-2008 In : Biochemical Journal. 415, p. 135-144, 10 p.

    Research output: Contribution to journal › Article

  71. Structural and mechanistic insights into type II trypanosomatid tryparedoxin-dependent peroxidases

    Alphey, M. S., Konig, J. & Fairlamb, A. H. 15-Sep-2008 In : Biochemical Journal. 414, 3, p. 375-381, 7 p.

    Research output: Contribution to journal › Article

  72. Regulation of gene expression by hypoxia

    Kenneth, N. S. & Rocha, S. 15-Aug-2008 In : Biochemical Journal. 414, p. 19-29, 11 p.

    Research output: Contribution to journal › Scientific review

  73. Regulation of hypoxia-inducible factor-1 alpha by NF-kappa B

    van Uden, P., Kenneth, N. S. & Rocha, S. 15-Jun-2008 In : Biochemical Journal. 412, p. 477-484, 8 p.

    Research output: Contribution to journal › Article

  74. Important role of the LKB1-AMPK pathway in suppressing tumorigenesis in PTEN-deficient mice

    Huang, X., Wullschleger, S., Shpiro, N., McGuire, V. A., Sakamoto, K., Woods, Y. L., McBurnie, W., Fleming, S. & Alessi, D. R. 1-Jun-2008 In : Biochemical Journal. 412, p. 211-221, 11 p.

    Research output: Contribution to journal › Article

  75. Negative-feedback regulation of FGF signalling by DUSP6/MKP-3 is driven by ERK1/2 and mediated by Ets factor binding to a conserved site within the DUSP6/MKP-3 gene promoter

    Ekerot, M., Stavridis, M. P., Delavaine, L., Mitchell, M. P., Staples, C., Owens, D. M., Keenan, I. D., Dickinson, R. J., Storey, K. G. & Keyse, S. M. 1-Jun-2008 In : Biochemical Journal. 412, p. 287-298, 12 p.

    Research output: Contribution to journal › Article

  76. Control of AMPK-related kinases by USP9X and atypical Lys(29)/Lys(33)-inked polyubiquitin chains

    Al-Hakim, A. K., Zagorska, A., Chapman, L., Deak, M., Peggie, M. & Alessi, D. R. 15-Apr-2008 In : Biochemical Journal. 411, p. 249-260, 12 p.

    Research output: Contribution to journal › Article

  77. The identification and characterization of novel PKC epsilon phosphorylation sites provide evidence for functional cross-talk within the PKC superfamily

    Durgan, J., Cameron, A. J., Saurin, A. I., Hanrahan, S., Totty, N., Messing, R. O. & Parker, P. J. 15-Apr-2008 In : Biochemical Journal. 411, p. 319-331, 13 p.

    Research output: Contribution to journal › Article

  78. Targeting of PKC zeta and PKB to caveolin-enriched microdomains represents a crucial step underpinning the disruption in PKB-directed signalling by ceramide

    Hajduch, E., Turban, S., Le Liepvre, X., Le Lay, S., Lipina, C., Dimopoulos, N., Dugail, I. & Hundal, H. S. 1-Mar-2008 In : Biochemical Journal. 410, p. 369-379, 11 p.

    Research output: Contribution to journal › Article

  79. Roles for TAB1 in regulating the IL-1-dependent phosphorylation of the TAB3 regulatory subunit and activity of the TAK1 complex

    Mendoza, H., Campbell, D. G., Burness, K., Hastie, J., Ronkina, N., Shim, J-H., Arthur, J. S. C., Davis, R. J., Gaestel, M., Johnson, G. L., Ghosh, S. & Cohen, P. 1-Feb-2008 In : Biochemical Journal. 409, p. 711-722, 12 p.

    Research output: Contribution to journal › Article

  80. Two different classes of E2 ubiquitin-conjugating enzymes are required for the mono-ubiquitination of proteins and elongation by polyubiquitin chains with a specific topology

    Windheim, M., Peggie, M. & Cohen, P. 1-Feb-2008 In : Biochemical Journal. 409, p. 723-729, 7 p.

