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  1. Heterozygous SOD2 Deletion Impairs Glucose-Stimulated Insulin Secretion, but not Insulin Action in High Fat-Fed Mice

    Kang, L., Dai, C., Lustig, M. E., Bonner, J. S., Mayes, W. H., Mokshagundam, S., James, F. D., Thompson, C. S., Lin, C-T., Perry, C. G. R., Anderson, E. J., Neufer, P. D., Wasserman, D. H. & Powers, A. C. 2014 In : Diabetes.

    Research output: Contribution to journalArticle

  2. Glucose-6-phosphate-mediated activation of liver glycogen synthase plays a key role in hepatic glycogen synthesis

    von Wilamowitz-Moellendorff, A., Hunter, R. W., García-Rocha, M., Kang, L., López-Soldado, I., Lantier, L., Patel, K., Peggie, M. W., Martínez-Pons, C., Voss, M., Calbó, J., Cohen, P. T. W., Wasserman, D. H., Guinovart, J. J. & Sakamoto, K. Dec 2013 In : Diabetes. 62, 12, p. 4070-4082 13 p.

    Research output: Contribution to journalArticle

  3. Mendelian randomisation studies do not support a causal role for reduced circulating adiponectin levels in insulin resistance and type 2 diabetes

    Morris, A. D. & 77 others Yaghootkar, H., Lamina, C., Scott, R. A., Dastani, Z., Hivert, M-F., Warren, L. L., Stancáková, A., Buxbaum, S. G., Lyytikäinen, L-P., Henneman, P., Wu, Y., Cheung, C. Y. Y., Pankow, J. S., Jackson, A. U., Gustafsson, S., Zhao, J. H., Ballantyne, C. M., Xie, W., Bergman, R. N., Boehnke, M., el Bouazzaoui, F., Collins, F. S., Dunn, S. H., Dupuis, J., Forouhi, N. G., Gillson, C., Hattersley, A. T., Hong, J., Kähönen, M., Kuusisto, J., Kedenko, L., Kronenberg, F., Doria, A., Assimes, T. L., Ferrannini, E., Hansen, T., Hao, K., Häring, H., Knowles, J. W., Lindgren, C. M., Nolan, J. J., Paananen, J., Pedersen, O., Quertermous, T., Smith, U., the GENESIS consortium, the RISC consortium, Lehtimäki, T., Liu, C-T., Loos, R. J. F., McCarthy, M. I., Vasan, R. S., Spector, T. D., Teslovich, T. M., Tuomilehto, J., Willems van Dijk, K., Viikari, J. S., Zhu, N., Langenberg, C., Ingelsson, E., Semple, R. K., Sinaiko, A. R., Palmer, C. N. A., Walker, M., Lam, K. S. L., Paulweber, B., Mohlke, K. L., van Duijn, C., Raitakari, O. T., Bidulescu, A., Wareham, N. J., Laakso, M., Waterworth, D. M., Lawlor, D. A., Meigs, J. B., Richards, J. B. & Frayling, T. M. Oct 2013 In : Diabetes. 62, 10, p. 3589-3598 10 p.

    Research output: Contribution to journalArticle

  4. Mitochondrial Substrate Availability and its Role in Lipid-Induced Insulin Resistance and Proinflammatory Signalling in Skeletal Muscle

    Lipina, C., Macrae, K., Suhm, T., Weigert, C., Blachnio-Zabielska, A., Baranowksi, M., Gorski, J., Burgess, K. & Hundal, H. S. Oct 2013 In : Diabetes. 62, 10, p. 3426-3436 11 p.

    Research output: Contribution to journalArticle

  5. AMPK: a target for drugs and natural products with effects on both diabetes and cancer

    Hardie, D. G. Jul 2013 In : Diabetes. 62, 7, p. 2164-2172 9 p.

    Research output: Contribution to journalArticle

  6. Biomarkers for type 2 diabetes and impaired fasting glucose using a non-targeted metabolomics approach

    Menni, C. , Fauman, E. , Erte, I. , Perry, J. R. B. , Kastenmüller, G. , Shin, S-Y. , Petersen, A-K. , Hyde, C. , Psatha, M. , Ward, K. J. , Yuan, W. , Milburn, M. , Palmer, C. N. A. , Frayling, T. M. , Trimmer, J. , Bell, J. T. , Gieger, C. , Mohney, R. , Brosnan, M. J. , Suhre, K. & 2 others Soranzo, N. & Spector, T. D. 2013 In : Diabetes.

