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  1. Mutagenic analysis of the intracellular portals of the human 5-HT3A receptor

    Carland, J. E., Cooper, M. A., Livesey, M. R., Hales, T. G., Lambert, J. J. & Peters, J. A. 1 Nov 2013 In : Journal of Biological Chemistry. 288, 44, p. 31592-31601 10 p.

    Research output: Contribution to journalArticle

  2. The Geminin and Idas coiled coils preferentially form a heterodimer that inhibits Geminin function in DNA replication licensing

    Caillat, C., Pefani, D-E., Gillespie, P. J., Taraviras, S., Blow, J. J., Lygerou, Z. & Perrakis, A. Nov 2013 In : Journal of Biological Chemistry. 288, 44, p. 31624-31634 11 p.

    Research output: Contribution to journalArticle

  3. The minimum M3-M4 loop length of neurotransmitteractivated pentameric receptors is critical for the structural integrity of cytoplasmic portals

    Baptista-Hon, D. T., Deeb, T. Z., Lambert, J. J., Peters, J. A. & Hales, T. G. 26 Jul 2013 In : Journal of Biological Chemistry. 288, 30, p. 21558-21568 11 p.

    Research output: Contribution to journalArticle

  4. The spontaneously adhesive leukocyte function-associated antigen-1 (LFA-1) integrin in effector T cells mediates rapid actin- and calmodulin-dependent adhesion strengthening to ligand under shear flow

    Lek, H. S., Morrison, V. L., Conneely, M., Campbell, P. A., McGloin, D., Kliche, S., Watts, C., Prescott, A. & Fagerholm, S. C. 24 May 2013 In : Journal of Biological Chemistry. 288, 21, p. 14698-14708 11 p.

    Research output: Contribution to journalArticle

  5. A separate pool of cardiac phospholemman that does not regulate or associate with the sodium pump: multimers of phospholemman in ventricular muscle

    Wypijewski, K. J., Howie, J., Reilly, L., Tulloch, L. B., Aughton, K. L., McLatchie, L. M., Shattock, M. J., Calaghan, S. C. & Fuller, W. 10 May 2013 In : Journal of Biological Chemistry. 288, 19, p. 13808-13820 13 p.

    Research output: Contribution to journalArticle

  6. Structure of a complex phosphoglycan epitope from gp72 of Trypanosoma cruzi

    Allen, S., Richardson, J. M., Mehlert, A. & Ferguson, M. A. J. 19 Apr 2013 In : Journal of Biological Chemistry. 288, 16, p. 11093-11105 13 p.

    Research output: Contribution to journalArticle

  7. Ca2+ signalling through CatSper and Ca2+ stores regulate different behaviours in human sperm

    Alasmari, W., Costello, S., Correia, J., Oxenham, S. K., Morris, J., Fernandes, L., Ramalho Santos, J., Kirkman-Brown, J., Michelangeli, F., Publicover, S. & Barratt, C. L. R. 1 Mar 2013 In : Journal of Biological Chemistry. 288, 9, p. 6248-6258 11 p.

    Research output: Contribution to journalArticle

  8. Dual regulation of Glycogen Synthase Kinase 3 (GSK3)alpha/beta by Protein Kinase C (PKC)alpha and Akt promotes Thrombin-mediated Integrin alpha(IIb)beta(3) activation and granule secretion in platelets

    Moore, S. F., van den Bosch, M. T. J., Hunter, R. W., Sakamoto, K., Poole, A. W. & Hers, I. 2013 In : Journal of Biological Chemistry. 288, 6, p. 3918-3928 11 p.

    Research output: Contribution to journalArticle

  9. N-terminal serine dephosphorylation is required for KCC3 cotransporter full activation by cell swelling

    Melo, Z., De Los Heros, P., Cruz-Rangel, S., Vázquez, N., Bobadilla, N. A., Pasantes-Morales, H., Alessi, D. R., Mercado, A. & Gamba, G. 2013 In : Journal of Biological Chemistry. 288, 44, p. 31468-31476 9 p.

    Research output: Contribution to journalArticle

  10. The involvement of mitochondrial amidoxime reducing components 1 and 2 and mitochondrial cytochrome b5 in N-reductive metabolism in human cells

    Plitzko, B., Ott, G., Reichmann, D., Henderson, C. J., Wolf, C. R., Mendel, R., Bittner, F., Clement, B. & Havemeyer, A. 2013 In : Journal of Biological Chemistry. 288, 28, p. 20228-20237 10 p.

    Research output: Contribution to journalArticle

  11. Family with Sequence Similarity 60A (FAM60A) Protein Is a Cell Cycle-fluctuating Regulator of the SIN3-HDAC1 Histone Deacetylase Complex

    Munoz, I. M., Macartney, T., Sanchez-Pulido, L., Ponting, C. P., Rocha, S. & Rouse, J. 21 Sep 2012 In : Journal of Biological Chemistry. 287, 39, p. 32346-53 8 p.

    Research output: Contribution to journalArticle

  12. Monoubiquitination Promotes Calpain Cleavage of the Protein Phosphatase 2A (PP2A) Regulatory Subunit alpha 4, Altering PP2A Stability and Microtubule-associated Protein Phosphorylation

    Watkins, G. R., Wang, N., Mazalouskas, M. D., Gomez, R. J., Guthrie, C. R., Kraemer, B. C., Schweiger, S., Spiller, B. W. & Wadzinski, B. E. 13 Jul 2012 In : Journal of Biological Chemistry. 287, 29, p. 24207-24215 9 p.