    Research output: Contribution to journal › Article

  81. Complementary regulation of TBC1D1 and AS160 by growth factors, insulin and AMPK activators

    Chen, S., Murphy, J., Toth, R., Campbell, D. G., Morrice, N. A. & Mackintosh, C. 15-Jan-2008 In : Biochemical Journal. 409, p. 449-459, 11 p.

    Research output: Contribution to journal › Article

  82. The IRAK-catalysed activation of the E3 ligase function of Pellino isoforms induces the Lys(63)-linked polyubiquitination of IRAK1

    Ordureau, A., Smith, H., Windheim, M., Peggie, M., Carrick, E., Morrice, N. & Cohen, P. 2008 In : Biochemical Journal. 409, p. 43-52, 10 p.

    Research output: Contribution to journal › Article

  83. The Ser(186) phospho-acceptor site within ERK4 is essential for its ability to interact with and activate PRAK/MK5

    Perander, M., Aberg, E., Johansen, B., Dreyer, B., Guldvik, I. J., Outzen, H., Keyse, S. M. & Seternes, O-M. 2008 In : Biochemical Journal. 411, 3, p. 613-22, 10 p.

    Research output: Contribution to journal › Article

  84. The selectivity of protein kinase inhibitors: a further update

    Bain, J., Plater, L., Elliott, M., Shpiro, N., Hastie, C. J., Mclauchlan, H., Klevernic, I., Arthur, J. S. C., Alessi, D. R. & Cohen, P. 15-Dec-2007 In : Biochemical Journal. 408, p. 297-315, 19 p.

    Research output: Contribution to journal › Article

  85. BI-D1870 is a specific inhibitor of the p90 RSK (ribosomal S6 kinase) isoforms in vitro and in vivo

    Sapkota, G. P., Cummings, L., Newell, F. S., Armstrong, C., Bain, J., Frodin, M., Grauert, M., Hoffmann, M., Schnapp, G., Steegmaier, M., Cohen, P. & Alessi, D. R. 16-Oct-2007 In : Biochemical Journal. 401, 1, p. 29-38, 10 p.

    Research output: Contribution to journal › Article

  86. Regulation of multisite phosphorylation and 14-3-3 binding of AS160 in response to IGF-1, EGF, PMA and AICAR

    Geraghty, K. M., Chen, S., Harthill, J. E., Ibrahim, A. F., Toth, R., Morrice, N. A., Vandermoere, F., Moorhead, G. B., Hardie, D. G. & MacKintosh, C. 15-Oct-2007 In : Biochemical Journal. 407, p. 231-241, 11 p.

    Research output: Contribution to journal › Article

  87. The NHB1 (N-terminal homology box 1) sequence in transcription factor Nrf1 is required to anchor it to the endoplasmic reticulum and also to enable its asparagine-glycosylation

    Zhang, Y., Lucocq, J. M., Yamamoto, M. & Hayes, J. D. 2007 In : Biochemical Journal. 408, 2, p. 161-172, 12 p.

    Research output: Contribution to journal › Article

  88. TAK1-binding protein 1 is a pseudophosphatase

    Conner, S. H., Kular, G., Peggie, M., Shepherd, S., Schüttelkopf, A. W., Cohen, P. & van Aalten, D. M. F. 1-Nov-2006 In : Biochemical Journal. 399, 3, p. 427-434, 8 p.

    Research output: Contribution to journal › Article

  89. Negative regulation of the Nrf1 transcription factor by its N-terminal domain is independent of Keap1: Nrf1, but not Nrf2, is targeted to the endoplasmic reticulum

    Zhang, Y., Crouch, D. H., Yamamoto, M. & Hayes, J. D. Nov-2006 In : Biochemical Journal. 399, 3, p. 373-385, 13 p.

    Research output: Contribution to journal › Article

  90. Evidence for allosteric regulation of pH-sensitive System A (SNAT2) and System N (SNAT5) amino acid transporter activity involving a conserved histidine residue

    Baird, F. E., Pinilla-Tenas, J. J., Ogilvie, W. L. J., Ganapathy, V., Hundal, H. S. & Taylor, P. M. 15-Jul-2006 In : Biochemical Journal. 397, 2, p. 369-375, 7 p.

