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Proceedings of the National Academy of Sciences of the United States of America

  1. Bacterial formate hydrogenlyase complex

    McDowall, J. S., Murphy, B. J., Haumann, M., Palmer, T., Armstrong, F. A. & Sargent, F. 23 Sep 2014 In : Proceedings of the National Academy of Sciences of the United States of America. 111, 38, p. E3948-E3956 9 p.

    Research output: Contribution to journalArticle

  2. Common genetic variants associated with cognitive performance identified using the proxy-phenotype method

    Smith, B. H. & 58 others Rietveld, C. A., Esko, T., Davies, G., Pers, T. H., Turley, P., Benyamin, B., Chabris, C. F., Emilsson, V., Johnson, A. D., Lee, J. J., Leeuw, C. D., Marioni, R. E., Medland, S. E., Miller, M. B., Rostapshova, O., van der Lee, S. J., Vinkhuyzen, A. A. E., Amin, N., Conley, D., Derringer, J., van Duijn, C. M., Fehrmann, R., Franke, L., Glaeser, E. L., Hansell, N. K., Hayward, C., Iacono, W. G., Ibrahim-Verbaas, C., Jaddoe, V., Karjalainen, J., Laibson, D., Lichtenstein, P., Liewald, D. C., Magnusson, P. K. E., Martin, N. G., McGue, M., McMahon, G., Pedersen, N. L., Pinker, S., Porteous, D. J., Posthuma, D., Rivadeneira, F., Starr, J. M., Tiemeier, H., Timpson, N. J., Trzaskowski, M., Uitterlinden, A. G., Verhulst, F. C., Ward, M. E., Wright, M. J., Davey Smith, G., Deary, I. J., Johannesson, M., Plomin, R., Visscher, P. M., Benjamin, D. J., Cesarini, D. & Koellinger, P. D. 23 Sep 2014 In : Proceedings of the National Academy of Sciences of the United States of America. 111, 38, p. 13790-13794 5 p.

    Research output: Contribution to journalArticle

  3. How oxygen reacts with oxygen-tolerant respiratory [NiFe]-hydrogenases

    Wulff, P., Day, C. C., Sargent, F. & Armstrong, F. A. 6 May 2014 In : Proceedings of the National Academy of Sciences of the United States of America. 111, 18, p. 6606-6611 6 p.

    Research output: Contribution to journalArticle

  4. Inverse hormesis of cancer growth mediated by narrow ranges of tumor-directed antibodies

    Pearce, O. M. T., Läubli, H., Verhagen, A., Secrest, P., Zhang, J., Varki, N. M., Crocker, P. R., Bui, J. D. & Varki, A. 22 Apr 2014 In : Proceedings of the National Academy of Sciences of the United States of America. 111, 16, p. 5998-6003 6 p.

    Research output: Contribution to journalArticle

  5. O-GlcNAc reports ambient temperature and confers heat resistance on ectotherm development

    Radermacher, P. T., Myachina, F., Bosshardt, F., Pandey, R., Mariappa, D., Müller, H-A. J. & Lehner, C. F. 15 Apr 2014 In : Proceedings of the National Academy of Sciences of the United States of America. 111, 15, p. 5592-5597 6 p.

    Research output: Contribution to journalArticle

  6. Distinct phosphatases antagonize the p53 response in different phases of the cell cycle

    Shaltiel, I. A., Aprelia, M., Saurin, A. T., Chowdhury, D., Kops, G. J. P. L., Voest, E. E. & Medema, R. H. 2014 In : Proceedings of the National Academy of Sciences of the United States of America. 111, 20, p. 7313-7318 6 p.

    Research output: Contribution to journalArticle

  7. Protein kinase IKKβ-catalyzed phosphorylation of IRF5 at Ser462 induces its dimerization and nuclear translocation in myeloid cells

    Lopez Pelaez, M., Lamont, D. J., Peggie, M., Shpiro, N., Gray, N. S. & Cohen, P. 2014 In : Proceedings of the National Academy of Sciences of the United States of America. 6 p.

    Research output: Contribution to journalArticle

  8. Signals in migrating cardiac progenitor cells

    Song, J., McColl, J., Camp, E., Kennerley, N., Mok, G. F., McCormick, D., Grocott, T., Wheeler, G. N. & Münsterberg, A. E. 2014 In : Proceedings of the National Academy of Sciences of the United States of America. 111, 20, p. 7337-7342 6 p.

    Research output: Contribution to journalArticle

  9. Structural basis for the recruitment of glycogen synthase by glycogenin

    Zeqiraj, E., Tang, X., Hunter, R. W., García-Rocha, M., Judd, A., Deak, M., Von Wilamowitz-Moellendorff, A., Kurinov, I., Guinovart, J. J., Tyers, M., Sakamoto, K. & Sicheri, F. 2014 In : Proceedings of the National Academy of Sciences of the United States of America. 111, 28, p. E2831-E2840 10 p.

    Research output: Contribution to journalArticle

  10. Substrate recognition by the cell surface palmitoyl transferase DHHC5

    Howie, J., Reilly, L., Fraser, N. J., Vlachaki Walker, J., Wypijewski, K., Ashford, M. L. J., Calaghan, S., McClafferty, H., Tian, L., Shipston, M. J., Boguslavskyi, A., Shattock, M. J. & Fuller, W. 2014 In : Proceedings of the National Academy of Sciences of the United States of America. 6 p.

