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Diabetes

  1. A Genome-Wide Association Study of IVGTT-Based Measures of First Phase Insulin Secretion Refines the Underlying Physiology of Type 2 Diabetes Variants

    Wood, A. R. , Jonsson, A. , Jackson, A. U. , Wang, N. , van Leewen, N. , Palmer, N. D. , Kobes, S. , Deelen, J. , Boquete-Vilarino, L. , Paananen, J. , Stančáková, A. , Boomsma, D. I. , de Geus, E. J. C. , Eekhoff, E. M. W. , Fritsche, A. , Kramer, M. H. H. , Nijpels, G. , Simonis-Bik, A. M. C. , van Haeften, T. W. , Mahajan, A. & 31 others Boehnke, M., Bergman, R. N., Tuomilehto, J., Collins, F. S., Mohlke, K. L., Banasik, K., Groves, C. J., McCarthy, M. I., Pearson, E. R., Natali, A., Mari, A., Buchanan, T. A., Taylor, K. D., Xiang, A. H., Gjesing, A. P., Grarup, N., Eiberg, H., Pedersen, O., Chen, Y-D., Laakso, M., Norris, J. M., Smith, U., Wagenknecht, L. E., Baier, L., Bowden, D. W., Hansen, T., Walker, M., Watanabe, R. M., 't Hart, L. M., Hanson, R. L. & Frayling, T. M. 21 Jul 2017 In : Diabetes. 66, 8, p. 2296-2309 14 p.

    Research output: Contribution to journalArticle

  2. High intensity exercise as a dishabituating stimulus restores counterregulatory responses in recurrently hypoglycemic rodents

    McNeilly, A. D., Gallagher, J. R., Huang, J. T-J., Ashford, M. L. J. & McCrimmon, R. J. 1 Jun 2017 In : Diabetes. 66, 6, p. 1696-1702 7 p.

    Research output: Contribution to journalArticle

  3. An expanded genome-wide association study of type 2 diabetes in Europeans

    Palmer, C., Prokopenko, I., McCarthy, M. I. & Boehnke, M. May 2017 In : Diabetes.

    Research output: Contribution to journalArticle

  4. A Low-Frequency Inactivating Akt2 Variant Enriched in the Finnish Population is Associated With Fasting Insulin Levels and Type 2 Diabetes Risk

