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  1. PDK1 regulates VDJ recombination, cell-cycle exit and survival during B-cell development

    Venigalla, R. K. C., McGuire, V. A., Clarke, R., Patterson-Kane, J. C., Najafov, A., Toth, R., McCarthy, P. C., Simeons, F., Stojanovski, L. & Arthur, J. S. C. 3-Apr-2013 In : EMBO Journal. 32, 7, p. 1008-22, 15 p.

    Research output: Contribution to journal › Article

  2. A sweet TET-a-tete-synergy of TET proteins and O-GlcNAc transferase in transcription

    Mariappa, D., Pathak, S. & van Aalten, D. M. F. 2013 In : EMBO Journal. 32, 5, p. 612-613, 2 p.

    Research output: Contribution to journal › Editorial

  3. Sperm are promiscuous and CatSper is to blame...

    Barratt, C. L. R. & Publicover, S. J. 4-Apr-2012 In : EMBO Journal. 31, 7, p. 1624-1626, 3 p.

    Research output: Contribution to journal › Article

  4. O-GlcNAcylation of TAB1 modulates TAK1-mediated cytokine release

    Pathak, S., Borodkin, V. S., Albarbarawi, O., Campbell, D. G., Ibrahim, A. & van Aalten, D. M. F. 21-Mar-2012 In : EMBO Journal. 31, 6, p. 1394-1404, 11 p.

    Research output: Contribution to journal › Article

  5. The DNA-binding domain of the Chd1 chromatin-remodelling enzyme contains SANT and SLIDE domains

    Ryan, D. P., Sundaramoorthy, R., Martin, D., Singh, V. & Owen-Hughes, T. 6-Jul-2011 In : EMBO Journal. 30, 13, p. 2596-2609, 14 p.

    Research output: Contribution to journal › Article

  6. The SWI/SNF complex acts to constrain distribution of the centromeric histone variant Cse4

    Gkikopoulos, T., Singh, V., Tsui, K., Awad, S., Renshaw, M. J., Scholfield, P., Barton, G. J., Nislow, C., Tanaka, T. U. & Owen-Hughes, T. 18-May-2011 In : EMBO Journal. 30, 10, p. 1919-1927, 9 p.

    Research output: Contribution to journal › Article

  7. MO25 is a master regulator of SPAK/OSR1 and MST3/MST4/YSK1 protein kinases

    Filippi, B. M., de los Heros, P., Mehellou, Y., Navratilova, I., Gourlay, R., Deak, M., Plater, L., Toth, R., Zeqiraj, E. & Alessi, D. R. 4-May-2011 In : EMBO Journal. 30, 9, p. 1730-1741, 12 p.

    Research output: Contribution to journal › Article

  8. AMPK and autophagy get connected

    Hardie, D. G. 16-Feb-2011 In : EMBO Journal. 30, 4, p. 634-635, 2 p.

    Research output: Contribution to journal › Editorial

  9. Kinetochore-microtubule interactions: steps towards bi-orientation

    Tanaka, T. U. 15-Dec-2010 In : EMBO Journal. 29, 24, p. 4070-4082, 13 p.

    Research output: Contribution to journal › Scientific review

  10. RNAi-based screening identifies the Mms22L-Nfkbil2 complex as a novel regulator of DNA replication in human cells

    Piwko, W., Olma, M. H., Held, M., Pedrioli, P. G. A., Gerlich, D. W., Peter, M., Bianco, J. N., Pasero, P. & Hofmann, K. 15-Dec-2010 In : EMBO Journal. 29, 24, p. 4210-4222, 13 p.

    Research output: Contribution to journal › Article

  11. Tyrosine dephosphorylation is required for Bak activation in apoptosis

    Fox, J. L., Ismail, F., Azad, A., Ternette, N., Leverrier, S., Edelmann, M. J., Kessler, B. M., Leigh, I. M., Jackson, S. & Storey, A. 17-Nov-2010 In : EMBO Journal. 29, 22, p. 3853-3868, 16 p.

    Research output: Contribution to journal › Article

  12. IKK and NF-kappa B-mediated regulation of Claspin impacts on ATR checkpoint function

    Kenneth, N. S., Mudie, S. & Rocha, S. 1-Sep-2010 In : EMBO Journal. 29, 17, p. 2966-2978, 13 p.

    Research output: Contribution to journal › Article

  13. S6K1 is a multifaceted regulator of Mdm2 that connects nutrient status and DNA damage response

    Lai, K. P., Leong, W. F., Chau, J. F. L., Jia, D., Zeng, L., Liu, H., He, L., Hao, A., Zhang, H., Meek, D., Velagapudi, C., Habib, S. L. & Li, B. 1-Sep-2010 In : EMBO Journal. 29, 17, p. 2994-3006, 13 p.

