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  1. The CTRB1/2 locus affects diabetes susceptibility and treatment via the incretin pathway

    't Hart, L. M. , Fritsche, A. , Nijpels, G. , van Leeuwen, N. , Donnelly, L. A. , Dekker, J. M. , Alssema, M. , Fadista, J. , Carlotti, F. , Gjesing, A. P. , Palmer, C. N. A. , van Haeften, T. W. , Herzberg-Schäfer, S. A. , Simonis-Bik, A. M. C. , Houwing-Duistermaat, J. J. , Helmer, Q. , Deelen, J. , Guigas, B. , Hansen, T. , Machicao, F. & 14 others Willemsen, G., Heine, R. J., Kramer, M. H. H., Holst, J. J., de Koning, E. J. P., Häring, H-U., Pedersen, O., Groop, L., de Geus, E. J. C., Slagboom, P. E., Boomsma, D. I., Eekhoff, E. M. W., Pearson, E. R. & Diamant, M. 2013 In : Diabetes.

    Research output: Contribution to journalArticle

  2. Cellular Responses to the Metal-Binding Properties of Metformin

    Logie, L., Harthill, J., Patel, K., Bacon, S., Hamilton, D. L., Macrae, K., McDougall, G., Wang, H-H., Xue, L., Jiang, H., Sakamoto, K., Prescott, A. R. & Rena, G. Jun-2012 In : Diabetes. 61, 6, p. 1423-1433, 11 p.

    Research output: Contribution to journalArticle

  3. Deep Resequencing Unveils Genetic Architecture of ADIPOQ and Identifies a Novel Low-Frequency Variant Strongly Associated With Adiponectin Variation

    Warren, L. L. , Li, L. , Nelson, M. R. , Ehm, M. G. , Shen, J. , Fraser, D. J. , Aponte, J. L. , Nangle, K. L. , Slater, A. J. , Woollard, P. M. , Hall, M. D. , Topp, S. D. , Yuan, X. , Cardon, L. R. , Chissoe, S. L. , Mooser, V. , Morris, A. D. , Palmer, C. N. A. , Perry, J. R. , Frayling, T. M. & 2 others Whittaker, J. C. & Waterworth, D. M. May-2012 In : Diabetes. 61, 5, p. 1297-1301, 5 p.

    Research output: Contribution to journalArticle

  4. Total soluble and endogenous secretory receptor for advanced glycation end products as predictive biomarkers of coronary heart disease risk in patients with type 2 Diabetes: an analysis from the CARDS trial

    Colhoun, H. M., Betteridge, D. J., Durrington, P., Hitman, G., Neil, A., Livingstone, S., Charlton-Menys, V., Bao, W., DeMicco, D. A., Preston, G. M., Deshmukh, H., Tan, K. & Fuller, J. H. Sep-2011 In : Diabetes. 60, 9, p. 2379-2385, 7 p.

    Research output: Contribution to journalArticle

  5. Deletion of Lkb1 in Pro-Opiomelanocortin Neurons Impairs Peripheral Glucose Homeostasis in Mice

    Claret, M. , Smith, M. A. , Knauf, C. , Al-Qassab, H. , Woods, A. , Heslegrave, A. , Piipari, K. , Emmanuel, J. J. , Colom, A. , Valet, P. , Cani, P. D. , Begum, G. , White, A. , Mucket, P. , Peters, M. , Mizuno, K. , Batterham, R. L. , Giese, K. P. , Ashworth, A. , Burcelin, R. & 3 others Ashford, M. L., Carling, D. & Withers, D. J. Mar-2011 In : Diabetes. 60, 3, p. 735-745, 11 p.

    Research output: Contribution to journalArticle

  6. Mendelian randomization studies do not support a role for raised circulating triglyceride levels influencing type 2 diabetes, glucose levels, or insulin resistance.

