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EMBO Journal

  1. The hVPS34-SGK3 pathway counteracts inhibition of the PI3K-Akt to maintain mTORC1 and tumour growth

    Bago, R., Eskelinen, E-L., Castel , P., Crafter, C., Bailey, F. P., Shpiro, N., Baselga, J., Cross, D., Eyers, P. & Alessi, D. 15 Aug 2016 In : EMBO Journal. 35, 16, p. 1721-1843 33 p., e201693929

    Research output: Contribution to journalArticle

  2. Phosphopeptide binding by Sld3 links Dbf4-dependent kinase to MCM replicative helicase activation

    Deegan, T. D., Yeeles, J. T. P. & Diffley, J. F. X. 2016 In : EMBO Journal. 35

    Research output: Contribution to journalArticle

  3. Disruption of the autoinhibited state primes the E3 ligase parkin for activation and catalysis

    Kumar, A., Aguirre, J. D., Condos, T. E. C., Martinez-Torres, R. J., Chaugule, V. K., Toth, R., Sundaramoorthy, R., Mercier, P., Knebel, A., Spratt, D. E., Barber, K. R., Shaw, G. S. & Walden, H. 14 Oct 2015 In : EMBO Journal. 34, 20, p. 2506-2521 16 p.

    Research output: Contribution to journalArticle

  4. mTOR activates the VPS34-UVRAG complex to regulate autolysosomal tubulation and cell survival

    Munson, M. J., Allen, G. F. G., Toth, R., Campbell, D. G., Lucocq, J. M. & Ganley, I. G. 2 Sep 2015 In : EMBO Journal. 34, 17, p. 2272-2290 19 p.

    Research output: Contribution to journalArticle

  5. Single cell tuning of Myc expression by antigen receptor signal strength and interleukin-2 in T lymphocytes

    Preston, G. C., Sinclair, L. V., Kaskar, A., Hukelmann, J. L., Navarro, M., Ferrero, I., MacDonald, H. R., Cowling, V. H. & Cantrell, D. A. 4 Aug 2015 In : EMBO Journal. 34, 15, p. 2008-2024 17 p.

    Research output: Contribution to journalArticle

  6. USP45 deubiquitylase controls ERCC1-XPF endonuclease-mediated DNA damage responses

    Perez-Oliva, A. B., Lachaud, C., Szyniarowski, P., Muñoz, I., Macartney, T., Hickson, I., Rouse, J. & Alessi, D. R. 3 Feb 2015 In : EMBO Journal. 34, 3, p. 326-343 18 p.

    Research output: Contribution to journalArticle

  7. Phosphoproteomic screening identifies Rab GTPases as novel downstream targets of PINK1

    Lai, Y-C., Kondapalli, C., Lehneck, R., Procter, J. B., Dill, B. D., Woodroof, H. I., Gourlay, R., Peggie, M., Macartney, T. J., Corti, O., Corvol, J-C., Campbell, D. G., Itzen, A., Trost, M. & Muqit, M. M. K. 2015 In : EMBO Journal. 22 p.

    Research output: Contribution to journalArticle

  8. A cyclic GMP-dependent signalling pathway regulates bacterial phytopathogenesis

    An, S-Q., Chin, K-H., Febrer, M., McCarthy, Y., Yang, J-G., Liu, C-L., Swarbreck, D., Rogers, J., Dow, J. M., Chou, S-H. & Ryan, R. P. 11 Sep 2013 In : EMBO Journal. 32, 18, p. 2430-2438

    Research output: Contribution to journalArticle

  9. Deficiency of terminal ADP-ribose protein glycohydrolase TARG1/C6orf130 in neurodegenerative disease

    Sharifi, R. , Morra, R. , Appel, C. D. , Tallis, M. , Chioza, B. , Jankevicius, G. , Simpson, M. A. , Matic, I. , Ozkan, E. , Golia, B. , Schellenberg, M. J. , Weston, R. , Williams, J. G. , Rossi, M. N. , Galehdari, H. , Krahn, J. , Wan, A. , Trembath, R. C. , Crosby, A. H. & 6 others Ahel, D., Hay, R., Ladurner, A. G., Timinszky, G., Williams, R. S. & Ahel, I. 2 May 2013 In : EMBO Journal. 32, 9, p. 1225-1237 13 p.

    Research output: Contribution to journalArticle

  10. PDK1 regulates VDJ recombination, cell-cycle exit and survival during B-cell development

    Venigalla, R. K. C., McGuire, V. A., Clarke, R., Patterson-Kane, J. C., Najafov, A., Toth, R., McCarthy, P. C., Simeons, F., Stojanovski, L. & Arthur, J. S. C. 3 Apr 2013 In : EMBO Journal. 32, 7, p. 1008-22 15 p.

