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  1. The anti-inflammatory drug BAY 11-7082 suppresses the MyD88-dependent signalling network by targeting the ubiquitin system

    Strickson, S., Campbell, D. G., Emmerich, C. H., Knebel, A., Plater, L., Ritorto, M. S., Shpiro, N. & Cohen, P. 1-May-2013 In : Biochemical Journal. 451, 3, p. 427-437, 11 p.

    Research output: Contribution to journal › Article

  2. The P-body component USP52/PAN2 is a novel regulator of HIF1A mRNA stability

    Bett, J. S., Ibrahim, A. F. M., Garg, A. K., Kelly, V., Pedrioli, P., Rocha, S. & Hay, R. T. 15-Apr-2013 In : Biochemical Journal. 451, 2, p. 185-194, 10 p., BJ20130026

    Research output: Contribution to journal › Article

  3. The CUL3-KLHL3 E3 ligase complex mutated in Gordon's hypertension syndrome interacts with and ubiquitylates WNK isoforms: disease-causing mutations in KLHL3 and WNK4 disrupt interaction

    Ohta, A., Schumacher, F-R., Mehellou, Y., Johnson, C., Knebel, A., Macartney, T. J., Wood, N. T., Alessi, D. R. & Kurz, T. 1-Apr-2013 In : Biochemical Journal. 451, 1, p. 111-122, 12 p.

    Research output: Contribution to journal › Article

  4. Characterisation of a pre-export enzyme-chaperone complex on the twin-arginine transport pathway

    Dow, J. M., Gabel, F., Sargent, F. & Palmer, T. 1-Mar-2013 In : Biochemical Journal.

    Research output: Contribution to journal › Article

  5. DNA-binding regulates site-specific ubiquitination of IRF-1

    Landré, V., Pion, E., Narayan, V., Xirodimas, D. P. & Ball, K. L. 1-Feb-2013 In : Biochemical Journal. 449, 3, p. 707-717, 11 p.

    Research output: Contribution to journal › Article

  6. AS160 deficiency causes whole-body insulin resistance via composite effects in multiple tissues.

    Chen, H-Y., Ducommun, S., Quan, C., Xie, B., Li, M., Wasserman, D. H., Sakamoto, K., MacKintosh, C. & Chen, S. 15-Jan-2013 In : Biochemical Journal. 449, 2, p. 479-489, 11 p.

    Research output: Contribution to journal › Article

  7. Characterization of Staphylococcus aureus EssB, an integral membrane component of the Type VII secretion system: atomic resolution crystal structure of the cytoplasmic segment

    Zoltner, M., Fyfe, P. K., Palmer, T. & Hunter, W. N. 15-Jan-2013 In : Biochemical Journal. 449, 2, p. 469-477, 9 p.

    Research output: Contribution to journal › Article

  8. CFTR mutations altering CFTR fragmentation

    Tosoni, K., Stobbart, M., Cassidy, D. M., Venerando, A., Pagano, M. A., Luz, S., Amaral, M. D., Kunzelmann, K., Pinna, L. A., Farinha, C. M. & Mehta, A. 2013 In : Biochemical Journal. 449, 1, p. 295-305, 11 p.

    Research output: Contribution to journal › Article

  9. TfR1 interacts with the IKK complex and is involved in IKK-NF-kappaB signalling

    Kenneth, N. S., Mudie, S., Naron, S. & Rocha, S. 2013 In : Biochemical Journal. 449, p. 275-284

    Research output: Contribution to journal › Article

  10. 2-APB-potentiated channels amplify CatSper-induced Ca signals in human sperm

    Lefièvre, L., Nash, K., Mansell, S., Costello, S., Punt, E., Correia, J., Morris, J., Kirkman-Brown, J., Wilson, S. M., Barratt, C. L. R. & Publicover, S. Dec-2012 In : Biochemical Journal. 448, 2, p. 189-200, 12 p.

    Research output: Contribution to journal › Article

  11. Akt is efficiently activated by PIF-pocket- and PtdIns(3,4,5)P-3-dependent mechanisms leading to resistance to PDK1 inhibitors

    Najafov, A., Shpiro, N. & Alessi, D. R. Dec-2012 In : Biochemical Journal. 448, 2, p. 285-295, 11 p.

    Research output: Contribution to journal › Article

  12. AMP-activated protein kinase phosphorylates and inactivates liver glycogen synthase

    Bultot, L., Guigas, B., Von Wilamowitz-Moellendorff, A., Maisin, L., Vertommen, D., Hussain, N., Beullens, M., Guinovart, J. J., Foretz, M., Viollet, B., Sakamoto, K., Hue, L. & Rider, M. H. 1-Apr-2012 In : Biochemical Journal. 443, p. 193-203, 11 p.

    Research output: Contribution to journal › Article

  13. The anti-neurodegenerative agent clioquinol regulates the transcription factor FOXO1a

    Cameron, A. R., Wallace, K., Logie, L., Prescott, A. R., Unterman, T. G., Harthill, J. & Rena, G. 1-Apr-2012 In : Biochemical Journal. 443, p. 57-64, 8 p.

    Research output: Contribution to journal › Article

  14. Protein kinase D2 has a restricted but critical role in T-cell antigen receptor signalling in mature T-cells

    Navarro, M. N., Sinclair, L. V., Feijoo-Carnero, C., Clarke, R., Matthews, S. A. & Cantrell, D. A. 15-Mar-2012 In : Biochemical Journal. 442, 3, p. 649-659, 11 p.

    Research output: Contribution to journal › Article

  15. Both p110 alpha and p110 beta isoforms of PI3K can modulate the impact of loss-of-function of the PTEN tumour suppressor

    Berenjeno, I. M., Guillermet-Guibert, J., Pearce, W., Gray, A., Fleming, S. & Vanhaesebroeck, B. 15-Feb-2012 In : Biochemical Journal. 442, p. 151-159, 9 p.

    Research output: Contribution to journal › Article

  16. Changes in the ratio of free NEDD8 to ubiquitin triggers NEDDylation by ubiquitin enzymes

    Hjerpe, R., Thomas, Y., Chen, J., Zemla, A., Curran, S., Shpiro, N., Dick, L. R. & Kurz, T. 1-Feb-2012 In : Biochemical Journal. 441, p. 927-936, 10 p.

    Research output: Contribution to journal › Article

  17. Characterization of the cellular action of the MSK inhibitor SB-747651A

    Naqvi, S., Macdonald, A., McCoy, C. E., Darragh, J., Reith, A. D. & Arthur, J. S. C. 1-Jan-2012 In : Biochemical Journal. 441, p. 347-357, 11 p.

    Research output: Contribution to journal › Article

  18. Identification of the protein kinases that activate the E3 ubiquitin ligase Pellino 1 in the innate immune system

    Goh, E. T. H., Arthur, J. S. C., Cheung, P. C. F., Akira, S., Toth, R. & Cohen, P. 1-Jan-2012 In : Biochemical Journal. 441, p. 339-346, 8 p.

    Research output: Contribution to journal › Article

  19. Reduction in BACE1 decreases body weight, protects against diet-induced obesity and enhances insulin sensitivity in mice

    Meakin, P. J., Harper, A. J., Hamilton, D. L., Gallagher, J., McNeilly, A. D., Burgess, L. A., Vaanholt, L. M., Bannon, K. A., Latcham, J., Hussain, I., Speakman, J. R., Howlett, D. R. & Ashford, M. L. J. 1-Jan-2012 In : Biochemical Journal. 441, p. 285-296, 12 p.

    Research output: Contribution to journal › Article

  20. SPAK/OSR1 regulate NKCC1 and WNK activity: analysis of WNK isoform interactions and activation by T-loop trans-autophosphorylation

    Thastrup, J. O., Rafiqi, F. H., Vitari, A. C., Pozo-Guisado, E., Deak, M., Mehellou, Y. & Alessi, D. R. 1-Jan-2012 In : Biochemical Journal. 441, p. 325-337, 13 p.

    Research output: Contribution to journal › Article

  21. Human YKL-39 is a pseudo-chitinase with retained chitooligosaccharide- binding properties

    Schimpl, M., Rush, C. L., Betou, M., Eggleston, I. M., Recklies, A. D. & van Aalten, D. M. F. 2012 In : Biochemical Journal. 446, 1, p. 149-157, 9 p.

    Research output: Contribution to journal › Article

  22. The AMPK-related kinase SIK2 is regulated by cAMP via phosphorylation at Ser in adipocytes

    Henriksson, E., Jones, H. A., Patel, K., Peggie, M., Morrice, N., Sakamoto, K. & Göransson, O. 2012 In : Biochemical Journal. 444, 3, p. 503-514, 12 p.