    Research output: Contribution to journalArticle

  7. The CTRB1/2 locus affects diabetes susceptibility and treatment via the incretin pathway

    't Hart, L. M. , Fritsche, A. , Nijpels, G. , van Leeuwen, N. , Donnelly, L. A. , Dekker, J. M. , Alssema, M. , Fadista, J. , Carlotti, F. , Gjesing, A. P. , Palmer, C. N. A. , van Haeften, T. W. , Herzberg-Schäfer, S. A. , Simonis-Bik, A. M. C. , Houwing-Duistermaat, J. J. , Helmer, Q. , Deelen, J. , Guigas, B. , Hansen, T. , Machicao, F. & 14 others Willemsen, G., Heine, R. J., Kramer, M. H. H., Holst, J. J., de Koning, E. J. P., Häring, H-U., Pedersen, O., Groop, L., de Geus, E. J. C., Slagboom, P. E., Boomsma, D. I., Eekhoff, E. M. W., Pearson, E. R. & Diamant, M. 2013 In : Diabetes.

    Research output: Contribution to journalArticle

  8. Cellular Responses to the Metal-Binding Properties of Metformin

    Logie, L., Harthill, J., Patel, K., Bacon, S., Hamilton, D. L., Macrae, K., McDougall, G., Wang, H-H., Xue, L., Jiang, H., Sakamoto, K., Prescott, A. R. & Rena, G. Jun 2012 In : Diabetes. 61, 6, p. 1423-1433 11 p.

    Research output: Contribution to journalArticle

  9. Deep Resequencing Unveils Genetic Architecture of ADIPOQ and Identifies a Novel Low-Frequency Variant Strongly Associated With Adiponectin Variation

    Morris, A. D. & 21 others Warren, L. L., Li, L., Nelson, M. R., Ehm, M. G., Shen, J., Fraser, D. J., Aponte, J. L., Nangle, K. L., Slater, A. J., Woollard, P. M., Hall, M. D., Topp, S. D., Yuan, X., Cardon, L. R., Chissoe, S. L., Mooser, V., Palmer, C. N. A., Perry, J. R., Frayling, T. M., Whittaker, J. C. & Waterworth, D. M. May 2012 In : Diabetes. 61, 5, p. 1297-1301 5 p.

    Research output: Contribution to journalArticle

  10. Total soluble and endogenous secretory receptor for advanced glycation end products as predictive biomarkers of coronary heart disease risk in patients with type 2 Diabetes: an analysis from the CARDS trial

    Colhoun, H. M., Betteridge, D. J., Durrington, P., Hitman, G., Neil, A., Livingstone, S., Charlton-Menys, V., Bao, W., DeMicco, D. A., Preston, G. M., Deshmukh, H., Tan, K. & Fuller, J. H. Sep 2011 In : Diabetes. 60, 9, p. 2379-2385 7 p.

    Research output: Contribution to journalArticle

  11. Deletion of Lkb1 in Pro-Opiomelanocortin Neurons Impairs Peripheral Glucose Homeostasis in Mice

    Ashford, M. L. & 22 others Claret, M., Smith, M. A., Knauf, C., Al-Qassab, H., Woods, A., Heslegrave, A., Piipari, K., Emmanuel, J. J., Colom, A., Valet, P., Cani, P. D., Begum, G., White, A., Mucket, P., Peters, M., Mizuno, K., Batterham, R. L., Giese, K. P., Ashworth, A., Burcelin, R., Carling, D. & Withers, D. J. Mar 2011 In : Diabetes. 60, 3, p. 735-745 11 p.

    Research output: Contribution to journalArticle

  12. Mendelian randomization studies do not support a role for raised circulating triglyceride levels influencing type 2 diabetes, glucose levels, or insulin resistance.