    Research output: Contribution to journal › Article

  14. Ubiquitin-specific proteases 7 and 11 modulate Polycomb regulation of the INK4a tumour suppressor

    Maertens, G. N., El Messaoudi-Aubert, S., Elderkin, S., Hiom, K. & Peters, G. 4-Aug-2010 In : EMBO Journal. 29, 15, p. 2553-2565, 13 p.

    Research output: Contribution to journal › Article

  15. Phosphorylation of Mcl-1 by CDK1-cyclin B1 initiates its Cdc20-dependent destruction during mitotic arrest

    Harley, M. E., Allan, L. A., Sanderson, H. S. & Clarke, P. R. 21-Jul-2010 In : EMBO Journal. 29, 14, p. 2407-2420, 14 p.

    Research output: Contribution to journal › Article

  16. Analysis of small RNA in fission yeast; centromeric siRNAs are potentially generated through a structured RNA

    Djupedal, I., Kos-Braun, I. C., Mosher, R. A., Soderholm, N., Simmer, F., Hardcastle, T. J., Fender, A., Heidrich, N., Kagansky, A., Bayne, E., Wagner, E. G. H., Baulcombe, D. C., Allshire, R. C. & Ekwall, K. 16-Dec-2009 In : EMBO Journal. 28, 24, p. 3832-3844, 13 p.

    Research output: Contribution to journal › Article

  17. Cullin neddylation and substrate-adaptors counteract SCF inhibition by the CAND1-like protein Lag2 in Saccharomyces cerevisiae

    Siergiejuk, E., Scott, D. C., Schulman, B. A., Hofmann, K., Kurz, T. & Peter, M. 16-Dec-2009 In : EMBO Journal. 28, 24, p. 3845-3856, 12 p.

    Research output: Contribution to journal › Article

  18. The MRT-1 nuclease is required for DNA crosslink repair and telomerase activity in vivo in Caenorhabditis elegans

    Meier, B., Barber, L. J., Liu, Y., Shtessel, L., Boulton, S. J., Gartner, A. & Ahmed, S. 18-Nov-2009 In : EMBO Journal. 28, 22, p. 3549-3563, 15 p.

    Research output: Contribution to journal › Article

  19. Distinct donor and acceptor specificities of Trypanosoma brucei oligosaccharyltransferases

    Izquierdo, L., Schulz, B. L., Rodrigues, J. A., Guther, M. L. S., Procter, J. B., Barton, G. J., Aebi, M. & Ferguson, M. A. J. 2-Sep-2009 In : EMBO Journal. 28, 17, p. 2650-2661, 12 p.

    Research output: Contribution to journal › Article

  20. Gene activation at the edge of the nucleus

    Chubb, J. R. 5-Aug-2009 In : EMBO Journal. 28, 15, p. 2145-2146, 2 p.

    Research output: Contribution to journal › Comment/debate

  21. Molecular dissection of the eukaryotic initiation factor 4E (eIF4E) export-competent RNP

    Topisirovic, I., Siddiqui, N., Lapointe, V. L., Trost, M., Thibault, P., Bangeranye, C., Pinol-Roma, S. & Borden, K. L. B. 22-Apr-2009 In : EMBO Journal. 28, 8, p. 1087-1098, 12 p.

    Research output: Contribution to journal › Article

  22. FACT facilitates chromatin transcription by RNA polymerases I and III

    Birch, J. L., Tan, B. C-M., Panov, K. I., Panova, T. B., Andersen, J. S., Owen-Hughes, T. A., Russell, J., Lee, S-C. & Zomerdijk, J. C. B. M. 8-Apr-2009 In : EMBO Journal. 28, 7, p. 854-865, 12 p.

    Research output: Contribution to journal › Article

  23. TRF2 promotes, remodels and protects telomeric Holliday junctions

    Poulet, A., Buisson, R., Faivre-Moskalenko, C., Koelblen, M., Amiard, S., Montel, F., Cuesta-Lopez, S., Bornet, O., Guerlesquin, F., Godet, T., Moukhtar, J., Argoul, F., Declais, A-C., Lilley, D. M. J., Ip, S. C. Y., West, S. C., Gilson, E. & Giraud-Panis, M-J. 18-Mar-2009 In : EMBO Journal. 28, 6, p. 641-651, 11 p.

    Research output: Contribution to journal › Article

  24. Structural insights into mechanism and specificity of O-GlcNAc transferase

    Clarke, A. J., Hurtado-Guerrero, R., Pathak, S., Schuettelkopf, A., Borodkin, V., Shepherd, S. M., Ibrahim, A. F. M. & van Aalten, D. M. F. 22-Oct-2008 In : EMBO Journal. 27, 20, p. 2780-2788, 9 p.