    Manning, A. , Highland, H. M. , Gasser, J. , Sim, X. , Tukiainen, T. , Fontanillas, P. , Grarup, N. , Rivas, M. A. , Mahajan, A. , Locke, A. E. , Cingolani, P. , Pers, T. H. , Viñuela, A. , Brown, A. A. , Wu, Y. , Flannick, J. , Fuchsberger, C. , Gamazon, E. R. , Gaulton, K. J. , Im, H. K. & 242 others Teslovich, T. M., Blackwell, T. W., Bork-Jensen, J., Burtt, N. P., Chen, Y., Green, T., Hartl, C., Kang, H. M., Kumar, A., Ladenvall, C., Ma, C., Moutsianas, L., Pearson, R. D., Perry, J. R. B., Rayner, N. W., Robertson, N. R., Scott, L. J., van de Bunt, M., Eriksson, J. G., Jula, A., Koskinen, S., Lehtimäki, T., Palotie, A., Raitakari, O. T., Jacobs, S. B., Wessel, J., Chu, A. Y., Scott, R. A., Goodarzi, M. O., Blancher, C., Buck, G., Buck, D., Chines, P. S., Gabriel, S., Gjesing, A. P., Groves, C. J., Hollensted, M., Huyghe, J. R., Jackson, A. U., Jun, G., Justesen, J. M., Mangino, M., Murphy, J., Neville, M., Onofrio, R., Small, K. S., Stringham, H. M., Trakalo, J., Banks, E., Carey, J., Carneiro, M. O., DePristo, M., Farjoun, Y., Fennell, T., Goldstein, J. I., Grant, G., Hrabé de Angelis, M., Maguire, J., Neale, B. M., Poplin, R., Purcell, S., Schwarzmayr, T., Shakir, K., Smith, J. D., Strom, T. M., Wieland, T., Lindstrom, J., Brandslund, I., Christensen, C., Surdulescu, G. L., Lakka, T. A., Doney, A. S. F., Nilsson, P., Wareham, N. J., Langenberg, C., Varga, T. V., Franks, P. W., Rolandsson, O., Rosengren, A. H., Farook, V. S., Thameem, F., Puppala, S., Kumar, S., Lehman, D. M., Jenkinson, C. P., Curran, J. E., Fowler, S. P., Arya, R., DeFronzo, R. A., Abboud, H. E., Syvänen, A-C., Hicks, P. J., Palmer, N. D., Ng, M. C. Y., Bowden, D. W., Freedman, B. I., Esko, T., Mägi, R., Milani, L., Mihailov, E., Metspalu, A., Narisu, N., Kinnunen, L., Bonnycastle, L. L., Swift, A., Pasko, D., Wood, A. R., Fadista, J., Pollin, T. I., Barzilai, N., Atzmon, G., Glaser, B., Thorand, B., Strauch, K., Peters, A., Roden, M., Müller-Nurasyid, M., Liang, L., Kriebel, J., Illig, T., Grallert, H., Gieger, C., Meisinger, C., Lannfelt, L., Musani, S. K., Griswold, M., Taylor, H. A., Wilson, G., Correa, A., Oksa, H., Scott, W. R., Afzal, U., Tan, S-T., Loh, M., Chambers, J. C., Sehmi, J., Kooner, J. S., Lehne, B., Cho, Y. S., Lee, J-Y., Han, B-G., Käräjämäki, A., Qi, Q., Qi, L., Huang, J., Hu, F. B., Melander, O., Orho-Melander, M., Below, J. E., Aguilar, D., Wong, T. Y., Liu, J., Khor, C-C., Chia, K. S., Lim, W. Y., Cheng, C-Y., Chan, E., Tai, E. S., Aung, T., Linneberg, A., Isomaa, B., Meitinger, T., Tuomi, T., Hakaste, L., Kravic, J., Jørgensen, M. E., Lauritzen, T., Deloukas, P., Stirrups, K. E., Owen, K. R., Farmer, A. J., Frayling, T. M., O'Rahilly, S. P., Walker, M., Levy, J. C., Hodgkiss, D., Hattersley, A. T., Kuulasmaa, T., Stančáková, A., Barroso, I., Bharadwaj, D., Chan, J., Chandak, G. R., Daly, M. J., Donnelly, P. J., Ebrahim, S. B., Elliott, P., Fingerlin, T., Froguel, P., Hu, C., Jia, W., Ma, R. C. W., McVean, G., Park, T., Prabhakaran, D., Sandhu, M., Scott, J., Sladek, R., Tandon, N., Teo, Y. Y., Zeggini, E., Watanabe, R. M., Koistinen, H. A., Kesaniemi, Y. A., Uusitupa, M., Spector, T. D., Salomaa, V., Rauramaa, R., Palmer, C. N. A., Prokopenko, I., Morris, A. D., Bergman, R. N., Collins, F. S., Lind, L., Ingelsson, E., Tuomilehto, J., Karpe, F., Groop, L., Jørgensen, T., Hansen, T., Pedersen, O., Kuusisto, J., Abecasis, G., Bell, G. I., Blangero, J., Cox, N. J., Duggirala, R., Seielstad, M., Wilson, J. G., Dupuis, J., Ripatti, S., Hanis, C. L., Florez, J. C., Mohlke, K. L., Meigs, J. B., Laakso, M., Morris, A. P., Boehnke, M., Altshuler, D., McCarthy, M. I., Gloyn, A. L. & Lindgren, C. M. 24 Mar 2017 In : Diabetes.

    Research output: Contribution to journalArticle

  5. Nrf2-mediated neuroprotection response to recurrent hypoglycemia is insufficient to prevent cognitive impairment in a rodent model of type 1 diabetes

    McNeilly, A. D., Gallagher, J. R., Dinkova-Kostova, A. T., Hayes, J. D., Sharkey, J., Ashford, M. L. J. & McCrimmon, R. J. 1 Oct 2016 In : Diabetes. 65, 10, p. 3151-3160 10 p.