    Research output: Contribution to journalArticle

  11. A sweet TET-a-tete-synergy of TET proteins and O-GlcNAc transferase in transcription

    Mariappa, D., Pathak, S. & van Aalten, D. M. F. 2013 In : EMBO Journal. 32, 5, p. 612-613 2 p.

    Research output: Contribution to journalEditorial

  12. TRIAD1 and HHARI bind to and are activated by distinct neddylated Cullin-RING ligase complexes

    Kelsall, I. R., Duda, D. M., Olszewski, J. L., Hofmann, K., Knebel, A., Langevin, F., Wood, N., Wightman, M., Schulman, B. A. & Alpi, A. F. 2013 In : EMBO Journal. 32, p. 2848-2860 13 p.

    Research output: Contribution to journalArticle

  13. The Mitotic Exit Network and Cdc14 phosphatase initiate cytokinesis by counteracting CDK phosphorylations and blocking polarised growth

    Sanchez-Diaz, A., Nkosi, P. J., Murray, S. & Labib, K. 29 Aug 2012 In : EMBO Journal. 31, 17, p. 3620-3634 15 p.

    Research output: Contribution to journalArticle

  14. Mcm10 associates with the loaded DNA helicase at replication origins and defines a novel step in its activation

    van Deursen, F., Sengupta, S., De Piccoli, G., Sanchez-Diaz, A. & Labib, K. 2 May 2012 In : EMBO Journal. 31, 9, p. 2195-2206 12 p.

    Research output: Contribution to journalArticle

  15. Sperm are promiscuous and CatSper is to blame...

    Barratt, C. L. R. & Publicover, S. J. 4 Apr 2012 In : EMBO Journal. 31, 7, p. 1624-1626 3 p.

    Research output: Contribution to journalArticle

  16. O-GlcNAcylation of TAB1 modulates TAK1-mediated cytokine release

    Pathak, S., Borodkin, V. S., Albarbarawi, O., Campbell, D. G., Ibrahim, A. & van Aalten, D. M. F. 21 Mar 2012 In : EMBO Journal. 31, 6, p. 1394-1404 11 p.

    Research output: Contribution to journalArticle

  17. Building a double hexamer of DNA helicase at eukaryotic replication origins

    Labib, K. 14 Dec 2011 In : EMBO Journal. 30, 24, p. 4853-4855 3 p.

    Research output: Contribution to journalArticle

  18. Autoregulation of Parkin activity through its ubiquitin-like domain

    Chaugule, V. K., Burchell, L., Barber, K. R., Sidhu, A., Leslie, S. J., Shaw, G. S. & Walden, H. 20 Jul 2011 In : EMBO Journal. 30, 14, p. 2853-2867 15 p.

    Research output: Contribution to journalArticle

  19. The DNA-binding domain of the Chd1 chromatin-remodelling enzyme contains SANT and SLIDE domains

    Ryan, D. P., Sundaramoorthy, R., Martin, D., Singh, V. & Owen-Hughes, T. 6 Jul 2011 In : EMBO Journal. 30, 13, p. 2596-2609 14 p.

    Research output: Contribution to journalArticle

  20. The SWI/SNF complex acts to constrain distribution of the centromeric histone variant Cse4

    Gkikopoulos, T., Singh, V., Tsui, K., Awad, S., Renshaw, M. J., Scholfield, P., Barton, G. J., Nislow, C., Tanaka, T. U. & Owen-Hughes, T. 18 May 2011 In : EMBO Journal. 30, 10, p. 1919-1927 9 p.

    Research output: Contribution to journalArticle

  21. MO25 is a master regulator of SPAK/OSR1 and MST3/MST4/YSK1 protein kinases

    Filippi, B. M., de los Heros, P., Mehellou, Y., Navratilova, I., Gourlay, R., Deak, M., Plater, L., Toth, R., Zeqiraj, E. & Alessi, D. R. 4 May 2011 In : EMBO Journal. 30, 9, p. 1730-1741 12 p.

    Research output: Contribution to journalArticle

  22. AMPK and autophagy get connected

    Hardie, D. G. 16 Feb 2011 In : EMBO Journal. 30, 4, p. 634-635 2 p.

    Research output: Contribution to journalEditorial

  23. Kinetochore-microtubule interactions: steps towards bi-orientation

    Tanaka, T. U. 15 Dec 2010 In : EMBO Journal. 29, 24, p. 4070-4082 13 p.

    Research output: Contribution to journalLiterature review

  24. RNAi-based screening identifies the Mms22L-Nfkbil2 complex as a novel regulator of DNA replication in human cells

    Piwko, W., Olma, M. H., Held, M., Pedrioli, P. G. A., Gerlich, D. W., Peter, M., Bianco, J. N., Pasero, P. & Hofmann, K. 15 Dec 2010 In : EMBO Journal. 29, 24, p. 4210-4222 13 p.

