Journal of Medicinal Chemistry

Synthesis, chemical reactivity as Michael acceptors, and biological potency of monocyclic cyanoenones, novel and highly potent anti-inflammatory and cytoprotective agents

Zheng, S., Laxmi, Y. R. S., David, E., Dinkova-Kostova, A. T., Shiavoni, K. H., Ren, Y., Zheng, Y., Trevino, I., Bumeister, R., Ojima, I., Wigley, W. C., Bliska, J. B., Mierke, D. F. & Honda, T. 24-May-2012 In : Journal of Medicinal Chemistry. 55, 10, p. 4837-4846, 10 p.

Research output: Contribution to journal › Article

Discovery of a Novel Class of Orally Active Trypanocidal N-Myristoyltransferase Inhibitors

Brand, S., Cleghorn, L. A. T., McElroy, S. P., Robinson, D. A., Smith, V. C., Hallyburton, I., Harrison, J. R., Norcross, N. R., Spinks, D., Bayliss, T., Norval, S., Stojanovski, L., Torrie, L. S., Frearson, J. A., Brenk, R., Fairlamb, A. H., Ferguson, M. A. J., Read, K. D., Wyatt, P. G. & Gilbert, I. H. 12-Jan-2012 In : Journal of Medicinal Chemistry. 55, 1, p. 140-152, 13 p.

Research output: Contribution to journal › Article

Synthesis and Evaluation of α-Thymidine Analogues as Novel Antimalarials

Cui, H., Carrero-Lérida, J., Silva, A. P. G., Whittingham, J. L., Brannigan, J. A., Ruiz-Pérez, L. M., Read, K. D., Wilson, K. S., González-Pacanowska, D. & Gilbert, I. H. 2012 In : Journal of Medicinal Chemistry. 55, 24, p. 10948-57, 10 p.

Research output: Contribution to journal › Article

Dihydroquinazolines as a Novel Class of Trypanosoma brucei Trypanothione Reductase Inhibitors: Discovery, Synthesis, and Characterization of their Binding Mode by Protein Crystallography

Patterson, S., Alphey, M. S., Jones, D. C., Shanks, E. J., Street, I. P., Frearson, J. A., Wyatt, P. G., Gilbert, I. H. & Fairlamb, A. H. 13-Oct-2011 In : Journal of Medicinal Chemistry. 54, 19, p. 6514-6530, 17 p.

Research output: Contribution to journal › Article

Aryl Phosphoramidates of 5-Phospho Erythronohydroxamic Acid, A New Class of Potent Trypanocidal Compounds

Ruda, G. F., Wong, P. E., Alibu, V. P., Norval, S., Read, K. D., Barrett, M. P. & Gilbert, I. H. 26-Aug-2010 In : Journal of Medicinal Chemistry. 53, 16, p. 6071-6078, 8 p.

Research output: Contribution to journal › Article

6-(3,4-dichlorophenyl)-1-[(methyloxy)methyl]-3-azabicyclo[4.1.0]heptane: a new potent and selective triple reuptake inhibitor

Micheli, F. , Cavanni, P. , Andreotti, D. , Arban, R. , Benedetti, R. , Bertani, B. , Bettati, M. , Bettelini, L. , Bonanomi, G. , Braggio, S. , Carletti, R. , Checchia, A. , Corsi, M. , Fazzolari, E. , Fontana, S. , Marchioro, C. , Merlo-Pich, E. , Negri, M. , Oliosi, B. , Ratti, E. & 11 others Read, K. D., Roscic, M., Sartori, I., Spada, S., Tedesco, G., Tarsi, L., Terreni, S., Visentini, F., Zocchi, A., Zonzini, L. & Di Fabio, R. 8-Jul-2010 In : Journal of Medicinal Chemistry. 53, 13, p. 4989-5001, 13 p.

Research output: Contribution to journal › Article

Computer-aided identification of Trypanosoma brucei uridine diphosphate galactose 4 '-epimerase inhibitors: toward the development of novel therapies for African sleeping sickness

Durrant, J. D., Urbaniak, M. D., Ferguson, M. A. J. & McCammon, J. A. 8-Jul-2010 In : Journal of Medicinal Chemistry. 53, 13, p. 5025-5032, 8 p.

Research output: Contribution to journal › Article

Discovery of N-Phenyl-4-(thiazol-5-yl)pyrimidin-2-amine aurora kinase inhibitors

Wang, S. , Midgley, C. A. , Scaërou, F. , Grabarek, J. B. , Griffiths, G. , Jackson, W. , Kontopidis, G. , McClue, S. J. , McInnes, C. , Meades, C. , Mezna, M. , Plater, A. , Stuart, I. , Thomas, M. P. , Wood, G. , Clarke, R. G. , Blake, D. G. , Zheleva, D. I. , Lane, D. P. , Jackson, R. C. & 2 others Glover, D. M. & Fischer, P. M. 10-Jun-2010 In : Journal of Medicinal Chemistry. 53, 11, p. 4367-4378, 12 p.

Research output: Contribution to journal › Article

1-(aryl)-6-[alkoxyalkyl]-3-azabicyclo[3.1.0]hexanes and 6-(aryl)-6-[alkoxyalkyl]-3-azabicyclo[3.1.0]hexanes: a new series of potent and selective triple reuptake inhibitors

Micheli, F. , Cavanni, P. , Arban, R. , Benedetti, R. , Bertani, B. , Bettati, M. , Bettelini, L. , Bonanomi, G. , Braggio, S. , Checchia, A. , Davalli, S. , Di Fabio, R. , Fazzolari, E. , Fontana, S. , Marchioro, C. , Minick, D. , Negri, M. , Oliosi, B. , Read, K. D. , Sartori, I. & 6 others Tedesco, G., Tarsi, L., Terreni, S., Visentini, F., Zocchi, A. & Zonzini, L. 25-Mar-2010 In : Journal of Medicinal Chemistry. 53, 6, p. 2534-2551, 18 p.

Research output: Contribution to journal › Article

Structure-based design of pteridine reductase inhibitors targeting African sleeping sickness and the Leishmaniases

Tulloch, L. B., Martini, V. P., Iulek, J., Huggan, J. K., Lee, J. H., Gibson, C. L., Smith, T. K., Suckling, C. J. & Hunter, W. N. 14-Jan-2010 In : Journal of Medicinal Chemistry. 53, 1, p. 221-229, 9 p.

Research output: Contribution to journal › Article