    Research output: Contribution to journalArticle

  6. The common p.R114W HNF4A mutation causes a distinct clinical subtype of monogenic diabetes

    Laver, T. W., Colclough, K., Shepherd, M., Patel, K., Houghton, J. A. L., Dusatkova, P., Pruhova, S., Morris, A. D., Palmer, C. N., McCarthy, M. I., Ellard, S., Hattersley, A. T. & Weedon, M. N. Oct 2016 In : Diabetes. 65, 10, p. 3212-3217 6 p.

    Research output: Contribution to journalArticle

  7. Genetic evidence for a link between favorable adiposity and lower risk of type 2 diabetes, hypertension and heart disease

    Yaghootkar, H. , Lotta, L. A. , Tyrrell, J. , Smit, R. A. J. , Jones, S. E. , Donnelly, L. , Beaumont, R. , Campbell, A. , Tuke, M. A. , Hayward, C. , Ruth, K. S. , Padmanabhan, S. , Jukema, J. W. , Palmer, C. C. , Hattersley, A. , Freathy, R. M. , Langenberg, C. , Wareham, N. J. , Wood, A. R. , Murray, A. & 5 others Weedon, M. N., Sattar, N., Pearson, E., Scott, R. A. & Frayling, T. M. Aug 2016 In : Diabetes. 65, 8, p. 2448-2460 13 p.

    Research output: Contribution to journalArticle

  8. The Na+/glucose co-transporter inhibitor canagliflozin activates AMP-activated protein kinase by inhibiting mitochondrial function and increasing cellular AMP levels

    Hawley, S., Ford, R. J., Smith, B. K., Gowans, G. J., Mancini, S. J., Pitt, R. D., A. Day, E., Salt, I. P., Steinberg, G. R. & Hardie, D. G. 1 Jul 2016 In : Diabetes. 65, 9, p. 2784-2794 11 p.

    Research output: Contribution to journalArticle

  9. Integrin-linked kinase in muscle is necessary for the development of insulin resistance in diet-induced obese mice

    Kang, L., Mokshagundam, S., Reuter, B., Lark, D. S., Sneddon, C. C., Hennayake, C., Williams, A. S., Bracy, D. P., James, F. D., Pozzi, A., Zent, R. & Wasserman, D. H. 1 Jun 2016 In : Diabetes. 65, 6, p. 1590-1600 11 p.

    Research output: Contribution to journalArticle

  10. Dissecting the etiology of type 2 diabetes in the Pima Indian population

    Pearson, E. R. Dec 2015 In : Diabetes. 64, 12, p. 3993-3995 3 p.

    Research output: Contribution to journalComment/debate

  11. Association analysis of 29,956 individuals confirms that a low-frequency variant at CCND2 halves the risk of type 2 diabetes by enhancing insulin secretion

    Yaghootkar, H. , Stancáková, A. , Freathy, R. M. , Vangipurapu, J. , Weedon, M. N. , Xie, W. , Wood, A. R. , Ferrannini, E. , Mari, A. , Ring, S. M. , Lawlor, D. A. , Davey Smith, G. , Jørgensen, T. , Hansen, T. , Pedersen, O. , Steinthorsdottir, V. , Guðbjartsson, D. F. , Thorleifsson, G. , Thorsteinsdottir, U. , Stefansson, K. & 7 others Hattersley, A. T., Walker, M., Morris, A. D., McCarthy, M. I., Palmer, C. N. A., Laakso, M. & Frayling, T. M. Jun 2015 In : Diabetes. 64, 6, p. 2279-2285 7 p.

    Research output: Contribution to journalArticle

  12. Diazoxide improves hormonal counterregulatory responses to acute hypoglycemia in long-standing Type 1 Diabetes

    George, P. S., Tavendale, R., Palmer, C. N. A. & McCrimmon, R. J. Jun 2015 In : Diabetes. 64, 6, p. 2234-2241 8 p.

