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Diabetes

  1. 5-aminoimidazole-4-carboxamide 1-beta-D-ribofuranoside acutely stimulates skeletal muscle 2-deoxyglucose uptake in healthy men

    Cuthbertson, D. J., Babraj, J. A., Mustard, K. J. W., Towler, M. C., Green, K. A., Wackerhage, H., Leese, G. P., Baar, K., Thomason-Hughes, M., Sutherland, C., Hardie, D. G. & Rennie, M. J. 2007 In : Diabetes. 56, 8, p. 2078-2084 7 p.

    Research output: Contribution to journalArticle

  2. 5-aminoimidazole-4-carboxamide riboside mimics the effects of insulin on the expression of the 2 key gluconeogenic genes PEPCK and glucose-6-phosphatase

    Lochhead, P. A., Salt, I. P., Walker, K. S., Hardie, D. G. & Sutherland, C. 2000 In : Diabetes. 49, 6, p. 896-903 8 p.

    Research output: Contribution to journalArticle

  3. A Genome-Wide Association Study of IVGTT-Based Measures of First Phase Insulin Secretion Refines the Underlying Physiology of Type 2 Diabetes Variants

    Wood, A. R. , Jonsson, A. , Jackson, A. U. , Wang, N. , van Leewen, N. , Palmer, N. D. , Kobes, S. , Deelen, J. , Boquete-Vilarino, L. , Paananen, J. , Stančáková, A. , Boomsma, D. I. , de Geus, E. J. C. , Eekhoff, E. M. W. , Fritsche, A. , Kramer, M. H. H. , Nijpels, G. , Simonis-Bik, A. M. C. , van Haeften, T. W. , Mahajan, A. & 31 others Boehnke, M., Bergman, R. N., Tuomilehto, J., Collins, F. S., Mohlke, K. L., Banasik, K., Groves, C. J., McCarthy, M. I., Pearson, E. R., Natali, A., Mari, A., Buchanan, T. A., Taylor, K. D., Xiang, A. H., Gjesing, A. P., Grarup, N., Eiberg, H., Pedersen, O., Chen, Y-D., Laakso, M., Norris, J. M., Smith, U., Wagenknecht, L. E., Baier, L., Bowden, D. W., Hansen, T., Walker, M., Watanabe, R. M., 't Hart, L. M., Hanson, R. L. & Frayling, T. M. 21 Jul 2017 In : Diabetes. 66, 8, p. 2296-2309 14 p.

    Research output: Contribution to journalArticle

  4. A Low-Frequency Inactivating Akt2 Variant Enriched in the Finnish Population is Associated With Fasting Insulin Levels and Type 2 Diabetes Risk

    Manning, A. , Highland, H. M. , Gasser, J. , Sim, X. , Tukiainen, T. , Fontanillas, P. , Grarup, N. , Rivas, M. A. , Mahajan, A. , Locke, A. E. , Cingolani, P. , Pers, T. H. , Viñuela, A. , Brown, A. A. , Wu, Y. , Flannick, J. , Fuchsberger, C. , Gamazon, E. R. , Gaulton, K. J. , Im, H. K. & 242 others Teslovich, T. M., Blackwell, T. W., Bork-Jensen, J., Burtt, N. P., Chen, Y., Green, T., Hartl, C., Kang, H. M., Kumar, A., Ladenvall, C., Ma, C., Moutsianas, L., Pearson, R. D., Perry, J. R. B., Rayner, N. W., Robertson, N. R., Scott, L. J., van de Bunt, M., Eriksson, J. G., Jula, A., Koskinen, S., Lehtimäki, T., Palotie, A., Raitakari, O. T., Jacobs, S. B., Wessel, J., Chu, A. Y., Scott, R. A., Goodarzi, M. O., Blancher, C., Buck, G., Buck, D., Chines, P. S., Gabriel, S., Gjesing, A. P., Groves, C. J., Hollensted, M., Huyghe, J. R., Jackson, A. U., Jun, G., Justesen, J. M., Mangino, M., Murphy, J., Neville, M., Onofrio, R., Small, K. S., Stringham, H. M., Trakalo, J., Banks, E., Carey, J., Carneiro, M. O., DePristo, M., Farjoun, Y., Fennell, T., Goldstein, J. I., Grant, G., Hrabé de Angelis, M., Maguire, J., Neale, B. M., Poplin, R., Purcell, S., Schwarzmayr, T., Shakir, K., Smith, J. D., Strom, T. M., Wieland, T., Lindstrom, J., Brandslund, I., Christensen, C., Surdulescu, G. L., Lakka, T. A., Doney, A. S. F., Nilsson, P., Wareham, N. J., Langenberg, C., Varga, T. V., Franks, P. W., Rolandsson, O., Rosengren, A. H., Farook, V. S., Thameem, F., Puppala, S., Kumar, S., Lehman, D. M., Jenkinson, C. P., Curran, J. E., Fowler, S. P., Arya, R., DeFronzo, R. A., Abboud, H. E., Syvänen, A-C., Hicks, P. J., Palmer, N. D., Ng, M. C. Y., Bowden, D. W., Freedman, B. I., Esko, T., Mägi, R., Milani, L., Mihailov, E., Metspalu, A., Narisu, N., Kinnunen, L., Bonnycastle, L. L., Swift, A., Pasko, D., Wood, A. R., Fadista, J., Pollin, T. I., Barzilai, N., Atzmon, G., Glaser, B., Thorand, B., Strauch, K., Peters, A., Roden, M., Müller-Nurasyid, M., Liang, L., Kriebel, J., Illig, T., Grallert, H., Gieger, C., Meisinger, C., Lannfelt, L., Musani, S. K., Griswold, M., Taylor, H. A., Wilson, G., Correa, A., Oksa, H., Scott, W. R., Afzal, U., Tan, S-T., Loh, M., Chambers, J. C., Sehmi, J., Kooner, J. S., Lehne, B., Cho, Y. S., Lee, J-Y., Han, B-G., Käräjämäki, A., Qi, Q., Qi, L., Huang, J., Hu, F. B., Melander, O., Orho-Melander, M., Below, J. E., Aguilar, D., Wong, T. Y., Liu, J., Khor, C-C., Chia, K. S., Lim, W. Y., Cheng, C-Y., Chan, E., Tai, E. S., Aung, T., Linneberg, A., Isomaa, B., Meitinger, T., Tuomi, T., Hakaste, L., Kravic, J., Jørgensen, M. E., Lauritzen, T., Deloukas, P., Stirrups, K. E., Owen, K. R., Farmer, A. J., Frayling, T. M., O'Rahilly, S. P., Walker, M., Levy, J. C., Hodgkiss, D., Hattersley, A. T., Kuulasmaa, T., Stančáková, A., Barroso, I., Bharadwaj, D., Chan, J., Chandak, G. R., Daly, M. J., Donnelly, P. J., Ebrahim, S. B., Elliott, P., Fingerlin, T., Froguel, P., Hu, C., Jia, W., Ma, R. C. W., McVean, G., Park, T., Prabhakaran, D., Sandhu, M., Scott, J., Sladek, R., Tandon, N., Teo, Y. Y., Zeggini, E., Watanabe, R. M., Koistinen, H. A., Kesaniemi, Y. A., Uusitupa, M., Spector, T. D., Salomaa, V., Rauramaa, R., Palmer, C. N. A., Prokopenko, I., Morris, A. D., Bergman, R. N., Collins, F. S., Lind, L., Ingelsson, E., Tuomilehto, J., Karpe, F., Groop, L., Jørgensen, T., Hansen, T., Pedersen, O., Kuusisto, J., Abecasis, G., Bell, G. I., Blangero, J., Cox, N. J., Duggirala, R., Seielstad, M., Wilson, J. G., Dupuis, J., Ripatti, S., Hanis, C. L., Florez, J. C., Mohlke, K. L., Meigs, J. B., Laakso, M., Morris, A. P., Boehnke, M., Altshuler, D., McCarthy, M. I., Gloyn, A. L. & Lindgren, C. M. 24 Mar 2017 In : Diabetes.