    Research output: Contribution to journal › Article

  23. mTORC2 targets AGC kinases through Sin1-dependent recruitment

    Cameron, A. J. M., Linch, M. D., Saurin, A. T., Escribano, C. & Parker, P. J. 15-Oct-2011 In : Biochemical Journal. 439, p. 287-297, 11 p.

    Research output: Contribution to journal › Article

  24. Exo70, a subunit of the exocyst complex, interacts with SNEVhPrp19/hPso4 and is involved in pre-mRNA splicing

    Dellago, H., Loescher, M., Ajuh, P., Ryder, U., Kaisermayer, C., Grillari-Voglauer, R., Fortschegger, K., Gross, S., Gstraunthaler, A., Borth, N., Eisenhaber, F., Lamond, A. I. & Grillari, J. 15-Aug-2011 In : Biochemical Journal. 438, p. 81-91, 11 p.

    Research output: Contribution to journal › Article

  25. TTBK2 kinase substrate specificity and the impact of spinocerebellar-ataxia-causing mutations on expression, activity, localization and development

    Bouskila, M., Esoof, N., Gay, L., Fang, E. H., Deak, M., Begley, M. J., Cantley, L. C., Prescott, A., Storey, K. G. & Alessi, D. R. 1-Jul-2011 In : Biochemical Journal. 437, p. 157-167, 11 p.

    Research output: Contribution to journal › Article

  26. Structural investigation of inhibitor designs targeting 3-dehydroquinate dehydratase from the shikimate pathway of Mycobacterium tuberculosis

    Dias, M. V. B., Snee, W. C., Bromfield, K. M., Payne, R. J., Palaninathan, S. K., Ciulli, A., Howard, N. I., Abell, C., Sacchettini, J. C. & Blundell, T. L. 15-Jun-2011 In : Biochemical Journal. 436, 3, p. 729-739, 11 p.

    Research output: Contribution to journal › Article

  27. Protor-1 is required for efficient mTORC2-mediated activation of SGK1 in the kidney

    Pearce, L. R., Sommer, E. M., Sakamoto, K., Wullschleger, S. & Alessi, D. R. 15-May-2011 In : Biochemical Journal. 436, p. 169-179, 11 p.

    Research output: Contribution to journal › Article

  28. Phosphorylation of cAMP-specific PDE4A5 (phosphodiesterase-4A5) by MK2 (MAPKAPK2) attenuates its activation through protein kinase A phosphorylation

    MacKenzie, K. F., Wallace, D. A., Hill, E. V., Anthony, D. F., Henderson, D. J. P., Houslay, D. M., Arthur, J. S. C., Baillie, G. S. & Houslay, M. D. 1-May-2011 In : Biochemical Journal. 435, p. 755-769, 15 p.

    Research output: Contribution to journal › Article

  29. Counter-modulation of fatty acid-induced pro-inflammatory nuclear factor kappa B signalling in rat skeletal muscle cells by AMP-activated protein kinase

    Green, C. J., Macrae, K., Fogarty, S., Hardie, D. G., Sakamoto, K. & Hundal, H. S. 15-Apr-2011 In : Biochemical Journal. 435, p. 463-474, 12 p.

    Research output: Contribution to journal › Article

  30. Identification and characterization of AtI-2, an Arabidopsis homologue of an ancient protein phosphatase 1 (PP1) regulatory subunit

    Templeton, G. W., Nimick, M., Morrice, N., Campbell, D., Goudreault, M., Gingras, A-C., Takemiya, A., Shimazaki, K. & Moorhead, G. B. G. 1-Apr-2011 In : Biochemical Journal. 435, p. 73-83, 11 p.

    Research output: Contribution to journal › Article

  31. The role of TBK1 and IKK epsilon in the expression and activation of Pellino 1

    Smith, H., Liu, X-Y., Da, L., Goh, E. T. H., Chan, A-T., Xi, J., Seh, C-C., Qureshi, I. A., Lescar, J., Ruedl, C., Gourlay, R., Morton, S., Hough, J., McIver, E. G., Cohen, P. & Cheung, P. C. F. 15-Mar-2011 In : Biochemical Journal. 434, p. 537-548, 12 p.

    Research output: Contribution to journal › Article

  32. Functional interactions between ubiquitin E2 enzymes and TRIM proteins

    Napolitano, L. M., Jaffray, E. G., Hay, R. T. & Meroni, G. 1-Mar-2011 In : Biochemical Journal. 434, p. 309-319, 11 p.

    Research output: Contribution to journal › Article

  33. Role of TAPP1 and TAPP2 adaptor binding to PtdIns(3,4)P-2 in regulating insulin sensitivity defined by knock-in analysis

    Wullschleger, S., Wasserman, D. H., Gray, A., Sakamoto, K. & Alessi, D. R. 1-Mar-2011 In : Biochemical Journal. 434, p. 265-274, 10 p.

    Research output: Contribution to journal › Article

  34. Novel cross-talk within the IKK family controls innate immunity

    Clark, K., Peggie, M., Plater, L., Sorcek, R. J., Young, E. R. R., Madwed, J. B., Hough, J., McIver, E. G. & Cohen, P. 15-Feb-2011 In : Biochemical Journal. 434, p. 93-104, 12 p.

    Research output: Contribution to journal › Article

  35. ERK/p90(RSK)/14-3-3 signalling has an impact on expression of PEA3 Ets transcription factors via the transcriptional repressor capicua

    Dissanayake, K., Toth, R., Blakey, J., Olsson, O., Campbell, D. G., Prescott, A. R. & MacKintosh, C. 1-Feb-2011 In : Biochemical Journal. 433, p. 515-525, 11 p.

    Research output: Contribution to journal › Article

  36. Characterization of GSK2334470, a novel and highly specific inhibitor of PDK1

    Najafov, A., Sommer, E. M., Axten, J. M., DeYoung, M. P. & Alessi, D. R. 15-Jan-2011 In : Biochemical Journal. 433, p. 357-369, 13 p.

    Research output: Contribution to journal › Article

  37. Human OGA binds substrates in a conserved peptide recognition groove

    Schimpl, M., Schuettelkopf, A. W., Borodkin, V. S. & van Aalten, D. M. F. 15-Nov-2010 In : Biochemical Journal. 432, p. 1-7, 7 p.

    Research output: Contribution to journal › Article

  38. Unique functions for protein kinase D1 and protein kinase D2 in mammalian cells

    Matthews, S. A., Navarro, M. N., Sinclair, L. V., Emslie, E., Feijoo-Carnero, C. & Cantrell, D. A. 15-Nov-2010 In : Biochemical Journal. 432, p. 153-163, 11 p.

    Research output: Contribution to journal › Article

  39. Characterization of PF-4708671, a novel and highly specific inhibitor of p70 ribosomal S6 kinase (S6K1)

    Pearce, L. R., Alton, G. R., Richter, D. T., Kath, J. C., Lingardo, L., Chapman, J., Hwang, C. & Alessi, D. R. 15-Oct-2010 In : Biochemical Journal. 431, p. 245-255, 11 p.

    Research output: Contribution to journal › Article

  40. 14-3-3 binding to LRRK2 is disrupted by multiple Parkinson's disease-associated mutations and regulates cytoplasmic localization

    Nichols, R. J., Dzamko, N., Morrice, N. A., Campbell, D. G., Deak, M., Ordureau, A., Macartney, T., Tong, Y., Shen, J., Prescott, A. R. & Alessi, D. R. 15-Sep-2010 In : Biochemical Journal. 430, p. 393-404, 12 p.

    Research output: Contribution to journal › Article

  41. Identification of topological determinants in the N-terminal domain of transcription factor Nrf1 that control its orientation in the endoplasmic reticulum membrane

    Zhang, Y. & Hayes, J. D. 15-Sep-2010 In : Biochemical Journal. 430, p. 497-510, 14 p.

    Research output: Contribution to journal › Article

  42. Inhibition of LRRK2 kinase activity leads to dephosphorylation of Ser(910)/Ser(935), disruption of 14-3-3 binding and altered cytoplasmic localization

    Dzamko, N., Deak, M., Hentati, F., Reith, A. D., Prescott, A. R., Alessi, D. R. & Nichols, R. J. 15-Sep-2010 In : Biochemical Journal. 430, p. 405-413, 9 p.

