ChemMedChem

Design, Synthesis and Biological Evaluation of Trypanosoma brucei Trypanothione Synthetase Inhibitors

Spinks, D., Torrie, L. S., Thompson, S., Harrison, J. R., Frearson, J. A., Read, K. D., Fairlamb, A. H., Wyatt, P. G. & Gilbert, I. H. 2-Jan-2012 In : ChemMedChem. 7, 1, p. 95-106, 12 p.

Research output: Contribution to journal › Article

Identification of Inhibitors of the Leishmania cdc2-Related Protein Kinase CRK3

Cleghorn, L. A. T., Woodland, A., Collie, I. T., Torrie, L. S., Norcross, N., Luksch, T., Mpamhanga, C., Walker, R. G., Mottram, J. C., Brenk, R., Frearson, J. A., Gilbert, I. H. & Wyatt, P. G. 9-Dec-2011 In : ChemMedChem. 6, 12, p. 2214-2224, 11 p.

Research output: Contribution to journal › Article

Design, Synthesis, and Evaluation of 5 '-Diphenyl Nucleoside Analogues as Inhibitors of the Plasmodium falciparum dUTPase

Hampton, S. E., Baragana, B., Schipani, A., Bosch-Navarrete, C., Alexander Musso-Buendia, J., Recio, E., Kaiser, M., Whittingham, J. L., Roberts, S. M., Shevtsov, M., Brannigan, J. A., Kahnberg, P., Brun, R., Wilson, K. S., Gonzalez-Pacanowska, D., Johansson, N. G. & Gilbert, I. H. 4-Oct-2011 In : ChemMedChem. 6, 10, p. 1816-1831, 16 p.

Research output: Contribution to journal › Article

Optimisation of the Anti-Trypanosoma brucei Activity of the Opioid Agonist U50488

Smith, V. C., Cleghorn, L. A. T., Woodland, A., Spinks, D., Hallyburton, I., Collie, I. T., Mok, N. Y., Norval, S., Brenk, R., Fairlamb, A. H., Frearson, J. A., Read, K. D., Gilbert, I. H. & Wyatt, P. G. 4-Oct-2011 In : ChemMedChem. 6, 10, p. 1832-1840, 9 p.

Research output: Contribution to journal › Article

Design, Synthesis and Biological Evaluation of Novel Inhibitors of Trypanosoma brucei Pteridine Reductase 1

Spinks, D., Ong, H. B., Mpamhanga, C. P., Shanks, E. J., Robinson, D. A., Collie, I. T., Read, K. D., Frearson, J. A., Wyatt, P. G., Brenk, R., Fairlamb, A. H. & Gilbert, I. H. 7-Feb-2011 In : ChemMedChem. 6, 2, p. 302-308, 7 p.

Research output: Contribution to journal › Article

Modified 5'-trityl nucleosides as inhibitors of plasmodium falciparum dUTPase

Gilbert, I. H., Ruda, G. F., Nguyen, C., Kasinathan, G., Ziemkowski, P., Felczak, K., Kulikowski, T., Musso-Buendia, A., Ruiz-Pérez, L. M., González-Pacanowska, D., Sund, C., Zhou, X. X., Johansson, N. G., Kaiser, M. & Brun, R. 7-Feb-2011 In : ChemMedChem. 6, 2, p. 309-320, 12 p.

Research output: Contribution to journal › Article

Synthesis and Evaluation of Indatraline-Based Inhibitors for Trypanothione Reductase

Walton, J. G. A., Jones, D. C., Kiuru, P., Durie, A. J., Westwood, N. J. & Fairlamb, A. H. 7-Feb-2011 In : ChemMedChem. 6, 2, p. 321-328, 8 p.

Research output: Contribution to journal › Article

Toward a consensus model of the hERG potassium channel

Stary, A., Wacker, S. J., Boukharta, L., Zachariae, U., Karimi-Nejad, Y., Åqvist, J., Vriend, G. & De Groot, B. L. 1-Mar-2010 In : ChemMedChem. 5, 3, p. 455-467, 13 p.

Research output: Contribution to journal › Article

Investigation of Trypanothione Reductase as a Drug Target in Trypanosoma brucei

Spinks, D., Shanks, E. J., Cleghorn, L. A. T., McElroy, S., Jones, D., James, D., Fairlamb, A. H., Frearson, J. A., Wyatt, P. G. & Gilbert, I. H. Dec-2009 In : ChemMedChem. 4, 12, p. 2060-2069, 10 p.

Research output: Contribution to journal › Article

Improved Tricyclic Inhibitors of Trypanothione Reductase by Screening and Chemical Synthesis

Richardson, J. L., Nett, I. R. E., Jones, D. C., Abdille, M. H., Gilbert, I. H. & Fairlamb, A. H. Aug-2009 In : ChemMedChem. 4, 8, p. 1333-1340, 8 p.

Research output: Contribution to journal › Article