    Research output: Contribution to journalArticle

  11. The Irish potato famine pathogen Phytophthora infestans originated in central Mexico rather than the Andes

    Goss, E. M., Tabima, J. F., Cooke, D. E. L., Restrepo, S., Fry, W. E., Forbes, G. A., Fieland, V. J., Cardenas, M. & Grünwald, N. J. 2014 In : Proceedings of the National Academy of Sciences of the United States of America.

    Research output: Contribution to journalArticle

  12. Pyrethroid activity-based probes for profiling cytochrome P450 activities associated with insecticide interactions

    Ismail, H. M., O'Neill, P. M., Hong, D. W., Finn, R. D., Henderson, C. J., Wright, A. T., Cravatt, B. F., Hemingway, J. & Paine, M. J. I. 3 Dec 2013 In : Proceedings of the National Academy of Sciences of the United States of America. 110, 49, p. 19766-19771 6 p.

    Research output: Contribution to journalArticle

  13. Variation in the interaction between alleles of HvAPETALA2 and microRNA172 determines the density of grains on the barley inflorescence

    Houston, K., McKim, S. M., Comadran, J., Bonar, N., Druka, I., Uzrek, N., Cirillo, E., Guzy-Wrobelska, J., Collins, N. C., Halpin, C., Hansson, M., Dockter, C., Druka, A. & Waugh, R. 8 Oct 2013 In : Proceedings of the National Academy of Sciences of the United States of America. 110, 41, p. 16675-16680 6 p.

    Research output: Contribution to journalArticle

  14. Activation of the canonical IKK complex by K63/M1-linked hybrid ubiquitin chains

    Emmerich, C. H., Ordureau, A., Strickson, S., Arthur, J. S. C., Pedrioli, P. G. A., Komander, D. & Cohen, P. 17 Sep 2013 In : Proceedings of the National Academy of Sciences of the United States of America. 110, 38, p. 15247-15252 6 p.

    Research output: Contribution to journalArticle

  15. Live cell imaging shows reversible assembly of the TatA component of the twin-arginine protein transport system

    Alcock, F., Baker, M. A. B., Greene, N. P., Palmer, T., Wallace, M. I. & Berks, B. C. 17 Sep 2013 In : Proceedings of the National Academy of Sciences of the United States of America. 110, 38, p. E3650-E3659 10 p.

    Research output: Contribution to journalArticle

  16. BslA is a self-assembling bacterial hydrophobin that coats the Bacillus subtilis biofilm

    Hobley, L., Ostrowski, A., Rao, F. V., Bromley, K. M., Porter, M., Prescott, A. R., Macphee, C. E., van Aalten, D. M. F. & Stanley-Wall, N. R. 13 Aug 2013 In : Proceedings of the National Academy of Sciences of the United States of America. 110, 33, p. 13600-13605 6 p.

    Research output: Contribution to journalArticle

  17. Integrated biophysical approach to fragment screening and validation for fragment-based lead discovery

    Silvestre, H. L., Blundell, T. L., Abell, C. & Ciulli, A. 6 Aug 2013 In : Proceedings of the National Academy of Sciences of the United States of America. 110, 32, p. 12984-12989 6 p.

    Research output: Contribution to journalArticle

  18. TRNA tKUUU, tQUUG, and tEUUC wobble position modifications fine-tune protein translation by promoting ribosome A-site binding

    Rezgui, V. A. N., Tyagi, K., Ranjan, N., Konevega, A. L., Mittelstaet, J., Rodnina, M. V., Peter, M. & Pedrioli, P. G. A. 23 Jul 2013 In : Proceedings of the National Academy of Sciences of the United States of America. 110, 30, p. 12289-12294 6 p.

    Research output: Contribution to journalArticle

  19. Targeted delivery of lipid antigen to macrophages via the CD169/sialoadhesin endocytic pathway induces robust invariant natural killer T cell activation

    Kawasaki, N., Vela, J. L., Nycholat, C. M., Rademacher, C., Khurana, A., van Rooijen, N., Crocker, P. R., Kronenberg, M. & Paulson, J. C. 7 May 2013 In : Proceedings of the National Academy of Sciences of the United States of America. 110, 19, p. 7826-7831 6 p.

    Research output: Contribution to journalArticle

  20. Evolution of modular intraflagellar transport from a coatomer-like progenitor

    van Dam, T. J. P., Townsend, M. J., Turk, M., Schlessinger, A., Sali, A., Field, M. C. & Huynen, M. A. 23 Apr 2013 In : Proceedings of the National Academy of Sciences of the United States of America. 110, 17, p. 6943-6948 6 p.

    Research output: Contribution to journalArticle

  21. Mechanical model of blebbing in nuclear lamin meshworks

    Funkhouser, C. M., Sknepnek, R., Shimi, T., Goldman, A. E., Goldman, R. D. & de la Cruz, M. O. 26 Feb 2013 In : Proceedings of the National Academy of Sciences of the United States of America. 110, 9, p. 3248-3253 6 p.

    Research output: Contribution to journalArticle

  22. Crystal structure and functional mechanism of a human antimicrobial membrane channel

    Song, C., Weichbrodt, C., Salnikov, E. S., Dynowski, M., Forsberg, B. O., Bechinger, B., Steinem, C., De Groot, B. L., Zachariae, U. & Zeth, K. 2013 In : Proceedings of the National Academy of Sciences of the United States of America. 110, 12, p. 4586-4591 6 p.

    Research output: Contribution to journalArticle

  23. Extracellular matrix of secondary lymphoid organs impacts on B-cell fate and survival

    Song, J., Lokmic, Z., Lämmermann, T., Rolf, J., Wu, C., Zhang, X., Hallmann, R., Hannocks, M-J., Horn, N., Ruegg, M. A., Sonnenberg, A., Georges-Labouesse, E., Winkler, T. H., Kearney, J. F., Cardell, S. & Sorokin, L. 2013 In : Proceedings of the National Academy of Sciences of the United States of America. 110, 31, p. E2915-E2924 10 p.