    Research output: Contribution to journal › Article

  43. Loss of AMP-activated protein kinase alpha 2 subunit in mouse beta-cells impairs glucose-stimulated insulin secretion and inhibits their sensitivity to hypoglycaemia

    Beall, C., Piipari, K., Al-Qassab, H., Smith, M. A., Parker, N., Carling, D., Viollet, B., Withers, D. J. & Ashford, M. L. J. 15-Jul-2010 In : Biochemical Journal. 429, p. 323-333, 11 p.

    Research output: Contribution to journal › Article

  44. Structural basis for the efficient phosphorylation of AZT-MP (3 '-azido-3 '-deoxythymidine monophosphate) and dGMP by Plasmodium falciparum type I thymidylate kinase

    Whittingham, J. L., Carrero-Lerida, J., Brannigan, J. A., Ruiz-Perez, L. M., Silva, A. P. G., Fogg, M. J., Wilkinson, A. J., Gilbert, I. H., Wilson, K. S. & Gonzalez-Pacanowska, D. 15-Jun-2010 In : Biochemical Journal. 428, p. 499-509, 11 p.

    Research output: Contribution to journal › Article

  45. Regulation of the miR-212/132 locus by MSK1 and CREB in response to neurotrophins

    Remenyi, J., Hunter, C. J., Cole, C., Ando, H., Impey, S., Monk, C. E., Martin, K. J., Barton, G. J., Hutvagner, G. & Arthur, J. S. C. 1-Jun-2010 In : Biochemical Journal. 428, p. 281-291, 11 p.

    Research output: Contribution to journal › Article

  46. Selective SUMO modification of cAMP-specific phosphodiesterase-4D5 (PDE4D5) regulates the functional consequences of phosphorylation by PKA and ERK

    Li, X., Vadrevu, S., Dunlop, A., Day, J., Advant, N., Troeger, J., Klussmann, E., Jaffray, E., Hay, R. T., Adams, D. R., Houslay, M. D. & Baillie, G. S. 15-May-2010 In : Biochemical Journal. 428, p. 55-65, 11 p.

    Research output: Contribution to journal › Article

  47. Bioinformatic and experimental survey of 14-3-3-binding sites

    Johnson, C., Crowther, S., Stafford, M. J., Campbell, D. G., Toth, R. & MacKintosh, C. 1-Apr-2010 In : Biochemical Journal. 427, p. 69-78, 10 p.

    Research output: Contribution to journal › Article

  48. Molecular mechanism of elongation factor 1A inhibition by a Legionella pneumophila glycosyltransferase

    Hurtado-Guerrero, R., Zusman, T., Pathak, S., Ibrahim, A. F. M., Shepherd, S., Prescott, A., Segal, G. & van Aalten, D. M. F. 15-Mar-2010 In : Biochemical Journal. 426, p. 281-292, 12 p.

    Research output: Contribution to journal › Article

  49. Calmodulin-dependent protein kinase kinase-beta activates AMPK without forming a stable complex: synergistic effects of Ca2+ and AMP

    Fogarty, S., Hawley, S. A., Green, K. A., Saner, N., Mustard, K. J. & Hardie, D. G. 15-Feb-2010 In : Biochemical Journal. 426, p. 109-118, 10 p.

    Research output: Contribution to journal › Article

  50. Cystic fibrosis transmembrane regulator fragments with the Phe(508) deletion exert a dual allosteric control over the master kinase CK2

    Pagano, M. A., Marin, O., Cozza, G., Sarno, S., Meggio, F., Treharne, K. J., Mehta, A. & Pinna, L. A. 15-Feb-2010 In : Biochemical Journal. 426, p. 19-29, 11 p.

    Research output: Contribution to journal › Article

  51. Insulin-stimulated phosphorylation of endothelial nitric oxide synthase at serine-615 contributes to nitric oxide synthesis

    Ritchie, S. A., Kohlhaas, C. F., Boyd, A. R., Yalla, K. C., Walsh, K., Connell, J. M. C. & Salt, I. P. 15-Feb-2010 In : Biochemical Journal. 426, p. 85-90, 6 p.

    Research output: Contribution to journal › Article

  52. MSK1 regulates the transcription of IL-1ra in response to TLR activation in macrophages

    Darragh, J., Ananieva, O., Courtney, A., Elcombe, S. & Arthur, J. S. C. 1-Feb-2010 In : Biochemical Journal. 425, p. 595-602, 8 p.

    Research output: Contribution to journal › Article

  53. Regulation of mRNA cap methylation

    Cowling, V. H. 15-Jan-2010 In : Biochemical Journal. 425, p. 295-302, 8 p.

    Research output: Contribution to journal › Scientific review

  54. Guidelines for the effective use of chemical inhibitors of protein function to understand their roles in cell regulation

    Cohen, P. 1-Jan-2010 In : Biochemical Journal. 425, p. 53-54, 2 p.

    Research output: Contribution to journal › Scientific review

  55. IRAK1-independent pathways required for the interleukin-1-stimulated activation of the Tpl2 catalytic subunit and its dissociation from ABIN2

    Handoyo, H., Stafford, M. J., McManus, E., Baltzis, D., Peggie, M. & Cohen, P. 15-Nov-2009 In : Biochemical Journal. 424, p. 109-118, 10 p.

    Research output: Contribution to journal › Article

  56. Substrate specificity and inhibitors of LRRK2, a protein kinase mutated in Parkinson's disease

    Nichols, R. J., Dzamko, N., Hutti, J. E., Cantley, L. C., Deak, M., Moran, J., Bamborough, P., Reith, A. D. & Alessi, D. R. 15-Nov-2009 In : Biochemical Journal. 424, p. 47-60, 14 p.

    Research output: Contribution to journal › Article

  57. Glucocorticoids can activate the alpha-EnaC gene promoter independently of SGK1

    McTavish, N., Getty, J., Burchell, A. & Wilson, S. M. 15-Oct-2009 In : Biochemical Journal. 423, p. 189-197, 9 p.

    Research output: Contribution to journal › Article

  58. Characterization of SENP7, a SUMO-2/3-specific isopeptidase

    Shen, L. N., Geoffroy, M-C., Jaffray, E. G. & Hay, R. T. 15-Jul-2009 In : Biochemical Journal. 421, p. 223-230, 8 p.

    Research output: Contribution to journal › Article

  59. Ku-0063794 is a specific inhibitor of the mammalian target of rapamycin (mTOR)

    Garcia-Martinez, J. M., Moran, J., Clarke, R. G., Gray, A., Cosulich, S. C., Chresta, C. M. & Alessi, D. R. 1-Jul-2009 In : Biochemical Journal. 421, p. 29-42, 14 p.

    Research output: Contribution to journal › Article

  60. GIcNAcstatins are nanomolar inhibitors of human O-GIcNAcase inducing cellular hyper-O-GIcNAcylation

    Dorfmueller, H. C., Borodkin, V. S., Schimpl, M. & van Aalten, D. M. F. 1-Jun-2009 In : Biochemical Journal. 420, p. 221-227, 7 p.

    Research output: Contribution to journal › Article

  61. Insulin resistance in polycystic ovary syndrome is associated with defective regulation of ERK1/2 by insulin in skeletal muscle in vivo

    Rajkhowa, M., Brett, S., Cuthbertson, D. J., Lipina, C., Ruiz-Alcaraz, A. J., Thomas, G. E., Logie, L., Petrie, J. R. & Sutherland, C. 15-Mar-2009 In : Biochemical Journal. 418, p. 665-671, 7 p.

    Research output: Contribution to journal › Article

  62. Phosphorylation of Ewing's sarcoma protein (EWS) and EWS-Fli1 in response to DNA damage

    Klevernic, I. V., Morton, S., Davis, R. J. & Cohen, P. 15-Mar-2009 In : Biochemical Journal. 418, p. 625-634, 10 p.

    Research output: Contribution to journal › Article

  63. The Nrf1 CNC/bZIP protein is a nuclear envelope-bound transcription factor that is activated by t-butyl hydroquinone but not by endoplasmic reticulum stressors

    Zhang, Y., Lucocq, J. M. & Hayes, J. D. 1-Mar-2009 In : Biochemical Journal. 418, p. 293-310, 18 p.

    Research output: Contribution to journal › Article

  64. Modulating serine palmitoyl transferase (SPT) expression and activity unveils a crucial role in lipid-induced insulin resistance in rat skeletal muscle cells

    Watson, M. L., Coghlan, M. & Hundal, H. S. 1-Feb-2009 In : Biochemical Journal. 417, p. 791-801, 11 p.

