Molecular and Cellular Biology

MSK1 and 2 inhibit LPS induced prostaglandin production via an IL-10 feedback loop

Mackenzie, K. F., Van Den Bosch, M. W. M., Naqvi, S., Elcombe, S. E., McGuire, V. A., Reith, A. D., Blackshear, P. J., Dean, J. L. & Arthur, J. S. C. 2013 In : Molecular and Cellular Biology.

Research output: Contribution to journal › Article

Structural and functional characterization of Nrf2 degradation by the glycogen synthase kinase 3/β-TrCP Axis

Rada, P., Rojo, A. I., Evrard-Todeschi, N., Innamorato, N. G., Cotte, A., Jaworski, T., Tobón-Velasco, J. C., Devijver, H., García-Mayoral, M. F., Van Leuven, F., Hayes, J. D., Bertho, G. & Cuadrado, A. 2012 In : Molecular and Cellular Biology. 32, 17, p. 3486-99, 14 p.

Research output: Contribution to journal › Article

Contribution of Casein Kinase 2 and Spleen Tyrosine Kinase to CFTR Trafficking and Protein Kinase A-Induced Activity

Luz, S., Kongsuphol, P., Mendes, A. I., Romeiras, F., Sousa, M., Schreiber, R., Matos, P., Jordan, P., Mehta, A., Amaral, M. D., Kunzelmann, K. & Farinha, C. M. Nov-2011 In : Molecular and Cellular Biology. 31, 22, p. 4392-4404, 13 p.

Research output: Contribution to journal › Article

SCF/{beta}-TrCP promotes glycogen synthase kinase 3-dependent degradation of the Nrf2 transcription factor in a Keap1-independent manner

Rada, P., Rojo, A. I., Chowdhry, S., McMahon, M., Hayes, J. D. & Cuadrado, A. Mar-2011 In : Molecular and Cellular Biology. 31, 6, p. 1121-1133, 13 p.

Research output: Contribution to journal › Article

Mechanism of Hypoxia-Induced NF-kappa B

Culver, C., Sundqvist, A., Mudie, S., Melvin, A., Xirodimas, D. & Rocha, S. 10-Oct-2010 In : Molecular and Cellular Biology. 30, 20, p. 4901-4921, 21 p.

Research output: Contribution to journal › Article

miR-31 functions as a negative regulator of lymphatic vascular lineage-specific differentiation in vitro and vascular development in vivo

Leslie Pedrioli, D. M., Karpanen, T., Dabouras, V., Jurisic, G., Shin, J. W., Marino, D., Kälin, R. E., Brändli, A. W., Detmar, M., Van De Hoek, G., Schulte-Merker, S., Leidel, S. & Cinelli, P. Jul-2010 In : Molecular and Cellular Biology. 30, 14, p. 3620-3634, 15 p.

Research output: Contribution to journal › Article

SORLA/SORL1 functionally interacts with SPAK to control renal activation of Na+-K+-Cl- cotransporter 2

Reiche, J., Theilig, F., Rafiqi, F. H., Carlo, A-S., Militz, D., Mutig, K., Todiras, M., Christensen, E. I., Ellison, D. H., Bader, M., Nykjaer, A., Bachmann, S., Alessi, D. & Willnow, T. E. 15-Jun-2010 In : Molecular and Cellular Biology. 30, 12, p. 3027-3037, 11 p.

Research output: Contribution to journal › Article

S-Adenosyl Homocysteine Hydrolase Is Required for Myc-Induced mRNA Cap Methylation, Protein Synthesis, and Cell Proliferation

Fernandez-Sanchez, M. E., Gonatopoulos-Pournatzis, T., Preston, G., Lawlor, M. A. & Cowling, V. H. 1-Dec-2009 In : Molecular and Cellular Biology. 29, 23, p. 6182-6191, 10 p.

Research output: Contribution to journal › Article

Phosphoinositide (3,4,5)-triphosphate binding to phosphoinositide-dependent kinase 1 regulates a protein kinase B/Akt signaling threshold that dictates T-cell migration, not proliferation

Waugh, C., Sinclair, L., Finlay, D., Bayascas, J. R. & Cantrell, D. 1-Nov-2009 In : Molecular and Cellular Biology. 29, 21, p. 5952-5962, 11 p.

