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  1. Phosphopeptide binding by Sld3 links Dbf4-dependent kinase to MCM replicative helicase activation

    Deegan, T. D., Yeeles, J. T. P. & Diffley, J. F. X. 2016 In : EMBO Journal. 35

    Research output: Contribution to journalArticle

  2. Disruption of the autoinhibited state primes the E3 ligase parkin for activation and catalysis

    Kumar, A., Aguirre, J. D., Condos, T. E. C., Martinez-Torres, R. J., Chaugule, V. K., Toth, R., Sundaramoorthy, R., Mercier, P., Knebel, A., Spratt, D. E., Barber, K. R., Shaw, G. S. & Walden, H. 14 Oct 2015 In : EMBO Journal. 34, 20, p. 2506-2521 16 p.

    Research output: Contribution to journalArticle

  3. mTOR activates the VPS34-UVRAG complex to regulate autolysosomal tubulation and cell survival

    Munson, M. J., Allen, G. F. G., Toth, R., Campbell, D. G., Lucocq, J. M. & Ganley, I. G. 2 Sep 2015 In : EMBO Journal. 34, 17, p. 2272-2290 19 p.

    Research output: Contribution to journalArticle

  4. Single cell tuning of Myc expression by antigen receptor signal strength and interleukin-2 in T lymphocytes

    Preston, G. C., Sinclair, L. V., Kaskar, A., Hukelmann, J. L., Navarro, M., Ferrero, I., MacDonald, H. R., Cowling, V. H. & Cantrell, D. A. 4 Aug 2015 In : EMBO Journal. 34, 15, p. 2008-2024 17 p.

    Research output: Contribution to journalArticle

  5. USP45 deubiquitylase controls ERCC1-XPF endonuclease-mediated DNA damage responses

    Perez-Oliva, A. B., Lachaud, C., Szyniarowski, P., Muñoz, I., Macartney, T., Hickson, I., Rouse, J. & Alessi, D. R. 3 Feb 2015 In : EMBO Journal. 34, 3, p. 326-343 18 p.

    Research output: Contribution to journalArticle

  6. Phosphoproteomic screening identifies Rab GTPases as novel downstream targets of PINK1

    Lai, Y-C., Kondapalli, C., Lehneck, R., Procter, J. B., Dill, B. D., Woodroof, H. I., Gourlay, R., Peggie, M., Macartney, T. J., Corti, O., Corvol, J-C., Campbell, D. G., Itzen, A., Trost, M. & Muqit, M. M. K. 2015 In : EMBO Journal. 22 p.

    Research output: Contribution to journalArticle

  7. A cyclic GMP-dependent signalling pathway regulates bacterial phytopathogenesis

    An, S-Q., Chin, K-H., Febrer, M., McCarthy, Y., Yang, J-G., Liu, C-L., Swarbreck, D., Rogers, J., Dow, J. M., Chou, S-H. & Ryan, R. P. 11 Sep 2013 In : EMBO Journal. 32, 18, p. 2430-2438

    Research output: Contribution to journalArticle

  8. Deficiency of terminal ADP-ribose protein glycohydrolase TARG1/C6orf130 in neurodegenerative disease

    Sharifi, R. , Morra, R. , Appel, C. D. , Tallis, M. , Chioza, B. , Jankevicius, G. , Simpson, M. A. , Matic, I. , Ozkan, E. , Golia, B. , Schellenberg, M. J. , Weston, R. , Williams, J. G. , Rossi, M. N. , Galehdari, H. , Krahn, J. , Wan, A. , Trembath, R. C. , Crosby, A. H. & 6 others Ahel, D., Hay, R., Ladurner, A. G., Timinszky, G., Williams, R. S. & Ahel, I. 2 May 2013 In : EMBO Journal. 32, 9, p. 1225-1237 13 p.