    De Silva, N. M. G. , Freathy, R. M. , Palmer, T. M. , Donnelly, L. A. , Luan, J. , Gaunt, T. , Langenberg, C. , Weedon, M. N. , Shields, B. , Knight, B. A. , Ward, K. J. , Sandhu, M. S. , Harbord, R. M. , McCarthy, M. I. , Smith, G. D. , Ebrahim, S. , Hattersley, A. T. , Wareham, N. , Lawlor, D. A. , Morris, A. D. & 2 others Palmer, C. N. A. & Frayling, T. M. Mar-2011 In : Diabetes. 60, 3, p. 1008-1018, 11 p.

    Research output: Contribution to journalArticle

  7. Combined effect of inflammatory gene polymorphisms and the risk of ischemic stroke in a prospective cohort of subjects with type 2 diabetes: A Go-DARTS study

    Palmer, C. N. A., Kimber, C. H., Doney, A. S. F., Proia, A. S., Morris, A. D., Gaetani, E., Quarta, M., Smith, R. C. & Pola, R. Nov-2010 In : Diabetes. 59, 11, p. 2945-2948, 4 p.

    Research output: Contribution to journalArticle

  8. Hypoglycemia in Type 1 Diabetes

    McCrimmon, R. J. & Sherwin, R. S. Oct-2010 In : Diabetes. 59, 10, p. 2333-2339, 7 p.

    Research output: Contribution to journalArticle

  9. The Medial Amygdalar Nucleus: A Novel Glucose-Sensing Region That Modulates the Counterregulatory Response to Hypoglycemia

    Zhou, L., Podolsky, N., Sang, Z., Ding, Y., Fan, X., Tong, Q., Levin, B. E. & McCrimmon, R. J. Oct-2010 In : Diabetes. 59, 10, p. 2646-2652, 7 p.

    Research output: Contribution to journalArticle

  10. Hypothalamic FKBP5 Is Induced by Fasting and Leptin Deficiency and Elevated Expression Promotes Obese Phenotypes

    Nguyen, L., Yen, K., Mastaitis, J., Dunn-Meynell, A., Levin, B., Routh, V., McCrimmon, R., Isoda, F., Sherwin, R., Musatov, S. & Mobbs, C. Jun-2010 In : Diabetes. 59, p. A470-A470, 1 p.

    Research output: Contribution to journalBook/Film/Article review

  11. Influence of Insulin in the Ventromedial Hypothalamus on Pancreatic Glucagon Secretion In Vivo

    Paranjape, S. A., Chan, O., Zhu, W., Horblitt, A. M., McNay, E. C., Cresswell, J. A., Bogan, J. S., McCrimmon, R. J. & Sherwin, R. S. Jun-2010 In : Diabetes. 59, 6, p. 1521-1527, 7 p.

    Research output: Contribution to journalArticle

  12. Multimodal Characterization of Brain Responses to Acute Insulin-Induced Hypoglycemia: An In Vivo fMRI and Electrophysiology Study

    Herman, P., Herzog, R., Zhou, L., Sherwin, R., Hyder, F. & McCrimmon, R. Jun-2010 In : Diabetes. 59, p. A213-A213, 1 p.

    Research output: Contribution to journalBook/Film/Article review

  13. PPARG, insulin resistance and metformin pharmacogenetics-A GoDARTS study

    Zhou, K., Burch, L., Hattersley, A. T., McCarthy, M. I., Morris, A. D., Palmer, C. N. A. & Pearson, E. R. Jun-2010 In : Diabetes. 59, p. A115-A115, 1 p.

    Research output: Contribution to journalBook/Film/Article review

  14. Thiazolidinedione associated fractures are not limited to distal fractures and occur in men as well as women

    Colhoun, H. M. & Scottish Diabet Research Network Epidemiology Group Jun-2010 In : Diabetes. 59, p. A20-A21, 2 p.