    Morris, A. D. & 21 others De Silva, N. M. G., Freathy, R. M., Palmer, T. M., Donnelly, L. A., Luan, J., Gaunt, T., Langenberg, C., Weedon, M. N., Shields, B., Knight, B. A., Ward, K. J., Sandhu, M. S., Harbord, R. M., McCarthy, M. I., Smith, G. D., Ebrahim, S., Hattersley, A. T., Wareham, N., Lawlor, D. A., Palmer, C. N. A. & Frayling, T. M. Mar 2011 In : Diabetes. 60, 3, p. 1008-1018 11 p.

    Research output: Contribution to journalArticle

  13. Combined effect of inflammatory gene polymorphisms and the risk of ischemic stroke in a prospective cohort of subjects with type 2 diabetes: A Go-DARTS study

    Palmer, C. N. A., Kimber, C. H., Doney, A. S. F., Proia, A. S., Morris, A. D., Gaetani, E., Quarta, M., Smith, R. C. & Pola, R. Nov 2010 In : Diabetes. 59, 11, p. 2945-2948 4 p.

    Research output: Contribution to journalArticle

  14. Hypoglycemia in Type 1 Diabetes

    McCrimmon, R. J. & Sherwin, R. S. Oct 2010 In : Diabetes. 59, 10, p. 2333-2339 7 p.

    Research output: Contribution to journalArticle

  15. The Medial Amygdalar Nucleus: A Novel Glucose-Sensing Region That Modulates the Counterregulatory Response to Hypoglycemia

    Zhou, L., Podolsky, N., Sang, Z., Ding, Y., Fan, X., Tong, Q., Levin, B. E. & McCrimmon, R. J. Oct 2010 In : Diabetes. 59, 10, p. 2646-2652 7 p.

    Research output: Contribution to journalArticle

  16. Hypothalamic FKBP5 Is Induced by Fasting and Leptin Deficiency and Elevated Expression Promotes Obese Phenotypes

    Nguyen, L., Yen, K., Mastaitis, J., Dunn-Meynell, A., Levin, B., Routh, V., McCrimmon, R., Isoda, F., Sherwin, R., Musatov, S. & Mobbs, C. Jun 2010 In : Diabetes. 59, p. A470-A470 1 p.

    Research output: Contribution to journalBook/Film/Article review

  17. Influence of Insulin in the Ventromedial Hypothalamus on Pancreatic Glucagon Secretion In Vivo

    Paranjape, S. A., Chan, O., Zhu, W., Horblitt, A. M., McNay, E. C., Cresswell, J. A., Bogan, J. S., McCrimmon, R. J. & Sherwin, R. S. Jun 2010 In : Diabetes. 59, 6, p. 1521-1527 7 p.

    Research output: Contribution to journalArticle

  18. Multimodal Characterization of Brain Responses to Acute Insulin-Induced Hypoglycemia: An In Vivo fMRI and Electrophysiology Study

    Herman, P., Herzog, R., Zhou, L., Sherwin, R., Hyder, F. & McCrimmon, R. Jun 2010 In : Diabetes. 59, p. A213-A213 1 p.

    Research output: Contribution to journalBook/Film/Article review

  19. PPARG, insulin resistance and metformin pharmacogenetics-A GoDARTS study

    Zhou, K., Burch, L., Hattersley, A. T., McCarthy, M. I., Morris, A. D., Palmer, C. N. A. & Pearson, E. R. Jun 2010 In : Diabetes. 59, p. A115-A115 1 p.

    Research output: Contribution to journalBook/Film/Article review

  20. Thiazolidinedione associated fractures are not limited to distal fractures and occur in men as well as women

    Colhoun, H. M. & Scottish Diabet Research Network Epidemiology Group Jun 2010 In : Diabetes. 59, p. A20-A21 2 p.

    Research output: Contribution to journalBook/Film/Article review

  21. Regulation of MAP Kinase-Directed Mitogenic and Protein Kinase B-Mediated Signaling by Cannabinoid Receptor Type 1 in Skeletal Muscle Cells

    Lipina, C., Stretton, C., Hastings, S., Hundal, J. S., Mackie, K., Irving, A. J. & Hundal, H. S. Feb 2010 In : Diabetes. 59, 2, p. 375-385 11 p.