    Research output: Contribution to journal › Article

  25. The kinase Syk as an adaptor controlling sustained calcium signalling and B-cell development

    Kulathu, Y., Hobeika, E., Turchinovich, G. & Reth, M. 7-May-2008 In : EMBO Journal. 27, 9, p. 1333-44, 12 p.

    Research output: Contribution to journal › Article

  26. Cystatin F is a cathepsin C-directed protease inhibitor regulated by proteolysis

    Hamilton, G., Colbert, J. D., Schuettelkopf, A. W. & Watts, C. 6-Feb-2008 In : EMBO Journal. 27, 3, p. 499-508, 10 p.

    Research output: Contribution to journal › Article

  27. Cajal bodies and the nucleolus are required for a plant virus systemic infection

    Kim, S. H., Ryabov, E. V., Kalinina, N. O., Rakitina, D. V., Gillespie, T., MacFarlane, S., Haupt, S., Brown, J. W. S. & Taliansky, M. Apr-2007 In : The EMBO Journal. 26, 8, p. 2169-2179, 11 p.

    Research output: Contribution to journal › Article

  28. A novel TBP-associated factor of SL1 functions in RNA polymerase I transcription

    Gorski, J. J., Pathak, S., Panov, K., Kasciukovic, T., Panova, T., Russell, J. & Zomerdijk, J. C. B. M. Mar-2007 In : The EMBO Journal. 26, 6, p. 1560-1568, 9 p.

    Research output: Contribution to journal › Article

  29. A cell cycle regulatory network controlling NF-B subunit activity and function

    Barre, B. & Perkins, N. 2007 In : The EMBO Journal. 26, 23, p. 4841-4855, 15 p.

    Research output: Contribution to journal › Article

  30. The deubiquitinating enzyme USP2a regulates the p53 pathway by targeting Mdm2

    Stevenson, L. F., Sparks, A., Allende-Vega, N., Xirodimas, D. P., Lane, D. & Saville, M. K. 2007 In : The EMBO Journal. 26, 4, p. 976-986, 11 p.

    Research output: Contribution to journal › Article

  31. Regulation of p53 tumour suppressor target gene expression by the p52 NF-kappaB subunit

    Schumm, K., Rocha, S., Caamano, J. & Perkins, N. D. Oct-2006 In : The EMBO Journal. 25, 20, p. 4820-4832, 13 p.

    Research output: Contribution to journal › Article

  32. A novel leptin signalling pathway via PTEN inhibition in hypothalamic cell lines and pancreatic β-cells

    Ning, K., Miller, L. C., Laidlaw, H. A., Burgess, L. A., Perera, N. M., Downes, C. P., Leslie, N. R. & Ashford, M. L. J. Jun-2006 In : The EMBO Journal. 25, 11, p. 2377-2387, 11 p.

    Research output: Contribution to journal › Article

  33. Structural insights into the mechanism and inhibition of eukaryotic O-GlcNAc hydrolysis

    Rao, F. V., Dorfmueller, H. C., Villa, F., Allwood, M., Eggleston, I. M. & van Aalten, D. M. F. 2006 In : The EMBO Journal. 25, 7, p. 1569-1578, 10 p.

    Research output: Contribution to journal › Article

  34. UBF activates RNA polymerase I transcription by stimulating promoter escape

    Panov, K. I., Friedrich, J. K., Russell, J. & Zomerdijk, J. C. B. M. 2006 In : The EMBO Journal. 25, 14, p. 3310-3322, 13 p.

    Research output: Contribution to journal › Article

  35. Deficiency of LKB1 in skeletal muscle prevents AMPK activation and glucose uptake during contraction

    Sakamoto, K., McCarthy, A., Smith, D., Green, K. A., Hardie, D. G., Ashworth, A. & Alessi, D. R. May-2005 In : The EMBO Journal. 24, 10, p. 1810-1820, 11 p.

    Research output: Contribution to journal › Article

  36. The tRNA methylase METTL1 is phosphorylated and inactivated by PKB and RSK in vitro and in cells

    Cartlidge, R. A., Knebel, A., Peggie, M., Alexandrov, A., Phizicky, E. M. & Cohen, P. May-2005 In : The EMBO Journal. 24, 9, p. 1696-1705, 10 p.

    Research output: Contribution to journal › Article

  37. Role that phosphorylation of GSK3 plays in insulin and Wnt signalling defined by knockin analysis

    McManus, E. J., Sakamoto, K., Armit, L. J., Ronaldson, L., Shpiro, N., Marquez, R. & Alessi, D. R. Apr-2005 In : The EMBO Journal. 24, 8, p. 1571-1583, 13 p.