    Research output: Contribution to journalArticle

  13. A conserved motif in the C-terminal tail of DNA polymerase α tethers primase to the eukaryotic replisome

    Kilkenny, M. L., De Piccoli, G., Perera, R. L., Labib, K. & Pellegrini, L. 6 Jul 2012 In : Journal of Biological Chemistry. 287, 28, p. 23740-23747 8 p.

    Research output: Contribution to journalArticle

  14. IQGAP Proteins Reveal an Atypical Phosphoinositide (aPI) Binding Domain with a Pseudo C2 Domain Fold

    Dixon, M. J., Gray, A., Schenning, M., Agacan, M., Tempel, W., Tong, Y., Nedyalkova, L., Park, H-W., Leslie, N. R., van Aalten, D. M. F., Downes, C. P. & Batty, I. H. 29 Jun 2012 In : Journal of Biological Chemistry. 287, 27, p. 22483-22496 14 p.

    Research output: Contribution to journalArticle

  15. Defining the contribution of AMP-activated protein kinase (AMPK) and protein kinase C (PKC) in regulation of glucose uptake by metformin in skeletal muscle cells

    Turban, S., Stretton, C., Drouin, O., Green, C. J., Watson, M. L., Gray, A., Ross, F., Lantier, L., Viollet, B., Hardie, D. G., Marette, A. & Hundal, H. S. 8 Jun 2012 In : Journal of Biological Chemistry. 287, 24, p. 20088-20099 12 p.

    Research output: Contribution to journalArticle

  16. Essential Role for IKK beta in Production of Type 1 Interferons by Plasmacytoid Dendritic Cells

    Pauls, E., Shpiro, N., Peggie, M., Young, E. R., Sorcek, R. J., Tan, L., Choi, H. G. & Cohen, P. 1 Jun 2012 In : Journal of Biological Chemistry. 287, 23, p. 19216-19228 13 p.

    Research output: Contribution to journalArticle

  17. Escherichia coli TatA and TatB Proteins Have N-out, C-in Topology in Intact Cells

    Koch, S., Fritsch, M. J., Buchanan, G. & Palmer, T. 27 Apr 2012 In : Journal of Biological Chemistry. 287, 18, p. 14420-14431 12 p.

    Research output: Contribution to journalArticle

  18. Distinct control of MyD88 adapter-dependent and Akt kinase-regulated responses by the interleukin (IL)-1RI co-receptor, TILRR

    Zhang, X., Montagut Pino, G., Shephard, F., Kiss-Toth, E. & Qwarnstrom, E. E. 6 Apr 2012 In : Journal of Biological Chemistry. 287, 15, p. 12348-12352 5 p.

    Research output: Contribution to journalArticle

  19. Phosphorylation of FOXO3a on Ser-7 by p38 promotes its nuclear localization in response to doxorubicin

    Ho, K-K., McGuire, V. A., Koo, C-Y., Muir, K. W., de Olano, N., Maifoshie, E., Kelly, D. J., McGovern, U. B., Monteiro, L. J., Gomes, A. R., Nebreda, A. R., Campbell, D. G., Arthur, J. S. C. & Lam, E. W. -F. 6 Jan 2012 In : Journal of Biological Chemistry. 287, 2, p. 1545-1555 11 p.

    Research output: Contribution to journalArticle

  20. Modulation of L-alpha-Lysophosphatidylinositol/GPR55 Mitogen-activated Protein Kinase (MAPK) Signaling by Cannabinoids

    Anavi-Goffer, S., Baillie, G., Irving, A. J., Gertsch, J., Greig, I. R., Pertwee, R. G. & Ross, R. A. 2 Jan 2012 In : Journal of Biological Chemistry. 287, 1, p. 91-104 14 p.

    Research output: Contribution to journalArticle

  21. Avirulence protein 3a (AVR3a) from the potato pathogen Phytophthora infestans forms homodimers through its predicted translocation region and does not specifically bind phospholipids

    Wawra, S., Agacan, M., Boddey, J. A., Davidson, I., Gachon, C. M. M., Zanda, M., Grouffaud, S., Whisson, S. C., Birch, P. R. J., Porter, A. J. & Van West, P. 2012 In : Journal of Biological Chemistry. 287, 45, p. 38101-38109 9 p.

    Research output: Contribution to journalArticle

  22. Pellino1 Is Required for Interferon Production by Viral Double-stranded RNA

    Enesa, K., Ordureau, A., Smith, H., Barford, D., Cheung, P. C. F., Patterson-Kane, J., Arthur, J. S. C. & Cohen, P. 2012 In : Journal of Biological Chemistry. 287, 41, p. 34825-34835 11 p.

    Research output: Contribution to journalArticle

  23. Role of binding and nucleoside diphosphate kinase A in the regulation of the cystic fibrosis transmembrane conductance regulator by AMP-activated protein kinase

    King, J. D., Lee, J., Riemen, C. E., Neumann, D., Xiong, S., Foskett, J. K., Mehta, A., Muimo, R. & Hallows, K. R. 2012 In : Journal of Biological Chemistry. 287, 40, p. 33389-33400 12 p.

    Research output: Contribution to journalArticle

  24. Transforming Growth Factor-β directly induces PUMA during the rapid induction of apoptosis in Myc-driven B-cell lymphomas.

