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Diabetes

  1. High intensity exercise as a dishabituating stimulus restores counterregulatory responses in recurrently hypoglycemic rodents

    McNeilly, A. D., Gallagher, J. R., Huang, J. T-J., Ashford, M. L. J. & McCrimmon, R. J. 1 Jun 2017 In : Diabetes. 66, 6, p. 1696-1702 7 p.

    Research output: Contribution to journalArticle

  2. A Genome-Wide Association Study of IVGTT-Based Measures of First Phase Insulin Secretion Refines the Underlying Physiology of Type 2 Diabetes Variants

    Wood, A. R. , Jonsson, A. , Jackson, A. U. , Wang, N. , van Leewen, N. , Palmer, N. D. , Kobes, S. , Deelen, J. , Boquete-Vilarino, L. , Paananen, J. , Stančáková, A. , Boomsma, D. I. , de Geus, E. J. C. , Eekhoff, E. M. W. , Fritsche, A. , Kramer, M. H. H. , Nijpels, G. , Simonis-Bik, A. M. C. , van Haeften, T. W. & 32 others Mahajan, A., Boehnke, M., Bergman, R. N., Tuomilehto, J., Collins, F. S., Mohlke, K. L., Banasik, K., Groves, C. J., McCarthy, M. I., Pearson, E. R., Natali, A., Mari, A., Buchanan, T. A., Taylor, K. D., Xiang, A. H., Gjesing, A. P., Grarup, N., Eiberg, H., Pedersen, O., Chen, Y-D., Laakso, M., Norris, J. M., Smith, U., Wagenknecht, L. E., Baier, L., Bowden, D. W., Hansen, T., Walker, M., Watanabe, R. M., 't Hart, L. M., Hanson, R. L. & Frayling, T. M. 10 May 2017 In : Diabetes.

    Research output: Contribution to journalArticle

  3. An expanded genome-wide association study of type 2 diabetes in Europeans

    Palmer, C., Prokopenko, I., McCarthy, M. I. & Boehnke, M. May 2017 In : Diabetes.

    Research output: Contribution to journalArticle

  4. A Low-Frequency Inactivating Akt2 Variant Enriched in the Finnish Population is Associated With Fasting Insulin Levels and Type 2 Diabetes Risk

    Manning, A. , Highland, H. M. , Gasser, J. , Sim, X. , Tukiainen, T. , Fontanillas, P. , Grarup, N. , Rivas, M. A. , Mahajan, A. , Locke, A. E. , Cingolani, P. , Pers, T. H. , Viñuela, A. , Brown, A. A. , Wu, Y. , Flannick, J. , Fuchsberger, C. , Gamazon, E. R. , Gaulton, K. J. & 243 others Im, H. K., Teslovich, T. M., Blackwell, T. W., Bork-Jensen, J., Burtt, N. P., Chen, Y., Green, T., Hartl, C., Kang, H. M., Kumar, A., Ladenvall, C., Ma, C., Moutsianas, L., Pearson, R. D., Perry, J. R. B., Rayner, N. W., Robertson, N. R., Scott, L. J., van de Bunt, M., Eriksson, J. G., Jula, A., Koskinen, S., Lehtimäki, T., Palotie, A., Raitakari, O. T., Jacobs, S. B., Wessel, J., Chu, A. Y., Scott, R. A., Goodarzi, M. O., Blancher, C., Buck, G., Buck, D., Chines, P. S., Gabriel, S., Gjesing, A. P., Groves, C. J., Hollensted, M., Huyghe, J. R., Jackson, A. U., Jun, G., Justesen, J. M., Mangino, M., Murphy, J., Neville, M., Onofrio, R., Small, K. S., Stringham, H. M., Trakalo, J., Banks, E., Carey, J., Carneiro, M. O., DePristo, M., Farjoun, Y., Fennell, T., Goldstein, J. I., Grant, G., Hrabé de Angelis, M., Maguire, J., Neale, B. M., Poplin, R., Purcell, S., Schwarzmayr, T., Shakir, K., Smith, J. D., Strom, T. M., Wieland, T., Lindstrom, J., Brandslund, I., Christensen, C., Surdulescu, G. L., Lakka, T. A., Doney, A. S. F., Nilsson, P., Wareham, N. J., Langenberg, C., Varga, T. V., Franks, P. W., Rolandsson, O., Rosengren, A. H., Farook, V. S., Thameem, F., Puppala, S., Kumar, S., Lehman, D. M., Jenkinson, C. P., Curran, J. E., Fowler, S. P., Arya, R., DeFronzo, R. A., Abboud, H. E., Syvänen, A-C., Hicks, P. J., Palmer, N. D., Ng, M. C. Y., Bowden, D. W., Freedman, B. I., Esko, T., Mägi, R., Milani, L., Mihailov, E., Metspalu, A., Narisu, N., Kinnunen, L., Bonnycastle, L. L., Swift, A., Pasko, D., Wood, A. R., Fadista, J., Pollin, T. I., Barzilai, N., Atzmon, G., Glaser, B., Thorand, B., Strauch, K., Peters, A., Roden, M., Müller-Nurasyid, M., Liang, L., Kriebel, J., Illig, T., Grallert, H., Gieger, C., Meisinger, C., Lannfelt, L., Musani, S. K., Griswold, M., Taylor, H. A., Wilson, G., Correa, A., Oksa, H., Scott, W. R., Afzal, U., Tan, S-T., Loh, M., Chambers, J. C., Sehmi, J., Kooner, J. S., Lehne, B., Cho, Y. S., Lee, J-Y., Han, B-G., Käräjämäki, A., Qi, Q., Qi, L., Huang, J., Hu, F. B., Melander, O., Orho-Melander, M., Below, J. E., Aguilar, D., Wong, T. Y., Liu, J., Khor, C-C., Chia, K. S., Lim, W. Y., Cheng, C-Y., Chan, E., Tai, E. S., Aung, T., Linneberg, A., Isomaa, B., Meitinger, T., Tuomi, T., Hakaste, L., Kravic, J., Jørgensen, M. E., Lauritzen, T., Deloukas, P., Stirrups, K. E., Owen, K. R., Farmer, A. J., Frayling, T. M., O'Rahilly, S. P., Walker, M., Levy, J. C., Hodgkiss, D., Hattersley, A. T., Kuulasmaa, T., Stančáková, A., Barroso, I., Bharadwaj, D., Chan, J., Chandak, G. R., Daly, M. J., Donnelly, P. J., Ebrahim, S. B., Elliott, P., Fingerlin, T., Froguel, P., Hu, C., Jia, W., Ma, R. C. W., McVean, G., Park, T., Prabhakaran, D., Sandhu, M., Scott, J., Sladek, R., Tandon, N., Teo, Y. Y., Zeggini, E., Watanabe, R. M., Koistinen, H. A., Kesaniemi, Y. A., Uusitupa, M., Spector, T. D., Salomaa, V., Rauramaa, R., Palmer, C. N. A., Prokopenko, I., Morris, A. D., Bergman, R. N., Collins, F. S., Lind, L., Ingelsson, E., Tuomilehto, J., Karpe, F., Groop, L., Jørgensen, T., Hansen, T., Pedersen, O., Kuusisto, J., Abecasis, G., Bell, G. I., Blangero, J., Cox, N. J., Duggirala, R., Seielstad, M., Wilson, J. G., Dupuis, J., Ripatti, S., Hanis, C. L., Florez, J. C., Mohlke, K. L., Meigs, J. B., Laakso, M., Morris, A. P., Boehnke, M., Altshuler, D., McCarthy, M. I., Gloyn, A. L. & Lindgren, C. M. 24 Mar 2017 In : Diabetes.