    Research output: Contribution to journalArticle

  13. Association of organic cation transporter 1 with intolerance to metformin in Type 2 diabetes: a GoDARTS study

    Dujic, T., Zhou, K., Donnelly, L. A., Tavendale, R., Palmer, C. N. A. & Pearson, E. R. May 2015 In : Diabetes. 64, 5, p. 1786-1793 8 p.

    Research output: Contribution to journalArticle

  14. Methotrexate promotes glucose uptake and lipid oxidation in skeletal muscle via AMPK activation

    Pirkmajer, S., Kulkarni, S. S., Tom, R. Z., Ross, F. A., Hawley, S. A., Hardie, D. G., Zierath, J. R. & Chibalin, A. V. Feb 2015 In : Diabetes. 64, 2, p. 360-369 10 p.

    Research output: Contribution to journalArticle

  15. Heterozygous SOD2 deletion impairs glucose-stimulated insulin secretion, but not insulin action in high fat-fed mice

    Kang, L., Dai, C., Lustig, M. E., Bonner, J. S., Mayes, W. H., Mokshagundam, S., James, F. D., Thompson, C. S., Lin, C-T., Perry, C. G. R., Anderson, E. J., Neufer, P. D., Wasserman, D. H. & Powers, A. C. Nov 2014 In : Diabetes. 63, 11, p. 3699-3710 12 p.

    Research output: Contribution to journalArticle

  16. Glucose-6-phosphate-mediated activation of liver glycogen synthase plays a key role in hepatic glycogen synthesis

    von Wilamowitz-Moellendorff, A., Hunter, R. W., García-Rocha, M., Kang, L., López-Soldado, I., Lantier, L., Patel, K., Peggie, M. W., Martínez-Pons, C., Voss, M., Calbó, J., Cohen, P. T. W., Wasserman, D. H., Guinovart, J. J. & Sakamoto, K. Dec 2013 In : Diabetes. 62, 12, p. 4070-4082 13 p.

    Research output: Contribution to journalArticle

  17. Mendelian randomisation studies do not support a causal role for reduced circulating adiponectin levels in insulin resistance and type 2 diabetes

    Yaghootkar, H. , Lamina, C. , Scott, R. A. , Dastani, Z. , Hivert, M-F. , Warren, L. L. , Stancáková, A. , Buxbaum, S. G. , Lyytikäinen, L-P. , Henneman, P. , Wu, Y. , Cheung, C. Y. Y. , Pankow, J. S. , Jackson, A. U. , Gustafsson, S. , Zhao, J. H. , Ballantyne, C. M. , Xie, W. , Bergman, R. N. , Boehnke, M. & 58 others el Bouazzaoui, F., Collins, F. S., Dunn, S. H., Dupuis, J., Forouhi, N. G., Gillson, C., Hattersley, A. T., Hong, J., Kähönen, M., Kuusisto, J., Kedenko, L., Kronenberg, F., Doria, A., Assimes, T. L., Ferrannini, E., Hansen, T., Hao, K., Häring, H., Knowles, J. W., Lindgren, C. M., Nolan, J. J., Paananen, J., Pedersen, O., Quertermous, T., Smith, U., the GENESIS consortium, the RISC consortium, Lehtimäki, T., Liu, C-T., Loos, R. J. F., McCarthy, M. I., Morris, A. D., Vasan, R. S., Spector, T. D., Teslovich, T. M., Tuomilehto, J., Willems van Dijk, K., Viikari, J. S., Zhu, N., Langenberg, C., Ingelsson, E., Semple, R. K., Sinaiko, A. R., Palmer, C. N. A., Walker, M., Lam, K. S. L., Paulweber, B., Mohlke, K. L., van Duijn, C., Raitakari, O. T., Bidulescu, A., Wareham, N. J., Laakso, M., Waterworth, D. M., Lawlor, D. A., Meigs, J. B., Richards, J. B. & Frayling, T. M. Oct 2013 In : Diabetes. 62, 10, p. 3589-3598 10 p.

    Research output: Contribution to journalArticle

  18. Mitochondrial Substrate Availability and its Role in Lipid-Induced Insulin Resistance and Proinflammatory Signalling in Skeletal Muscle

    Lipina, C., Macrae, K., Suhm, T., Weigert, C., Blachnio-Zabielska, A., Baranowksi, M., Gorski, J., Burgess, K. & Hundal, H. S. Oct 2013 In : Diabetes. 62, 10, p. 3426-3436 11 p.