    Spender, L. C., Carter, M. J., O'Brien, D. I., Clark, L. J., Yu, J., Michalak, E. M., Happo, L., Cragg, M. S. & Inman, G. J. 2012 In : Journal of Biological Chemistry.

    Research output: Contribution to journalArticle

  25. Distinct Docking Mechanisms Mediate Interactions between the Msg5 Phosphatase and Mating or Cell Integrity Mitogen-activated Protein Kinases (MAPKs) in Saccharomyces cerevisiae

    Palacios, L., Dickinson, R. J., Sacristan-Reviriego, A., Didmon, M. P., Jose Marin, M., Martin, H., Keyse, S. M. & Molina, M. 9 Dec 2011 In : Journal of Biological Chemistry. 286, 49, p. 42037-42050 14 p.

    Research output: Contribution to journalArticle

  26. Internalization of Exogenous Cystatin F Supresses Cysteine Proteases and Induces the Accumulation of Single-chain Cathepsin L by Multiple Mechanisms

    Colbert, J. D., Matthews, S. P., Kos, J. & Watts, C. 9 Dec 2011 In : Journal of Biological Chemistry. 286, 49, p. 42082-42090 9 p.

    Research output: Contribution to journalArticle

  27. Chemical structure of Trichomonas vaginalis surface lipoglycan: a role for short galactose (beta 1-4/3) N-acetylglucosamine repeats in host cell interaction

    Ryan, C. M., Mehlert, A., Richardson, J. M., Ferguson, M. A. J. & Johnson, P. J. 25 Nov 2011 In : Journal of Biological Chemistry. 286, 47, p. 40494-40508 15 p.

    Research output: Contribution to journalArticle

  28. Protein Phosphatase 2A (PP2A)-specific Ubiquitin Ligase MID1 Is a Sequence-dependent Regulator of Translation Efficiency Controlling 3-Phosphoinositide-dependent Protein Kinase-1 (PDPK-1)

    Aranda-Orgilles, B., Rutschow, D., Zeller, R., Karagiannidis, A. I., Koehler, A., Chen, C., Wilson, T., Krause, S., Roepcke, S., Lilley, D., Schneider, R. & Schweiger, S. 18 Nov 2011 In : Journal of Biological Chemistry. 286, 46, p. 39945-39957 13 p.

    Research output: Contribution to journalArticle

  29. Phosphorylation of the Kinase Interaction Motif in Mitogen-activated Protein (MAP) Kinase Phosphatase-4 Mediates Cross-talk between Protein Kinase A and MAP Kinase Signaling Pathways

    Dickinson, R. J., Delavaine, L., Cejudo-Marin, R., Stewart, G., Staples, C. J., Didmon, M. P., Garcia Trinidad, A., Alonso, A., Pulido, R. & Keyse, S. M. 4 Nov 2011 In : Journal of Biological Chemistry. 286, 44, p. 38018-38026 9 p.

    Research output: Contribution to journalArticle

  30. Polyubiquitin Binding to Optineurin Is Required for Optimal Activation of TANK-binding Kinase 1 and Production of Interferon beta

    Gleason, C. E., Ordureau, A., Gourlay, R., Arthur, J. S. C. & Cohen, P. 14 Oct 2011 In : Journal of Biological Chemistry. 286, 41, p. 35663-35674 12 p.

    Research output: Contribution to journalArticle

  31. The inhibitory effect of phospholemman on the sodium pump requires Its palmitoylation

    Tulloch, L. B., Howie, J., Wypijewski, K. J., Wilson, C. R., Bernard, W. G., Shattock, M. J. & Fuller, W. 14 Oct 2011 In : Journal of Biological Chemistry. 286, 41, p. 36020-36031 12 p.

    Research output: Contribution to journalArticle

  32. Early murine T-lymphocyte activation is accompanied by a switch from N-glycolyl- to N-acetyl-neuraminic acid and generation of ligands for siglec-E

    Redelinghuys, P., Antonopoulos, A., Liu, Y., Campanero-Rhodes, M. A., McKenzie, E., Haslam, S. M., Dell, A., Feizi, T. & Crocker, P. R. 7 Oct 2011 In : Journal of Biological Chemistry. 286, 40, p. 34522-34532 11 p.

    Research output: Contribution to journalArticle

  33. Structural analysis of human FANCL, the E3 ligase in the Fanconi anemia pathway

    Hodson, C., Cole, A. R., Lewis, L. P. C., Miles, J. A., Purkiss, A. & Walden, H. 16 Sep 2011 In : Journal of Biological Chemistry. 286, 37, p. 32628-32637 10 p.

    Research output: Contribution to journalArticle

  34. Low Resolution Structure of a Bacterial SLC26 Transporter Reveals Dimeric Stoichiometry and Mobile Intracellular Domains

    Compton, E. L. R., Karinou, E., Naismith, J. H., Gabel, F. & Javelle, A. 29 Jul 2011 In : Journal of Biological Chemistry. 286, 30, p. 27058-27067 10 p.

    Research output: Contribution to journalArticle

  35. Bioinformatic Prediction and Confirmation of beta-Adducin as a Novel Substrate of Glycogen Synthase Kinase 3

    Farghaian, H., Turnley, A. M., Sutherland, C. & Cole, A. R. 15 Jul 2011 In : Journal of Biological Chemistry. 286, 28, p. 25274-25283 10 p.