    Research output: Contribution to journal › Article

  65. Unsaturated fatty acid regulation of cytochrome P450 expression via a CAR-dependent pathway

    Finn, R. D., Henderson, C. J., Scott, C. L. & Wolf, C. R. 1-Jan-2009 In : Biochemical Journal. 417, p. 43-54, 12 p.

    Research output: Contribution to journal › Article

  66. mTOR complex 2 (mTORC2) controls hydrophobic motif phosphorylation and activation of serum- and glucocorticoid-induced protein kinase 1 (SGK1)

    Garcia-Martinez, J. M. & Alessi, D. R. 15-Dec-2008 In : Biochemical Journal. 416, p. 375-385, 11 p.

    Research output: Contribution to journal › Article

  67. A novel short splice variant of the tumour suppressor LKB1 is required for spermiogenesis

    Towler, M. C., Fogarty, S., Hawley, S. A., Pan, D. A., Martin, D. M. A., Morrice, N. A., McCarthy, A., Galardo, M. N., Meroni, S. B., Cigorraga, S. B., Ashworth, A., Sakamoto, K. & Hardie, D. G. 15-Nov-2008 In : Biochemical Journal. 416, p. 114, 14 p.

    Research output: Contribution to journal › Article

  68. Identification and characterization of FUS/TLS as a new target of ATM

    Gardiner, M., Toth, R., Vandermoere, F., Morrice, N. A. & Rouse, J. 15-Oct-2008 In : Biochemical Journal. 415, p. 297-307, 11 p.

    Research output: Contribution to journal › Article

  69. Structural and kinetic differences between human and Aspergillus fumigatus D-glucosamine-6-phosphate N-acetyltransferase

    Hurtado-Guerrero, R., Raimi, O. G., Min, J., Zeng, H., Vallius, L., Shepherd, S., Ibrahim, A. F. M., Wu, H., Plotnikov, A. N. & van Aalten, D. M. F. 15-Oct-2008 In : Biochemical Journal. 415, p. 217-223, 7 p.

    Research output: Contribution to journal › Article

  70. Biochemical characterization of the initial steps of the Kennedy pathway in Trypanosoma brucei: the ethanolamine and choline kinases

    Gibellini, F., Hunter, W. N. & Smith, T. K. 1-Oct-2008 In : Biochemical Journal. 415, p. 135-144, 10 p.

    Research output: Contribution to journal › Article

  71. Structural and mechanistic insights into type II trypanosomatid tryparedoxin-dependent peroxidases

    Alphey, M. S., Konig, J. & Fairlamb, A. H. 15-Sep-2008 In : Biochemical Journal. 414, 3, p. 375-381, 7 p.

    Research output: Contribution to journal › Article

  72. Regulation of gene expression by hypoxia

    Kenneth, N. S. & Rocha, S. 15-Aug-2008 In : Biochemical Journal. 414, p. 19-29, 11 p.

    Research output: Contribution to journal › Scientific review

  73. Regulation of hypoxia-inducible factor-1 alpha by NF-kappa B

    van Uden, P., Kenneth, N. S. & Rocha, S. 15-Jun-2008 In : Biochemical Journal. 412, p. 477-484, 8 p.

    Research output: Contribution to journal › Article

  74. Important role of the LKB1-AMPK pathway in suppressing tumorigenesis in PTEN-deficient mice

    Huang, X., Wullschleger, S., Shpiro, N., McGuire, V. A., Sakamoto, K., Woods, Y. L., McBurnie, W., Fleming, S. & Alessi, D. R. 1-Jun-2008 In : Biochemical Journal. 412, p. 211-221, 11 p.

    Research output: Contribution to journal › Article

  75. Negative-feedback regulation of FGF signalling by DUSP6/MKP-3 is driven by ERK1/2 and mediated by Ets factor binding to a conserved site within the DUSP6/MKP-3 gene promoter

    Ekerot, M., Stavridis, M. P., Delavaine, L., Mitchell, M. P., Staples, C., Owens, D. M., Keenan, I. D., Dickinson, R. J., Storey, K. G. & Keyse, S. M. 1-Jun-2008 In : Biochemical Journal. 412, p. 287-298, 12 p.

    Research output: Contribution to journal › Article

  76. Control of AMPK-related kinases by USP9X and atypical Lys(29)/Lys(33)-inked polyubiquitin chains

    Al-Hakim, A. K., Zagorska, A., Chapman, L., Deak, M., Peggie, M. & Alessi, D. R. 15-Apr-2008 In : Biochemical Journal. 411, p. 249-260, 12 p.

    Research output: Contribution to journal › Article

  77. The identification and characterization of novel PKC epsilon phosphorylation sites provide evidence for functional cross-talk within the PKC superfamily

    Durgan, J., Cameron, A. J., Saurin, A. I., Hanrahan, S., Totty, N., Messing, R. O. & Parker, P. J. 15-Apr-2008 In : Biochemical Journal. 411, p. 319-331, 13 p.

    Research output: Contribution to journal › Article

  78. Targeting of PKC zeta and PKB to caveolin-enriched microdomains represents a crucial step underpinning the disruption in PKB-directed signalling by ceramide

    Hajduch, E., Turban, S., Le Liepvre, X., Le Lay, S., Lipina, C., Dimopoulos, N., Dugail, I. & Hundal, H. S. 1-Mar-2008 In : Biochemical Journal. 410, p. 369-379, 11 p.

    Research output: Contribution to journal › Article

  79. Roles for TAB1 in regulating the IL-1-dependent phosphorylation of the TAB3 regulatory subunit and activity of the TAK1 complex

    Mendoza, H., Campbell, D. G., Burness, K., Hastie, J., Ronkina, N., Shim, J-H., Arthur, J. S. C., Davis, R. J., Gaestel, M., Johnson, G. L., Ghosh, S. & Cohen, P. 1-Feb-2008 In : Biochemical Journal. 409, p. 711-722, 12 p.

    Research output: Contribution to journal › Article

  80. Two different classes of E2 ubiquitin-conjugating enzymes are required for the mono-ubiquitination of proteins and elongation by polyubiquitin chains with a specific topology

    Windheim, M., Peggie, M. & Cohen, P. 1-Feb-2008 In : Biochemical Journal. 409, p. 723-729, 7 p.

    Research output: Contribution to journal › Article

  81. Complementary regulation of TBC1D1 and AS160 by growth factors, insulin and AMPK activators

    Chen, S., Murphy, J., Toth, R., Campbell, D. G., Morrice, N. A. & Mackintosh, C. 15-Jan-2008 In : Biochemical Journal. 409, p. 449-459, 11 p.

    Research output: Contribution to journal › Article

  82. The IRAK-catalysed activation of the E3 ligase function of Pellino isoforms induces the Lys(63)-linked polyubiquitination of IRAK1

    Ordureau, A., Smith, H., Windheim, M., Peggie, M., Carrick, E., Morrice, N. & Cohen, P. 2008 In : Biochemical Journal. 409, p. 43-52, 10 p.

    Research output: Contribution to journal › Article

  83. The Ser(186) phospho-acceptor site within ERK4 is essential for its ability to interact with and activate PRAK/MK5

    Perander, M., Aberg, E., Johansen, B., Dreyer, B., Guldvik, I. J., Outzen, H., Keyse, S. M. & Seternes, O-M. 2008 In : Biochemical Journal. 411, 3, p. 613-22, 10 p.

    Research output: Contribution to journal › Article

  84. The selectivity of protein kinase inhibitors: a further update

    Bain, J., Plater, L., Elliott, M., Shpiro, N., Hastie, C. J., Mclauchlan, H., Klevernic, I., Arthur, J. S. C., Alessi, D. R. & Cohen, P. 15-Dec-2007 In : Biochemical Journal. 408, p. 297-315, 19 p.

    Research output: Contribution to journal › Article

  85. BI-D1870 is a specific inhibitor of the p90 RSK (ribosomal S6 kinase) isoforms in vitro and in vivo

    Sapkota, G. P., Cummings, L., Newell, F. S., Armstrong, C., Bain, J., Frodin, M., Grauert, M., Hoffmann, M., Schnapp, G., Steegmaier, M., Cohen, P. & Alessi, D. R. 16-Oct-2007 In : Biochemical Journal. 401, 1, p. 29-38, 10 p.

    Research output: Contribution to journal › Article

  86. Regulation of multisite phosphorylation and 14-3-3 binding of AS160 in response to IGF-1, EGF, PMA and AICAR

    Geraghty, K. M., Chen, S., Harthill, J. E., Ibrahim, A. F., Toth, R., Morrice, N. A., Vandermoere, F., Moorhead, G. B., Hardie, D. G. & MacKintosh, C. 15-Oct-2007 In : Biochemical Journal. 407, p. 231-241, 11 p.