    Research output: Contribution to journalArticle

  19. AMPK: a target for drugs and natural products with effects on both diabetes and cancer

    Hardie, D. G. Jul 2013 In : Diabetes. 62, 7, p. 2164-2172 9 p.

    Research output: Contribution to journalArticle

  20. Biomarkers for type 2 diabetes and impaired fasting glucose using a non-targeted metabolomics approach

    Menni, C. , Fauman, E. , Erte, I. , Perry, J. R. B. , Kastenmüller, G. , Shin, S-Y. , Petersen, A-K. , Hyde, C. , Psatha, M. , Ward, K. J. , Yuan, W. , Milburn, M. , Palmer, C. N. A. , Frayling, T. M. , Trimmer, J. , Bell, J. T. , Gieger, C. , Mohney, R. , Brosnan, M. J. , Suhre, K. & 2 others Soranzo, N. & Spector, T. D. 2013 In : Diabetes.

    Research output: Contribution to journalArticle

  21. The CTRB1/2 locus affects diabetes susceptibility and treatment via the incretin pathway

    't Hart, L. M. , Fritsche, A. , Nijpels, G. , van Leeuwen, N. , Donnelly, L. A. , Dekker, J. M. , Alssema, M. , Fadista, J. , Carlotti, F. , Gjesing, A. P. , Palmer, C. N. A. , van Haeften, T. W. , Herzberg-Schäfer, S. A. , Simonis-Bik, A. M. C. , Houwing-Duistermaat, J. J. , Helmer, Q. , Deelen, J. , Guigas, B. , Hansen, T. , Machicao, F. & 14 others Willemsen, G., Heine, R. J., Kramer, M. H. H., Holst, J. J., de Koning, E. J. P., Häring, H-U., Pedersen, O., Groop, L., de Geus, E. J. C., Slagboom, P. E., Boomsma, D. I., Eekhoff, E. M. W., Pearson, E. R. & Diamant, M. 2013 In : Diabetes.

    Research output: Contribution to journalArticle

  22. Cellular Responses to the Metal-Binding Properties of Metformin

    Logie, L., Harthill, J., Patel, K., Bacon, S., Hamilton, D. L., Macrae, K., McDougall, G., Wang, H-H., Xue, L., Jiang, H., Sakamoto, K., Prescott, A. R. & Rena, G. Jun 2012 In : Diabetes. 61, 6, p. 1423-1433 11 p.

    Research output: Contribution to journalArticle

  23. Deep Resequencing Unveils Genetic Architecture of ADIPOQ and Identifies a Novel Low-Frequency Variant Strongly Associated With Adiponectin Variation

    Warren, L. L. , Li, L. , Nelson, M. R. , Ehm, M. G. , Shen, J. , Fraser, D. J. , Aponte, J. L. , Nangle, K. L. , Slater, A. J. , Woollard, P. M. , Hall, M. D. , Topp, S. D. , Yuan, X. , Cardon, L. R. , Chissoe, S. L. , Mooser, V. , Morris, A. D. , Palmer, C. N. A. , Perry, J. R. , Frayling, T. M. & 2 others Whittaker, J. C. & Waterworth, D. M. May 2012 In : Diabetes. 61, 5, p. 1297-1301 5 p.

    Research output: Contribution to journalArticle

  24. Total soluble and endogenous secretory receptor for advanced glycation end products as predictive biomarkers of coronary heart disease risk in patients with type 2 Diabetes: an analysis from the CARDS trial

    Colhoun, H. M., Betteridge, D. J., Durrington, P., Hitman, G., Neil, A., Livingstone, S., Charlton-Menys, V., Bao, W., DeMicco, D. A., Preston, G. M., Deshmukh, H., Tan, K. & Fuller, J. H. Sep 2011 In : Diabetes. 60, 9, p. 2379-2385 7 p.