    Research output: Contribution to journalArticle

  25. Tyrosine dephosphorylation is required for Bak activation in apoptosis

    Fox, J. L., Ismail, F., Azad, A., Ternette, N., Leverrier, S., Edelmann, M. J., Kessler, B. M., Leigh, I. M., Jackson, S. & Storey, A. 17 Nov 2010 In : EMBO Journal. 29, 22, p. 3853-3868 16 p.

    Research output: Contribution to journalArticle

  26. IKK and NF-kappa B-mediated regulation of Claspin impacts on ATR checkpoint function

    Kenneth, N. S., Mudie, S. & Rocha, S. 1 Sep 2010 In : EMBO Journal. 29, 17, p. 2966-2978 13 p.

    Research output: Contribution to journalArticle

  27. S6K1 is a multifaceted regulator of Mdm2 that connects nutrient status and DNA damage response

    Lai, K. P., Leong, W. F., Chau, J. F. L., Jia, D., Zeng, L., Liu, H., He, L., Hao, A., Zhang, H., Meek, D., Velagapudi, C., Habib, S. L. & Li, B. 1 Sep 2010 In : EMBO Journal. 29, 17, p. 2994-3006 13 p.

    Research output: Contribution to journalArticle

  28. Ubiquitin-specific proteases 7 and 11 modulate Polycomb regulation of the INK4a tumour suppressor

    Maertens, G. N., El Messaoudi-Aubert, S., Elderkin, S., Hiom, K. & Peters, G. 4 Aug 2010 In : EMBO Journal. 29, 15, p. 2553-2565 13 p.

    Research output: Contribution to journalArticle

  29. Phosphorylation of Mcl-1 by CDK1-cyclin B1 initiates its Cdc20-dependent destruction during mitotic arrest

    Harley, M. E., Allan, L. A., Sanderson, H. S. & Clarke, P. R. 21 Jul 2010 In : EMBO Journal. 29, 14, p. 2407-2420 14 p.

    Research output: Contribution to journalArticle

  30. Analysis of small RNA in fission yeast; centromeric siRNAs are potentially generated through a structured RNA

    Djupedal, I., Kos-Braun, I. C., Mosher, R. A., Soderholm, N., Simmer, F., Hardcastle, T. J., Fender, A., Heidrich, N., Kagansky, A., Bayne, E., Wagner, E. G. H., Baulcombe, D. C., Allshire, R. C. & Ekwall, K. 16 Dec 2009 In : EMBO Journal. 28, 24, p. 3832-3844 13 p.

    Research output: Contribution to journalArticle

  31. Cullin neddylation and substrate-adaptors counteract SCF inhibition by the CAND1-like protein Lag2 in Saccharomyces cerevisiae

    Siergiejuk, E., Scott, D. C., Schulman, B. A., Hofmann, K., Kurz, T. & Peter, M. 16 Dec 2009 In : EMBO Journal. 28, 24, p. 3845-3856 12 p.

    Research output: Contribution to journalArticle

  32. The MRT-1 nuclease is required for DNA crosslink repair and telomerase activity in vivo in Caenorhabditis elegans

    Meier, B., Barber, L. J., Liu, Y., Shtessel, L., Boulton, S. J., Gartner, A. & Ahmed, S. 18 Nov 2009 In : EMBO Journal. 28, 22, p. 3549-3563 15 p.

    Research output: Contribution to journalArticle

  33. A key role for Ctf4 in coupling the MCM2-7 helicase to DNA polymerase alpha within the eukaryotic replisome

    Gambus, A., van Deursen, F., Polychronopoulos, D., Foltman, M., Jones, R. C., Edmondson, R. D., Calzada, A. & Labib, K. 7 Oct 2009 In : EMBO Journal. 28, 19, p. 2992-3004 13 p.

    Research output: Contribution to journalArticle

  34. Distinct donor and acceptor specificities of Trypanosoma brucei oligosaccharyltransferases

    Izquierdo, L., Schulz, B. L., Rodrigues, J. A., Guther, M. L. S., Procter, J. B., Barton, G. J., Aebi, M. & Ferguson, M. A. J. 2 Sep 2009 In : EMBO Journal. 28, 17, p. 2650-2661 12 p.

    Research output: Contribution to journalArticle

  35. Gene activation at the edge of the nucleus

    Chubb, J. R. 5 Aug 2009 In : EMBO Journal. 28, 15, p. 2145-2146 2 p.