    Research output: Contribution to journal › Article

  87. The NHB1 (N-terminal homology box 1) sequence in transcription factor Nrf1 is required to anchor it to the endoplasmic reticulum and also to enable its asparagine-glycosylation

    Zhang, Y., Lucocq, J. M., Yamamoto, M. & Hayes, J. D. 2007 In : Biochemical Journal. 408, 2, p. 161-172, 12 p.

    Research output: Contribution to journal › Article

  88. TAK1-binding protein 1 is a pseudophosphatase

    Conner, S. H., Kular, G., Peggie, M., Shepherd, S., Schüttelkopf, A. W., Cohen, P. & van Aalten, D. M. F. 1-Nov-2006 In : Biochemical Journal. 399, 3, p. 427-434, 8 p.

    Research output: Contribution to journal › Article

  89. Negative regulation of the Nrf1 transcription factor by its N-terminal domain is independent of Keap1: Nrf1, but not Nrf2, is targeted to the endoplasmic reticulum

    Zhang, Y., Crouch, D. H., Yamamoto, M. & Hayes, J. D. Nov-2006 In : Biochemical Journal. 399, 3, p. 373-385, 13 p.

    Research output: Contribution to journal › Article

  90. Evidence for allosteric regulation of pH-sensitive System A (SNAT2) and System N (SNAT5) amino acid transporter activity involving a conserved histidine residue

    Baird, F. E., Pinilla-Tenas, J. J., Ogilvie, W. L. J., Ganapathy, V., Hundal, H. S. & Taylor, P. M. 15-Jul-2006 In : Biochemical Journal. 397, 2, p. 369-375, 7 p.

    Research output: Contribution to journal › Article

  91. The structure of siglec-7 in complex with sialosides: leads for rational structure-based inhibitor design

    Attrill, H., Takazawa, H., Witt, S., Kelm, S., Isecke, R., Brossmer, R., Ando, T., Ishida, H., Kiso, M., Crocker, P. R. & van Aalten, D. M. F. 15-Jul-2006 In : Biochemical Journal. 397, 2, p. 271-278, 8 p.

    Research output: Contribution to journal › Article

  92. The ubiquitin-associated domain of AMPK-related kinases regulates conformation and LKB1-mediated phosphorylation and activation

    Jaleel, M., Villa, F., Deak, M., Toth, R., Prescott, A. R., van Aalten, D. M. F. & Alessi, D. R. 15-Mar-2006 In : Biochemical Journal. 394, 3, p. 545-555, 11 p.

    Research output: Contribution to journal › Article

  93. Kinetic, inhibition and structural studies on 3-oxoacyl-ACP reductase from plasmodium falciparum, a key enzyme in fatty acid biosynthesis

    Wickramasinghe, S. R., Inglis, K. A., Urch, J. E., Müller, S., van Aalten, D. M. F. & Fairlamb, A. H. 15-Jan-2006 In : Biochemical Journal. 393, 2, p. 447-457, 11 p.

    Research output: Contribution to journal › Article

  94. A novel regulation of IRS1 (insulin receptor substrate-1) expression following short term insulin administration

    Ruiz-Alcaraz, A. J., Liu, H-K., Cuthbertson, D. J., McManus, E. J., Akhtar, S., Lipina, C., Morris, A. D., Petrie, J. R., Hundal, H. S. & Sutherland, C. 1-Dec-2005 In : Biochemical Journal. 392, p. 345-352, 8 p.

    Research output: Contribution to journal › Article

  95. The WNK1 and WNK4 protein kinases that are mutated in Gordon's hypertension syndrome phosphorylate and activate SPAK and OSR1 protein kinases

    Alessi, D., Deak, M., Morrice, N. & Vitari, A. Oct-2005 In : Biochemical Journal. 391, 1, p. 17-24, 8 p.

    Research output: Contribution to journal › Article

  96. Relationship between hepatic phenotype and changes in gene expression in cytochrome P450 reductase (POR) null mice

    Wang, X. J., Chamberlain, M., Vassieva, O., Henderson, C. J. & Wolf, C. R. 15-Jun-2005 In : Biochemical Journal. 388, 3, p. 857-867, 11 p.

    Research output: Contribution to journal › Article

  97. Human protein phosphatase 5 dissociates from heat-shock proteins and is proteolytically activated in response to arachidonic acid and the microtubule-depolymerizing drug nocodazole

    Zeke, T., Morrice, N., Vazquez-Martin, C. & Cohen, T. Jan-2005 In : Biochemical Journal. 385, 1, p. 45-56, 12 p.

    Research output: Contribution to journal › Article

  98. Analysis of hepatic gene transcription in mice expressing insulin-insensitive GSK3

    Lipina, C., Huang, X., Finlay, D., McManus, E. J., Alessi, D. R. & Sutherland, C. 2005 In : Biochemical Journal. 392, 3, p. 633-639, 7 p.

    Research output: Contribution to journal › Article

  99. Deficiency of PDK1 in liver results in glucose intolerance, impairment of insulin-regulated gene expression and liver failure

    Mora, A., Lipina, C., Tronche, F., Sutherland, C. & Alessi, D. R. 2005 In : Biochemical Journal. 385, 3, p. 639-648, 10 p.

    Research output: Contribution to journal › Article

  100. In vivo functional characterization of the Escherichia coli ammonium channel AmtB: evidence for metabolic coupling of AmtB to glutamine synthetase

    Javelle, A., Thomas, G., Marini, A-M., Krämer, R. & Merrick, M. 2005 In : Biochemical Journal. 390, 1, p. 215-22, 8 p.

    Research output: Contribution to journal › Article

  101. Linking Smads and transcriptional activation

    Inman, G. J. 2005 In : Biochemical Journal. 386, Pt 1, p. e1-e3

    Research output: Contribution to journal › Article

  102. Phosphodiesterase 3A binds to 14-3-3 proteins in response to PMA-induced phosphorylation of Ser428

    Pozuelo-Rubio, M., Campbell, D. G., Morrice, N. A. & MacKintosh, C. 2005 In : Biochemical Journal. 392, 1, p. 163-172, 10 p.

    Research output: Contribution to journal › Article

  103. Slx4 becomes phosphorylated after DNA damage in a Mec1/Tel1-dependent manner and is required for repair of DNA alkylation damage

    Flott, S. & Rouse, J. 2005 In : Biochemical Journal. 391, 2, p. 325-333, 9 p.

    Research output: Contribution to journal › Article

  104. Dynamic interactions between 14-3-3 proteins and phosphoproteins regulate diverse cellular processes

    Mackintosh, C. 15-Jul-2004 In : Biochemical Journal. 381, p. 329-342, 14 p.

    Research output: Contribution to journal › Scientific review

  105. 14-3-3-affinity purification of over 200 human phosphoproteins reveals new links to regulation of cellular metabolism, proliferation and trafficking

    Pozuelo-Rubio, M., Geraghty, K. M., Wong, B. H. C., Wood, N. T., Campbell, D. G., Morrice, N. & MacKintosh, C. 15-Apr-2004 In : Biochemical Journal. 379, 2, p. 395-408, 14 p.

    Research output: Contribution to journal › Article

  106. Tumour necrosis factor a decreases glucose-6-phosphatase gene expression by activation of nuclear factor kB

    Grempler, R., Kienitz, A., Werner, T., Meyer, M., Barthel, A., Ailett, F., Sutherland, C., Walther, R. & Schmoll, D. 2004 In : Biochemical Journal. 382, p. 471-479, 9 p.

    Research output: Contribution to journal › Article

  107. Regulation of targets of mTOR (mammalian target of rapamycin) signalling by intracellular amino acid availability

    Beugnet, A., Tee, A. R., Taylor, P. M. & Proud, C. G. 1-Jun-2003 In : Biochemical Journal. 372, 2, p. 555-566, 12 p.

    Research output: Contribution to journal › Article

  108. Amino acid transporters: roles in amino acid sensing and signalling in animal cells

    Hyde, R., Taylor, P. M. & Hundal, H. S. 2003 In : Biochemical Journal. 373, 1, p. 1-18, 18 p.

    Research output: Contribution to journal › Article

  109. Biochemical and genetic characterization of a murine class Kappa glutathione S-transferase

    Jowsey, I. R., Thomson, R. E., Orton, T. C., Elcombe, C. R. & Hayes, J. D. 2003 In : Biochemical Journal. 373, Pt 2, p. 559-69, 11 p.