Research output: Contribution to journal › Article

Efficient chromosome biorientation and the tension checkpoint in saccharomyces cerevisiae both require Bir1

Makrantoni, V. & Stark, M. J. R. 15-Aug-2009 In : Molecular and Cellular Biology. 29, 16, p. 4552-4562, 11 p.

Research output: Contribution to journal › Article

SWI/SNF and Asf1p cooperate to displace histones during induction of the saccharomyces cerevisiae HO promoter

Gkikopoulos, T., Havas, K. M., Dewar, H. & Owen-Hughes, T. Aug-2009 In : Molecular and Cellular Biology. 29, 15, p. 4057-4066, 10 p.

Research output: Contribution to journal › Article

Cholesterol Metabolism: the Main Pathway Acting Downstream of Cytochrome P450 Oxidoreductase in Skeletal Development of the Limb

Schmidt, K., Hughes, C., Chudek, J. A., Goodyear, S. R., Aspden, R. M., Talbot, R., Gundersen, T. E., Blomhoff, R., Henderson, C., Wolf, C. R. & Tickle, C. 15-May-2009 In : Molecular and Cellular Biology. 29, 10, p. 2716-2729, 14 p.

Research output: Contribution to journal › Article

Mutation of the PDK1 PH domain inhibits protein kinase B/Akt, leading to small size and insulin resistance

Bayascas, J. R., Wullschleger, S., Sakamoto, K., Garcia-Martinez, J. M., Clacher, C., Komander, D., van Aalten, D. M. F., Boini, K. M., Lan, F., Lipina, C., Logie, L., Sutherland, C., Chudek, J. A., van Diepen, J. A., Voshol, P. J., Lucocq, J. M. & Alessi, D. R. May-2008 In : Molecular and Cellular Biology. 28, 10, p. 3258-3272, 15 p.

Research output: Contribution to journal › Article

Interleukin-1 (IL-1) induces the Lys63-linked polyubiquitination of IL-1 receptor-associated kinase 1 to facilitate NEMO binding and the activation of IκBα kinase

Windheim, M., Stafford, M., Cohen, P. & Peggie, M. Mar-2008 In : Molecular and Cellular Biology. 28, 5, p. 1783-1791, 9 p.

Research output: Contribution to journal › Article

c-Myc transforms human mammary epithelial cells through repression of the Wnt inhibitors DKK1 and SFRP1

Cowling, V. H., D'Cruz, C. M., Chodosh, L. A. & Cole, M. D. 2007 In : Molecular and Cellular Biology. 27, 14, p. 5135-5146, 12 p.

Research output: Contribution to journal › Article

Histone tails and the H3 alphaN helix regulate nucleosome mobility and stability

Ferreira, H., Somers, J., Webster, R., Flaus, A. & Owen-Hughes, T. 2007 In : Molecular and Cellular Biology. 27, 11, p. 4037-48, 12 p.

Research output: Contribution to journal › Article

The Myc transactivation domain promotes global phosphorylation of the RNA polymerase II carboxy-terminal domain independently of direct DNA binding

Cowling, V. H. & Cole, M. D. 2007 In : Molecular and Cellular Biology. 27, 6, p. 2059-2073, 15 p.

Research output: Contribution to journal › Article

UBE2T, the Fanconi anemia core complex, and FANCD2 are recruited independently to chromatin: a basis for the regulation of FANCD2 monoubiquitination

Alpi, A., Langevin, F., Mosedale, G., Machida, Y. J., Dutta, A. & Patel, K. J. 2007 In : Molecular and Cellular Biology. 27, 24, p. 8421-8430, 10 p.

Research output: Contribution to journal › Article

RNA polymerase I-specific subunit CAST/hPAF49 has a role in the activation of transcription by upstream binding factor

Panov, K. I., Panova, T. B., Gadal, O., Nishiyama, K., Saito, T., Russell, J. & Zomerdijk, J. C. B. M. Jul-2006 In : Molecular and Cellular Biology. 26, 14, p. 5436-5448, 13 p.

Research output: Contribution to journal › Article

A conserved Myc protein domain, MBIV, regulates DNA binding, apoptosis, transformation, and G2 arrest

Cowling, V. H., Chandriani, S., Whitfield, M. L. & Cole, M. D. Jun-2006 In : Molecular and Cellular Biology. 26, 11, p. 4226-4239, 14 p.

Research output: Contribution to journal › Article