    Research output: Contribution to journalArticle

  24. Structural basis for cooperativity of CRM1 export complex formation

    Monecke, T., Haselbach, D., Voß, B., Russek, A., Neumann, P., Thomson, E., Hurt, E., Zachariae, U., Stark, H., Grubmul̈ler, H., Dickmanns, A. & Ficner, R. 2013 In : Proceedings of the National Academy of Sciences of the United States of America. 110, 3, p. 960-965 6 p.

    Research output: Contribution to journalArticle

  25. P38γ and p38δ kinases regulate the Toll-like receptor 4 (TLR4)-induced cytokine production by controlling ERK1/2 protein kinase pathway activation

    Risco, A., Del Dresno, C., Mambol, A., Alsina-Beauchamp, D., MacKenzie, K. F., Yang, H-T., Barber, D. F., Morcelle, C., Arthur, J. S. C., Ley, S. C., Ardavin, C. F. & Cuenda, A. 10 Jul 2012 In : Proceedings of the National Academy of Sciences of the United States of America. 109, 28, p. 11200-11205 6 p.

    Research output: Contribution to journalArticle

  26. Aquaglyceroporin 2 controls susceptibility to melarsoprol and pentamidine in African trypanosomes

    Baker, N., Glover, L., Munday, J. C., Andres, D. A., Barrett, M. P., de Koning, H. P. & Horn, D. 3 Jul 2012 In : Proceedings of the National Academy of Sciences of the United States of America. 109, 27, p. 10996-11001 6 p.

    Research output: Contribution to journalArticle

  27. Extending the timescale and range of ecosystem services through paleoenvironmental analyses, exemplified in the lower Yangtze basin

    Dearing, J. A., Yang, X., Dong, X., Zhang, E., Chen, X., Langdon, P. G., Zhang, K., Zhang, W. & Dawson, T. P. 1 May 2012 In : Proceedings of the National Academy of Sciences of the United States of America. 109, 18, p. E1111-E1120 10 p.

    Research output: Contribution to journalArticle

  28. Role of autophagy in histone deacetylase inhibitor-induced apoptotic and nonapoptotic cell death

    Gammoh, N., Lam, D., Puente, C., Marks, P. A., Jiang, X. & Ganley, I. 24 Apr 2012 In : Proceedings of the National Academy of Sciences of the United States of America. 109, 17, p. 6561-6565 5 p.

    Research output: Contribution to journalArticle

  29. Electroconvulsive therapy reduces frontal cortical connectivity in severe depressive disorder

    Perrin, J. S., Merz, S., Bennett, D. M., Currie, J., Steele, D. J., Reid, I. C. & Schwarzbauer, C. 3 Apr 2012 In : Proceedings of the National Academy of Sciences of the United States of America. 109, 14, p. 5464-5468 5 p.

    Research output: Contribution to journalArticle

  30. Host-targeting protein 1 (SpHtp1) from the oomycete Saprolegnia parasitica translocates specifically into fish cells in a tyrosine-O-sulphate-dependent manner

    Wawra, S., Bain, J., Durward, E., de Bruijn, I., Minor, K. L., Matena, A., Löbach, L., Whisson, S. C., Bayer, P., Porter, A. J., Birch, P. R. J., Secombes, C. J. & van West, P. 7 Feb 2012 In : Proceedings of the National Academy of Sciences of the United States of America. 109, 6, p. 2096-2101 6 p.

    Research output: Contribution to journalArticle

  31. Activation of the renal Na+:Cl- cotransporter by angiotensin II is a WNK4-dependent process

    Castaneda-Bueno, M., Graciela Cervantes-Perez, L., Vazquez, N., Uribe, N., Kantesaria, S., Morla, L., Bobadilla, N. A., Doucet, A., Alessi, D. R. & Gamba, G. 2012 In : Proceedings of the National Academy of Sciences of the United States of America. 109, 20, p. 7929-7934 6 p.

    Research output: Contribution to journalArticle

  32. Leishmania TDR1 structure, a unique trimeric glutathione transferase capable of deglutathionylation and antimonial prodrug activation

    Fyfe, P. K., Westrop, G. D., Silva, A. M., Coombs, G. H. & Hunter, W. N. 2012 In : Proceedings of the National Academy of Sciences of the United States of America. 109, 29, p. 11693-11698 6 p.

    Research output: Contribution to journalArticle

  33. Live imaging of nascent RNA dynamics reveals distinct types of transcriptional pulse regulation

    Muramoto, T., Cannon, D., Gierlinski, M., Corrigan, A., Barton, G. J. & Chubb, J. R. 2012 In : Proceedings of the National Academy of Sciences of the United States of America. 109, 19, p. 7350-7355 6 p.

    Research output: Contribution to journalArticle

  34. Phosphorylation of CRTC3 by the salt-inducible kinases controls the interconversion of classically activated and regulatory macrophages

    Clark, K., Mackenzie, K. F., Petkevicius, K., Kristariyanto, Y., Zhang, J., Choi, H. G., Peggie, M., Plater, L., Pedrioli, P. G. A., McIver, E., Gray, N. S., Arthur, J. S. C. & Cohen, P. 2012 In : Proceedings of the National Academy of Sciences of the United States of America. 109, 42, p. 16986-91 6 p.