    Research output: Contribution to journal › Article

  110. Identification of a novel Nrf2-regulated antioxidant response element (ARE) in the mouse NAD(P)H:quinone oxidoreductase 1 gene: reassessment of the ARE consensus sequence

    Nioi, P., McMahon, M., Itoh, K., Yamamoto, M. & Hayes, J. D. 2003 In : Biochemical Journal. 374, Pt 2, p. 337-48, 12 p.

    Research output: Contribution to journal › Article

  111. Regulation of the 14-3-3-binding protein p39 by growth factors and nutrients in rat PC12 pheochromocytoma cells

    Harthill, J. E., Pozuelo-Rubio, M., Milne, F. C. & MacKintosh, C. 1-Dec-2002 In : Biochemical Journal. 368, p. 565-572, 8 p.

    Research output: Contribution to journal › Article

  112. Identification of in vitro and in vivo phosphorylation sites in the catalytic subunit of the DNA-dependent protein kinase

    Douglas, P., Sapkota, G. P., Morrice, N., Yu, Y., Goodarzi, A. A., Merkle, D., Meek, K., Alessi, D. R. & Lees-Miller, S. P. 19-Aug-2002 In : Biochemical Journal. 368, 1, p. 243-251, 9 p.

    Research output: Contribution to journal › Article

  113. Characterization of a murine gene encoding a developmentally regulated cytoplasmic dual-specificity mitogen-activated protein kinase phosphatase

    Dickinson, R. J., Williams, D. J., Slack, D. N., Williamson, J., Seternes, O-M. & Keyse, S. M. 15-May-2002 In : Biochemical Journal. 364, 1, p. 145-55, 11 p.

    Research output: Contribution to journal › Article

  114. Subcellular localization of phosphatidylinositol 4,5-bisphosphate using the pleckstrin homology domain of phospholipase C delta1

    Watt, S. A., Kular, G., Fleming, I. N., Downes, C. P. & Lucocq, J. M. Jan-2002 In : Biochemical Journal. 363, 3, p. 657-666, 10 p.

    Research output: Contribution to journal › Article

  115. Identification and characterization of four novel phosphorylation sites (Ser31, Ser325, Thr336 and Thr366) on LKB1/STK11, the protein kinase mutated in Peutz-Jeghers cancer syndrome

    Sapkota, G. P., Boudeau, J., Deak, M., Kieloch, A., Morrice, N. & Alessi, D. R. 2002 In : Biochemical Journal. 362, Pt 2, p. 481-90, 10 p.

    Research output: Contribution to journal › Article

  116. Insulin regulation of hepatic insulin-like growth factor-binding protein-1 (IGFBP-1) gene expression and mammalian target of rapamycin (mTOR) signalling is impaired by the presence of hydrogen peroxide

    Patel, S., Van-Der-Kaay, J. & Sutherland, C. 2002 In : Biochemical Journal. 365, p. 537-545, 9 p.

    Research output: Contribution to journal › Article

  117. Ionizing radiation induces ataxia telangiectasia mutated kinase (ATM)-mediated phosphorylation of LKB1/STK11 at Thr-366

    Sapkota, G. P., Deak, M., Kieloch, A., Morrice, N., Goodarzi, A. A., Smythe, C., Shiloh, Y., Lees-Miller, S. P. & Alessi, D. R. 2002 In : Biochemical Journal. 368, 2, p. 507-516, 10 p.

    Research output: Contribution to journal › Article

  118. Loss of the Nrf2 transcription factor causes a marked reduction in constitutive and inducible expression of the glutathione S-transferase Gsta1, Gsta2, Gstm1, Gstm2, Gstm3 and Gstm4 genes in the livers of male and female mice

    Chanas, S. A., Jiang, Q., McMahon, M., McWalter, G. K., McLellan, L. I., Elcombe, C. R., Henderson, C. J., Wolf, C. R., Moffat, G. J., Itoh, K., Yamamoto, M. & Hayes, J. D. 2002 In : Biochemical Journal. 365, Pt 2, p. 405-16, 12 p.

    Research output: Contribution to journal › Article

  119. Novel homodimeric and heterodimeric rat g-hydroxybutyrate synthases that associate with the Golgi apparatus define a distinct subclass of aldo-keto reductase 7 family proteins

    Kelly, V. P., Sherratt, P. J., Crouch, D. H. & Hayes, J. D. 2002 In : Biochemical Journal. 366, Pt 3, p. 847-61, 15 p.

    Research output: Contribution to journal › Article

  120. Antagonistic effects of phorbol esters on insulin regulation of insulin-like growth factor-binding protein-1 (IGFBP-1) but not glucose-6-phosphatase gene expression

    Patel, S., Lochhead, P. A., Rena, G. & Sutherland, C. 1-Nov-2001 In : Biochemical Journal. 359, 3, p. 611-619, 9 p.

    Research output: Contribution to journal › Article

  121. Critical roles for the serine 20, but not the serine 15, phosphorylation site and for the polyproline domain in regulating p53 turnover

    Dumaz, N., Milne, D. M., Jardine, L. J. & Meek, D. W. 15-Oct-2001 In : Biochemical Journal. 359, 2, p. 459-464, 6 p.

    Research output: Contribution to journal › Article

  122. Glucose 6-phosphate transport in fibroblast microsomes from glycogen storage disease type 1b patients: evidence for multiple glucose 6-phosphate transport systems

    Leuzzi, R., Fulceri, R., Marcolongo, P., Banhegyi, G., Zammarchi, E., Stafford, K., Burchell, A. & Benedetti, A. Jul-2001 In : Biochemical Journal. 357, 2, p. 557-562, 6 p.

    Research output: Contribution to journal › Article

  123. Role of the System L permease LAT1 in amino acid and iodothyronine transport in placenta

    Ritchie, J. W. A. & Taylor, P. M. 15-Jun-2001 In : Biochemical Journal. 356, 3, p. 719-725, 7 p.

    Research output: Contribution to journal › Article

  124. Human NADPH-P450 oxidoreductase modulates the level of cytochrome P450 CYP2D6 holoprotein via haem oxygenase-dependent and -independent pathways

    Ding, S-H., Yao, D., Deeni, Y. Y., Burchell, B., Wolf, C. R. & Friedberg, T. Jun-2001 In : Biochemical Journal. 356, 2, p. 613-619, 7 p.

    Research output: Contribution to journal › Article

  125. Phosphorylation of murine double minute clone 2 (MDM2) protein at serine-267 by protein kinase CK2 in vitro and in cultured cells

    Hjerrild, M., Milne, D., Dumaz, N., Hay, T., Issinger, O-G. & Meek, D. 15-Apr-2001 In : Biochemical Journal. 355, P2, p. 347-56, 10 p.

    Research output: Contribution to journal › Article

  126. Roles of the forkhead in rhabdomyosarcoma (FKHR) phosphorylation sites in regulating 14-3-3 binding, transactivation and nuclear targetting

    Rena, G., Prescott, A. R., Guo, S., Cohen, P. & Unterman, T. G. 2001 In : Biochemical Journal. 354, 3, p. 605-612, 8 p.

    Research output: Contribution to journal › Article

  127. The kinase DYRK1A phosphorylates the transcription factor FKHR at Ser329 in vitro, a novel in vivo phosphorylation site

    Woods, Y. L., Rena, G., Morrice, N., Barthel, A., Becker, W., Guo, S., Unterman, T. G. & Cohen, P. 2001 In : Biochemical Journal. 355, 3, p. 597-607, 11 p.

    Research output: Contribution to journal › Article

  128. TPIP: a novel phosphoinositide 3-phosphatase

    Walker, S., Downes, P. & Leslie, N. 2001 In : Biochemical Journal. 360, 2, p. 277-283, 7 p.

    Research output: Contribution to journal › Article

  129. Isolation and characterization of glycosylphosphatidylinositol-anchored, mucin-like surface glycoproteins from bloodstream forms of the freshwater-fish parasite Trypanosoma carassii

    Lischke, A., Klein, C., Stierhof, Y-D., Hempel, M., Mehlert, A., Almeida, I. C., Ferguson, M. A. J. & Overath, P. 1-Feb-2000 In : Biochemical Journal. 345, p. 693-700, 8 p.