    Research output: Contribution to journalArticle

  36. Identification of a Proline-rich Inositol Polyphosphate 5-Phosphatase (PIPP)center dot Collapsin Response Mediator Protein 2 (CRMP2) Complex That Regulates Neurite Elongation

    Astle, M. V., Ooms, L. M., Cole, A. R., Binge, L. C., Dyson, J. M., Layton, M. J., Petratos, S., Sutherland, C. & Mitchell, C. A. 1 Jul 2011 In : Journal of Biological Chemistry. 286, 26, p. 23407-23418 12 p.

    Research output: Contribution to journalArticle

  37. A Systemic Lupus Erythematosus-associated R77H Substitution in the CD11b Chain of the Mac-1 Integrin Compromises Leukocyte Adhesion and Phagocytosis

    MacPherson, M., Lek, H. S., Prescott, A. & Fagerholm, S. C. 13 May 2011 In : Journal of Biological Chemistry. 286, 19, p. 17303-17310 8 p.

    Research output: Contribution to journalArticle

  38. Rings of Charge within the Extracellular Vestibule Influence Ion Permeation of the 5-HT(3)A Receptor

    Livesey, M. R., Cooper, M. A., Lambert, J. J. & Peters, J. A. 6 May 2011 In : Journal of Biological Chemistry. 286, 18, p. 16008-16017 10 p.

    Research output: Contribution to journalArticle

  39. A multiprotein binding interface in an intrinsically disordered region of the tumor suppressor protein interferon regulatory factor-1

    Narayan, V., Halada, P., Hernychová, L., Chong, Y. P., Žáková, J., Hupp, T. R., Vojtesek, B. & Ball, K. L. 22 Apr 2011 In : Journal of Biological Chemistry. 286, 16, p. 14291-14303 13 p.

    Research output: Contribution to journalArticle

  40. Selective Expression in Carotid Body Type I Cells of a Single Splice Variant of the Large Conductance Calcium- and Voltage-activated Potassium Channel Confers Regulation by AMP-activated Protein Kinase

    Ross, F. A., Rafferty, J. N., Dallas, M. L., Ogunbayo, O., Ikematsu, N., McClafferty, H., Tian, L., Widmer, H., Rowe, I. C. M., Wyatt, C. N., Shipston, M. J., Peers, C., Hardie, D. G. & Evans, A. M. 8 Apr 2011 In : Journal of Biological Chemistry. 286, 14, p. 11929-11936 8 p.

    Research output: Contribution to journalArticle

  41. MCM2-7 Form Double Hexamers at Licensed Origins in Xenopus Egg Extract

    Gambus, A., Khoudoli, G. A., Jones, R. C. & Blow, J. J. 1 Apr 2011 In : Journal of Biological Chemistry. 286, 13, p. 11855-11864 10 p.

    Research output: Contribution to journalArticle

  42. Dissecting the Metabolic Roles of Pteridine Reductase 1 in Trypanosoma brucei and Leishmania major

    Ong, H. B., Sienkiewicz, N., Wyllie, S. & Fairlamb, A. H. 25 Mar 2011 In : Journal of Biological Chemistry. 286, 12, p. 10429-10438 10 p.

    Research output: Contribution to journalArticle

  43. Antitumor Quinol PMX464 Is a Cytocidal Anti-trypanosomal Inhibitor Targeting Trypanothione Metabolism

    Konig, J., Wyllie, S., Wells, G., Stevens, M. F., Wyatt, P. G. & Fairlamb, A. H. 11 Mar 2011 In : Journal of Biological Chemistry. 286, 10, p. 8523-8533 11 p.

    Research output: Contribution to journalArticle

  44. Activation loop phosphorylation of ERK3/ERK4 by group I p21-activated kinases (PAKs) defines a novel PAK-ERK3/4-MAPK-activated protein kinase 5 signaling pathway

    Deleris, P., Trost, M., Topisirovic, I., Tanguay, P-L., Borden, K. L. B., Thibault, P. & Meloche, S. 25 Feb 2011 In : Journal of Biological Chemistry. 286, 8, p. 6470-6478 9 p.

    Research output: Contribution to journalArticle

  45. Cooperative Binding and Activation of Fibronectin by a Bacterial Surface Protein

    Marjenberg, Z. R., Ellis, I. R., Hagan, R. M., Prabhakaran, S., Hoeoek, M., Talay, S. R., Potts, J. R., Staunton, D. & Schwarz-Linek, U. 21 Jan 2011 In : Journal of Biological Chemistry. 286, 3, p. 1884-1894 11 p.

    Research output: Contribution to journalArticle

  46. Docking-dependent ubiquitination of the interferon regulatory factor-1 tumor suppressor protein by the ubiquitin ligase CHIP

    Narayan, V., Pion, E., Landré, V., Müller, P. & Ball, K. L. 7 Jan 2011 In : Journal of Biological Chemistry. 286, 1, p. 607-619 13 p.

    Research output: Contribution to journalArticle

  47. Functional dissection of Adenylate Cyclase R, an inducer of spore encapsulation

    Chen, Z., Schilde, C. & Schaap, P. 31 Dec 2010 In : Journal of Biological Chemistry. 285, 53, p. 41724-41731 8 p.

    Research output: Contribution to journalArticle

  48. Intracellular activation of interferon regulatory factor-1 by nanobodies to the multifunctional (Mf1) domain

    Möller, A., Pion, E., Narayan, V. & Ball, K. L. 3 Dec 2010 In : Journal of Biological Chemistry. 285, 49, p. 38348-38361 14 p.