    Research output: Contribution to journalArticle

  35. Tibet is one of the centers of domestication of cultivated barley

    Dai, F., Nevo, E., Wu, D., Comadran, J., Zhou, M., Qiu, L., Chen, Z., Beiles, A., Chen, G. & Zhang, G. 2012 In : Proceedings of the National Academy of Sciences of the United States of America. 109, 42, p. 16969-16973 5 p.

    Research output: Contribution to journalArticle

  36. Pannexins in ischemia-induced neurodegeneration

    Bargiotas, P., Krenz, A., Hormuzdi, S. G., Ridder, D. A., Herb, A., Barakat, W., Penuela, S., von Engelhardt, J., Monyer, H. & Schwaninger, M. 20 Dec 2011 In : Proceedings of the National Academy of Sciences of the United States of America. 108, 51, p. 20772-20777 6 p.

    Research output: Contribution to journalArticle

  37. Phytophthora infestans effector AVRblb2 prevents secretion of a plant immune protease at the haustorial interface

    Bozkurt, T. O., Schornack, S., Win, J., Shindo, T., Ilyas, M., Oliva, R., Cano, L. M., Jones, A. M. E., Huitema, E., van der Hoorn, R. A. L. & Kamoun, S. 20 Dec 2011 In : Proceedings of the National Academy of Sciences of the United States of America. 108, 51, p. 20832-20837 6 p.

    Research output: Contribution to journalArticle

  38. Phosphorylation of the voltage-gated potassium channel Kv2.1 by AMP-activated protein kinase regulates membrane excitability

    Ikematsu, N., Dallas, M. L., Ross, F. A., Lewis, R. W., Rafferty, J. N., David, J. A., Suman, R., Peers, C., Hardie, D. G. & Evans, A. M. 1 Nov 2011 In : Proceedings of the National Academy of Sciences of the United States of America. 108, 44, p. 18132-18137 6 p.

    Research output: Contribution to journalArticle

  39. Loss-of-function mutations in Notch receptors in cutaneous and lung squamous cell carcinoma

    Leigh, I. M. & 32 others Wang, N. J., Sanborn, Z., Arnett, K. L., Bayston, L. J., Liao, W., Proby, C. M., Collisson, E. A., Gordon, P. B., Jakkula, L., Pennypacker, S., Zou, Y., Sharma, M., North, J. P., Vemula, S. S., Mauro, T. M., Neuhaus, I. M., LeBoit, P. E., Hur, J. S., Park, K., Huh, N., Kwok, P-Y., Arron, S. T., Massion, P. P., Bale, A. E., Haussler, D., Cleaver, J. E., Gray, J. W., Spellman, P. T., South, A. P., Aster, J. C., Blacklow, S. C. & Cho, R. J. 25 Oct 2011 In : Proceedings of the National Academy of Sciences of the United States of America. 108, 43, p. 17761-17766 6 p.

    Research output: Contribution to journalArticle

  40. The TRAF-associated protein TANK facilitates cross-talk within the I kappa B kinase family during Toll-like receptor signaling

    Clark, K., Takeuchi, O., Akira, S. & Cohen, P. 11 Oct 2011 In : Proceedings of the National Academy of Sciences of the United States of America. 108, 41, p. 17093-17098 6 p.

    Research output: Contribution to journalArticle

  41. Genetic analysis of specific and redundant roles for p38 alpha and p38 beta MAPKs during mouse development

    del Barco Barrantes, I., Manuel Coya, J., Maina, F., Arthur, J. S. C. & Nebreda, A. R. 2 Aug 2011 In : Proceedings of the National Academy of Sciences of the United States of America. 108, 31, p. 12764-12769 6 p.

    Research output: Contribution to journalArticle

  42. Control of mTORC1 signaling by the Opitz syndrome protein MID1

    Liu, E., Knutzen, C. A., Krauss, S., Schweiger, S. & Chiang, G. G. 24 May 2011 In : Proceedings of the National Academy of Sciences of the United States of America. 108, 21, p. 8680-8685 6 p.

    Research output: Contribution to journalArticle

  43. Platonic and Archimedean geometries in multicomponent elastic membranes

    Vernizzi, G., Sknepnek, R. & de la Cruz, M. O. 15 Mar 2011 In : Proceedings of the National Academy of Sciences of the United States of America. 108, 11, p. 4292-4296 5 p.

    Research output: Contribution to journalArticle

  44. Temperature-sensitive ipl1-2/Aurora B mutation is suppressed by mutations in TOR complex 1 via the Glc7/PP1 phosphatase

    Tatchell, K., Makrantoni, V., Stark, M. J. R. & Robinson, L. C. 8 Mar 2011 In : Proceedings of the National Academy of Sciences of the United States of America. 108, 10, p. 3994-3999 6 p.

    Research output: Contribution to journalArticle

  45. Molecular basis for ubiquitin and ISG15 cross-reactivity in viral ovarian tumor domains

    Akutsu, M., Ye, Y., Virdee, S., Chin, J. W. & Komander, D. 8 Feb 2011 In : Proceedings of the National Academy of Sciences of the United States of America. 108, 6, p. 2228-2233 6 p.

    Research output: Contribution to journalArticle

  46. Mild oxidative stress activates Nrf2 in astrocytes, which contributes to neuroprotective ischemic preconditioning

    Bell, K. F., Al-Mubarak, B., Fowler, J. H., Baxter, P. S., Gupta, K., Tsujita, T., Chowdhry, S., Patani, R., Chandran, S., Horsburgh, K., Hayes, J. D. & Hardingham, G. E. 4 Jan 2011 In : Proceedings of the National Academy of Sciences of the United States of America. 108, 1, p. E1-E2 2 p.