    Research output: Contribution to journal › Article

  130. Evidence that serine 304 is not a key ligand-binding residue in the active site of cytochrome P450 2D6

    Ellis, S. W., Hayhurst, G. P., Lightfoot, T., Smith, G., Harlow, J., Rowland-Yeo, K., Larsson, C., Mahling, J., Lim, C. K., Wolf, C. R., Blackburn, M. G., Lennard, M. S. & Tucker, G. T. 2000 In : Biochemical Journal. 345 , 3, p. 565-571, 7 p.

    Research output: Contribution to journal › Article

  131. Determinants of the substrate specificity of human cytochrome P-450 CYP2D6: design and construction of a mutant with testosterone hydroxylase activity

    Smith, G., Modi, S., Pillai, I., Lian, L-Y., Sutcliffe, M. J., Pritchard, M. P., Friedberg, T., Roberts, G. C. K. & Wolf, C. R. 1998 In : Biochemical Journal. 331 , 3, p. 783-792, 10 p.

    Research output: Contribution to journal › Article

  132. Identification and characterization of the human homologue of the short PDE4A cAMP-specific phosphodiesterase RD1 (PDE4A1) by analysis of the human HSPDE4A gene locus located at chromosome 19p13.2

    Sullivan, M., Rena, G., Begg, F., Gordon, L., Olsen, A. S. & Houslay, M. D. 1998 In : Biochemical Journal. 333, 3, p. 693-703, 11 p.

    Research output: Contribution to journal › Article

  133. Early steps in glycosylphosphatidylinositol biosynthesis in Leishmania major

    Smith, T. K., Milne, F. C., Sharma, D. K., Crossman, A., Brimacombe, J. S. & Ferguson, M. A. J. 1-Sep-1997 In : Biochemical Journal. 326, 2, p. 393-400, 8 p.

    Research output: Contribution to journal › Article

  134. Expression of a variant surface glycoprotein of Trypanosoma gambiense in procyclic forms of Trypanosoma brucei shows that the cell type dictates the nature of the glycosylphosphatidylinositol membrane anchor attached to the glycoprotein

    Paturiaux-Hanocq, F., Zitzmann, N., Hanocq-Quertier, J., Vanhamme, L., Rolin, S., Geuskens, M., Ferguson, M. A. J. & Pays, E. 1997 In : Biochemical Journal. 324, 3, p. 885-895, 16 p.

    Research output: Contribution to journal › Article

  135. Intracellular localization of the PDE4A cAMP-specific phosphodiesterase splice variant RD1 (RNPDE4A1A) in stably transfected human thyroid carcinoma FTC cell lines

    Pooley, L., Shakur, Y., Rena, G. & Houslay, M. D. 1997 In : Biochemical Journal. 321, 1, p. 177-185, 9 p.

    Research output: Contribution to journal › Article

  136. Receptor-mediated stimulation of lipid signalling pathways in CHO cells elicits the rapid transient induction of the PDE1B isoform of Ca2+/calmodulin-stimulated cAMP phosphodiesterase

    Spence, S., Rena, G., Sullivan, M., Erdogan, S. & Houslay, M. D. 1997 In : Biochemical Journal. 321, 1, p. 157-163, 7 p.

    Research output: Contribution to journal › Article

  137. Substrate specificity of the N-acetylglucosaminyl-phosphatidylinositol de-N-acetylase of glycosylphosphatidylinositol membrane anchor biosynthesis in African trypanosomes and human cells

    Sharma, D. K., Smith, T. K., Crossman, A., Brimacombe, J. S. & Ferguson, M. A. J. 1997 In : Biochemical Journal. 328, 1, p. 171-177, 7 p.

    Research output: Contribution to journal › Article

  138. Three spinach leaf nitrate reductase-3-hydroxy-3-methylglutaryl-CoA reductase kinases that are regulated by reversible phosphorylation and/or Ca2+ ions

    Douglas, P., Pigaglio, E., Ferrer, A., Halford, N. G. & MacKintosh, C. 1997 In : Biochemical Journal. 325, 1, p. 101-109, 9 p.

    Research output: Contribution to journal › Article

  139. Structural studies on a lipoarabinogalactan of Crithidia fasciculata

    Schneider, P., Treumann, A., Milne, K. G., McConville, M. J., Zitzmann, N. & Ferguson, M. A. J. 1-Feb-1996 In : Biochemical Journal. 313, 3, p. 963-971, 9 p.

    Research output: Contribution to journal › Article

  140. Biosynthesis of the glycolipid anchor of lipophosphoglycan and the structurally related glycoinositolphospholipids from Leishmania major

    Proudfoot, L., Schneider, P., Ferguson, M. A. J. & McConville, M. J. 1-Jan-1995 In : Biochemical Journal. 308, 1, p. 45-55, 11 p.

    Research output: Contribution to journal › Article

  141. Hydrophobic glycosides of N-acetylglucosamine can act as primers for polylactosamine synthesis and can affect glycolipid synthesis in vivo

    Neville, D. C. A., Field, R. A. & Ferguson, M. A. J. 1-Jan-1995 In : Biochemical Journal. 307, 3, p. 791-797, 7 p.

    Research output: Contribution to journal › Article

  142. The biosynthesis of GDP-D-arabinopyranose in Crithidia fasciculata: characterization of a D-arabino-1-kinase activity and its use in the synthesis of GDP-[5-3H]D-arabinopyranose

    Schneider, P., Nikolaev, A. & Ferguson, M. A. J. 1-Jan-1995 In : Biochemical Journal. 311, 1, p. 307-315, 9 p.

    Research output: Contribution to journal › Article

  143. The glycoinositol-phospholipids of Phytomonas

    Redman, C. A., Schneider, P., Mehlert, A. & Ferguson, M. A. J. 1-Jan-1995 In : Biochemical Journal. 311, 2, p. 495-503, 9 p.

    Research output: Contribution to journal › Article

  144. The hydrophobic mannoside Manα1-6Manα1-S-(CH2)7-CH3 acts as an acceptor for the UDP-Gal: glycosylphosphatidylinositol anchor α1,3-galactosyltransferase of Trypanosoma brucei

    Pingel, S., Field, R. A., Guther, M. L. S., Duszenko, M. & Ferguson, M. A. J. 1-Jan-1995 In : Biochemical Journal. 309, 3, p. 877-882, 6 p.

    Research output: Contribution to journal › Article

  145. Induction of Ca2+/calmodulin-stimulated cyclic AMP phosphodiesterase (PDE1) activity in Chinese hamster ovary cells (CHO) by phorbol 12-myristate 13-acetate and by the selective overexpression of protein kinase C isoforms

    Spence, S., Rena, G., Sweeney, G. & Houslay, M. D. 1995 In : Biochemical Journal. 310, 3, p. 975-982, 8 p.

    Research output: Contribution to journal › Article

  146. Inositol trisphosphate metabolism in Saccharomyces cerevisiae - identification, purification and properties of Inositol 1,4,5-trisphosphae 6-kinase

    ESTEVEZ, F., PULFORD, D., STARK, M. J. R., CARTER, A. N. & Downes, C. P. 15-Sep-1994 In : Biochemical Journal. 302, p. 709-716, 8 p.

    Research output: Contribution to journal › Article

  147. Glycoinositol-phospholipid profiles of four serotypically distinct Old World Leishmania strains

    Schneider, P., Schnur, L. F., Jaffe, C. L., Ferguson, M. A. J. & McConville, M. J. 1-Jan-1994 In : Biochemical Journal. 304, 2, p. 603-609, 7 p.

    Research output: Contribution to journal › Article

  148. Structure of the glycosylphosphatidylinositol membrane anchor of human placental alkaline phosphatase

    Redman, C. A., Thomas-Oates, J. E., Ogata, S., Ikehara, Y. & Ferguson, M. A. J. 1-Jan-1994 In : Biochemical Journal. 302, 3, p. 861-865, 5 p.

    Research output: Contribution to journal › Article

  149. Lytic anti-α-galactosyl antibodies from patients with chronic Chagas' disease recognize novel O-linked oligosaccharides on mucin-like glycosyl-phosphatidylinositol-anchored glycoproteins of Trypanosoma cruzi

    Almeida, I. C., Ferguson, M. A. J., Schenkman, S. & Travassos, L. R. 1994 In : Biochemical Journal. 304 ( Pt 3), p. 793-802, 10 p.

    Research output: Contribution to journal › Article

  150. Inactivation of glycogen-synthase kinase-3-beta by phosphorylation: new kinase connections in insulin and growth-factor signaling

    Sutherland, C., Leighton, I. A. & Cohen, P. 15-Nov-1993 In : Biochemical Journal. 296, 1, p. 15-19, 5 p.