    Research output: Contribution to journalComment/debate

  36. Molecular dissection of the eukaryotic initiation factor 4E (eIF4E) export-competent RNP

    Topisirovic, I., Siddiqui, N., Lapointe, V. L., Trost, M., Thibault, P., Bangeranye, C., Pinol-Roma, S. & Borden, K. L. B. 22 Apr 2009 In : EMBO Journal. 28, 8, p. 1087-1098 12 p.

    Research output: Contribution to journalArticle

  37. FACT facilitates chromatin transcription by RNA polymerases I and III

    Birch, J. L., Tan, B. C-M., Panov, K. I., Panova, T. B., Andersen, J. S., Owen-Hughes, T. A., Russell, J., Lee, S-C. & Zomerdijk, J. C. B. M. 8 Apr 2009 In : EMBO Journal. 28, 7, p. 854-865 12 p.

    Research output: Contribution to journalArticle

  38. TRF2 promotes, remodels and protects telomeric Holliday junctions

    Poulet, A., Buisson, R., Faivre-Moskalenko, C., Koelblen, M., Amiard, S., Montel, F., Cuesta-Lopez, S., Bornet, O., Guerlesquin, F., Godet, T., Moukhtar, J., Argoul, F., Declais, A-C., Lilley, D. M. J., Ip, S. C. Y., West, S. C., Gilson, E. & Giraud-Panis, M-J. 18 Mar 2009 In : EMBO Journal. 28, 6, p. 641-651 11 p.

    Research output: Contribution to journalArticle

  39. Structural insights into mechanism and specificity of O-GlcNAc transferase

    Clarke, A. J., Hurtado-Guerrero, R., Pathak, S., Schuettelkopf, A., Borodkin, V., Shepherd, S. M., Ibrahim, A. F. M. & van Aalten, D. M. F. 22 Oct 2008 In : EMBO Journal. 27, 20, p. 2780-2788 9 p.

    Research output: Contribution to journalArticle

  40. Phosphorylation-dependent binding of 14-3-3 terminates signalling by the Gab2 docking protein

    Brummer, T., Larance, M., Herrera Abreu, M. T., Lyons, R. J., Timpson, P., Emmerich, C. H., Fleuren, E. D. G., Lehrbach, G. M., Schramek, D., Guilhaus, M., James, D. E. & Daly, R. J. 3 Sep 2008 In : EMBO Journal. 27, 17, p. 2305-2316 12 p.

    Research output: Contribution to journalArticle

  41. The kinase Syk as an adaptor controlling sustained calcium signalling and B-cell development

    Kulathu, Y., Hobeika, E., Turchinovich, G. & Reth, M. 7 May 2008 In : EMBO Journal. 27, 9, p. 1333-44 12 p.

    Research output: Contribution to journalArticle

  42. Cystatin F is a cathepsin C-directed protease inhibitor regulated by proteolysis

    Hamilton, G., Colbert, J. D., Schuettelkopf, A. W. & Watts, C. 6 Feb 2008 In : EMBO Journal. 27, 3, p. 499-508 10 p.

    Research output: Contribution to journalArticle

  43. Notch-induced T cell development requires phosphoinositide-dependent kinase 1

    Kelly, A. P., Finlay, D. K., Hinton, H. J., Clarke, R. G., Fiorini, E., Radtke, F. & Cantrell, D. A. 25 Jul 2007 In : EMBO Journal. 26, 14, p. 3441-3450 10 p.

    Research output: Contribution to journalArticle

  44. A guanine nucleobase important for catalysis by the VS ribozyme

    Wilson, T. J., McLeod, A. C. & Lilley, D. M. J. 16 May 2007 In : EMBO Journal. 26, 10, p. 2489-2500 12 p.

    Research output: Contribution to journalArticle

  45. Reconstruction of a pathway of antigen processing and class II MHC peptide capture

    Moss, C. X., Tree, T. I. & Watts, C. 18 Apr 2007 In : EMBO Journal. 26, 8, p. 2137-47 11 p.

    Research output: Contribution to journalArticle

  46. Cajal bodies and the nucleolus are required for a plant virus systemic infection

    Kim, S. H., Ryabov, E. V., Kalinina, N. O., Rakitina, D. V., Gillespie, T., Macfarlane, S., Haupt, S., Brown, J. W. S. & Taliansky, M. Apr 2007 In : The EMBO Journal. 26, 8, p. 2169-2179 11 p.

    Research output: Contribution to journalArticle

  47. A novel TBP-associated factor of SL1 functions in RNA polymerase I transcription

    Gorski, J. J., Pathak, S., Panov, K., Kasciukovic, T., Panova, T., Russell, J. & Zomerdijk, J. C. B. M. Mar 2007 In : The EMBO Journal. 26, 6, p. 1560-1568 9 p.