    Research output: Contribution to journalLetter

  47. Functional dynamics in the voltage-dependent anion channel

    Villinger, S., Briones, R., Giller, K., Zachariae, U., Lange, A., De Groot, B. L., Griesinger, C., Becker, S. & Zweckstetter, M. 28 Dec 2010 In : Proceedings of the National Academy of Sciences of the United States of America. 107, 52, p. 22546-22551 6 p.

    Research output: Contribution to journalArticle

  48. Biguanide metformin acts on tau phosphorylation via mTOR/protein phosphatase 2A (PP2A) signaling

    Kickstein, E., Krauss, S., Thornhill, P., Rutschow, D., Zeller, R., Sharkey, J., Williamson, R., Fuchs, M., Koehler, A., Glossmann, H., Schneider, R., Sutherland, C. & Schweiger, S. 14 Dec 2010 In : Proceedings of the National Academy of Sciences of the United States of America. 107, 50, p. 21830-21835 6 p.

    Research output: Contribution to journalArticle

  49. Uncoupling the Warburg effect from cancer

    Najafov, A. & Alessi, D. R. 9 Nov 2010 In : Proceedings of the National Academy of Sciences of the United States of America. 107, 45, p. 19135-19136 2 p.

    Research output: Contribution to journalComment/debate

  50. Ancient class of translocated oomycete effectors targets the host nucleus

    Schornack, S., van Damme, M., Bozkurt, T. O., Cano, L. M., Smoker, M., Thines, M., Gaulin, E., Kamoun, S. & Huitema, E. 5 Oct 2010 In : Proceedings of the National Academy of Sciences of the United States of America. 107, 40, p. 17421-17426 6 p.

    Research output: Contribution to journalArticle

  51. Advanced hardware and software tools for fast multidimensional imaging of living cells

    Swedlow, J. R. 14 Sep 2010 In : Proceedings of the National Academy of Sciences of the United States of America. 107, 37, p. 16005-16006 2 p.

    Research output: Contribution to journalEditorial

  52. The serine/arginine-rich protein SF2/ASF regulates protein sumoylation

    Pelisch, F., Gerez, J., Druker, J., Schor, I. E., Munoz, M. J., Risso, G., Petrillo, E., Westman, B. J., Lamond, A. I., Arzt, E. & Srebrow, A. 14 Sep 2010 In : Proceedings of the National Academy of Sciences of the United States of America. 107, 37, p. 16119-16124 6 p.

    Research output: Contribution to journalArticle

  53. DNA polymerase theta up-regulation is associated with poor survival in breast cancer, perturbs DNA replication, and promotes genetic instability

    Bourdon, J-C. & 23 others Lemee, F., Bergoglio, V., Fernandez-Vidal, A., Machado-Silva, A., Pillaire, M-J., Bieth, A., Gentil, C., Baker, L., Martin, A-L., Leduc, C., Lam, E., Magdeleine, E., Filleron, T., Oumouhou, N., Kaina, B., Seki, M., Grimal, F., Lacroix-Triki, M., Thompson, A., Roche, H., Wood, R. D., Hoffmann, J-S. & Cazaux, C. 27 Jul 2010 In : Proceedings of the National Academy of Sciences of the United States of America. 107, 30, p. 13390-13395 6 p.

    Research output: Contribution to journalArticle

  54. Nucleobase-mediated general acid-base catalysis in the Varkud satellite ribozyme

    Wilson, T. J., Li, N-S., Lu, J., Frederiksen, J. K., Piccirilli, J. A. & Lilley, D. M. J. 29 Jun 2010 In : Proceedings of the National Academy of Sciences of the United States of America. 107, 26, p. 11751-11756 6 p.

    Research output: Contribution to journalArticle

  55. Activity of any class IA PI3K isoform can sustain cell proliferation and survival

    Foukas, L. C., Berenjeno, I. M., Gray, A., Khwaja, A. & Vanhaesebroeck, B. 22 Jun 2010 In : Proceedings of the National Academy of Sciences of the United States of America. 107, 25, p. 11381-11386 6 p.

    Research output: Contribution to journalArticle

  56. Enhanced hepatitis C virus genome replication and lipid accumulation mediated by inhibition of AMP-activated protein kinase

    Mankouri, J., Tedbury, P. R., Gretton, S., Hughes, M. E., Griffin, S. D. C., Dallas, M. L., Green, K. A., Hardie, D. G., Peers, C. & Harris, M. 22 Jun 2010 In : Proceedings of the National Academy of Sciences of the United States of America. 107, 25, p. 11549-11554 6 p.

    Research output: Contribution to journalArticle

  57. Electrophilic tuning of the chemoprotective natural product sulforaphane

    Ahn, Y-H., Hwang, Y., Liu, H., Wang, X-J., Zhang, Y., Stephenson, K. K., Boronina, T. N., Cole, R. N., Dinkova-Kostova, A. T., Talalay, P. & Cole, P. A. 25 May 2010 In : Proceedings of the National Academy of Sciences of the United States of America. 107, 21, p. 9590-9595 6 p.

    Research output: Contribution to journalArticle

  58. Phytophthora infestans effector AVR3a is essential for virulence and manipulates plant immunity by stabilizing host E3 ligase CMPG1

    Bos, J., Armstrong, M. R., Gilroy, E. M., Boevink, P. C., Hein, I., Taylor, R. M., Zhendong, T., Engelhardt, S., Vetukuri, R. R., Harrower, B., Dixelius, C., Bryan, G., Sadanandom, A., Whisson, S. C., Kamoun, S. & Birch, P. R. J. 25 May 2010 In : Proceedings of the National Academy of Sciences of the United States of America. 107, 21, p. 9909-9914 6 p.