    Research output: Contribution to journal › Comment/debate

  151. Characterization of glycoinositol phospholipids in the amastigote stage of the protozoan parasite Leishmania major

    Schneider, P., Rosat, J-P., Ransijn, A., Ferguson, M. A. J. & McConville, M. J. 15-Oct-1993 In : Biochemical Journal. 295, 2, p. 555-564, 10 p.

    Research output: Contribution to journal › Article

  152. 1,4-Bis[2-(3,5-dichloropyridyloxy)]benzene, an extremely potent modulator of mouse hepatic cytochrome P-450 gene expression.

    Smith, G., Henderson, C. J., WHITE, R., Parker, M. G., Bars, R. G. & Wolf, C. R. 1-Feb-1993 In : Biochemical Journal. 289, 3, p. 807-813, 7 p.

    Research output: Contribution to journal › Article

  153. A simple purification of procyclic acidic repetitive protein and demonstration of a sialylated glycosyl-phosphatidylinositol membrane anchor

    Ferguson, M. A. J., Murray, P., Rutherford, H. & McConville, M. J. 1993 In : Biochemical Journal. 291 , Pt 1, p. 51-55, 5 p.

    Research output: Contribution to journal › Article

  154. Structure of the CAMPATH-1 antigen, a glycosylphosphatidylinositol-anchored glycoprotein which is an exceptionally good target for complement lysis

    Xia, M-Q., Hale, G., Lifely, M. R., Ferguson, M. A. J., Campbell, D., Packman, L. & Waldmann, H. 1993 In : Biochemical Journal. 293 ( Pt 3), p. 633-640, 8 p.

    Research output: Contribution to journal › Article

  155. Structure of the glycosyl-phosphatidylinositol membrane anchor of acetylcholinesterase from the electric organ of the electric-fish, Torpedo californica

    Mehlert, A., Varon, L., Silman, I., Homans, S. W. & Ferguson, M. A. J. 1993 In : Biochemical Journal. 296 ( Pt 2), p. 473-479, 7 p.

    Research output: Contribution to journal › Article

  156. The structure, biosynthesis and function of glycosylated phosphatidylinositols in the parasitic protozoa and higher eukaryotes

    McConville, M. J. & Ferguson, M. A. 1993 In : Biochemical Journal. 294, 2, p. 305-324, 20 p.

    Research output: Contribution to journal › Article

  157. Site of palmitoylation of a phospholipase-c-resistant glycosyl-phosphatidylinositol membrane anchor.

    Ferguson, M. A. J. 1-Jun-1992 In : Biochemical Journal. 284, 2, p. 297-300, 4 p.

    Research output: Contribution to journal › Comment/debate

  158. Relative expression of cytochrome P450 isoenzymes in human liver and association with the metabolism of drugs and xenobiotics

    Forrester, L. M., Henderson, C., Glancey, M. J., Back, D. J., Park, B. K., Ball, S. E., Kitteringham, N. R., McLaren, A. W., Miles, J. S., Skett, P. & Wolf, C. R. 15-Jan-1992 In : Biochemical Journal. 281, 2, p. 359-368, 10 p.

    Research output: Contribution to journal › Article

  159. Nuclear protein phosphorylation and growth control

    Meek, D. W. & Street, A. J. 10-Jan-1992 In : Biochemical Journal. 287, 1, p. 1-15, 15 p.

    Research output: Contribution to journal › Article

  160. Structural characterization of a novel glycosyl-phosphatidylinositol from the protozoan Tetrahymena mimbres

    Weinhart, U., Thomas, J. R., Pak, Y., Thompson Jnr., G. A. & Ferguson, M. A. J. 15-Oct-1991 In : Biochemical Journal. 279, 2, p. 605-608, 4 p.

    Research output: Contribution to journal › Article

  161. Evidence that the androgen receptor mediates sexual differentiation of mouse renal cytochrome P450 expression

    Henderson, C. & Wolf, C. R. 1-Sep-1991 In : Biochemical Journal. 278, 2, p. 499-503, 5 p.

    Research output: Contribution to journal › Article

  162. Plant protein phosphatases. Subcellular distribution, detection of protein phosphatase 2C and identification of protein phosphatase 2A as the major quinate dehydrogenase phosphatase

    MacKintosh, C., Coggins, J. & Cohen, P. 1991 In : Biochemical Journal. 273, 3, p. 733-738, 6 p.

    Research output: Contribution to journal › Article

  163. Testosterone-mediated regulation of mouse renal cytochrome P-450 isoenzymes

    Henderson, C., Scott, A. R., Yang, C. S. & Wolf, C. R. 15-Mar-1990 In : Biochemical Journal. 266, 3, p. 675-681, 7 p.

    Research output: Contribution to journal › Article

  164. Inositol is a constituent of detergent-solubilized immunoaffinity-purified rat liver 5′-nucleotidase

    Bailyes, E. M., Ferguson, M. A. J., Colaco, C. A. L. S. & Luzio, J. P. 1-Feb-1990 In : Biochemical Journal. 265, 3, p. 907-909, 3 p.

    Research output: Contribution to journal › Article

  165. Identification of a cysteine residue at the active site of Escherichia coli isocitrate lyase

    Nimmo, H. G., Douglas, F., Kleanthous, C., Campbell, D. G. & MacKintosh, C. 1989 In : Biochemical Journal. 261, 2, p. 431-435, 5 p.

    Research output: Contribution to journal › Article

  166. Identification of high levels of type 1 and type 2A protein phosphatases in higher plants

    MacKintosh, C. & Cohen, P. 1989 In : Biochemical Journal. 262, 1, p. 335-339, 5 p.

    Research output: Contribution to journal › Article

  167. Purification and regulatory properties of isocitrate lyase from Escherichia coli ML308

    MacKintosh, C. & Nimmo, H. G. 15-Feb-1988 In : Biochemical Journal. 250, 1, p. 25-31, 7 p.

    Research output: Contribution to journal › Article

  168. Direct measurement of inositol in bovine myelin basic protein

    Smith, R., Braun, P. E., Ferguson, M. A. J., Low, M. G. & Sherman, W. R. 15-Nov-1987 In : Biochemical Journal. 248, 1, p. 285-288, 4 p.

    Research output: Contribution to journal › Article

  169. Identification of phosphorylated 3-deoxy-manno-octulosonic acid as a component of Haemophilus influenzae lipopolysaccharide.

    Zamze, S. E., Ferguson, M. A. J., Moxon, E. R., Dwek, R. A. & Rademacher, T. W. 15-Jul-1987 In : Biochemical Journal. 245, 2, p. 583-587, 5 p.

    Research output: Contribution to journal › Article

  170. Molecular cloning and over-expression of the glyoxylate bypass operon from Escherichia coli ML308

    el-Mansi, E. M., MacKintosh, C., Duncan, K., Holms, W. H. & Nimmo, H. G. 15-Mar-1987 In : Biochemical Journal. 242, 3, p. 661-665, 5 p.

    Research output: Contribution to journal › Article

  171. Trypanosoma brucei brucei variant surface glycoprotein contains non-N-acetylated glucosamine

    Strang, A-M., Williams, J. M., Ferguson, M. A. J., Holder, A. A. & Allen, A. K. 1-Mar-1986 In : Biochemical Journal. 234, 2, p. 481-484, 4 p.

    Research output: Contribution to journal › Article

  172. Effects of phosphorylation on the kinetic properties of rat liver fructose-1,6-bisphosphatase

    Meek, D. W. & Nimmo, H. G. 15-Aug-1984 In : Biochemical Journal. 222, 1, p. 125-130, 6 p.

    Research output: Contribution to journal › Article

  173. The allosteric properties of rat liver fructose-1,6-bisphosphatase

    Meek, D. W. & Nimmo, H. G. 15-Aug-1984 In : Biochemical Journal. 222, 1, p. 131-138, 8 p.

    Research output: Contribution to journal › Article

  174. Studies on the structure of a phosphoglycoprotein from the parasitic protozoan Trypanosoma cruzi.

    Ferguson, M. A. J., Allen, A. K. & Snary, D. 1-Aug-1983 In : Biochemical Journal. 213, 2, p. 313-319, 7 p.

    Research output: Contribution to journal › Article

  175. The detection of phosphonolipids in the protozoan Trypanosoma cruzi

    Ferguson, M. A. J., Allen, A. K. & Snary, D. 1-Oct-1982 In : Biochemical Journal. 207, 1, p. 171-174, 4 p.

    Research output: Contribution to journal › Article

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