    Research output: Contribution to journalArticle

  48. Regulation of AMP-activated protein kinase by a pseudosubstrate sequence on the gamma subunit

    Scott, J. W., Ross, F. A., Liu, J. K. D. & Hardie, D. G. 7 Feb 2007 In : EMBO Journal. 26, 3, p. 806-15 10 p.

    Research output: Contribution to journalArticle

  49. A cell cycle regulatory network controlling NF-B subunit activity and function

    Barre, B. & Perkins, N. 2007 In : The EMBO Journal. 26, 23, p. 4841-4855 15 p.

    Research output: Contribution to journalArticle

  50. The deubiquitinating enzyme USP2a regulates the p53 pathway by targeting Mdm2

    Stevenson, L. F., Sparks, A., Allende-Vega, N., Xirodimas, D. P., Lane, D. & Saville, M. K. 2007 In : The EMBO Journal. 26, 4, p. 976-986 11 p.

    Research output: Contribution to journalArticle

  51. Regulation of p53 tumour suppressor target gene expression by the p52 NF-kappaB subunit

    Schumm, K., Rocha, S., Caamano, J. & Perkins, N. D. Oct 2006 In : The EMBO Journal. 25, 20, p. 4820-4832 13 p.

    Research output: Contribution to journalArticle

  52. A novel leptin signalling pathway via PTEN inhibition in hypothalamic cell lines and pancreatic β-cells

    Ning, K., Miller, L. C., Laidlaw, H. A., Burgess, L. A., Perera, N. M., Downes, C. P., Leslie, N. R. & Ashford, M. L. J. Jun 2006 In : The EMBO Journal. 25, 11, p. 2377-2387 11 p.

    Research output: Contribution to journalArticle

  53. Distinct roles for Sld3 and GINS during establishment and progression of eukaryotic DNA replication forks

    Kanemaki, M. & Labib, K. 19 Apr 2006 In : EMBO Journal. 25, 8, p. 1753-1763 11 p.

    Research output: Contribution to journalArticle

  54. Structural insights into the mechanism and inhibition of eukaryotic O-GlcNAc hydrolysis

    Rao, F. V., Dorfmueller, H. C., Villa, F., Allwood, M., Eggleston, I. M. & van Aalten, D. M. F. 2006 In : The EMBO Journal. 25, 7, p. 1569-1578 10 p.

    Research output: Contribution to journalArticle

  55. UBF activates RNA polymerase I transcription by stimulating promoter escape

    Panov, K. I., Friedrich, J. K., Russell, J. & Zomerdijk, J. C. B. M. 2006 In : The EMBO Journal. 25, 14, p. 3310-3322 13 p.

    Research output: Contribution to journalArticle

  56. Deficiency of LKB1 in skeletal muscle prevents AMPK activation and glucose uptake during contraction

    Sakamoto, K., McCarthy, A., Smith, D., Green, K. A., Hardie, D. G., Ashworth, A. & Alessi, D. R. May 2005 In : The EMBO Journal. 24, 10, p. 1810-1820 11 p.

    Research output: Contribution to journalArticle

  57. The tRNA methylase METTL1 is phosphorylated and inactivated by PKB and RSK in vitro and in cells

    Cartlidge, R. A., Knebel, A., Peggie, M., Alexandrov, A., Phizicky, E. M. & Cohen, P. May 2005 In : The EMBO Journal. 24, 9, p. 1696-1705 10 p.

    Research output: Contribution to journalArticle

  58. Role that phosphorylation of GSK3 plays in insulin and Wnt signalling defined by knockin analysis

    McManus, E. J., Sakamoto, K., Armit, L. J., Ronaldson, L., Shpiro, N., Marquez, R. & Alessi, D. R. Apr 2005 In : The EMBO Journal. 24, 8, p. 1571-1583 13 p.

    Research output: Contribution to journalArticle

  59. Structural basis of NEDD8 ubiquitin discrimination by the deNEDDylating enzyme NEDP1

    Shen, L., Liu, H., Dong, C., Xirodimas, D., Naismith, J. H. & Hay, R. T. Apr 2005 In : The EMBO Journal. 24, 7, p. 1341-1351 11 p.

    Research output: Contribution to journalArticle

  60. Regulation of NF-kappaB and p53 through activation of ATR and Chk1 by the ARF tumour suppressor

    Rocha, S., Garrett, M. D., Campbell, K. J., Schumm, K. & Perkins, N. D. Mar 2005 In : EMBO Journal. 24, 6, p. 1157-1169 13 p.

    Research output: Contribution to journalArticle

  61. The DEAD box protein p68: a novel transcriptional coactivator of the p53 tumour suppressor

    Bates, G. J., Nicol, S. M., Wilson, B. J., Jacobs, A-M. F., Bourdon, J-C., Wardrop, J., Gregory, D. J., Lane, D. P., Perkins, N. D. & Fuller-Pace, F. V. 9 Feb 2005 In : The EMBO Journal. 24, 3, p. 543-553 11 p.