    Research output: Contribution to journalArticle

  59. Cell-cell signal-dependent dynamic interactions between HD-GYP and GGDEF domain proteins mediate virulence in Xanthomonas campestris

    Ryan, R. P., McCarthy, Y., Andrade, M., Farah, C. S., Armitage, J. P. & Dow, J. M. 30 Mar 2010 In : Proceedings of the National Academy of Sciences of the United States of America. 107, 13, p. 5989-5994 6 p.

    Research output: Contribution to journalArticle

  60. Protein localization and dynamics within a bacterial organelle

    Hughes, H. V., Huitema, E., Pritchard, S., Keiler, K. C., Brun, Y. V. & Viollier, P. H. 23 Mar 2010 In : Proceedings of the National Academy of Sciences of the United States of America. 107, 12, p. 5599-5604 6 p.

    Research output: Contribution to journalArticle

  61. Cocaine effects on mouse incentive-learning and human addiction are linked to alpha 2 subunit-containing GABA(A) receptors

    Dixon, C. I., Morris, H. V., Breen, G., Desrivieres, S., Jugurnauth, S., Steiner, R. C., Vallada, H., Guindalini, C., Laranjeira, R., Messas, G., Rosahl, T. W., Atack, J. R., Peden, D. R., Belelli, D., Lambert, J. J., King, S. L., Schumann, G. & Stephens, D. N. 2 Feb 2010 In : Proceedings of the National Academy of Sciences of the United States of America. 107, 5, p. 2289-2294 6 p.

    Research output: Contribution to journalArticle

  62. Structural insights into phosphoinositide 3-kinase activation by the influenza A virus NS1 protein

    Hale, B. G., Kerry, P. S., Jackson, D., Precious, B. L., Gray, A., Killip, M. J., Randall, R. E. & Russell, R. J. 2 Feb 2010 In : Proceedings of the National Academy of Sciences of the United States of America. 107, 5, p. 1954-1959 6 p.

    Research output: Contribution to journalArticle

  63. Markedly enhanced colon tumorigenesis in Apc(Min) mice lacking glutathione S-transferase Pi

    Ritchie, K. J., Walsh, S., Sansom, O. J., Henderson, C. J. & Wolf, C. R. 8 Dec 2009 In : Proceedings of the National Academy of Sciences of the United States of America. 106, 49, p. 20859-20864 6 p.

    Research output: Contribution to journalArticle

  64. Enzyme millisecond conformational dynamics do not catalyze the chemical step

    Pisliakov, A. V., Cao, J., Kamerlin, S. C. L. & Warshel, A. 13 Oct 2009 In : Proceedings of the National Academy of Sciences of the United States of America. 106, 41, p. 17359-17364 6 p.

    Research output: Contribution to journalArticle

  65. Structural analysis of substrate binding by the TatBC component of the twin-arginine protein transport system

    Tarry, M. J., Schäfer, E., Chen, S., Buchanan, G., Greene, N. P., Lea, S. M., Palmer, T., Saibil, H. R. & Berks, B. C. 11 Aug 2009 In : Proceedings of the National Academy of Sciences of the United States of America. 106, 32, p. 13284-13289 6 p.

    Research output: Contribution to journalArticle

  66. Activated cAMP receptors switch encystation into sporulation

    Kawabe, Y., Morio, T., James, J. L., Prescott, A. R., Tanaka, Y. & Schaap, P. 28 Apr 2009 In : Proceedings of the National Academy of Sciences of the United States of America. 106, 17, p. 7089-7094 6 p.

    Research output: Contribution to journalArticle

  67. Identification of the phosphorylation sites on the E3 ubiquitin ligase Pellino that are critical for activation by IRAK1 and IRAK4

    Smith, H., Peggie, M., Campbell, D. G., Vandermoere, F., Carrick, E. & Cohen, P. 24 Mar 2009 In : Proceedings of the National Academy of Sciences of the United States of America. 106, 12, p. 4584-4590 7 p.

    Research output: Contribution to journalArticle

  68. Angiotensin II signaling increases activity of the renal Na-Cl cotransporter through a WNK4-SPAK-dependent pathway

    San-Cristobal, P., Pacheco-Alvarez, D., Richardson, C., Ring, A. M., Vazquez, N., Rafiqi, F. H., Chari, D., Kahle, K. T., Leng, Q., Bobadilla, N. A., Hebert, S. C., Alessi, D. R., Lifton, R. P. & Gamba, G. 17 Mar 2009 In : Proceedings of the National Academy of Sciences of the United States of America. 106, 11, p. 4384-4389 6 p.

    Research output: Contribution to journalArticle

  69. Genome-wide association and meta-analysis of bipolar disorder in individuals of European ancestry

    Scott, L. J. , Muglia, P. , Kong, X. Q. , Guan, W. , Flickinger, M. , Upmanyu, R. , Tozzi, F. , Li, J. Z. , Burmeister, M. , Absher, D. , Thompson, R. C. , Francks, C. , Meng, F. , Antoniades, A. , Southwick, A. M. , Schatzberg, A. F. , Bunney, W. E. , Barchask, J. D. , Jones, E. G. , Day, R. & 13 others Matthews, K., McGuffin, P., Strauss, J. S., Kennedy, J. L., Middleton, L., Roses, A. D., Watson, S. J., Vincent, J. B., Myers, R. M., Farmer, A. E., Akil, H., Burns, D. K. & Boehnke, M. 2009 In : Proceedings of the National Academy of Sciences of the United States of America. 106, 18, p. 7501-7506 6 p.