    Research output: Contribution to journalArticle

  49. Evolution and Multiplicity of Arginine Decarboxylases in Polyamine Biosynthesis and Essential Role in Bacillus subtilis Biofilm Formation

    Burrell, M., Hanfrey, C. C., Murray, E. J., Stanley-Wall, N. R. & Michael, A. J. Dec 2010 In : Journal of Biological Chemistry. 285, 50, p. 39224-39238 15 p.

    Research output: Contribution to journalArticle

  50. Identification of key functional residues in the active site of human beta 1, 4-Galactosyltransferase 7: a major enzyme in the glycosaminoglycan synthesis pathway

    Talhaoui, I., Bui, C., Oriol, R., Mulliert, G., Gulberti, S., Netter, P., Coughtrie, M. W. H., Ouzzine, M. & Fournel-Gigleux, S. 26 Nov 2010 In : Journal of Biological Chemistry. 285, 48, p. 37342-37358 17 p.

    Research output: Contribution to journalArticle

  51. An Exceptionally Potent Inducer of Cytoprotective Enzymes elucidation of the structural features that determine inducer potency and reactivity with Keap1

    Dinkova-Kostova, A. T., Talalay, P., Sharkey, J., Zhang, Y., Holtzclaw, W. D., Wang, X. J., David, E., Schiavoni, K. H., Finlayson, S., Mierke, D. F. & Honda, T. 29 Oct 2010 In : Journal of Biological Chemistry. 285, 44, p. 33747-33755 9 p.

    Research output: Contribution to journalArticle

  52. Cot/tpl2 (MAP3K8) Mediates Myeloperoxidase Activity and Hypernociception following Peripheral Inflammation

    Soria-Castro, I., Krzyzanowska, A., Pelaéz, M. L., Regadera, J., Ferrer, G., Montoliu, L., Rodríguez-Ramos, R., Fernández, M. & Alemany, S. 29 Oct 2010 In : Journal of Biological Chemistry. 285, 44, p. 33805-33815 11 p.

    Research output: Contribution to journalArticle

  53. RIC-3 Exclusively Enhances the Surface Expression of Human Homomeric 5-Hydroxytryptamine Type 3A (5-HT(3)A) Receptors Despite Direct Interactions with 5-HT3A, -C, -D, and -E Subunits

    Walstab, J., Hammer, C., Lasitschka, F., Moeller, D., Connolly, C. N., Rappold, G., Bruess, M., Boenish, H. & Niesler, B. 27 Aug 2010 In : Journal of Biological Chemistry. 285, 35, p. 26956-26965 10 p.

    Research output: Contribution to journalArticle

  54. Cross-talk between the p38 alpha and JNK MAPK Pathways Mediated by MAP Kinase Phosphatase-1 Determines Cellular Sensitivity to UV Radiation

    Staples, C. J., Owens, D. M., Maier, J. V., Cato, A. C. B. & Keyse, S. M. 20 Aug 2010 In : Journal of Biological Chemistry. 285, 34, p. 25928-25940 13 p.

    Research output: Contribution to journalArticle

  55. Two novel Src homology 2 domain proteins interact to regulate Dictyostelium gene expression during growth and early development

    Sugden, C., Ross, S., Bloomfield, G., Ivens, A., Skelton, J., Mueller-Taubenberger, A. & Williams, J. G. 23 Jul 2010 In : Journal of Biological Chemistry. 285, 30, p. 22927-22935 9 p.

    Research output: Contribution to journalArticle

  56. p62/SQSTM1 is a target gene for transcription factor NRF2 and creates a positive feedback loop by inducing antioxidant response element-driven gene transcription

    Jain, A., Lamark, T., Sjottem, E., Larsen, K. B., Awuh, J. A., Overvatn, A., McMahon, M., Hayes, J. D. & Johansen, T. 16 Jul 2010 In : Journal of Biological Chemistry. 285, 29, p. 22576-22591 16 p.

    Research output: Contribution to journalArticle

  57. Nuclear DBF-2-related Kinases Are Essential Regulators of Cytokinesis in Bloodstream Stage Trypanosoma brucei

    Ma, J., Benz, C., Grimaldi, R., Stockdale, C., Wyatt, P., Frearson, J. & Hammarton, T. C. 14 May 2010 In : Journal of Biological Chemistry. 285, 20, p. 15356-15368 13 p.

    Research output: Contribution to journalArticle

  58. Ubiquitination of PTEN (Phosphatase and Tensin Homolog) Inhibits Phosphatase Activity and Is Enhanced by Membrane Targeting and Hyperosmotic Stress

    Maccario, H., Perera, N. M., Gray, A., Downes, C. P. & Leslie, N. R. 23 Apr 2010 In : Journal of Biological Chemistry. 285, 17, p. 12620-12628 9 p.

    Research output: Contribution to journalArticle

  59. The Snf2 Homolog Fun30 acts as a homodimeric ATP-dependent chromatin-remodeling enzyme

    Awad, S., Ryan, D., Prochasson, P., Owen-Hughes, T. & Hassan, A. H. 26 Mar 2010 In : Journal of Biological Chemistry. 285, 13, p. 9477-9484 8 p.

    Research output: Contribution to journalArticle

  60. How Escherichia coli is equipped to oxidize hydrogen under different redox conditions

    Lukey, M. J., Parkin, A., Roessler, M. M., Murphy, B. J., Harmer, J., Armstrong, F. A., Palmer, T. & Sargent, F. 5 Feb 2010 In : Journal of Biological Chemistry. 285, 6, p. 3928-3938 11 p.