    Research output: Contribution to journalArticle

  25. Deletion of Lkb1 in Pro-Opiomelanocortin Neurons Impairs Peripheral Glucose Homeostasis in Mice

    Claret, M. , Smith, M. A. , Knauf, C. , Al-Qassab, H. , Woods, A. , Heslegrave, A. , Piipari, K. , Emmanuel, J. J. , Colom, A. , Valet, P. , Cani, P. D. , Begum, G. , White, A. , Mucket, P. , Peters, M. , Mizuno, K. , Batterham, R. L. , Giese, K. P. , Ashworth, A. , Burcelin, R. & 3 others Ashford, M. L., Carling, D. & Withers, D. J. Mar 2011 In : Diabetes. 60, 3, p. 735-745 11 p.

    Research output: Contribution to journalArticle

  26. Mendelian randomization studies do not support a role for raised circulating triglyceride levels influencing type 2 diabetes, glucose levels, or insulin resistance.

    De Silva, N. M. G. , Freathy, R. M. , Palmer, T. M. , Donnelly, L. A. , Luan, J. , Gaunt, T. , Langenberg, C. , Weedon, M. N. , Shields, B. , Knight, B. A. , Ward, K. J. , Sandhu, M. S. , Harbord, R. M. , McCarthy, M. I. , Smith, G. D. , Ebrahim, S. , Hattersley, A. T. , Wareham, N. , Lawlor, D. A. , Morris, A. D. & 2 others Palmer, C. N. A. & Frayling, T. M. Mar 2011 In : Diabetes. 60, 3, p. 1008-1018 11 p.

    Research output: Contribution to journalArticle

  27. Combined effect of inflammatory gene polymorphisms and the risk of ischemic stroke in a prospective cohort of subjects with type 2 diabetes: A Go-DARTS study

    Palmer, C. N. A., Kimber, C. H., Doney, A. S. F., Proia, A. S., Morris, A. D., Gaetani, E., Quarta, M., Smith, R. C. & Pola, R. Nov 2010 In : Diabetes. 59, 11, p. 2945-2948 4 p.

    Research output: Contribution to journalArticle

  28. Hypoglycemia in Type 1 Diabetes

    McCrimmon, R. J. & Sherwin, R. S. Oct 2010 In : Diabetes. 59, 10, p. 2333-2339 7 p.

    Research output: Contribution to journalArticle

  29. The Medial Amygdalar Nucleus: A Novel Glucose-Sensing Region That Modulates the Counterregulatory Response to Hypoglycemia

    Zhou, L., Podolsky, N., Sang, Z., Ding, Y., Fan, X., Tong, Q., Levin, B. E. & McCrimmon, R. J. Oct 2010 In : Diabetes. 59, 10, p. 2646-2652 7 p.

    Research output: Contribution to journalArticle

  30. Hypothalamic FKBP5 Is Induced by Fasting and Leptin Deficiency and Elevated Expression Promotes Obese Phenotypes

    Nguyen, L., Yen, K., Mastaitis, J., Dunn-Meynell, A., Levin, B., Routh, V., McCrimmon, R., Isoda, F., Sherwin, R., Musatov, S. & Mobbs, C. Jun 2010 In : Diabetes. 59, p. A470-A470 1 p.

    Research output: Contribution to journalBook/Film/Article review

  31. Influence of Insulin in the Ventromedial Hypothalamus on Pancreatic Glucagon Secretion In Vivo

    Paranjape, S. A., Chan, O., Zhu, W., Horblitt, A. M., McNay, E. C., Cresswell, J. A., Bogan, J. S., McCrimmon, R. J. & Sherwin, R. S. Jun 2010 In : Diabetes. 59, 6, p. 1521-1527 7 p.

    Research output: Contribution to journalArticle

  32. Multimodal Characterization of Brain Responses to Acute Insulin-Induced Hypoglycemia: An In Vivo fMRI and Electrophysiology Study

    Herman, P., Herzog, R., Zhou, L., Sherwin, R., Hyder, F. & McCrimmon, R. Jun 2010 In : Diabetes. 59, p. A213-A213 1 p.

