Discovery - University of Dundee - Online Publications

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Drug Metabolism and Disposition

  1. A role for cytochrome b5 in the in vivo disposition of anti-cancer and cytochrome P450 probe drugs in mice

    Henderson, C. J., McLaughlin, L. A., Finn, R. D., Ronseaux, S., Kapelyukh, Y. & Wolf, C. R. Jan 2014 In : Drug Metabolism and Disposition. 42, 1, p. 70-77 8 p.

    Research output: Contribution to journalArticle

  2. Deletion of 30 murine cytochrome p450 genes results in viable mice with compromised drug metabolism

    Scheer, N., McLaughlin, L. A., Rode, A., MacLeod, A. K., Henderson, C. J. & Wolf, C. R. 2014 In : Drug Metabolism and Disposition. 42, 6, p. 1022-1030 9 p.

    Research output: Contribution to journalArticle

  3. NADPH-cytochrome P450 oxidoreductase: roles in physiology, pharmacology, and toxicology

    Riddick, D. S., Ding, X., Wolf, C. R., Porter, T. D., Pandey, A. V., Zhang, Q-Y., Gu, J., Finn, R. D., Ronseaux, S., McLaughlin, L. A., Henderson, C. J., Zou, L. & Flück, C. E. Jan 2013 In : Drug Metabolism and Disposition. 41, 1, p. 12-23 12 p.

    Research output: Contribution to journalArticle

  4. Characterization of a Human Keratinocyte HaCaT Cell Line Model to Study the Regulation of CYP2S1

    McNeilly, A. D., Woods, J. A., Ibbotson, S. H., Wolf, C. R. & Smith, G. Feb 2012 In : Drug Metabolism and Disposition. 40, 2, p. 283-289 7 p.

    Research output: Contribution to journalArticle

  5. Generation and characterization of a novel multidrug resistance protein 2 humanized mouse line

    Scheer, N., Balimane, P., Hayward, M. D., Buechel, S., Kauselmann, G. & Wolf, C. R. 2012 In : Drug Metabolism and Disposition. 40, 11, p. 2212-2218 7 p.

    Research output: Contribution to journalArticle

  6. Neonatal development of hepatic UGT1A9: implications of pediatric pharmacokinetics

    Miyagi, S. J., Milne, A. M., Coughtrie, M. W. H. & Collier, A. C. 2012 In : Drug Metabolism and Disposition. 40, 7, p. 1321-1327 7 p.

    Research output: Contribution to journalArticle

  7. Effect of hepatic cytochrome P450 (P450) oxidoreductase deficiency on 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine-DNA Adduct Formation in P450 reductase conditional null mice

    Arlt, V. M., Singh, R., Stiborova, M., da Costa, G. G., Frei, E., Evans, J. D., Farmer, P. B., Wolf, C. R., Henderson, C. J. & Phillips, D. H. Dec 2011 In : Drug Metabolism and Disposition. 39, 12, p. 2169-2173 5 p.

    Research output: Contribution to journalArticle

  8. The Imidazoacridinone Antitumor Drug, C-1311, Is Metabolized by Flavin Monooxygenases but Not by Cytochrome P450s

    Potega, A., Dabrowska, E., Niemira, M., Kot-Wasik, A., Ronseaux, S., Henderson, C. J., Wolf, C. R. & Mazerska, Z. Aug 2011 In : Drug Metabolism and Disposition. 39, 8, p. 1423-1432 10 p.

    Research output: Contribution to journalArticle

  9. A novel method for the immunoquantification of UDP-glucuronosyltransferases in human tissue

    Milne, A. M., Burchell, B. & Coughtrie, M. W. H. 2011 In : Drug Metabolism and Disposition. 39, 12, p. 2258-2263 6 p.

    Research output: Contribution to journalArticle

  10. In Vivo Responses of the Human and Murine Pregnane X Receptor to Dexamethasone in Mice

    Scheer, N., Ross, J., Kapelyukh, Y., Rode, A. & Wolf, C. R. Jul 2010 In : Drug Metabolism and Disposition. 38, 7, p. 1046-1053 8 p.

    Research output: Contribution to journalArticle

  11. Expression and Localization of Rat Aldo-Keto Reductases and Induction of the 1B13 and 1D2 Isoforms by Phenolic Antioxidants

    MacLeod, A. K., Kelly, V. P., Higgins, L. G., Kelleher, M. O., Price, S. A., Bigley, A. L., Betton, G. R. & Hayes, J. D. Feb 2010 In : Drug Metabolism and Disposition. 38, 2, p. 341-346 6 p.

    Research output: Contribution to journalArticle

  12. Quantitative evaluation of the expression and activity of five major sulfotransferases (SULTs) in human tissues: the SULT "pie"

    Riches, Z., Stanley, E. L., Bloomer, J. C. & Coughtrie, M. W. H. Nov 2009 In : Drug Metabolism and Disposition. 37, 11, p. 2255-2261 7 p.

    Research output: Contribution to journalArticle

  13. Receptor occupancy and brain free fraction

    Watson, J., Wright, S., Lucas, A., Clarke, K. L., Viggers, J., Cheetham, S., Jeffrey, P., Porter, R. & Read, K. D. Apr 2009 In : Drug Metabolism and Disposition. 37, 4, p. 753-760 8 p.

    Research output: Contribution to journalArticle

  14. Multiple substrate binding by cytochrome P450 3A4: Estimation of the number of bound substrate molecules

    Kapelyukh, Y., Paine, M., Marechal, J-D., Sutcliffe, M. J., Wolf, C. R. & Roberts, G. C. K. Oct 2008 In : Drug Metabolism and Disposition. 36, 10, p. 2136-2144 9 p.

    Research output: Contribution to journalArticle

  15. Functional expression and comparative characterization of nine murine cytochromes P450 by fluorescent inhibition screening

    McLaughlin, L. A., Dickmann, L. J., Wolf, C. R. & Henderson, C. J. Jul 2008 In : Drug Metabolism and Disposition. 36, 7, p. 1322-1331 10 p.

    Research output: Contribution to journalArticle

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