    Research output: Contribution to journalArticle

  61. Chemical Validation of Trypanothione Synthetase a potential drug targer for human trypanosomiasis

    Torrie, L. S., Wyllie, S., Spinks, D., Oza, S. L., Thompson, S., Harrison, J. R., Gilbert, I. H., Wyatt, P. G., Fairlamb, A. H. & Frearson, J. A. 25 Dec 2009 In : Journal of Biological Chemistry. 284, 52, p. 36137-36145 9 p.

    Research output: Contribution to journalArticle

  62. Identification of a novel family of laminin N-terminal alternate splice isoforms structural and functional characterization

    Hamill, K. J., Langbein, L., Jones, J. C. R. & McLean, W. H. I. 18 Dec 2009 In : Journal of Biological Chemistry. 284, 51, p. 35588-35596 9 p.

    Research output: Contribution to journalArticle

  63. CK1 alpha Plays a Central Role in Mediating MDM2 Control of p53 and E2F-1 Protein Stability

    Huart, A-S., MacLaine, N. J., Meek, D. W. & Hupp, T. R. 20 Nov 2009 In : Journal of Biological Chemistry. 284, 47, p. 32384-32394 11 p.

    Research output: Contribution to journalArticle

  64. Blom7 alpha Is a Novel Heterogeneous Nuclear Ribonucleoprotein K Homology Domain Protein Involved in Pre-mRNA Splicing That Interacts with SNEVPrp19-Pso4

    Grillari, J., Loescher, M., Denegri, M., Lee, K., Fortschegger, K., Eisenhaber, F., Ajuh, P., Lamond, A. I., Katinger, H. & Grillari-Voglauer, R. 16 Oct 2009 In : Journal of Biological Chemistry. 284, 42, p. 29193-29204 12 p.

    Research output: Contribution to journalArticle

  65. Cooperative regulation of the interferon regulatory factor-1 tumor suppressor protein by core components of the molecular chaperone machinery

    Narayan, V., Eckert, M., Zylicz, A., Zylicz, M. & Ball, K. L. 18 Sep 2009 In : Journal of Biological Chemistry. 284, 38, p. 25889-25899 11 p.

    Research output: Contribution to journalArticle

  66. ABC50 promotes translation initiation in mammalian cells

    Paytubi, S., Wang, X., Lam, Y. W., Izquierdo, L., Hunter, M. J., Jan, E., Hundal, H. S. & Proud, C. G. 4 Sep 2009 In : Journal of Biological Chemistry. 284, 36, p. 24061-24073 13 p.

    Research output: Contribution to journalArticle

  67. Keep Nibbling at the Edges

    Cohen, P. 4 Sep 2009 In : Journal of Biological Chemistry. 284, 36, p. 23891-23901 11 p.

    Research output: Contribution to journalEditorial

  68. Phosphorylation of histone H3 Thr-45 is linked to apoptosis

    Hurd, P. J., Bannister, A. J., Halls, K., Dawson, M. A., Vermeulen, M., Olsen, J. V., Ismail, H., Somers, J., Mann, M., Owen-Hughes, T., Gout, I. & Kouzarides, T. 12 Jun 2009 In : Journal of Biological Chemistry. 284, 24, p. 16575-16583 9 p.

    Research output: Contribution to journalArticle

  69. Angiotensin-converting enzyme Ii a modifier of hypertensive end organ damage

    Liu, X., Bellamy, C. O. C., Bailey, M. A., Mullins, L. J., Dunbar, D. R., Kenyon, C. J., Brooker, G., Kantachuvesiri, S., Maratou, K., Ashek, A., Clark, A. F., Fleming, S. & Mullins, J. J. 5 Jun 2009 In : Journal of Biological Chemistry. 284, 23, p. 15564-15572 9 p.

    Research output: Contribution to journalArticle

  70. Motogenic Sites in Human Fibronectin Are Masked by Long Range Interactions

    Vakonakis, I., Staunton, D., Ellis, I. R., Sarkies, P., Flanagan, A., Schor, A. M., Schor, S. L. & Campbell, I. D. 5 Jun 2009 In : Journal of Biological Chemistry. 284, 23, p. 15668-15675 8 p.

    Research output: Contribution to journalArticle

  71. Structure-based ligand design and the promise held for antiprotozoan drug discovery

    Hunter, W. N. 1 May 2009 In : Journal of Biological Chemistry. 284, 18, p. 11749-11753 5 p.

    Research output: Contribution to journalScientific review

  72. ULK1 center dot ATG13 center dot FIP200 Complex Mediates mTOR Signaling and Is Essential for Autophagy

    Ganley, I. G., Lam, D. H., Wang, J., Ding, X., Chen, S. & Jiang, X. 1 May 2009 In : Journal of Biological Chemistry. 284, 18, p. 12297-12305 9 p.

    Research output: Contribution to journalArticle

  73. RIG-I-mediated activation of p38 MAPK is essential for viral induction of interferon and activation of dendritic cells: dependence on TRAF2 and TAK1

    Mikkelsen, S. S., Jensen, S. B., Chiliveru, S., Melchjorsen, J., Julkunen, I., Gaestel, M., Arthur, J. S. C., Flavell, R. A., Ghosh, S. & Paludan, S. R. 17 Apr 2009 In : Journal of Biological Chemistry. 284, 16, p. 10774-10782 9 p.