    Research output: Contribution to journalArticle

  22. Ventromedial Hypothalamic Nitric Oxide Production Is Necessary for Hypoglycemia Detection and Counterregulation

    Fioramonti, X., Marsollier, N., Song, Z., Fakira, K. A., Patel, R. M., Brown, S., Duparc, T., Pica-Mendez, A., Sanders, N. M., Knauf, C., Valet, P., McCrimmon, R. J., Beuve, A., Magnan, C. & Routh, V. H. Feb 2010 In : Diabetes. 59, 2, p. 519-528 10 p.

    Research output: Contribution to journalArticle

  23. Novel Insights Into the Etiology of Diabetes From Genome-Wide Association Studies

    Palmer, C. N. A. Nov 2009 In : Diabetes. 58, 11, p. 2444-2447 4 p.

    Research output: Contribution to journalEditorial

  24. Linkage Disequilibrium Mapping of the Replicated Type 2 Diabetes Linkage Signal on Chromosome 1q

    Morris, A. D. & 32 others Prokopenko, I., Zeggini, E., Hanson, R. L., Mitchell, B. D., Rayner, N. W., Akan, P., Baier, L., Das, S. K., Elliott, K. S., Fu, M., Frayling, T. M., Groves, C. J., Gwilliam, R., Scott, L. J., Voight, B. F., Hattersley, A. T., Hu, C., Ng, M., Palmer, C. N. A., Tello-Ruiz, M., Vaxillaire, M., Wang, C., Stein, L., Chan, J., Jia, W., Froguel, P., Elbein, S. C., Deloukas, P., Bogardus, C., Shuldiner, A. R., McCarthy, M. I. & Int Type 2 Diabet 1q Consortium Jul 2009 In : Diabetes. 58, 7, p. 1704-1709 6 p.

    Research output: Contribution to journalArticle

  25. Activation of EphA5 Receptors in the Ventromedial Hypothalemus(VMH) Stimulates the Counterregulatory Response to Acute Hypoglycemia

    Szepietowska, B., Zhu, W., Chan, O., Paran-Jape, S., Zhou, L., Mccrimmon, R. J. & Sherwin, R. S. Jun 2009 In : Diabetes. 58, p. A169-A169 1 p.

    Research output: Contribution to journalBook/Film/Article review

  26. Insulin Acts in the VMH To Suppress Pancreatic Glucagon Secretion

    Paranjape, S. A., Chan, O., Zhu, W., Horblitt, A., McCrimmon, R. & Sherwin, R. Jun 2009 In : Diabetes. 58, p. A34-A34 1 p.

    Research output: Contribution to journalBook/Film/Article review

  27. Medial Amygadalar Nucleus, a Novel Limbic Glu - cosensing Region in Rodent, Modulates Counterregulatory Hormone Response to Hypoglycemia

    Zhou, L., Podolsky, N., Sang, Z., Tong, Q., Lowell, B., Vale, W., Levin, B. E. & McCrimmon, R. J. Jun 2009 In : Diabetes. 58, p. A15-A15 1 p.

    Research output: Contribution to journalBook/Film/Article review

  28. Reduced-function SLC22A1 polymorphisms encoding organic cation transporter 1 and glycemic response to metformin: A GoDARTS study

    Zhou, K., Donnelly, L. A., Kimber, C. H., Donnan, P. T., Doney, A. S. F., Leese, G., Hattersley, A. T., McCarthy, M. I., Morris, A. D., Palmer, C. N. A. & Pearson, E. R. Jun 2009 In : Diabetes. 58, 6, p. 1434-1439 6 p.

    Research output: Contribution to journalArticle

  29. The Sources of GABAergic Innervation of the Ventromedial Hypothalamus

    Zhou, L., Chan, O., McCrimmon, R. J. & Sherwin, R. S. Jun 2009 In : Diabetes. 58, p. A14-A15 2 p.

    Research output: Contribution to journalBook/Film/Article review

  30. Medium-Chain Fatty Acids Improve Cognitive Function in Intensively Treated Type 1 Diabetic Patients and Support In Vitro Synaptic Transmission During Acute Hypoglycemia

    Page, K. A., Williamson, A., Yu, N., McNay, E. C., Dzuira, J., McCrimmon, R. J. & Sherwin, R. S. May 2009 In : Diabetes. 58, 5, p. 1237-1244 8 p.