    Research output: Contribution to journalArticle

  70. Quaternary structure of the human Cdt1-Geminin complex regulates DNA replication licensing

    De Marco, V., Gillespie, P. J., Li, A., Karantzelis, N., Christodoulou, E., Klompmaker, R., van Gerwen, S., Fish, A., Petoukhov, M. V., Iliou, M. S., Lygerou, Z., Medema, R. H., Blow, J. J., Svergun, D. I., Taraviras, S. & Perrakis, A. 2009 In : Proceedings of the National Academy of Sciences of the United States of America. 106, 47, p. 19807-19812 6 p.

    Research output: Contribution to journalArticle

  71. Modeling the temporal evolution of the spindle assembly checkpoint and role of Aurora B kinase

    Mistry, H. B., MacCallum, D. E., Jackson, R. C., Chaplain, M. A. J. & Davidson, F. A. 23 Dec 2008 In : Proceedings of the National Academy of Sciences USA. 105, 51, p. 20215-20220 6 p.

    Research output: Contribution to journalArticle

  72. Variable stoichiometry of the TatA component of the twin-arginine protein transport system observed by in vivo single-molecule imaging

    Leake, M. C., Greene, N. P., Godun, R. M., Granjon, T., Buchanan, G., Chen, S., Berry, R. M., Palmer, T. & Berks, B. C. 7 Oct 2008 In : Proceedings of the National Academy of Sciences of the United States of America. 105, 40, p. 15376-15381 6 p.

    Research output: Contribution to journalArticle

  73. Cell cycle progression requires the CDC-48(UFD-1/NPL-4) complex for efficient DNA replication

    Mouysset, J., Deichsel, A., Moser, S., Hoege, C., Hyman, A. A., Gartner, A. & Hoppe, T. 2 Sep 2008 In : Proceedings of the National Academy of Sciences of the United States of America. 105, 35, p. 12879-12884 6 p.

    Research output: Contribution to journalArticle

  74. Orientation dependence in fluorescent energy transfer between Cy3 and Cy5 terminally attached to double-stranded nuclelic acids

    Iqbal, A., Arslan, S., Okumus, B., Wilson, T. J., Giraud, G., Norman, D. G., Ha, T. & Lilley, D. M. J. 12 Aug 2008 In : Proceedings of the National Academy of Sciences of the United States of America. 105, 32, p. 11176-11181 6 p.

    Research output: Contribution to journalArticle

  75. Where in the cell is the minor spliceosome?

    Steitz, J. A., Dreyfuss, G., Krainer, A. R., Lamond, A. I., Matera, A. G. & Padgett, R. A. 24 Jun 2008 In : Proceedings of the National Academy of Sciences of the United States of America. 105, 25, p. 8485-8486 2 p.

    Research output: Contribution to journalEditorial

  76. Electrostatic basis for the unidirectionality of the primary proton transfer in cytochrome c oxidase

    Pisliakov, A. V., Sharma, P. K., Chu, Z. T., Haranczyk, M. & Warshel, A. 3 Jun 2008 In : Proceedings of the National Academy of Sciences of the United States of America. 105, 22, p. 7726-7731 6 p.

    Research output: Contribution to journalArticle

  77. T cell receptor signaling controls Foxp3 expression via PI3K, Akt, and mTOR

    Sauer, S., Bruno, L., Hertweck, A., Finlay, D., Leleu, M., Spivakov, M., Knight, Z. A., Cobb, B. S., Cantrell, D., O'Connor, E., Shokat, K. M., Fisher, A. G. & Merkenschlager, M. 3 Jun 2008 In : Proceedings of the National Academy of Sciences of the United States of America. 105, 22, p. 7797-7802 6 p.

    Research output: Contribution to journalArticle

  78. A mechanism for cross-resistance to nifurtimox and benznidazole in trypanosomes

    Wilkinson, S. R., Taylor, M. C., Horn, D., Kelly, J. M. & Cheeseman, I. 1 Apr 2008 In : Proceedings of the National Academy of Sciences of the United States of America. 105, 13, p. 5022-5027 6 p.

    Research output: Contribution to journalArticle

  79. Substrate binding, deprotonation, and, selectivity at the periplasmic entrance of the Escherichia coli ammonia channel AmtB

    Javelle, A., Lupo, D., Ripoche, P., Fulford, T., Merrick, M. & Winkler, F. K. 1 Apr 2008 In : Proceedings of the National Academy of Sciences of the United States of America. 105, 13, p. 5040-5045 6 p.

    Research output: Contribution to journalArticle

  80. Discovery of potent pteridine reductase inhibitors to guide antiparasite drug development

    Cavazzuti, A., Paglietti, G., Hunter, W. N., Gamarro, F., Piras, S., Loriga, M., Alleca, S., Corona, P., McLuskey, K., Tulloch, L., Gibellini, F., Ferrari, S. & Costin, M. P. 5 Feb 2008 In : Proceedings of the National Academy of Sciences of the United States of America. 105, 5, p. 1448-1453 6 p.

    Research output: Contribution to journalArticle

  81. The photoreversible fluorescent protein iLOV outperforms GFP as a reporter of plant virus infection

    Chapman, S., Faulkner, C., Kaiserli, E., Garcia-Mata, C., Savenkov, E. I., Roberts, A. G., Oparka, K. J. & Christie, J. M. 2008 In : Proceedings of the National Academy of Sciences of the United States of America. 105, 50, p. 20038-20043 6 p.

