Bioorganic & Medicinal Chemistry Letters

Synthesis and structure-activity relationships of a novel series of pyrimidines as potent inhibitors of TBK1/IKKε kinases

McIver, E. G., Bryans, J., Birchall, K., Chugh, J., Drake, T., Lewis, S. J., Osborne, J., Smiljanic-Hurley, E., Tsang, W., Kamal, A., Levy, A., Newman, M., Taylor, D., Arthur, J. S. C., Clark, K. & Cohen, P. Dec-2012 In : Bioorganic & Medicinal Chemistry Letters. 22, 23, p. 7169-7173, 5 p.

Research output: Contribution to journal › Article

Characterization of TAE684 as a potent LRRK2 kinase inhibitor

Zhang, J., Deng, X., Choi, H. G., Alessi, D. R. & Gray, N. S. 1-Mar-2012 In : Bioorganic & Medicinal Chemistry Letters. 22, 5, p. 1864-1869, 6 p.

Research output: Contribution to journal › Article

GSK2578215A: a potent and highly selective 2-arylmethyloxy-5-substitutent-N-arylbenzamide LRRK2 kinase inhibitor

Reith, A. D., Bamborough, P., Jandu, K., Andreotti, D., Mensah, L., Dossang, P., Choi, H. G., Deng, X., Zhang, J., Alessi, D. R. & Gray, N. S. 2012 In : Bioorganic & Medicinal Chemistry Letters. 22, 17, p. 5625-5629, 5 p.

Research output: Contribution to journal › Article

High-affinity fluorescent ligands for the 5-HT3 receptor

Simonin, J., Vernekar, S. K. V., Thompson, A. J., Hothersall, J. D., Connolly, C. N., Lummis, S. C. R. & Lochner, M. 2012 In : Bioorganic & Medicinal Chemistry Letters. 22, 2, p. 1151-1155, 5 p.

Research output: Contribution to journal › Article

Synthesis and biological evaluation of 1-[2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oyl]-4-ethynylimidazole. A novel and highly potent anti-inflammatory and cytoprotective agent

Honda, T., Dinkova-Kostova, A. T., David, E., Padegimas, E. M., Sundararajan, C., Visnick, M., Bumeister, R. & Wigley, W. C. 15-Apr-2011 In : Bioorganic & Medicinal Chemistry Letters. 21, 8, p. 2188-2191, 4 p.

Research output: Contribution to journal › Article

Selective delivery of 2-hydroxy APA to Trypanosoma brucei using the melamine motif

Klee, N., Wong, P. E., Baragana, B., El Mazouni, F., Phillips, M. A., Barrett, M. P. & Gilbert, I. H. 1-Aug-2010 In : Bioorganic & Medicinal Chemistry Letters. 20, 15, p. 4364-4366, 3 p.

Research output: Contribution to journal › Article

The identification a novel, selective, non-steroidal, functional glucocorticoid receptor antagonist

Rimland, J., Dunne, A., Hunjan, S. S., Sasse, R., Uings, I., Montanari, D., Caivano, M., Shah, P., Standing, D., Gray, D., Brown, D., Cairns, W., Trump, R., Smith, P. W., Bertheleme, N., D'Alessandro, P., Gul, S., Vimal, M., Smith, D. N. & Watson, S. P. Apr-2010 In : Bioorganic & Medicinal Chemistry Letters. 20, 7, p. 2340-3, 4 p.

Research output: Contribution to journal › Article

Identification of novel inhibitors of UDP-Glc 4 '-epimerase, a validated drug target for African sleeping sickness

Urbaniak, M. D., Tabudravu, J. N., Msaki, A., Matera, K. M., Brenk, R., Jaspars, M. & Ferguson, M. A. J. 15-Nov-2006 In : Bioorganic & Medicinal Chemistry Letters. 16, 22, p. 5744-5747, 4 p.

Research output: Contribution to journal › Article

Array synthesis of progesterone receptor antagonists: 3-aryl-1,2-diazepines

Wiethe, R. W., Stewart, E. L., Drewry, D. H., Gray, D. W., Mehbob, A. & Hoekstra, W. J. 15-Jul-2006 In : Bioorganic & Medicinal Chemistry Letters. 16, 14, p. 3777-9, 3 p.

Research output: Contribution to journal › Article

Design, synthesis and evaluation of novel uracil amino acid conjugates for the inhibition of Trypanosoma cruzi dUTPase

Mc Carthy, O. K., Schipani, A., Buendia, A. M., Ruiz-Perez, L. M., Kaiser, M., Brun, R., Pacanowska, D. G. & Gilbert, I. H. 15-Jul-2006 In : Bioorganic & Medicinal Chemistry Letters. 16, 14, p. 3809-3812, 4 p.

Research output: Contribution to journal › Article