    Research output: Contribution to journalArticle

  31. Adiposity-Related Heterogeneity in Patterns of Type 2 Diabetes Susceptibility Observed in Genome-Wide Association Data

    Timpson, N. J., Lindgren, C. M., Weedon, M. N., Randall, J., Ouwehand, W. H., Strachan, D. P., Rayner, N. W., Walker, M., Hitman, G. A., Doney, A. S. F., Palmer, C. N. A., Morris, A. D., Hattersley, A. T., Zeggini, E., Frayling, T. M. & McCarthy, M. I. Feb 2009 In : Diabetes. 58, 2, p. 505-510 6 p.

    Research output: Contribution to journalArticle

  32. Amplified Hormonal Counterregulatory Responses to Hypoglycemia in Rats After Systemic Delivery of a SUR-1-Selective K+ Channel Opener?

    Fan, X., Ding, Y., Cheng, H., Gram, D. X., Sherwin, R. S. & McCrimmon, R. J. Dec 2008 In : Diabetes. 57, 12, p. 3327-3334 8 p.

    Research output: Contribution to journalArticle

  33. Assessing the combined impact of 18 common genetic variants of modest effect sizes on type 2 diabetes risk

    Lango, H., Palmer, C. N. A., Morris, A. D., Zeggini, E., Hattersley, A. T., McCarthy, M. I., Frayling, T. M., Weedon, M. N. & UK Type Diab Genetics Consortium Nov 2008 In : Diabetes. 57, 11, p. 3129-3135 7 p.

    Research output: Contribution to journalArticle

  34. Dual role of hypothalamic nitric oxide (NO) production in the control of the counter-regulatory response to hypoglycemia

    Fioramonti, X., Sayed, N., Marsollier, N., Mccrimmon, R. J., Pica-Mendez, A., Bogorff, D., Tobon, K. E., Smith, P. J., Sherwin, R. S., Sanders, N. M., Magnan, C., Beuve, A. & Routh, V. H. Jun 2008 In : Diabetes. 57, p. A171-A171 1 p.

    Research output: Contribution to journalBook/Film/Article review

  35. Insulin signaling in the ventromedial hypothalamus (VMH) regulates glucagon secretion during Eu- and hypoglycemia

    Paranjape, S. A., Chan, O., Zhu, W., Wang, A., Fan, X., Mccrimmon, R. & Sherwin, R. Jun 2008 In : Diabetes. 57, p. A39-A40 2 p.

    Research output: Contribution to journalBook/Film/Article review

  36. Medium chain triglycerides improve memory performance during acute hypoglycemia in intensively treated type 1 diabetics

    Page, K. A., McCrimmon, R., Yu, N., Dziura, J. & Sherwin, R. Jun 2008 In : Diabetes. 57, p. A5-A5 1 p.

    Research output: Contribution to journalBook/Film/Article review

  37. Orexin mediates feeding, but not counter regulatory hormonal responses to acute hypoglycemia

    Zhou, L., Sang, Z., Brown, S., Fan, X. & Mccrimmon, R. Jun 2008 In : Diabetes. 57, p. A39-A39 1 p.

    Research output: Contribution to journalBook/Film/Article review

  38. Common variation in the FTO gene alters diabetes-related metabolic traits to the extent expected given its effect on BMI

    Morris, A. D. & 24 others Freathy, R. M., Timpson, N. J., Lawlor, D. A., Pouta, A., Ben-Shlomo, Y., Ruokonen, A., Ebrahim, S., Shields, B., Zeggini, E., Weedon, M. N., Lindgren, C. M., Lango, H., Melzer, D., Ferrucci, L., Paolisso, G., Neville, M. J., Karpe, F., Palmer, C. N. A., Elliott, P., Jarvelin, M-R., Smith, G. D., McCarthy, M. I., Hattersley, A. T. & Frayling, T. M. May 2008 In : Diabetes. 57, 5, p. 1419-1426 8 p.

    Research output: Contribution to journalArticle

  39. Increased GABAergic tone in the ventromedial hypothalamus contributes to suppression of counterregulatory reponses after antecedent Hypoglycemia

    Chan, O., Cheng, H., Herzog, R., Czyzyk, D., Zhu, W., Wang, A., McCrimmon, R. J., Seashore, M. R. & Sherwin, R. S. May 2008 In : Diabetes. 57, 5, p. 1363-1370 8 p.