    Research output: Contribution to journalArticle

  9. PDK1 regulates VDJ recombination, cell-cycle exit and survival during B-cell development

    Venigalla, R. K. C., McGuire, V. A., Clarke, R., Patterson-Kane, J. C., Najafov, A., Toth, R., McCarthy, P. C., Simeons, F., Stojanovski, L. & Arthur, J. S. C. 3 Apr 2013 In : EMBO Journal. 32, 7, p. 1008-22 15 p.

    Research output: Contribution to journalArticle

  10. A sweet TET-a-tete-synergy of TET proteins and O-GlcNAc transferase in transcription

    Mariappa, D., Pathak, S. & van Aalten, D. M. F. 2013 In : EMBO Journal. 32, 5, p. 612-613 2 p.

    Research output: Contribution to journalEditorial

  11. TRIAD1 and HHARI bind to and are activated by distinct neddylated Cullin-RING ligase complexes

    Kelsall, I. R., Duda, D. M., Olszewski, J. L., Hofmann, K., Knebel, A., Langevin, F., Wood, N., Wightman, M., Schulman, B. A. & Alpi, A. F. 2013 In : EMBO Journal. 32, p. 2848-2860 13 p.

    Research output: Contribution to journalArticle

  12. The Mitotic Exit Network and Cdc14 phosphatase initiate cytokinesis by counteracting CDK phosphorylations and blocking polarised growth

    Sanchez-Diaz, A., Nkosi, P. J., Murray, S. & Labib, K. 29 Aug 2012 In : EMBO Journal. 31, 17, p. 3620-3634 15 p.

    Research output: Contribution to journalArticle

  13. Mcm10 associates with the loaded DNA helicase at replication origins and defines a novel step in its activation

    van Deursen, F., Sengupta, S., De Piccoli, G., Sanchez-Diaz, A. & Labib, K. 2 May 2012 In : EMBO Journal. 31, 9, p. 2195-2206 12 p.

    Research output: Contribution to journalArticle

  14. Sperm are promiscuous and CatSper is to blame...

    Barratt, C. L. R. & Publicover, S. J. 4 Apr 2012 In : EMBO Journal. 31, 7, p. 1624-1626 3 p.

    Research output: Contribution to journalArticle

  15. O-GlcNAcylation of TAB1 modulates TAK1-mediated cytokine release

    Pathak, S., Borodkin, V. S., Albarbarawi, O., Campbell, D. G., Ibrahim, A. & van Aalten, D. M. F. 21 Mar 2012 In : EMBO Journal. 31, 6, p. 1394-1404 11 p.

    Research output: Contribution to journalArticle

  16. Building a double hexamer of DNA helicase at eukaryotic replication origins

    Labib, K. 14 Dec 2011 In : EMBO Journal. 30, 24, p. 4853-4855 3 p.

    Research output: Contribution to journalArticle

  17. Autoregulation of Parkin activity through its ubiquitin-like domain

    Chaugule, V. K., Burchell, L., Barber, K. R., Sidhu, A., Leslie, S. J., Shaw, G. S. & Walden, H. 20 Jul 2011 In : EMBO Journal. 30, 14, p. 2853-2867 15 p.

    Research output: Contribution to journalArticle

  18. The DNA-binding domain of the Chd1 chromatin-remodelling enzyme contains SANT and SLIDE domains

    Ryan, D. P., Sundaramoorthy, R., Martin, D., Singh, V. & Owen-Hughes, T. 6 Jul 2011 In : EMBO Journal. 30, 13, p. 2596-2609 14 p.

    Research output: Contribution to journalArticle

  19. The SWI/SNF complex acts to constrain distribution of the centromeric histone variant Cse4

    Gkikopoulos, T., Singh, V., Tsui, K., Awad, S., Renshaw, M. J., Scholfield, P., Barton, G. J., Nislow, C., Tanaka, T. U. & Owen-Hughes, T. 18 May 2011 In : EMBO Journal. 30, 10, p. 1919-1927 9 p.

