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Journal of Medicinal Chemistry

  1. Mind the metal: a fragment library-derived zinc impurity binds the E2 ubiquitin-conjugating enzyme Ube2T and induces structural rearrangements

    Morreale, F., Testa, A., Chaugule, V., Bortoluzzi, A., Ciulli, A. & Walden, H. 21 Sep 2017 In : Journal of Medicinal Chemistry. 60, 19, p. 8183-8191

    Research output: Contribution to journalArticle

  2. Discovery and Optimization of 5-Amino-1,2,3-triazole-4-carboxamide Series against Trypanosoma cruzi

    Brand, S. , Ko, E. J. , Viayna, E. , Thompson, S. , Spinks, D. , Thomas, M. , Sandberg, L. , Francisco, A. F. , Jayawardhana, S. , Smith, V. C. , Jansen, C. , De Rycker, M. , Thomas, J. , MacLean, L. , Osuna-Cabello, M. , Riley, J. , Scullion, P. , Stojanovski, L. , Simeons, F. R. C. , Epemolu, O. & 16 others Shishikura, Y., Crouch, S. D., Bakshi, T. S., Nixon, C. J., Reid, I. H., Hill, A. P., Underwood, T. Z., Hindley, S. J., Robinson, S. A., Kelly, J. M., Fiandor, J. M., Wyatt, P. G., Marco, M., Miles, T. J., Read, K. D. & Gilbert, I. H. 14 Sep 2017 In : Journal of Medicinal Chemistry. 60, 17, p. 7284-7299 16 p.

    Research output: Contribution to journalArticle

  3. Allosteric targeting of the Fanconi anemia ubiquitin-conjugating enzyme Ube2T by fragment screening

    Morreale, F., Bortoluzzi, A., Chaugule, V., Arkinson, C., Walden, H. & Ciulli, A. 11 May 2017 In : Journal of Medicinal Chemistry. 60, 9, p. 4093-4098 6 p.

    Research output: Contribution to journalArticle

  4. Kinetin Riboside and Its ProTides Activate the Parkinson’s Disease Associated PTEN-Induced Putative Kinase 1 (PINK1) Independent of Mitochondrial Depolarization

    Osgerby, L., Lai, Y-C., Thornton, P. J., Amalfitano, J., Le Duff, C. S., Jabeen, I., Kadri, H., Miccoli, A., Tucker, J. H. R., Muqit, M. M. K. & Mehellou, Y. 27 Apr 2017 In : Journal of Medicinal Chemistry. 60, 8, p. 3518-3524 7 p.

    Research output: Contribution to journalArticle

  5. Targeting Bacillosamine Biosynthesis in Bacterial Pathogens: Development of Inhibitors to a Bacterial Amino-Sugar Acetyltransferase from Campylobacter jejuni

    De Schutter, J. W., Morrison, J. P., Morrison, M. J., Ciulli, A. & Imperiali, B. 9 Mar 2017 In : Journal of Medicinal Chemistry. 60, 5, p. 2099-2118 20 p.

    Research output: Contribution to journalArticle

  6. Discovery of a quinoline-4-carboxamide derivative with a novel mechanism of action, multistage antimalarial activity, and potent in vivo efficacy

    Baragaña, B. , Norcross, N. R. , Wilson, C. , Porzelle, A. , Hallyburton, I. , Grimaldi, R. , Osuna-Cabello, M. , Norval, S. , Riley, J. , Stojanovski, L. , Simeons, F. R. C. , Wyatt, P. G. , Delves, M. J. , Meister, S. , Duffy, S. , Avery, V. M. , Winzeler, E. A. , Sinden, R. E. , Wittlin, S. , Frearson, J. A. & 7 others Gray, D. W., Fairlamb, A. H., Waterson, D., Campbell, S. F., Willis, P., Read, K. D. & Gilbert, I. H. 10 Nov 2016 In : Journal of Medicinal Chemistry. 59, 21, p. 9672-9685 14 p.

    Research output: Contribution to journalArticle

  7. Hit-to-Lead Optimization of a Novel Class of Potent, Broad-Spectrum Trypanosomacides

    Russell, S. , Rahmani, R. , Jones, A. J. , Newson, H. L. , Neilde, K. , Cotillo, I. , Rahmani Khajouei, M. , Ferrins, L. , Qureishi, S. , Nguyen, N. , Martinez-Martinez, M. S. , Weaver, D. F. , Kaiser, M. , Riley, J. , Thomas, J. , De Rycker, M. , Read, K. D. , Flematti, G. R. , Ryan, E. , Tanghe, S. & 6 others Rodriguez, A., Charman, S. A., Kessler, A., Avery, V. M., Baell, J. B. & Piggott, M. J. 10 Nov 2016 In : Journal of Medicinal Chemistry. 59, 21, p. 9686-9720 35 p.

    Research output: Contribution to journalArticle

  8. From Companion Diagnostics to Theranostics: A New Avenue for Alzheimer's Disease?

    Bolognesi, M. L., Gandini, A., Prati, F. & Uliassi, E. 8 Sep 2016 In : Journal of Medicinal Chemistry. 59, 17, p. 7759-7770 12 p.

    Research output: Contribution to journalReview article

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