    Research output: Contribution to journalBook/Film/Article review

  15. Regulation of MAP Kinase-Directed Mitogenic and Protein Kinase B-Mediated Signaling by Cannabinoid Receptor Type 1 in Skeletal Muscle Cells

    Lipina, C., Stretton, C., Hastings, S., Hundal, J. S., Mackie, K., Irving, A. J. & Hundal, H. S. Feb-2010 In : Diabetes. 59, 2, p. 375-385, 11 p.

    Research output: Contribution to journalArticle

  16. Ventromedial Hypothalamic Nitric Oxide Production Is Necessary for Hypoglycemia Detection and Counterregulation

    Fioramonti, X., Marsollier, N., Song, Z., Fakira, K. A., Patel, R. M., Brown, S., Duparc, T., Pica-Mendez, A., Sanders, N. M., Knauf, C., Valet, P., McCrimmon, R. J., Beuve, A., Magnan, C. & Routh, V. H. Feb-2010 In : Diabetes. 59, 2, p. 519-528, 10 p.

    Research output: Contribution to journalArticle

  17. Novel Insights Into the Etiology of Diabetes From Genome-Wide Association Studies

    Palmer, C. N. A. Nov-2009 In : Diabetes. 58, 11, p. 2444-2447, 4 p.

    Research output: Contribution to journalEditorial

  18. Linkage Disequilibrium Mapping of the Replicated Type 2 Diabetes Linkage Signal on Chromosome 1q

    Prokopenko, I. , Zeggini, E. , Hanson, R. L. , Mitchell, B. D. , Rayner, N. W. , Akan, P. , Baier, L. , Das, S. K. , Elliott, K. S. , Fu, M. , Frayling, T. M. , Groves, C. J. , Gwilliam, R. , Scott, L. J. , Voight, B. F. , Hattersley, A. T. , Hu, C. , Morris, A. D. , Ng, M. , Palmer, C. N. A. & 13 others Tello-Ruiz, M., Vaxillaire, M., Wang, C., Stein, L., Chan, J., Jia, W., Froguel, P., Elbein, S. C., Deloukas, P., Bogardus, C., Shuldiner, A. R., McCarthy, M. I. & Int Type 2 Diabet 1q Consortium Jul-2009 In : Diabetes. 58, 7, p. 1704-1709, 6 p.

    Research output: Contribution to journalArticle

  19. Activation of EphA5 Receptors in the Ventromedial Hypothalemus(VMH) Stimulates the Counterregulatory Response to Acute Hypoglycemia

    Szepietowska, B., Zhu, W., Chan, O., Paran-Jape, S., Zhou, L., Mccrimmon, R. J. & Sherwin, R. S. Jun-2009 In : Diabetes. 58, p. A169-A169, 1 p.

    Research output: Contribution to journalBook/Film/Article review

  20. Insulin Acts in the VMH To Suppress Pancreatic Glucagon Secretion

    Paranjape, S. A., Chan, O., Zhu, W., Horblitt, A., McCrimmon, R. & Sherwin, R. Jun-2009 In : Diabetes. 58, p. A34-A34, 1 p.

    Research output: Contribution to journalBook/Film/Article review

  21. Medial Amygadalar Nucleus, a Novel Limbic Glu - cosensing Region in Rodent, Modulates Counterregulatory Hormone Response to Hypoglycemia

    Zhou, L., Podolsky, N., Sang, Z., Tong, Q., Lowell, B., Vale, W., Levin, B. E. & McCrimmon, R. J. Jun-2009 In : Diabetes. 58, p. A15-A15, 1 p.

    Research output: Contribution to journalBook/Film/Article review

  22. Reduced-function SLC22A1 polymorphisms encoding organic cation transporter 1 and glycemic response to metformin: A GoDARTS study

    Zhou, K., Donnelly, L. A., Kimber, C. H., Donnan, P. T., Doney, A. S. F., Leese, G., Hattersley, A. T., McCarthy, M. I., Morris, A. D., Palmer, C. N. A. & Pearson, E. R. Jun-2009 In : Diabetes. 58, 6, p. 1434-1439, 6 p.