    Research output: Contribution to journalArticle

  20. MO25 is a master regulator of SPAK/OSR1 and MST3/MST4/YSK1 protein kinases

    Filippi, B. M., de los Heros, P., Mehellou, Y., Navratilova, I., Gourlay, R., Deak, M., Plater, L., Toth, R., Zeqiraj, E. & Alessi, D. R. 4 May 2011 In : EMBO Journal. 30, 9, p. 1730-1741 12 p.

    Research output: Contribution to journalArticle

  21. AMPK and autophagy get connected

    Hardie, D. G. 16 Feb 2011 In : EMBO Journal. 30, 4, p. 634-635 2 p.

    Research output: Contribution to journalEditorial

  22. Kinetochore-microtubule interactions: steps towards bi-orientation

    Tanaka, T. U. 15 Dec 2010 In : EMBO Journal. 29, 24, p. 4070-4082 13 p.

    Research output: Contribution to journalLiterature review

  23. RNAi-based screening identifies the Mms22L-Nfkbil2 complex as a novel regulator of DNA replication in human cells

    Piwko, W., Olma, M. H., Held, M., Pedrioli, P. G. A., Gerlich, D. W., Peter, M., Bianco, J. N., Pasero, P. & Hofmann, K. 15 Dec 2010 In : EMBO Journal. 29, 24, p. 4210-4222 13 p.

    Research output: Contribution to journalArticle

  24. Tyrosine dephosphorylation is required for Bak activation in apoptosis

    Fox, J. L., Ismail, F., Azad, A., Ternette, N., Leverrier, S., Edelmann, M. J., Kessler, B. M., Leigh, I. M., Jackson, S. & Storey, A. 17 Nov 2010 In : EMBO Journal. 29, 22, p. 3853-3868 16 p.

    Research output: Contribution to journalArticle

  25. IKK and NF-kappa B-mediated regulation of Claspin impacts on ATR checkpoint function

    Kenneth, N. S., Mudie, S. & Rocha, S. 1 Sep 2010 In : EMBO Journal. 29, 17, p. 2966-2978 13 p.

    Research output: Contribution to journalArticle

  26. S6K1 is a multifaceted regulator of Mdm2 that connects nutrient status and DNA damage response

    Lai, K. P., Leong, W. F., Chau, J. F. L., Jia, D., Zeng, L., Liu, H., He, L., Hao, A., Zhang, H., Meek, D., Velagapudi, C., Habib, S. L. & Li, B. 1 Sep 2010 In : EMBO Journal. 29, 17, p. 2994-3006 13 p.

    Research output: Contribution to journalArticle

  27. Ubiquitin-specific proteases 7 and 11 modulate Polycomb regulation of the INK4a tumour suppressor

    Maertens, G. N., El Messaoudi-Aubert, S., Elderkin, S., Hiom, K. & Peters, G. 4 Aug 2010 In : EMBO Journal. 29, 15, p. 2553-2565 13 p.

    Research output: Contribution to journalArticle

  28. Phosphorylation of Mcl-1 by CDK1-cyclin B1 initiates its Cdc20-dependent destruction during mitotic arrest

    Harley, M. E., Allan, L. A., Sanderson, H. S. & Clarke, P. R. 21 Jul 2010 In : EMBO Journal. 29, 14, p. 2407-2420 14 p.

    Research output: Contribution to journalArticle

  29. Analysis of small RNA in fission yeast; centromeric siRNAs are potentially generated through a structured RNA

    Djupedal, I., Kos-Braun, I. C., Mosher, R. A., Soderholm, N., Simmer, F., Hardcastle, T. J., Fender, A., Heidrich, N., Kagansky, A., Bayne, E., Wagner, E. G. H., Baulcombe, D. C., Allshire, R. C. & Ekwall, K. 16 Dec 2009 In : EMBO Journal. 28, 24, p. 3832-3844 13 p.