    Research output: Contribution to journalArticle

  62. Cdt1 downregulation by proteolysis and geminin inhibition prevents DNA re-replication in Xenopus

    Li, A. & Blow, J. J. Jan 2005 In : The EMBO Journal. 24, 2, p. 395-404 10 p.

    Research output: Contribution to journalArticle

  63. Activation of MK5/PRAK by the atypical MAP kinase ERK3 defines a novel signal transduction pathway

    Seternes, O-M., Mikalsen, T., Johansen, B., Michaelsen, E., Armstrong, C. G., Morrice, N. A., Turgeon, B., Meloche, S., Moens, U. & Keyse, S. M. Dec 2004 In : The EMBO Journal. 23, 24, p. 4780-4791 12 p.

    Research output: Contribution to journalArticle

  64. Chemical validation of GPI biosynthesis as a drug target against African sleeping sickness

    Smith, T. K., Crossman, A., Brimacombe, J. S. & Ferguson, M. A. J. Nov 2004 In : The EMBO Journal. 23, 23, p. 4701-4708 8 p.

    Research output: Contribution to journalArticle

  65. LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1

    Lizcano, J. M., Goransson, O., Toth, R., Deak, M., Morrice, N. A., Boudeau, J., Hawley, S., Udd, L., Makela, T. P., Hardie, D. G. & Alessi, D. R. Feb 2004 In : The EMBO Journal. 23, 4, p. 833-843 11 p.

    Research output: Contribution to journalArticle

  66. Coordinating assembly and export of complex bacterial proteins

    Jack, R. L., Buchanan, G., Dubini, A., Hatzixanthis, K., Palmer, T. & Sargent, F. 2004 In : The EMBO Journal. 23, 20, p. 3962-3972 11 p.

    Research output: Contribution to journalArticle

  67. Esc4p, a new target of Mec1p (ATR), promotes resumption of DNA synthesis after DNA damage

    Rouse, J. 2004 In : The EMBO Journal. 23, 5, p. 1188-1197 10 p.

    Research output: Contribution to journalArticle

  68. Sin mutations alter inherent nucleosome mobility

    Flaus, A., Rencurel, C., Ferreira, H., Wiechens, N. & Owen-Hughes, T. 2004 In : The EMBO Journal. 23, 2, p. 343-353 11 p.

    Research output: Contribution to journalArticle

  69. Redox regulation of PI 3-kinase signalling via inactivation of PTEN

    Leslie, N., Bennett, D., Downes, P., Gray, A., Lindsay, Y. E. & Stewart, H. Oct 2003 In : EMBO Journal. 22, 20, p. 5501-5510 10 p.

    Research output: Contribution to journalArticle

  70. Deficiency of PDK1 in cardiac muscle results in heart failure and increased sensitivity to hypoxia

    Mora, A., Davies, A. M., Bertrand, L., Sharif, I., Budas, G. R., Jovanovic, S., Mouton, V., Kahn, C. R., Lucocq, J. M., Gray, G. A., Jovanovic, A. & Alessi, D. R. Sep 2003 In : The EMBO Journal. 22, 18, p. 4666-4676 11 p.

    Research output: Contribution to journalArticle

  71. Nonsense-mediated mRNA decay in Drosophila: at the intersection of the yeast and mammalian pathways

    Gatfield, D., Unterholzner, L., Ciccarelli, F. D., Bork, P. & Izaurralde, E. 1 Aug 2003 In : EMBO Journal. 22, 15, p. 3960-70 11 p.

    Research output: Contribution to journalArticle

  72. 14-3-3s regulate fructose-2,6-bisphosphate levels by binding to PKB-phosphorylated cardiac fructose-2,6-bisphosphate kinase/phosphatase

    Pozuelo-Rubio, M., Peggie, M., Wong, B. H. C., Morrice, N. & MacKintosh, C. 15 Jul 2003 In : The EMBO Journal. 22, 14, p. 3514-3523 10 p.

    Research output: Contribution to journalArticle

  73. MSK2 and MSK1 mediate the mitogen- and stress-induced phosphorylation of histone H3 and HMG-14

    Soloaga, A., Thomson, S., Wiggin, G. R., Rampersaud, N., Dyson, M. H., Hazzalin, C. A., Mahadevan, L. C. & Arthur, J. S. C. Jun 2003 In : The EMBO Journal. 22, 11, p. 2788-2797 10 p.

    Research output: Contribution to journalArticle

  74. Autoregulation of FCA pre-mRNA processing controls Arabidopsis flowering time

    Quesada, V., Macknight, R., Dean, C. & Simpson, G. G. Jan 2003 In : The EMBO Journal. 22, 12, p. 3142-3152 11 p.