    Research output: Contribution to journalArticle

  23. The Sources of GABAergic Innervation of the Ventromedial Hypothalamus

    Zhou, L., Chan, O., McCrimmon, R. J. & Sherwin, R. S. Jun-2009 In : Diabetes. 58, p. A14-A15, 2 p.

    Research output: Contribution to journalBook/Film/Article review

  24. Medium-Chain Fatty Acids Improve Cognitive Function in Intensively Treated Type 1 Diabetic Patients and Support In Vitro Synaptic Transmission During Acute Hypoglycemia

    Page, K. A., Williamson, A., Yu, N., McNay, E. C., Dzuira, J., McCrimmon, R. J. & Sherwin, R. S. May-2009 In : Diabetes. 58, 5, p. 1237-1244, 8 p.

    Research output: Contribution to journalArticle

  25. Adiposity-Related Heterogeneity in Patterns of Type 2 Diabetes Susceptibility Observed in Genome-Wide Association Data

    Timpson, N. J., Lindgren, C. M., Weedon, M. N., Randall, J., Ouwehand, W. H., Strachan, D. P., Rayner, N. W., Walker, M., Hitman, G. A., Doney, A. S. F., Palmer, C. N. A., Morris, A. D., Hattersley, A. T., Zeggini, E., Frayling, T. M. & McCarthy, M. I. Feb-2009 In : Diabetes. 58, 2, p. 505-510, 6 p.

    Research output: Contribution to journalArticle

  26. Amplified Hormonal Counterregulatory Responses to Hypoglycemia in Rats After Systemic Delivery of a SUR-1-Selective K+ Channel Opener?

    Fan, X., Ding, Y., Cheng, H., Gram, D. X., Sherwin, R. S. & McCrimmon, R. J. Dec-2008 In : Diabetes. 57, 12, p. 3327-3334, 8 p.

    Research output: Contribution to journalArticle

  27. Assessing the combined impact of 18 common genetic variants of modest effect sizes on type 2 diabetes risk

    Lango, H., Palmer, C. N. A., Morris, A. D., Zeggini, E., Hattersley, A. T., McCarthy, M. I., Frayling, T. M., Weedon, M. N. & UK Type Diab Genetics Consortium Nov-2008 In : Diabetes. 57, 11, p. 3129-3135, 7 p.

    Research output: Contribution to journalArticle

  28. Dual role of hypothalamic nitric oxide (NO) production in the control of the counter-regulatory response to hypoglycemia

    Fioramonti, X., Sayed, N., Marsollier, N., Mccrimmon, R. J., Pica-Mendez, A., Bogorff, D., Tobon, K. E., Smith, P. J., Sherwin, R. S., Sanders, N. M., Magnan, C., Beuve, A. & Routh, V. H. Jun-2008 In : Diabetes. 57, p. A171-A171, 1 p.

    Research output: Contribution to journalBook/Film/Article review

  29. Insulin signaling in the ventromedial hypothalamus (VMH) regulates glucagon secretion during Eu- and hypoglycemia

    Paranjape, S. A., Chan, O., Zhu, W., Wang, A., Fan, X., Mccrimmon, R. & Sherwin, R. Jun-2008 In : Diabetes. 57, p. A39-A40, 2 p.

    Research output: Contribution to journalBook/Film/Article review

  30. Medium chain triglycerides improve memory performance during acute hypoglycemia in intensively treated type 1 diabetics

    Page, K. A., McCrimmon, R., Yu, N., Dziura, J. & Sherwin, R. Jun-2008 In : Diabetes. 57, p. A5-A5, 1 p.