    Research output: Contribution to journalArticle

  30. Cullin neddylation and substrate-adaptors counteract SCF inhibition by the CAND1-like protein Lag2 in Saccharomyces cerevisiae

    Siergiejuk, E., Scott, D. C., Schulman, B. A., Hofmann, K., Kurz, T. & Peter, M. 16 Dec 2009 In : EMBO Journal. 28, 24, p. 3845-3856 12 p.

    Research output: Contribution to journalArticle

  31. The MRT-1 nuclease is required for DNA crosslink repair and telomerase activity in vivo in Caenorhabditis elegans

    Meier, B., Barber, L. J., Liu, Y., Shtessel, L., Boulton, S. J., Gartner, A. & Ahmed, S. 18 Nov 2009 In : EMBO Journal. 28, 22, p. 3549-3563 15 p.

    Research output: Contribution to journalArticle

  32. A key role for Ctf4 in coupling the MCM2-7 helicase to DNA polymerase alpha within the eukaryotic replisome

    Gambus, A., van Deursen, F., Polychronopoulos, D., Foltman, M., Jones, R. C., Edmondson, R. D., Calzada, A. & Labib, K. 7 Oct 2009 In : EMBO Journal. 28, 19, p. 2992-3004 13 p.

    Research output: Contribution to journalArticle

  33. Distinct donor and acceptor specificities of Trypanosoma brucei oligosaccharyltransferases

    Izquierdo, L., Schulz, B. L., Rodrigues, J. A., Guther, M. L. S., Procter, J. B., Barton, G. J., Aebi, M. & Ferguson, M. A. J. 2 Sep 2009 In : EMBO Journal. 28, 17, p. 2650-2661 12 p.

    Research output: Contribution to journalArticle

  34. Gene activation at the edge of the nucleus

    Chubb, J. R. 5 Aug 2009 In : EMBO Journal. 28, 15, p. 2145-2146 2 p.

    Research output: Contribution to journalComment/debate

  35. Molecular dissection of the eukaryotic initiation factor 4E (eIF4E) export-competent RNP

    Topisirovic, I., Siddiqui, N., Lapointe, V. L., Trost, M., Thibault, P., Bangeranye, C., Pinol-Roma, S. & Borden, K. L. B. 22 Apr 2009 In : EMBO Journal. 28, 8, p. 1087-1098 12 p.

    Research output: Contribution to journalArticle

  36. FACT facilitates chromatin transcription by RNA polymerases I and III

    Birch, J. L., Tan, B. C-M., Panov, K. I., Panova, T. B., Andersen, J. S., Owen-Hughes, T. A., Russell, J., Lee, S-C. & Zomerdijk, J. C. B. M. 8 Apr 2009 In : EMBO Journal. 28, 7, p. 854-865 12 p.

    Research output: Contribution to journalArticle

  37. TRF2 promotes, remodels and protects telomeric Holliday junctions

    Poulet, A., Buisson, R., Faivre-Moskalenko, C., Koelblen, M., Amiard, S., Montel, F., Cuesta-Lopez, S., Bornet, O., Guerlesquin, F., Godet, T., Moukhtar, J., Argoul, F., Declais, A-C., Lilley, D. M. J., Ip, S. C. Y., West, S. C., Gilson, E. & Giraud-Panis, M-J. 18 Mar 2009 In : EMBO Journal. 28, 6, p. 641-651 11 p.

    Research output: Contribution to journalArticle

  38. Structural insights into mechanism and specificity of O-GlcNAc transferase

    Clarke, A. J., Hurtado-Guerrero, R., Pathak, S., Schuettelkopf, A., Borodkin, V., Shepherd, S. M., Ibrahim, A. F. M. & van Aalten, D. M. F. 22 Oct 2008 In : EMBO Journal. 27, 20, p. 2780-2788 9 p.