    Research output: Contribution to journalArticle

  75. Activation of the tumour suppressor kinase LKB1 by the STE20-like pseudokinase STRAD

    Baas, A. F., Boudeau, J., Sapkota, G. P., Smit, L., Medema, R., Morrice, N. A., Alessi, D. R. & Clevers, H. C. 2003 In : EMBO Journal. 22, 12, p. 3062-3072 11 p.

    Research output: Contribution to journalArticle

  76. Feedback control of the protein kinase TAK1 by SAPK2a/p38

    Cheung, P. C. F., Campbell, D. G., Nebreda, A. R. & Cohen, P. 2003 In : The EMBO Journal. 22, 21, p. 5793-5805 13 p.

    Research output: Contribution to journalArticle

  77. Activation of the E3 ligase function of the BRCA1/BARD1 complex by polyubiquitin chains

    Mallery, D. L., Vandenberg, C. J. & Hiom, K. 16 Dec 2002 In : EMBO Journal. 21, 24, p. 6755-6762 8 p.

    Research output: Contribution to journalArticle

  78. Inhibition of SAPK2a/p38 prevents hnRNP A0 phosphorylation by MAPKAP-K2 and its interaction with cytokine mRNAs

    Rousseau, S., Morrice, N., Peggie, M., Campbell, D. G., Gaestel, M. & Cohen, P. Dec 2002 In : The EMBO Journal. 21, 23, p. 6505-6514 10 p.

    Research output: Contribution to journalArticle

  79. Altered aggregation properties of mutant γ-crystallins cause inherited cataract

    Sandilands, A., Hutcheson, A. M., Long, H. A., Prescott, A. R., Vrensen, G., Loster, J., Klopp, N., Lutz, R. B., Graw, J., Masaki, S., Dobson, C. M., MacPhee, C. E. & Quinlan, R. A. Nov 2002 In : The EMBO Journal. 21, 22, p. 6005-6014 10 p.

    Research output: Contribution to journalArticle

  80. Different Smad2 partners bind a common hydrophobic pocket in Smad2 via a defined proline-rich motif

    Randall, R. A., Germain, S., Inman, G. J., Bates, P. A. & Hill, C. S. 2002 In : EMBO Journal. 21, 1-2, p. 145-156 12 p.

    Research output: Contribution to journalArticle

  81. Four new subunits of the Dam1-Duo1 complex reveal novel functions in sister kinetochore biorientation

    Janke, C., Ortíz, J., Tanaka, T. U., Lechner, J. & Schiebel, E. 2002 In : EMBO Journal. 21, 1-2, p. 181-93 13 p.

    Research output: Contribution to journalArticle

  82. Metal ions bound at the active site of the junction-resolving enzyme T7 endonuclease I

    Hadden, J. M., Declais, A-C., Phillips, S. E. V. & Lilley, D. M. J. 2002 In : The EMBO Journal. 21, 13, p. 3505-3515 11 p.

    Research output: Contribution to journalArticle

  83. The global structure of the VS ribozyme

    Lafontaine, D. A., Norman, D. G. & Lilley, D. M. J. 2002 In : EMBO Journal. 21, 10, p. 2461-2471 11 p.

    Research output: Contribution to journalArticle

  84. Two novel phosphorylation sites on FKHR that are critical for its nuclear exclusion

    Rena, G., Woods, Y. L., Prescott, A. R., Peggie, M., Unterman, T. G., Williams, M. R. & Cohen, P. 2002 In : The EMBO Journal. 21, 9, p. 2263-2271 9 p.

    Research output: Contribution to journalArticle

  85. A novel method to identify protein kinase substrates: eEF2 kinase is phosphorylated and inhibited by SAPK4/p38

    Knebel, A., Morrice, N. & Cohen, P. Aug 2001 In : The EMBO Journal. 20, 16, p. 4360-4369 10 p.

    Research output: Contribution to journalArticle

  86. Specificity of GlcNAc-Pl de-N-acetylase of GPI biosynthesis and synthesis of parasite-specific suicide substrate inhibitors

    Smith, T. K., Crossman, A., Borissow, C. N., Paterson, M. J., Dix, A., Brimacombe, J. S. & Ferguson, M. A. J. 2 Jul 2001 In : EMBO Journal. 20, 13, p. 3322-3332 11 p.

    Research output: Contribution to journalArticle

  87. Human acrocentric chromosomes with transcriptionally silent nucleolar organizer regions associate with nucleoli

    Sullivan, G. J., Bridger, J. M., Cuthbert, A. P., Newbold, R. F., Bickmore, W. A. & McStay, B. Jun 2001 In : The EMBO Journal. 20, 11, p. 2867-2877 11 p.