    Research output: Contribution to journal › Article

  38. Structural basis of NEDD8 ubiquitin discrimination by the deNEDDylating enzyme NEDP1

    Shen, L., Liu, H., Dong, C., Xirodimas, D., Naismith, J. H. & Hay, R. T. Apr-2005 In : The EMBO Journal. 24, 7, p. 1341-1351, 11 p.

    Research output: Contribution to journal › Article

  39. Regulation of NF-kappaB and p53 through activation of ATR and Chk1 by the ARF tumour suppressor

    Rocha, S., Garrett, M. D., Campbell, K. J., Schumm, K. & Perkins, N. D. Mar-2005 In : EMBO Journal. 24, 6, p. 1157-1169, 13 p.

    Research output: Contribution to journal › Article

  40. The DEAD box protein p68: a novel transcriptional coactivator of the p53 tumour suppressor

    Bates, G. J., Nicol, S. M., Wilson, B. J., Jacobs, A-M. F., Bourdon, J-C., Wardrop, J., Gregory, D. J., Lane, D. P., Perkins, N. D. & Fuller-Pace, F. V. 9-Feb-2005 In : The EMBO Journal. 24, 3, p. 543-553, 11 p.

    Research output: Contribution to journal › Article

  41. Cdt1 downregulation by proteolysis and geminin inhibition prevents DNA re-replication in Xenopus

    Li, A. & Blow, J. J. Jan-2005 In : The EMBO Journal. 24, 2, p. 395-404, 10 p.

    Research output: Contribution to journal › Article

  42. Activation of MK5/PRAK by the atypical MAP kinase ERK3 defines a novel signal transduction pathway

    Seternes, O-M., Mikalsen, T., Johansen, B., Michaelsen, E., Armstrong, C. G., Morrice, N. A., Turgeon, B., Meloche, S., Moens, U. & Keyse, S. M. Dec-2004 In : The EMBO Journal. 23, 24, p. 4780-4791, 12 p.

    Research output: Contribution to journal › Article

  43. Chemical validation of GPI biosynthesis as a drug target against African sleeping sickness

    Smith, T. K., Crossman, A., Brimacombe, J. S. & Ferguson, M. A. J. Nov-2004 In : The EMBO Journal. 23, 23, p. 4701-4708, 8 p.

    Research output: Contribution to journal › Article

  44. LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1

    Lizcano, J. M., Goransson, O., Toth, R., Deak, M., Morrice, N. A., Boudeau, J., Hawley, S., Udd, L., Makela, T. P., Hardie, D. G. & Alessi, D. R. Feb-2004 In : The EMBO Journal. 23, 4, p. 833-843, 11 p.

    Research output: Contribution to journal › Article

  45. Coordinating assembly and export of complex bacterial proteins

    Jack, R. L., Buchanan, G., Dubini, A., Hatzixanthis, K., Palmer, T. & Sargent, F. 2004 In : The EMBO Journal. 23, 20, p. 3962-3972, 11 p.

    Research output: Contribution to journal › Article

  46. Esc4p, a new target of Mec1p (ATR), promotes resumption of DNA synthesis after DNA damage

    Rouse, J. 2004 In : The EMBO Journal. 23, 5, p. 1188-1197, 10 p.

    Research output: Contribution to journal › Article

  47. Sin mutations alter inherent nucleosome mobility

    Flaus, A., Rencurel, C., Ferreira, H., Wiechens, N. & Owen-Hughes, T. 2004 In : The EMBO Journal. 23, 2, p. 343-353, 11 p.

    Research output: Contribution to journal › Article

  48. Redox regulation of PI 3-kinase signalling via inactivation of PTEN

    Leslie, N., Bennett, D., Downes, P., Gray, A., Lindsay, Y. E. & Stewart, H. Oct-2003 In : EMBO Journal. 22, 20, p. 5501-5510, 10 p.

    Research output: Contribution to journal › Article

  49. Deficiency of PDK1 in cardiac muscle results in heart failure and increased sensitivity to hypoxia

    Mora, A., Davies, A. M., Bertrand, L., Sharif, I., Budas, G. R., Jovanovic, S., Mouton, V., Kahn, C. R., Lucocq, J. M., Gray, G. A., Jovanovic, A. & Alessi, D. R. Sep-2003 In : The EMBO Journal. 22, 18, p. 4666-4676, 11 p.

    Research output: Contribution to journal › Article

  50. Nonsense-mediated mRNA decay in Drosophila: at the intersection of the yeast and mammalian pathways

    Gatfield, D., Unterholzner, L., Ciccarelli, F. D., Bork, P. & Izaurralde, E. 1-Aug-2003 In : EMBO Journal. 22, 15, p. 3960-70, 11 p.

    Research output: Contribution to journal › Article

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