    Research output: Contribution to journal › Article

  91. The structure of siglec-7 in complex with sialosides: leads for rational structure-based inhibitor design

    Attrill, H., Takazawa, H., Witt, S., Kelm, S., Isecke, R., Brossmer, R., Ando, T., Ishida, H., Kiso, M., Crocker, P. R. & van Aalten, D. M. F. 15-Jul-2006 In : Biochemical Journal. 397, 2, p. 271-278, 8 p.

    Research output: Contribution to journal › Article

  92. The ubiquitin-associated domain of AMPK-related kinases regulates conformation and LKB1-mediated phosphorylation and activation

    Jaleel, M., Villa, F., Deak, M., Toth, R., Prescott, A. R., van Aalten, D. M. F. & Alessi, D. R. 15-Mar-2006 In : Biochemical Journal. 394, 3, p. 545-555, 11 p.

    Research output: Contribution to journal › Article

  93. Kinetic, inhibition and structural studies on 3-oxoacyl-ACP reductase from plasmodium falciparum, a key enzyme in fatty acid biosynthesis

    Wickramasinghe, S. R., Inglis, K. A., Urch, J. E., Müller, S., van Aalten, D. M. F. & Fairlamb, A. H. 15-Jan-2006 In : Biochemical Journal. 393, 2, p. 447-457, 11 p.

    Research output: Contribution to journal › Article

  94. A novel regulation of IRS1 (insulin receptor substrate-1) expression following short term insulin administration

    Ruiz-Alcaraz, A. J., Liu, H-K., Cuthbertson, D. J., McManus, E. J., Akhtar, S., Lipina, C., Morris, A. D., Petrie, J. R., Hundal, H. S. & Sutherland, C. 1-Dec-2005 In : Biochemical Journal. 392, p. 345-352, 8 p.

    Research output: Contribution to journal › Article

  95. The WNK1 and WNK4 protein kinases that are mutated in Gordon's hypertension syndrome phosphorylate and activate SPAK and OSR1 protein kinases

    Alessi, D., Deak, M., Morrice, N. & Vitari, A. Oct-2005 In : Biochemical Journal. 391, 1, p. 17-24, 8 p.

    Research output: Contribution to journal › Article

  96. Relationship between hepatic phenotype and changes in gene expression in cytochrome P450 reductase (POR) null mice

    Wang, X. J., Chamberlain, M., Vassieva, O., Henderson, C. J. & Wolf, C. R. 15-Jun-2005 In : Biochemical Journal. 388, 3, p. 857-867, 11 p.

    Research output: Contribution to journal › Article

  97. Human protein phosphatase 5 dissociates from heat-shock proteins and is proteolytically activated in response to arachidonic acid and the microtubule-depolymerizing drug nocodazole

    Zeke, T., Morrice, N., Vazquez-Martin, C. & Cohen, T. Jan-2005 In : Biochemical Journal. 385, 1, p. 45-56, 12 p.

    Research output: Contribution to journal › Article

  98. Analysis of hepatic gene transcription in mice expressing insulin-insensitive GSK3

    Lipina, C., Huang, X., Finlay, D., McManus, E. J., Alessi, D. R. & Sutherland, C. 2005 In : Biochemical Journal. 392, 3, p. 633-639, 7 p.

    Research output: Contribution to journal › Article

  99. Deficiency of PDK1 in liver results in glucose intolerance, impairment of insulin-regulated gene expression and liver failure

    Mora, A., Lipina, C., Tronche, F., Sutherland, C. & Alessi, D. R. 2005 In : Biochemical Journal. 385, 3, p. 639-648, 10 p.

    Research output: Contribution to journal › Article

  100. In vivo functional characterization of the Escherichia coli ammonium channel AmtB: evidence for metabolic coupling of AmtB to glutamine synthetase

    Javelle, A., Thomas, G., Marini, A-M., Krämer, R. & Merrick, M. 2005 In : Biochemical Journal. 390, 1, p. 215-22, 8 p.

    Research output: Contribution to journal › Article

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