    Research output: Contribution to journalBook/Film/Article review

  33. PPARG, insulin resistance and metformin pharmacogenetics-A GoDARTS study

    Zhou, K., Burch, L., Hattersley, A. T., McCarthy, M. I., Morris, A. D., Palmer, C. N. A. & Pearson, E. R. Jun 2010 In : Diabetes. 59, p. A115-A115 1 p.

    Research output: Contribution to journalBook/Film/Article review

  34. Thiazolidinedione associated fractures are not limited to distal fractures and occur in men as well as women

    Colhoun, H. M. & Scottish Diabet Research Network Epidemiology Group Jun 2010 In : Diabetes. 59, p. A20-A21 2 p.

    Research output: Contribution to journalBook/Film/Article review

  35. Regulation of MAP Kinase-Directed Mitogenic and Protein Kinase B-Mediated Signaling by Cannabinoid Receptor Type 1 in Skeletal Muscle Cells

    Lipina, C., Stretton, C., Hastings, S., Hundal, J. S., Mackie, K., Irving, A. J. & Hundal, H. S. Feb 2010 In : Diabetes. 59, 2, p. 375-385 11 p.

    Research output: Contribution to journalArticle

  36. Ventromedial Hypothalamic Nitric Oxide Production Is Necessary for Hypoglycemia Detection and Counterregulation

    Fioramonti, X., Marsollier, N., Song, Z., Fakira, K. A., Patel, R. M., Brown, S., Duparc, T., Pica-Mendez, A., Sanders, N. M., Knauf, C., Valet, P., McCrimmon, R. J., Beuve, A., Magnan, C. & Routh, V. H. Feb 2010 In : Diabetes. 59, 2, p. 519-528 10 p.

    Research output: Contribution to journalArticle

  37. Novel Insights Into the Etiology of Diabetes From Genome-Wide Association Studies

    Palmer, C. N. A. Nov 2009 In : Diabetes. 58, 11, p. 2444-2447 4 p.

    Research output: Contribution to journalEditorial

  38. Linkage Disequilibrium Mapping of the Replicated Type 2 Diabetes Linkage Signal on Chromosome 1q

    Prokopenko, I. , Zeggini, E. , Hanson, R. L. , Mitchell, B. D. , Rayner, N. W. , Akan, P. , Baier, L. , Das, S. K. , Elliott, K. S. , Fu, M. , Frayling, T. M. , Groves, C. J. , Gwilliam, R. , Scott, L. J. , Voight, B. F. , Hattersley, A. T. , Hu, C. , Morris, A. D. , Ng, M. , Palmer, C. N. A. & 13 others Tello-Ruiz, M., Vaxillaire, M., Wang, C., Stein, L., Chan, J., Jia, W., Froguel, P., Elbein, S. C., Deloukas, P., Bogardus, C., Shuldiner, A. R., McCarthy, M. I. & Int Type 2 Diabet 1q Consortium Jul 2009 In : Diabetes. 58, 7, p. 1704-1709 6 p.

    Research output: Contribution to journalArticle

  39. Activation of EphA5 Receptors in the Ventromedial Hypothalemus(VMH) Stimulates the Counterregulatory Response to Acute Hypoglycemia

    Szepietowska, B., Zhu, W., Chan, O., Paran-Jape, S., Zhou, L., Mccrimmon, R. J. & Sherwin, R. S. Jun 2009 In : Diabetes. 58, p. A169-A169 1 p.

    Research output: Contribution to journalBook/Film/Article review

  40. Insulin Acts in the VMH To Suppress Pancreatic Glucagon Secretion

    Paranjape, S. A., Chan, O., Zhu, W., Horblitt, A., McCrimmon, R. & Sherwin, R. Jun 2009 In : Diabetes. 58, p. A34-A34 1 p.

    Research output: Contribution to journalBook/Film/Article review

  41. Medial Amygadalar Nucleus, a Novel Limbic Glu - cosensing Region in Rodent, Modulates Counterregulatory Hormone Response to Hypoglycemia

    Zhou, L., Podolsky, N., Sang, Z., Tong, Q., Lowell, B., Vale, W., Levin, B. E. & McCrimmon, R. J. Jun 2009 In : Diabetes. 58, p. A15-A15 1 p.