    Research output: Contribution to journalArticle

  39. Phosphorylation-dependent binding of 14-3-3 terminates signalling by the Gab2 docking protein

    Brummer, T., Larance, M., Herrera Abreu, M. T., Lyons, R. J., Timpson, P., Emmerich, C. H., Fleuren, E. D. G., Lehrbach, G. M., Schramek, D., Guilhaus, M., James, D. E. & Daly, R. J. 3 Sep 2008 In : EMBO Journal. 27, 17, p. 2305-2316 12 p.

    Research output: Contribution to journalArticle

  40. The kinase Syk as an adaptor controlling sustained calcium signalling and B-cell development

    Kulathu, Y., Hobeika, E., Turchinovich, G. & Reth, M. 7 May 2008 In : EMBO Journal. 27, 9, p. 1333-44 12 p.

    Research output: Contribution to journalArticle

  41. Cystatin F is a cathepsin C-directed protease inhibitor regulated by proteolysis

    Hamilton, G., Colbert, J. D., Schuettelkopf, A. W. & Watts, C. 6 Feb 2008 In : EMBO Journal. 27, 3, p. 499-508 10 p.

    Research output: Contribution to journalArticle

  42. Notch-induced T cell development requires phosphoinositide-dependent kinase 1

    Kelly, A. P., Finlay, D. K., Hinton, H. J., Clarke, R. G., Fiorini, E., Radtke, F. & Cantrell, D. A. 25 Jul 2007 In : EMBO Journal. 26, 14, p. 3441-3450 10 p.

    Research output: Contribution to journalArticle

  43. A guanine nucleobase important for catalysis by the VS ribozyme

    Wilson, T. J., McLeod, A. C. & Lilley, D. M. J. 16 May 2007 In : EMBO Journal. 26, 10, p. 2489-2500 12 p.

    Research output: Contribution to journalArticle

  44. Reconstruction of a pathway of antigen processing and class II MHC peptide capture

    Moss, C. X., Tree, T. I. & Watts, C. 18 Apr 2007 In : EMBO Journal. 26, 8, p. 2137-47 11 p.

    Research output: Contribution to journalArticle

  45. Cajal bodies and the nucleolus are required for a plant virus systemic infection

    Kim, S. H., Ryabov, E. V., Kalinina, N. O., Rakitina, D. V., Gillespie, T., Macfarlane, S., Haupt, S., Brown, J. W. S. & Taliansky, M. Apr 2007 In : The EMBO Journal. 26, 8, p. 2169-2179 11 p.

    Research output: Contribution to journalArticle

  46. A novel TBP-associated factor of SL1 functions in RNA polymerase I transcription

    Gorski, J. J., Pathak, S., Panov, K., Kasciukovic, T., Panova, T., Russell, J. & Zomerdijk, J. C. B. M. Mar 2007 In : The EMBO Journal. 26, 6, p. 1560-1568 9 p.

    Research output: Contribution to journalArticle

  47. Regulation of AMP-activated protein kinase by a pseudosubstrate sequence on the gamma subunit

    Scott, J. W., Ross, F. A., Liu, J. K. D. & Hardie, D. G. 7 Feb 2007 In : EMBO Journal. 26, 3, p. 806-15 10 p.

    Research output: Contribution to journalArticle

  48. A cell cycle regulatory network controlling NF-B subunit activity and function

    Barre, B. & Perkins, N. 2007 In : The EMBO Journal. 26, 23, p. 4841-4855 15 p.

    Research output: Contribution to journalArticle

  49. The deubiquitinating enzyme USP2a regulates the p53 pathway by targeting Mdm2

    Stevenson, L. F., Sparks, A., Allende-Vega, N., Xirodimas, D. P., Lane, D. & Saville, M. K. 2007 In : The EMBO Journal. 26, 4, p. 976-986 11 p.

    Research output: Contribution to journalArticle

  50. Regulation of p53 tumour suppressor target gene expression by the p52 NF-kappaB subunit

    Schumm, K., Rocha, S., Caamano, J. & Perkins, N. D. Oct 2006 In : The EMBO Journal. 25, 20, p. 4820-4832 13 p.

    Research output: Contribution to journalArticle

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