Chemistry & Biology

A designed inhibitor of a clc antiporter blocks function through a unique binding mode

Howery, A. E., Elvington, S., Abraham, S. J., Choi, K-H., Dworschak-Simpson, S., Phillips, S., Ryan, C. M., Sanford, R. L., Almqvist, J., Tran, K., Chew, T. A., Zachariae, U., Andersen, O. S., Whitelegge, J., Matulef, K., Du Bois, J. & Maduke, M. C. 21-Nov-2012 In : Chemistry & Biology. 19, 11, p. 1460-1470, 11 p.

Research output: Contribution to journal › Article

Dissecting fragment-based lead discovery at the von hippel-lindau protein: Hypoxia inducible factor 1α protein-protein interface

Van Molle, I., Thomann, A., Buckley, D. L., So, E. C., Lang, S., Crews, C. M. & Ciulli, A. 26-Oct-2012 In : Chemistry & Biology. 19, 10, p. 1300-1312, 13 p.

Research output: Contribution to journal › Article

ALDH2 mediates 5-nitrofuran activity in multiple species

Zhou, L., Ishizaki, H., Spitzer, M., Taylor, K. L., Temperley, N. D., Johnson, S. L., Brear, P., Gautier, P., Zeng, Z., Mitchell, A., Narayan, V., McNeil, E. M., Melton, D. W., Smith, T. K., Tyers, M., Westwood, N. J. & Patton, E. E. 27-Jul-2012 In : Chemistry & Biology. 19, 7, p. 883-892, 10 p.

Research output: Contribution to journal › Article

Synergy of peptide and sugar in O-GlcNAcase substrate recognition

Schimpl, M., Borodkin, V. S., Gray, L. J. & van Aalten, D. M. F. 24-Feb-2012 In : Chemistry & Biology. 19, 2, p. 173-178, 6 p.

Research output: Contribution to journal › Article

Discovery of potent and selective covalent inhibitors of JNK

Zhang, T., Inesta-Vaquera, F., Niepel, M., Zhang, J., Ficarro, S. B., Machleidt, T., Xie, T., Marto, J. A., Kim, N., Sim, T., Laughlin, J. D., Park, H., LoGrasso, P. V., Patricelli, M., Nomanbhoy, T. K., Sorger, P. K., Alessi, D. R. & Gray, N. S. 27-Jan-2012 In : Chemistry & Biology. 19, 1, p. 140-154, 15 p.

Research output: Contribution to journal › Article

HSF1-Dependent Upregulation of Hsp70 by Sulfhydryl-Reactive Inducers of the KEAP1/NRF2/ARE Pathway

Zhang, Y., Ahn, Y-H., Benjamin, I. J., Honda, T., Hicks, R. J., Calabrese, V., Cole, P. A. & Dinkova-Kostova, A. T. 23-Nov-2011 In : Chemistry & Biology. 18, 11, p. 1355-1361, 7 p.

Research output: Contribution to journal › Article

Analyzing airway inflammation with chemical biology: dissection of acidic mammalian chitinase function with a selective drug-like inhibitor

Sutherland, T. E., Andersen, O. A., Betou, M., Eggleston, I. M., Maizels, R. M., van Aalten, D. & Allen, J. E. 27-May-2011 In : Chemistry & Biology. 18, 5, p. 569-579, 11 p.

Research output: Contribution to journal › Article

Novel Ligands for a Purine Riboswitch Discovered by RNA-Ligand Docking

Daldrop, P., Reyes, F. E., Robinson, D. A., Hammond, C. M., Lilley, D. M., Batey, R. T. & Brenk, R. 25-Mar-2011 In : Chemistry & Biology. 18, 3, p. 324-335, 12 p.

Research output: Contribution to journal › Article

Natural product-guided discovery of a fungal chitinase inhibitor

Rush, C. L., Schuettelkopf, A. W., Hurtado-Guerrero, R., Blair, D. E., Ibrahim, A. F. M., Desvergnes, S., Eggleston, I. M. & van Aalten, D. M. F. 22-Dec-2010 In : Chemistry & Biology. 17, 12, p. 1275-1281, 7 p.

Research output: Contribution to journal › Article

Cell-penetrant, nanomolar O-GlcNAcase inhibitors selective against lysosomal hexosaminidases

Dorfmueller, H. C., Borodkin, V. S., Schimpl, M., Zheng, X., Kime, R., Read, K. D. & van Aalten, D. M. F. 24-Nov-2010 In : Chemistry & Biology. 17, 11, p. 1250-1255, 6 p.

Research output: Contribution to journal › Article