    Research output: Contribution to journalArticle

  88. hRRN3 is essential in the SL1-mediated recruitment of RNA Polymerase I to rRNA gene promoters

    Miller, G., Panov, K. I., Friedrich, J. K., Trinkle-Mulcahy, L., Lamond, A. I. & Zomerdijk, J. C. B. M. Mar 2001 In : The EMBO Journal. 20, 6, p. 1373-1382 10 p.

    Research output: Contribution to journalArticle

  89. Control of chromosomal DNA replication in the early Xenopus embryo

    Blow, J. J. 2001 In : EMBO Journal. 20, 13, p. 3293-3297 5 p.

    Research output: Contribution to journalArticle

  90. Modes of spindle pole body inheritance and segregation of the Bfa1p-Bub2p checkpoint protein complex

    Pereira, G., Tanaka, T. U., Nasmyth, K. & Schiebel, E. 2001 In : EMBO Journal. 20, 22, p. 6359-70 12 p.

    Research output: Contribution to journalArticle

  91. Phosphorylation of serine 230 promotes inducible transcriptional activity of heat shock factor 1

    Holmberg, C. I., Hietakangas, V., Mikhailov, A., Rantanen, J. O., Kallio, M., Meinander, A., Hellman, J., Morrice, N., MacKintosh, C., Morimoto, R. I., Eriksson, J. E. & Sistonen, L. 2001 In : EMBO Journal. 20, 14, p. 3800-3810 11 p.

    Research output: Contribution to journalArticle

  92. Purification, cloning and characterization of a GPI inositol deacylase from Trypanosoma brucei

    Güther, M. L. S., Leal, S., Morrice, N. A., Cross, G. A. M. & Ferguson, M. A. J. 2001 In : The EMBO Journal. 20, 17, p. 4923-4934 12 p.

    Research output: Contribution to journalArticle

  93. Structure, folding and activity of the VS ribozyme: importance of the 2-3-6 helical junction

    Lafontaine, D. A., Norman, D. G. & Lilley, D. M. J. 2001 In : The EMBO Journal. 20, 6, p. 1415-1424 10 p.

    Research output: Contribution to journalArticle

  94. DNA synthesis at individual replication forks requires the essential initiation factor Cdc45p

    Tercero, J. A., Labib, K. & Diffley, J. F. X. 2 May 2000 In : EMBO Journal. 19, 9, p. 2082-2093 12 p.

    Research output: Contribution to journalArticle

  95. Chromatin binding of the fission yeast replication factor mcm4 occurs during anaphase and requires ORC and cdc18

    Kearsey, S. E., Montgomery, S., Labib, K. & Lindner, K. 3 Apr 2000 In : EMBO Journal. 19, 7, p. 1681-1690 10 p.

    Research output: Contribution to journalArticle

  96. Highly purified glycosylphosphatidylinositols from Trypanosoma cruzi are potent proinflammatory agents

    Almeida, I. C., Camargo, M. M., Procopio, D. O., Silva, L. S., Mehlert, A., Travassos, L. R., Gazzinelli, R. T. & Ferguson, M. A. J. 3 Apr 2000 In : EMBO Journal. 19, 7, p. 1476-1485 10 p.

    Research output: Contribution to journalArticle

  97. 14-3-3s regulate global cleavage of their diverse binding partners in sugar-starved Arabidopsis cells

    Cotelle, V., Meek, S. E. M., Provan, F., Milne, F. C., Morrice, N. & MacKintosh, C. 2000 In : EMBO Journal. 19, 12, p. 2869-2876 8 p.

    Research output: Contribution to journalArticle

  98. Functional analysis of the human CDC5L complex and identification of its components by mass spectrometry

    Ajuh, P., Kuster, B., Panov, K., Zomerdijk, J. C. B. M., Mann, M. & Lamond, A. I. 2000 In : EMBO Journal. 19, 23, p. 6569-6581 13 p.

    Research output: Contribution to journalArticle

  99. Prohibitins act as a membrane-bound chaperone for the stabilization of mitochondrial proteins

    Nijtmans, L. G. J., de Jong, L., Artal Sanz, M., Coates, P. J., Berden, J. A., Back, J. W., Muijsers, A. O., van der Spek, H. & Grivell, L. A. 2000 In : EMBO Journal. 19, 11, p. 2444-2451 8 p.

    Research output: Contribution to journalArticle

  100. Promiscuous targeting of Bacillus subtilis cell division protein DivIVA to division sites in Escherichia coli and fission yeast

    Edwards, D. H., Thomaides, H. B. & Errington, J. 2000 In : EMBO Journal. 19, 11, p. 2719-2727 9 p.

    Research output: Contribution to journalArticle

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