    Research output: Contribution to journalBook/Film/Article review

  31. Orexin mediates feeding, but not counter regulatory hormonal responses to acute hypoglycemia

    Zhou, L., Sang, Z., Brown, S., Fan, X. & Mccrimmon, R. Jun-2008 In : Diabetes. 57, p. A39-A39, 1 p.

    Research output: Contribution to journalBook/Film/Article review

  32. Common variation in the FTO gene alters diabetes-related metabolic traits to the extent expected given its effect on BMI

    Freathy, R. M. , Timpson, N. J. , Lawlor, D. A. , Pouta, A. , Ben-Shlomo, Y. , Ruokonen, A. , Ebrahim, S. , Shields, B. , Zeggini, E. , Weedon, M. N. , Lindgren, C. M. , Lango, H. , Melzer, D. , Ferrucci, L. , Paolisso, G. , Neville, M. J. , Karpe, F. , Palmer, C. N. A. , Morris, A. D. , Elliott, P. & 5 others Jarvelin, M-R., Smith, G. D., McCarthy, M. I., Hattersley, A. T. & Frayling, T. M. May-2008 In : Diabetes. 57, 5, p. 1419-1426, 8 p.

    Research output: Contribution to journalArticle

  33. Increased GABAergic tone in the ventromedial hypothalamus contributes to suppression of counterregulatory reponses after antecedent Hypoglycemia

    Chan, O., Cheng, H., Herzog, R., Czyzyk, D., Zhu, W., Wang, A., McCrimmon, R. J., Seashore, M. R. & Sherwin, R. S. May-2008 In : Diabetes. 57, 5, p. 1363-1370, 8 p.

    Research output: Contribution to journalArticle

  34. Key role for AMP-activated protein kinase in the ventromedial hypothalamus in regulating counterregulatory hormone responses to acute hypoglycemia

    McCrimmon, R. J., Shaw, M., Fan, X., Cheng, H., Ding, Y., Vella, M. C., Zhou, L., Mcnay, E. C. & Sherwin, R. S. Feb-2008 In : Diabetes. 57, 2, p. 444-450, 7 p.

    Research output: Contribution to journalArticle

  35. Identification of small compounds that mimic insulin action on the transcription factor FOXO1a

    Cameron, A., Anton, S., Reetoo, N., Melville, L., Houston, N., Dayal, S., McDougall, G., Stewart, D. & Rena, G. 2008 In : Diabetes. 57, Suppl., p. A699-A700, 2 p.

    Research output: Contribution to journalMeeting abstract

  36. Characterization of a protein kinase B inhibitor in vitro and in insulin-treated liver cells

    Logie, L., Ruiz-Alcaraz, A. J., Keane, M., Woods, Y. L., Bain, J., Marquez, R., Alessi, D. R. & Sutherland, C. Sep-2007 In : Diabetes. 56, 9, p. 2218-2227, 10 p.

    Research output: Contribution to journalArticle

  37. Variation in TCF7L2 influences therapeutic response to sulfonylureas: a GoDARTs study

    Pearson, E. R., Donnelly, L. A., Kimber, C., Whitley, A., Doney, A. S. F., McCarthy, M. I., Hattersley, A. T., Morris, A. D. & Palmer, C. N. A. Aug-2007 In : Diabetes. 56, 8, p. 2178-2182, 5 p.

    Research output: Contribution to journalArticle

  38. 5-aminoimidazole-4-carboxamide 1-beta-D-ribofuranoside acutely stimulates skeletal muscle 2-deoxyglucose uptake in healthy men

    Cuthbertson, D. J., Babraj, J. A., Mustard, K. J. W., Towler, M. C., Green, K. A., Wackerhage, H., Leese, G. P., Baar, K., Thomason-Hughes, M., Sutherland, C., Hardie, D. G. & Rennie, M. J. 2007 In : Diabetes. 56, 8, p. 2078-2084, 7 p.