    Research output: Contribution to journalArticle

  74. Leptin-dependent Phosphorylation of PTEN Mediates Actin Restructuring and Activation of ATP-sensitive K+ Channels

    Ning, K., Miller, L. C., Laidlaw, H. A., Watterson, K. R., Gallagher, J., Sutherland, C. & Ashford, M. L. J. 3 Apr 2009 In : Journal of Biological Chemistry. 284, 14, p. 9331-9340 10 p.

    Research output: Contribution to journalArticle

  75. Molecular mechanisms of yeast cell wall glucan remodeling

    Hurtado-Guerrero, R., Schuettelkopf, A. W., Mouyna, I., Ibrahim, A. F. M., Shepherd, S., Fontaine, T., Latge, J-P. & van Aalten, D. M. F. 27 Mar 2009 In : Journal of Biological Chemistry. 284, 13, p. 8461-8469 9 p.

    Research output: Contribution to journalArticle

  76. Enhancing the receptor affinity of the sialic acid-binding domain of Vibrio cholerae sialidase through multivalency

    Connaris, H., Crocker, P. R. & Taylor, G. L. 13 Mar 2009 In : Journal of Biological Chemistry. 284, 11, p. 7339-7351 13 p.

    Research output: Contribution to journalArticle

  77. Basic Residues Are Critical to the Activity of Peptide Inhibitors of Human T Cell Leukemia Virus Type 1 Entry

    Lamb, D., Mirsaliotis, A., Kelly, S. M. & Brighty, D. W. 6 Mar 2009 In : Journal of Biological Chemistry. 284, 10, p. 6575-6584 10 p.

    Research output: Contribution to journalArticle

  78. Mechanistic Insight into Control of CFTR by AMPK

    Kongsuphol, P., Cassidy, D., Hieke, B., Treharne, K. J., Schreiber, R., Mehta, A. & Kunzelmann, K. 27 Feb 2009 In : Journal of Biological Chemistry. 284, 9, p. 5645-5653 9 p.

    Research output: Contribution to journalArticle

  79. Suppression of the Deubiquitinating Enzyme USP5 Causes the Accumulation of Unanchored Polyubiquitin and the Activation of p53

    Dayal, S., Sparks, A., Jacob, J., Allende-Vega, N., Lane, D. & Saville, M. K. 20 Feb 2009 In : Journal of Biological Chemistry. 284, 8, p. 5030-5041 12 p.

    Research output: Contribution to journalArticle

  80. SWI/SNF regulates the cellular response to hypoxia

    Kenneth, N. S., Mudie, S., van Uden, P. & Rocha, S. 13 Feb 2009 In : Journal of Biological Chemistry. 284, 7, p. 4123-4131 9 p.

    Research output: Contribution to journalArticle

  81. The Nrf3 transcription factor is a membrane-bound glycoprotein targeted to the endoplasmic reticulum through Its N-terminal Homology Box 1 Sequence

    Zhang, Y., Kobayashi, A., Yamamoto, M. & Hayes, J. D. 30 Jan 2009 In : Journal of Biological Chemistry. 284, 5, p. 3195-3210 16 p.

    Research output: Contribution to journalArticle

  82. Characterization of the Effects of Charged Residues in the Intracellular Loop on Ion Permeation in alpha 1 Glycine Receptor Channels

    Carland, J. E., Cooper, M. A., Sugiharto, S., Jeong, H-J., Lewis, T. M., Barry, P. H., Peters, J. A., Lambert, J. J. & Moorhouse, A. J. 23 Jan 2009 In : Journal of Biological Chemistry. 284, 4, p. 2023-2030 8 p.

    Research output: Contribution to journalArticle

  83. TGF-beta Induces Growth Arrest in Burkitt Lymphoma Cells via Transcriptional Repression of E2F-1

    Spender, L. C. & Inman, G. J. 16 Jan 2009 In : Journal of Biological Chemistry. 284, 3, p. 1435-1442 8 p.

    Research output: Contribution to journalArticle

  84. ABF1-binding sites promote efficient global genome nucleotide excision repair

    Yu, S., Smirnova, J. B., Friedberg, E. C., Stillman, B., Akiyama, M., Owen-Hughes, T., Waters, R. & Reed, S. H. 9 Jan 2009 In : Journal of Biological Chemistry. 284, 2, p. 966-973 8 p.

    Research output: Contribution to journalArticle

  85. C-terminal phosphorylation of LKB1 is not required for regulation of AMP-activated protein kinase, BRSK1, BRSK2, or cell cycle arrest

    Fogarty, S. & Hardie, D. G. 2 Jan 2009 In : Journal of Biological Chemistry. 284, 1, p. 77-84 8 p.

    Research output: Contribution to journalArticle

  86. Docking of PRAK/MK5 to the atypical MAPKs ERK3 and ERK4 defines a novel MAPK interaction motif

    Aberg, E., Torgersen, K. M., Johansen, B., Keyse, S. M., Perander, M. & Seternes, O-M. 2009 In : Journal of Biological Chemistry. 284, 29, p. 19392-401 10 p.

    Research output: Contribution to journalArticle

  87. Protein Kinase C-mediated Phosphorylation and activation of PDE3A Regulate cAMP levels in human platelets

    Hunter, R., MacKintosh, C. & Hers, I. 2009 In : Journal of Biological Chemistry. 284, 18, p. 12339-12348 10 p.