    Research output: Contribution to journalArticle

  5. A role for uncoupling proteins in neuroprotection following recurrent hypoglycemia?

    McCrimmon, R., Andrews, Z., Coppola, A., Cheng, H., Sherwin, R. & Diano, S. Jun 2007 In : Diabetes. 56, Suppl 1, p. A166-A166 1 p., 626-P

    Research output: Contribution to journalArticle

  6. Activation of AMP-activated protein kinase within the ventromedial hypothalamus amplifies counterregulatory hormone responses in rats with defective counterregulation

    McCrimmon, R. J., Fan, X., Cheng, H., McNay, E., Chan, O., Shaw, M., Ding, Y., Zhu, W. & Sherwin, R. S. Jun 2006 In : Diabetes. 55, 6, p. 1755-1760 6 p.

    Research output: Contribution to journalArticle

  7. Activation of ATP-sensitive K+ channels in the ventromedial hypothalamus amplifies counterregulatory hormone responses to hypoglycemia in normal and recurrently hypoglycemic rats

    McCrimmon, R. J., Evans, M. L., Fan, X., McNay, E. C., Chan, O., Ding, Y., Zhu, W., Gram, D. X. & Sherwin, R. S. Nov 2005 In : Diabetes. 54, 11, p. 3169-3174 6 p.

    Research output: Contribution to journalArticle

  8. Acute hypoglycemia induces activated neurons in the lateral hypothalamus of the brain and in the intermediolateral cell column of the spinal cord; while recurrent hypoglycemia blunts them

    Zhou, L., Fan, X., Ding, Y., Zhu, W., Chan, O., Vella, M. C., Sherwin, R. S. & McCrimmon, R. J. Jun 2007 In : Diabetes. 56, Suppl 1, p. A101-A101 1 p., 385-OR

    Research output: Contribution to journalArticle

  9. Adiposity-Related Heterogeneity in Patterns of Type 2 Diabetes Susceptibility Observed in Genome-Wide Association Data

    Timpson, N. J., Lindgren, C. M., Weedon, M. N., Randall, J., Ouwehand, W. H., Strachan, D. P., Rayner, N. W., Walker, M., Hitman, G. A., Doney, A. S. F., Palmer, C. N. A., Morris, A. D., Hattersley, A. T., Zeggini, E., Frayling, T. M. & McCarthy, M. I. Feb 2009 In : Diabetes. 58, 2, p. 505-510 6 p.

    Research output: Contribution to journalArticle

  10. AMP-activated protein kinase (AMPK): A key mediator of hypoglycemia-sensing in the ventromedial hypothalamus (VMH)

    McCrimmon, R. J., Shaw, M., Fan, X., Cheng, H., Ding, Y., Wang, A. & Sherwin, R. S. Jun 2006 In : Diabetes. 55, Suppl 1, p. A15-A15 1 p., 62-OR

    Research output: Contribution to journalArticle

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