    Research output: Contribution to journalBook/Film/Article review

  42. Reduced-function SLC22A1 polymorphisms encoding organic cation transporter 1 and glycemic response to metformin: A GoDARTS study

    Zhou, K., Donnelly, L. A., Kimber, C. H., Donnan, P. T., Doney, A. S. F., Leese, G., Hattersley, A. T., McCarthy, M. I., Morris, A. D., Palmer, C. N. A. & Pearson, E. R. Jun 2009 In : Diabetes. 58, 6, p. 1434-1439 6 p.

    Research output: Contribution to journalArticle

  43. The Sources of GABAergic Innervation of the Ventromedial Hypothalamus

    Zhou, L., Chan, O., McCrimmon, R. J. & Sherwin, R. S. Jun 2009 In : Diabetes. 58, p. A14-A15 2 p.

    Research output: Contribution to journalBook/Film/Article review

  44. Medium-Chain Fatty Acids Improve Cognitive Function in Intensively Treated Type 1 Diabetic Patients and Support In Vitro Synaptic Transmission During Acute Hypoglycemia

    Page, K. A., Williamson, A., Yu, N., McNay, E. C., Dzuira, J., McCrimmon, R. J. & Sherwin, R. S. May 2009 In : Diabetes. 58, 5, p. 1237-1244 8 p.

    Research output: Contribution to journalArticle

  45. Adiposity-Related Heterogeneity in Patterns of Type 2 Diabetes Susceptibility Observed in Genome-Wide Association Data

    Timpson, N. J., Lindgren, C. M., Weedon, M. N., Randall, J., Ouwehand, W. H., Strachan, D. P., Rayner, N. W., Walker, M., Hitman, G. A., Doney, A. S. F., Palmer, C. N. A., Morris, A. D., Hattersley, A. T., Zeggini, E., Frayling, T. M. & McCarthy, M. I. Feb 2009 In : Diabetes. 58, 2, p. 505-510 6 p.

    Research output: Contribution to journalArticle

  46. Amplified Hormonal Counterregulatory Responses to Hypoglycemia in Rats After Systemic Delivery of a SUR-1-Selective K+ Channel Opener?

    Fan, X., Ding, Y., Cheng, H., Gram, D. X., Sherwin, R. S. & McCrimmon, R. J. Dec 2008 In : Diabetes. 57, 12, p. 3327-3334 8 p.

    Research output: Contribution to journalArticle

  47. Assessing the combined impact of 18 common genetic variants of modest effect sizes on type 2 diabetes risk

    Lango, H., Palmer, C. N. A., Morris, A. D., Zeggini, E., Hattersley, A. T., McCarthy, M. I., Frayling, T. M., Weedon, M. N. & UK Type Diab Genetics Consortium Nov 2008 In : Diabetes. 57, 11, p. 3129-3135 7 p.

    Research output: Contribution to journalArticle

  48. Dual role of hypothalamic nitric oxide (NO) production in the control of the counter-regulatory response to hypoglycemia

    Fioramonti, X., Sayed, N., Marsollier, N., Mccrimmon, R. J., Pica-Mendez, A., Bogorff, D., Tobon, K. E., Smith, P. J., Sherwin, R. S., Sanders, N. M., Magnan, C., Beuve, A. & Routh, V. H. Jun 2008 In : Diabetes. 57, p. A171-A171 1 p.

    Research output: Contribution to journalBook/Film/Article review

  49. Insulin signaling in the ventromedial hypothalamus (VMH) regulates glucagon secretion during Eu- and hypoglycemia

    Paranjape, S. A., Chan, O., Zhu, W., Wang, A., Fan, X., Mccrimmon, R. & Sherwin, R. Jun 2008 In : Diabetes. 57, p. A39-A40 2 p.

    Research output: Contribution to journalBook/Film/Article review

  50. Medium chain triglycerides improve memory performance during acute hypoglycemia in intensively treated type 1 diabetics

    Page, K. A., McCrimmon, R., Yu, N., Dziura, J. & Sherwin, R. Jun 2008 In : Diabetes. 57, p. A5-A5 1 p.

    Research output: Contribution to journalBook/Film/Article review

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