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Biochemical Journal

  1. Differential regulation by AMP and ADP of AMPK complexes containing different γ subunit isoforms

    Ross, F. A., Jensen, T. E. & Hardie, D. G. 15 Jan 2016 In : Biochemical Journal. 473, 2, p. 189-199 11 p.

    Research output: Contribution to journalArticle

  2. GSK3-mediated raptor phosphorylation supports amino acid-dependent Q2 mTORC1-directed signalling

    Stretton, C., Hoffmann, T. M., Munson, M. J., Prescott, A., Taylor, P. M., Ganley, I. G. & Hundal, H. 1 Sep 2015 In : Biochemical Journal. 470, 2, p. 207-221

    Research output: Contribution to journalArticle

  3. A mutant O-GlcNAcase as a probe to reveal global dynamics of protein O-GlcNAcylation during Drosophila embryonic development

    Mariappa, D., Selvan, N., Borodkin, V. S., Alonso , J., Ferenbach, A. T., Shepherd, C., Navratilova, I. H. & Van Aalten, D. M. F. Sep 2015 In : Biochemical Journal. 470, 2, p. 255-262 8 p.

    Research output: Contribution to journalArticle

  4. Regulation of the p53 response and its relationship to cancer

    Meek, D. W. 23 Jul 2015 In : Biochemical Journal. 469, 3, p. 325-346 22 p.

    Research output: Contribution to journalArticle

  5. Suppression of interferon β gene transcription by inhibitors of bromodomain and extra-terminal (BET) family members

    Malik, N., Vollmer, S., Nanda, S. K., Lopez-Pelaez, M., Prescott, A., Gray, N. & Cohen, P. 15 Jun 2015 In : Biochemical Journal. 468, 3, p. 363-372 10 p.

    Research output: Contribution to journalArticle

  6. Proteome-wide identification and quantification of S-glutathionylation targets in mouse liver

    McGarry, D. J., Chen, W., Chakravarty, P., Lamont, D. L., Wolf, C. R. & Henderson, C. J. Jun 2015 In : Biochemical Journal. 469, 1, p. 25-32 8 p.

    Research output: Contribution to journalArticle

  7. Targeting Cullin-RING E3 ubiquitin ligases for drug discovery: structure, assembly and small-molecule modulation

    Bulatov, E. & Ciulli, A. 1 May 2015 In : Biochemical Journal. 467, 3, p. 365-386 22 p.

    Research output: Contribution to journalArticle

  8. PT-1 selectively activates AMPK-γ 1 complexes in mouse skeletal muscle, but activates all three γ subunit complexes in cultured human cells by inhibiting the respiratory chain

    Jensen, T. E., Ross, F. A., Kleinert, M., Sylow, L., Knudsen, J. R., Gowans, G. J., Hardie, D. G. & Richter, E. A. May 2015 In : Biochemical Journal. 467, 3, p. 461-472 12 p.

    Research output: Contribution to journalArticle

  9. Assembly and structure of Lys33-linked polyubiquitin reveals distinct conformations

    Kristariyanto, Y. A., Choi, S-Y., Rehman, S. A. A., Ritorto, M. S., Campbell, D. G., Morrice, N. A., Toth, R. & Kulathu, Y. 15 Apr 2015 In : Biochemical Journal. 467, 2, p. 345-352 8 p.

    Research output: Contribution to journalArticle

  10. Ubiquitin-C-terminal hydrolases cleave isopeptide and peptide-linked ubiquitin from structured proteins but do not edit ubiquitin homopolymers

    Bett, J. S., Ritorto, M. S., Ewan, R., Jaffray, E. G., Virdee, S., Chin, J. W., Knebel, A., Kurz, T., Trost, M., Tatham, M. H. & Hay, R. T. 15 Mar 2015 In : Biochemical Journal. 466, 3, p. 489-498 10 p.

    Research output: Contribution to journalArticle

  11. Decreased adipogenesis and adipose tissue in mice with inactivated protein phosphatase 5

    Jacob, W., Rosenzweig, D., Vázquez-Martin, C., Duce, S. L. & Cohen, P. T. W. 15 Feb 2015 In : Biochemical Journal. 466, 1, p. 163-176 14 p.

    Research output: Contribution to journalArticle

  12. Application of a novel regulatable Cre recombinase system to define the role of liver and gut metabolism in drug oral bioavailability

    Henderson, C. J., McLaughlin, L. A., Osuna-Cabello, M., Taylor, M., Gilbert, I., McLaren, A. W. & Wolf, C. R. 1 Feb 2015 In : Biochemical Journal. 465, 3, p. 479-488 10 p.

    Research output: Contribution to journalArticle

  13. The clinically approved drugs dasatinib and bosutinib induce anti-inflammatory macrophages by inhibiting the salt-inducible kinases

    Ozanne, J., Prescott, A. R. & Clark, K. 15 Jan 2015 In : Biochemical Journal. 465, 2, p. 271-279 9 p.

    Research output: Contribution to journalArticle

  14. Characterization of VPS34-IN1, a selective inhibitor of Vps34, reveals that the phosphatidylinositol 3-phosphate-binding SGK3 protein kinase is a downstream target of class III phosphoinositide 3-kinase

    Bago, R., Malik, N., Munson, M. J., Prescott, A. R., Davies, P., Sommer, E., Shpiro, N., Ward, R., Cross, D., Ganley, I. G. & Alessi, D. R. Nov 2014 In : Biochemical Journal. 463, 3, p. 413-427 15 p.

    Research output: Contribution to journalArticle

  15. Conserved structure and domain organization among bacterial Slc26 transporters

    Compton, E. L. R., Page, K., Findlay, H. E., Haertlein, M., Moulin, M., Zachariae, U., Norman, D. G., Gabel, F. & Javelle, A. 15 Oct 2014 In : Biochemical Journal. 463, 2, p. 297-307 11 p.

    Research output: Contribution to journalArticle

  16. Chromatin and oxygen sensing in the context of JmjC histone demethylases

    Shmakova, A., Batie, M., Druker, J. & Rocha, S. 15 Sep 2014 In : Biochemical Journal. 462, 3, p. 385-395 11 p.

    Research output: Contribution to journalArticle

  17. Structures of bacterial kynurenine formamidase reveal a crowded binuclear zinc catalytic site primed to generate a potent nucleophile

    Díaz-Sáez, L., Srikannathasan, V., Zoltner, M. & Hunter, W. N. 15 Sep 2014 In : Biochemical Journal. 462, 3, p. 581-589 9 p.

    Research output: Contribution to journalArticle

  18. An unexpected twist to the activation of IKKβ: TAK1 primes IKKβ for activation by autophosphorylation

    Zhang, J., Clark, K., Lawrence, T., Peggie, M. W. & Cohen, P. 1 Aug 2014 In : Biochemical Journal. 461, 3, p. 531-537 7 p.

    Research output: Contribution to journalArticle

  19. Biochemical and genetic characterization of Trypanosoma cruzi N-myristoyltransferase

    Roberts, A. J., Torrie, L. S., Wyllie, S. & Fairlamb, A. H. 15 Apr 2014 In : Biochemical Journal. 459, 2, p. 323-332 10 p.

    Research output: Contribution to journalArticle

  20. Phosphorylation by Akt within the ST loop of AMPK-α1 down-regulates its activation in tumour cells

    Hawley, S. A., Ross, F. A., Gowans, G. J., Tibarewal, P., Leslie, N. R. & Hardie, D. G. 15 Apr 2014 In : Biochemical Journal. 459, 2, p. 275-287 13 p.

    Research output: Contribution to journalArticle

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