    Research output: Contribution to journalArticle

  5. Nrf2-mediated neuroprotection response to recurrent hypoglycemia is insufficient to prevent cognitive impairment in a rodent model of type 1 diabetes

    McNeilly, A. D., Gallagher, J. R., Dinkova-Kostova, A. T., Hayes, J. D., Sharkey, J., Ashford, M. L. J. & McCrimmon, R. J. 1 Oct 2016 In : Diabetes. 65, 10, p. 3151-3160 10 p.

    Research output: Contribution to journalArticle

  6. The common p.R114W HNF4A mutation causes a distinct clinical subtype of monogenic diabetes

    Laver, T. W., Colclough, K., Shepherd, M., Patel, K., Houghton, J. A. L., Dusatkova, P., Pruhova, S., Morris, A. D., Palmer, C. N., McCarthy, M. I., Ellard, S., Hattersley, A. T. & Weedon, M. N. Oct 2016 In : Diabetes. 65, 10, p. 3212-3217 6 p.

    Research output: Contribution to journalArticle

  7. Genetic evidence for a link between favorable adiposity and lower risk of type 2 diabetes, hypertension and heart disease

    Yaghootkar, H. , Lotta, L. A. , Tyrrell, J. , Smit, R. A. J. , Jones, S. E. , Donnelly, L. , Beaumont, R. , Campbell, A. , Tuke, M. A. , Hayward, C. , Ruth, K. S. , Padmanabhan, S. , Jukema, J. W. , Palmer, C. C. , Hattersley, A. , Freathy, R. M. , Langenberg, C. , Wareham, N. J. , Wood, A. R. & 6 others Murray, A., Weedon, M. N., Sattar, N., Pearson, E., Scott, R. A. & Frayling, T. M. Aug 2016 In : Diabetes. 65, 8, p. 2448-2460 13 p.

    Research output: Contribution to journalArticle

  8. The Na+/glucose co-transporter inhibitor canagliflozin activates AMP-activated protein kinase by inhibiting mitochondrial function and increasing cellular AMP levels

    Hawley, S., Ford, R. J., Smith, B. K., Gowans, G. J., Mancini, S. J., Pitt, R. D., A. Day, E., Salt, I. P., Steinberg, G. R. & Hardie, D. G. 1 Jul 2016 In : Diabetes. 65, 9, p. 2784-2794 11 p.

    Research output: Contribution to journalArticle

  9. Integrin-linked kinase in muscle is necessary for the development of insulin resistance in diet-induced obese mice

    Kang, L., Mokshagundam, S., Reuter, B., Lark, D. S., Sneddon, C. C., Hennayake, C., Williams, A. S., Bracy, D. P., James, F. D., Pozzi, A., Zent, R. & Wasserman, D. H. 1 Jun 2016 In : Diabetes. 65, 6, p. 1590-1600 11 p.

    Research output: Contribution to journalArticle

  10. Dissecting the etiology of type 2 diabetes in the Pima Indian population

    Pearson, E. R. Dec 2015 In : Diabetes. 64, 12, p. 3993-3995 3 p.

    Research output: Contribution to journalComment/debate

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