    Research output: Contribution to journalArticle

  40. Key role for AMP-activated protein kinase in the ventromedial hypothalamus in regulating counterregulatory hormone responses to acute hypoglycemia

    McCrimmon, R. J., Shaw, M., Fan, X., Cheng, H., Ding, Y., Vella, M. C., Zhou, L., Mcnay, E. C. & Sherwin, R. S. Feb 2008 In : Diabetes. 57, 2, p. 444-450 7 p.

    Research output: Contribution to journalArticle

  41. Identification of small compounds that mimic insulin action on the transcription factor FOXO1a

    Cameron, A., Anton, S., Reetoo, N., Melville, L., Houston, N., Dayal, S., McDougall, G., Stewart, D. & Rena, G. 2008 In : Diabetes. 57, Suppl., p. A699-A700 2 p.

    Research output: Contribution to journalMeeting abstract

  42. Characterization of a protein kinase B inhibitor in vitro and in insulin-treated liver cells

    Logie, L., Ruiz-Alcaraz, A. J., Keane, M., Woods, Y. L., Bain, J., Marquez, R., Alessi, D. R. & Sutherland, C. Sep 2007 In : Diabetes. 56, 9, p. 2218-2227 10 p.

    Research output: Contribution to journalArticle

  43. Variation in TCF7L2 influences therapeutic response to sulfonylureas: a GoDARTs study

    Pearson, E. R., Donnelly, L. A., Kimber, C., Whitley, A., Doney, A. S. F., McCarthy, M. I., Hattersley, A. T., Morris, A. D. & Palmer, C. N. A. Aug 2007 In : Diabetes. 56, 8, p. 2178-2182 5 p.

    Research output: Contribution to journalArticle

  44. 5-aminoimidazole-4-carboxamide 1-beta-D-ribofuranoside acutely stimulates skeletal muscle 2-deoxyglucose uptake in healthy men

    Cuthbertson, D. J., Babraj, J. A., Mustard, K. J. W., Towler, M. C., Green, K. A., Wackerhage, H., Leese, G. P., Baar, K., Thomason-Hughes, M., Sutherland, C., Hardie, D. G. & Rennie, M. J. 2007 In : Diabetes. 56, 8, p. 2078-2084 7 p.

    Research output: Contribution to journalArticle

  45. Contrasting insulin sensitivity of endogenous glucose production rate in subjects with hepatocyte nuclear factor-1β and -1α mutations

    Brackenridge, A., Pearson, E. R., Shojaee-Moradie, F., Hattersley, A. T., Russell-Jones, D. & Umpleby, A. M. Feb 2006 In : Diabetes. 55, 2, p. 405-411 7 p.

    Research output: Contribution to journalArticle

  46. Insulin-stimulated glucose uptake does not require p38 mitogen-activated protein kinase in adipose tissue or skeletal muscle

    Turban, S., Beardmore, V. A., Carr, J. M., Sakamoto, K., Hajduch, E., Arthur, J. S. C. & Hundal, H. S. Nov 2005 In : Diabetes. 54, 11, p. 3161-3168 8 p.

    Research output: Contribution to journalArticle

  47. Initial characterization of a rat model of diabetic nephropathy

    Nobrega, M. A., Fleming, S., Roman, R. J., Shiozawa, M., Schlick, N., Lazar, J. & Jacob, H. J. 2004 In : Diabetes. 53, 3, p. 735-42 8 p.

    Research output: Contribution to journalArticle

  48. Disruption of the striated muscle glycogen targeting subunit PPP1R3A of protein phosphatase 1 leads to increased weight gain, fat deposition, and development of insulin resistance

    Delibegovic, M., Armstrong, C. G., Dobbie, L., Watt, P. W., Smith, A. J. H. & Cohen, T. Mar 2003 In : Diabetes. 52, 3, p. 596-604 9 p.

    Research output: Contribution to journalArticle

  49. Relationship of phospholipid transfer protein activity to HDL and apolipoprotein B–Containing lipoproteins in subjects with and without type 1 diabetes

    Colhoun, H. M., Taskinen, M-R., Otvos, J. D., van den Berg, P., O'Connor, J. & Van Tol, A. Nov 2002 In : Diabetes. 51, 11, p. 3300-3305 6 p.

    Research output: Contribution to journalArticle

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