    Research output: Contribution to journalArticle

  82. A potent cytotoxic photoactivated platinum complex

    Mackay, F. S., Woods, J. A., Heringova, P., Kasparkova, J., Pizarro, A. M., Moggach, S. A., Parsons, S., Brabec, V. & Sadler, P. J. 26 Dec 2007 In : Proceedings of the National Academy of Sciences of the United States of America. 104, 52, p. 20743-20748 6 p.

    Research output: Contribution to journalArticle

  83. Complex spatial group patterns result from different animal communication mechanisms

    Eftimie, R., de Vries, G. & Lewis, M. A. 2007 In : Proceedings of the National Academy of Sciences USA. 104, 17

    Research output: Contribution to journalArticle

  84. Interaction of a plant virus-encoded protein with the major nucleolar protein fibrillarin is required for systemic virus infection

    Kim, S. H., Macfarlane, S., Kalinina, N. O., Rakitina, D. V., Ryabov, E. V., Gillespie, T., Haupt, S., Brown, J. W. S. & Taliansky, M. 2007 In : Proceedings of the National Academy of Sciences of the United States of America. 104, 26, p. 11115-20 6 p.

    Research output: Contribution to journalArticle

  85. Structural diversity in twin-arginine signal peptide-binding proteins

    Maillard, J., Spronk, C. A. E. M., Buchanan, G., Lyall, V., Richardson, D. J., Palmer, T., Vuister, G. W., Sargent, F. & Clemons, W. M. (ed.) 2007 In : Proceedings of the National Academy of Sciences. 104, 40, p. 15641-15646 6 p.

    Research output: Contribution to journalArticle

  86. Structure and reactivity of LpxD, the N-acyltransferase of lipid A biosynthesis

    Buetow, L., Smith, T. K., Dawson, A., Fyffe, S., Hunter, W. N. & Thornton, J. M. (ed.) 2007 In : Proceedings of the National Academy of Sciences of the United States of America. 104, 11, p. 4321-4326 6 p.

    Research output: Contribution to journalArticle

  87. Cell-cell signaling in Xanthomonas campestris involves an HD-GYP domain protein that functions in cyclic di-GMP turnover

    Ryan, R. P., Fouhy, Y., Lucey, J. F., Crossman, L. C., Spiro, S., He, Y-W., Zhang, L-H., Heeb, S., Cámara, M., Williams, P. & Dow, J. M. 25 Apr 2006 In : Proceedings of the National Academy of Sciences of the United States of America. 103, 17, p. 6712-6717 6 p.

    Research output: Contribution to journalArticle

  88. The twin-arginine translocation pathway is a major route of protein export in Streptomyces coelicolor

    Widdick, D., Dilks, K., Chandra, G., Bottrill, A., Naldrett, M., Pohlschroder, M., Palmer, T. & Beckwith, J. (ed.) 2006 In : Proceedings of the National Academy of Sciences of the United States of America. 103, 47, p. 17927-17932 6 p.

    Research output: Contribution to journalArticle

  89. Unique players in the BMP pathway: small C-terminal domain phosphatases dephosphorylate Smad1 to attenuate BMP signaling

    Knockaert, M., Sapkota, G., Alarcón, C., Massagué, J. & Brivanlou, A. H. 2006 In : Proceedings of the National Academy of Sciences of the United States of America. 103, 32, p. 11940-11945 6 p.

    Research output: Contribution to journalArticle

  90. Structure and reactivity of hydroxypropylphosphonic acid epoxidase in fosfomycin biosynthesis by a cation- and flavin-dependent mechanism

    McLuskey, K., Cameron, S., Hammerschmidt, F., Hunter, W. N. & Davies, D. R. (ed.) Oct 2005 In : Proceedings of the National Academy of Sciences of the United States of America. 102, 40, p. 14221-14226 6 p.

    Research output: Contribution to journalArticle

  91. An ancestral oomycete locus contains late blight avirulence gene Avr3a, encoding a protein that is recognized in the host cytoplasm

    Armstrong, M. R. , Whisson, S. C. , Pritchard, L. , Bos, J. I. B. , Venter, E. , Avrova, A. O. , Rehmany, A. P. , Bohme, U. , Brooks, K. , Cherevach, I. , Hamlin, N. , White, B. , Fraser, A. , Lord, A. , Quail, M. A. , Churcher, C. , Hall, N. , Berriman, M. , Huang, S. , Kamoun, S. & 3 others Beynon, J. L., Birch, P. R. J. & Cook, R. J. (ed.) May 2005 In : Proceedings of the National Academy of Sciences of the United States of America. 102, 21, p. 7766-7771 6 p.

    Research output: Contribution to journalArticle

  92. Diverse taxa of cyanobacteria produce β-N-methylamino-l-alanine, a neurotoxic amino acid

    Cox, P. A., Banack, S. A., Murch, S. J., Rasmussen, U., Tien, G., Bidigare, R. R., Metcalf, J. S., Morrison, L. F., Codd, G. A. & Bergman, B. Apr 2005 In : Proceedings of the National Academy of Sciences of the United States of America. 102, 14, p. 5074-5078 5 p.

    Research output: Contribution to journalArticle

  93. Extremely potent triterpenoid inducers of the phase 2 response: correlations of protection against oxidant and inflammatory stress

    Dinkova-Kostova, A. T., Liby, K. T., Stephenson, K. K., Holtzclaw, W. D., Gao, X., Suh, N., Williams, C., Risingsong, R., Honda, T., Gribble, G. W., Sporn, M. B. & Talalay, P. Mar 2005 In : Proceedings of the National Academy of Sciences of the United States of America. 102, 12, p. 4584-4589 6 p.

    Research output: Contribution to journalArticle

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