    Research output: Contribution to journalArticle

  39. Contrasting insulin sensitivity of endogenous glucose production rate in subjects with hepatocyte nuclear factor-1β and -1α mutations

    Brackenridge, A., Pearson, E. R., Shojaee-Moradie, F., Hattersley, A. T., Russell-Jones, D. & Umpleby, A. M. Feb-2006 In : Diabetes. 55, 2, p. 405-411, 7 p.

    Research output: Contribution to journalArticle

  40. Insulin-stimulated glucose uptake does not require p38 mitogen-activated protein kinase in adipose tissue or skeletal muscle

    Turban, S., Beardmore, V. A., Carr, J. M., Sakamoto, K., Hajduch, E., Arthur, J. S. C. & Hundal, H. S. Nov-2005 In : Diabetes. 54, 11, p. 3161-3168, 8 p.

    Research output: Contribution to journalArticle

  41. Initial characterization of a rat model of diabetic nephropathy

    Nobrega, M. A., Fleming, S., Roman, R. J., Shiozawa, M., Schlick, N., Lazar, J. & Jacob, H. J. 2004 In : Diabetes. 53, 3, p. 735-42, 8 p.

    Research output: Contribution to journalArticle

  42. Disruption of the striated muscle glycogen targeting subunit PPP1R3A of protein phosphatase 1 leads to increased weight gain, fat deposition, and development of insulin resistance

    Delibegovic, M., Armstrong, C. G., Dobbie, L., Watt, P. W., Smith, A. J. H. & Cohen, T. Mar-2003 In : Diabetes. 52, 3, p. 596-604, 9 p.

    Research output: Contribution to journalArticle

  43. Relationship of phospholipid transfer protein activity to HDL and apolipoprotein B–Containing lipoproteins in subjects with and without type 1 diabetes

    Colhoun, H. M., Taskinen, M-R., Otvos, J. D., van den Berg, P., O'Connor, J. & Van Tol, A. Nov-2002 In : Diabetes. 51, 11, p. 3300-3305, 6 p.

    Research output: Contribution to journalArticle

  44. Human skeletal muscle expresses a glycogen-targeting subunit of PP1 that is identical to the insulin-sensitive glycogen-targeting subunit G(L) of liver

    Munro, S., Cuthbertson, D. J. R., Cunningham, J., Sales, M. & Cohen, P. T. W. 2002 In : Diabetes. 51, 3, p. 591-598, 8 p.

    Research output: Contribution to journalArticle

  45. Potency of Michael reaction acceptors as inducers of enzymes that protect against carcinogenesis depends on their reactivity with sulfhydryl groups

    Dinkova-Kostova, A. T., Massiah, M. A., Bozak, R. E., Hicks, R. J. & Talalay, P. Mar-2001 In : Diabetes. 98, 6, p. 3404-3409, 6 p.

    Research output: Contribution to journalArticle

  46. Inhibition of GSK-3 selectively reduces glucose-6-phosphatase and phosphoenolpyruvate carboxykinase gene expression

    Lochhead, P. A., Coghlan, M., Rice, S. Q. J. & Sutherland, C. 2001 In : Diabetes. 50, 5, p. 937-946, 10 p.

    Research output: Contribution to journalArticle

  47. 5-aminoimidazole-4-carboxamide riboside mimics the effects of insulin on the expression of the 2 key gluconeogenic genes PEPCK and glucose-6-phosphatase

    Lochhead, P. A., Salt, I. P., Walker, K. S., Hardie, D. G. & Sutherland, C. 2000 In : Diabetes. 49, 6, p. 896-903, 8 p.

    Research output: Contribution to journalArticle

  48. Oxidative and chemical stress mimic insulin by selectively inhibiting the expression of phosphoenolpyruvate carboxykinase in hepatoma cells

    Sutherland, C., Tebbey, P. W. & Granner, D. K. 1997 In : Diabetes. 46, 1, p. 17-22, 6 p.

    Research output: Contribution to journalArticle

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