    Research output: Contribution to journalArticle

  88. FANCJ Is a Structure-specific DNA Helicase Associated with the Maintenance of Genomic G/C Tracts

    London, T. B. C., Barber, L. J., Mosedale, G., Kelly, G. P., Balasubramanian, S., Hickson, I. D., Boulton, S. J. & Hiom, K. 26 Dec 2008 In : Journal of Biological Chemistry. 283, 52, p. 36132-36139 8 p.

    Research output: Contribution to journalArticle

  89. Nrf1 and Nrf2 Play Distinct Roles in Activation of Antioxidant Response Element-dependent Genes

    Ohtsuji, M., Katsuoka, F., Kobayashi, A., Aburatani, H., Hayes, J. D. & Yamamoto, M. 28 Nov 2008 In : Journal of Biological Chemistry. 283, 48, p. 33554-33562 9 p.

    Research output: Contribution to journalArticle

  90. Defining the in Vivo Role for Cytochrome b(5) in Cytochrome P450 Function through the Conditional Hepatic Deletion of Microsomal Cytochrome b(5)

    Finn, R. D., McLaughlin, L. A., Ronseaux, S., Rosewell, I., Houston, J. B., Henderson, C. J. & Wolf, C. R. 14 Nov 2008 In : Journal of Biological Chemistry. 283, 46, p. 31385-31393 9 p.

    Research output: Contribution to journalArticle

  91. Structures of the cIAP2 RING Domain Reveal Conformational Changes Associated with Ubiquitin-conjugating Enzyme (E2) Recruitment

    Mace, P. D., Linke, K., Feltham, R., Schumacher, F-R., Smith, C. A., Vaux, D. L., Silke, J. & Day, C. L. 14 Nov 2008 In : Journal of Biological Chemistry. 283, 46, p. 31633-31640 8 p.

    Research output: Contribution to journalArticle

  92. A central role for CK1 in catalyzing phosphorylation of the p53 transactivation domain at serine 20 after HHV-6B viral infection

    MacLaine, N. J., Oster, B., Bundgaard, B., Fraser, J. A., Buckner, C., Lazo, P. A., Meek, D. W., Hoellsberg, P. & Hupp, T. R. 17 Oct 2008 In : Journal of Biological Chemistry. 283, 42, p. 28563-28573 11 p.

    Research output: Contribution to journalArticle

  93. Use of Akt inhibitor and a drug-resistant mutant validates a critical role for protein kinase B/Akt in the insulin-dependent regulation of glucose and system A amino acid uptake

    Green, C. J., Goransson, O., Kular, G. S., Leslie, N. R., Gray, A., Alessi, D. R., Sakamoto, K. & Hundal, H. S. 10 Oct 2008 In : Journal of Biological Chemistry. 283, 41, p. 27653-27667 15 p.

    Research output: Contribution to journalArticle

  94. DsbA plays a critical and multifaceted role in the production of secreted virulence factors by the phytopathogen Erwinia carotovora subsp atroseptica

    Coulthurst, S. J., Lilley, K. S., Hedley, P. E., Liu, H., Toth, I. K. & Salmond, G. P. C. 29 Aug 2008 In : Journal of Biological Chemistry. 283, 35, p. 23739-23753 15 p.

    Research output: Contribution to journalArticle

  95. Phosphatidylethanolamine in Trypanosoma brucei is organized in two separate pools and is synthesized exclusively by the Kennedy pathway

    Signorell, A., Rauch, M., Jelk, J., Ferguson, M. A. J. & Buetikofer, P. 29 Aug 2008 In : Journal of Biological Chemistry. 283, 35, p. 23636-23644 9 p.

    Research output: Contribution to journalArticle

  96. Structural determinants of Ca2+ permeability and conduction in the human 5-hydroxytryptamine type 3A receptor

    Livesey, M. R., Cooper, M. A., Deeb, T. Z., Carland, J. E., Kozuska, J., Hales, T. G., Lambert, J. J. & Peters, J. A. 11 Jul 2008 In : Journal of Biological Chemistry. 283, 28, p. 19301-19313 13 p.

    Research output: Contribution to journalArticle

  97. The scaffold MyD88 acts to couple protein kinase C epsilon to toll-like receptors

    Faisal, A., Saurin, A., Gregory, B., Foxwell, B. & Parker, P. J. 4 Jul 2008 In : Journal of Biological Chemistry. 283, 27, p. 18591-18600 10 p.

    Research output: Contribution to journalArticle

  98. Elevated levels of oncogenic protein kinase pim-1 induce the p53 pathway in cultured cells and correlate with increased mdm2 in mantle cell lymphoma

    Hogan, C., Hutchison, C., Marcar, L., Milne, D., Saville, M., Goodlad, J., Kernohan, N. & Meek, D. 27 Jun 2008 In : Journal of Biological Chemistry. 283, 26, p. 18012-18023 12 p.

    Research output: Contribution to journalArticle

  99. Relative resistance of Cdk5-phosphorylated CRMP2 to dephosphorylation

    Cole, A. R., Soutar, M. P. M., Rembutsu, M., van Aalten, L., Hastie, C. J., Mclauchlan, H., Peggie, M., Balastik, M., Lu, K. P. & Sutherland, C. 27 Jun 2008 In : Journal of Biological Chemistry. 283, 26, p. 18227-18237 11 p.

    Research output: Contribution to journalArticle

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