Proceedings of the National Academy of Sciences of the United States of America

Crystal structure and functional mechanism of a human antimicrobial membrane channel

Song, C., Weichbrodt, C., Salnikov, E. S., Dynowski, M., Forsberg, B. O., Bechinger, B., Steinem, C., De Groot, B. L., Zachariae, U. & Zeth, K. 19-Mar-2013 In : Proceedings of the National Academy of Sciences of the United States of America. 110, 12, p. 4586-4591, 6 p.

Research output: Contribution to journal › Article

Structural basis for cooperativity of CRM1 export complex formation

Monecke, T., Haselbach, D., Voß, B., Russek, A., Neumann, P., Thomson, E., Hurt, E., Zachariae, U., Stark, H., Grubmul̈ler, H., Dickmanns, A. & Ficner, R. 15-Jan-2013 In : Proceedings of the National Academy of Sciences of the United States of America. 110, 3, p. 960-965, 6 p.

Research output: Contribution to journal › Article

P38γ and p38δ kinases regulate the Toll-like receptor 4 (TLR4)-induced cytokine production by controlling ERK1/2 protein kinase pathway activation

Risco, A., Del Dresno, C., Mambol, A., Alsina-Beauchamp, D., MacKenzie, K. F., Yang, H-T., Barber, D. F., Morcelle, C., Arthur, J. S. C., Ley, S. C., Ardavin, C. F. & Cuenda, A. 10-Jul-2012 In : Proceedings of the National Academy of Sciences of the United States of America. 109, 28, p. 11200-11205, 6 p.

Research output: Contribution to journal › Article

Extending the timescale and range of ecosystem services through paleoenvironmental analyses, exemplified in the lower Yangtze basin

Dearing, J. A., Yang, X., Dong, X., Zhang, E., Chen, X., Langdon, P. G., Zhang, K., Zhang, W. & Dawson, T. P. 1-May-2012 In : Proceedings of the National Academy of Sciences of the United States of America. 109, 18, p. E1111-E1120, 10 p.

Research output: Contribution to journal › Article

Role of autophagy in histone deacetylase inhibitor-induced apoptotic and nonapoptotic cell death

Gammoh, N., Lam, D., Puente, C., Marks, P. A., Jiang, X. & Ganley, I. 24-Apr-2012 In : Proceedings of the National Academy of Sciences of the United States of America. 109, 17, p. 6561-6565, 5 p.

Research output: Contribution to journal › Article

Electroconvulsive therapy reduces frontal cortical connectivity in severe depressive disorder

Perrin, J. S., Merz, S., Bennett, D. M., Currie, J., Steele, D. J., Reid, I. C. & Schwarzbauer, C. 3-Apr-2012 In : Proceedings of the National Academy of Sciences of the United States of America. 109, 14, p. 5464-5468, 5 p.

Research output: Contribution to journal › Article

Host-targeting protein 1 (SpHtp1) from the oomycete Saprolegnia parasitica translocates specifically into fish cells in a tyrosine-O-sulphate-dependent manner

Wawra, S., Bain, J., Durward, E., de Bruijn, I., Minor, K. L., Matena, A., Loebach, L., Whisson, S. C., Bayer, P., Porter, A. J., Birch, P. R. J., Secombes, C. J. & van West, P. 7-Feb-2012 In : Proceedings of the National Academy of Sciences of the United States of America. 109, 6, p. 2096-2101, 6 p.

Research output: Contribution to journal › Article

Activation of the renal Na+:Cl- cotransporter by angiotensin II is a WNK4-dependent process

Castaneda-Bueno, M., Graciela Cervantes-Perez, L., Vazquez, N., Uribe, N., Kantesaria, S., Morla, L., Bobadilla, N. A., Doucet, A., Alessi, D. R. & Gamba, G. 2012 In : Proceedings of the National Academy of Sciences of the United States of America. 109, 20, p. 7929-7934, 6 p.

Research output: Contribution to journal › Article

Identification of the kinase that activates a nonmetazoan STAT gives insights into the evolution of phosphotyrosine-SH2 domain signaling

Araki, T., Kawata, T. & Williams, J. G. 2012 In : Proceedings of the National Academy of Sciences of the United States of America. 109, 28, p. E1931-E1937

Research output: Contribution to journal › Article

Leishmania TDR1 structure, a unique trimeric glutathione transferase capable of deglutathionylation and antimonial prodrug activation

Fyfe, P. K., Westrop, G. D., Silva, A. M., Coombs, G. H. & Hunter, W. N. 2012 In : Proceedings of the National Academy of Sciences of the United States of America. 109, 29, p. 11693-11698, 6 p.

Research output: Contribution to journal › Article

Live imaging of nascent RNA dynamics reveals distinct types of transcriptional pulse regulation

Muramoto, T., Cannon, D., Gierlinski, M., Corrigan, A., Barton, G. J. & Chubb, J. R. 2012 In : Proceedings of the National Academy of Sciences of the United States of America. 109, 19, p. 7350-7355, 6 p.

Research output: Contribution to journal › Article

Phosphorylation of CRTC3 by the salt-inducible kinases controls the interconversion of classically activated and regulatory macrophages

Clark, K., Mackenzie, K. F., Petkevicius, K., Kristariyanto, Y., Zhang, J., Choi, H. G., Peggie, M., Plater, L., Pedrioli, P. G. A., McIver, E., Gray, N. S., Arthur, J. S. C. & Cohen, P. 2012 In : Proceedings of the National Academy of Sciences of the United States of America. 109, 42, p. 16986-91, 6 p.

Research output: Contribution to journal › Article

Tibet is one of the centers of domestication of cultivated barley

Dai, F., Nevo, E., Wu, D., Comadran, J., Zhou, M., Qiu, L., Chen, Z., Beiles, A., Chen, G. & Zhang, G. 2012 In : Proceedings of the National Academy of Sciences of the United States of America. 109, 42, p. 16969-16973, 5 p.

Research output: Contribution to journal › Article

Pannexins in ischemia-induced neurodegeneration

Bargiotas, P., Krenz, A., Hormuzdi, S. G., Ridder, D. A., Herb, A., Barakat, W., Penuela, S., von Engelhardt, J., Monyer, H. & Schwaninger, M. 20-Dec-2011 In : Proceedings of the National Academy of Sciences of the United States of America. 108, 51, p. 20772-20777, 6 p.

Research output: Contribution to journal › Article

Phytophthora infestans effector AVRblb2 prevents secretion of a plant immune protease at the haustorial interface

Bozkurt, T. O., Schornack, S., Win, J., Shindo, T., Ilyas, M., Oliva, R., Cano, L. M., Jones, A. M. E., Huitema, E., van der Hoorn, R. A. L. & Kamoun, S. 20-Dec-2011 In : Proceedings of the National Academy of Sciences of the United States of America. 108, 51, p. 20832-20837, 6 p.

Research output: Contribution to journal › Article

Phosphorylation of the voltage-gated potassium channel Kv2.1 by AMP-activated protein kinase regulates membrane excitability

Ikematsu, N., Dallas, M. L., Ross, F. A., Lewis, R. W., Rafferty, J. N., David, J. A., Suman, R., Peers, C., Hardie, D. G. & Evans, A. M. 1-Nov-2011 In : Proceedings of the National Academy of Sciences of the United States of America. 108, 44, p. 18132-18137, 6 p.

Research output: Contribution to journal › Article

Loss-of-function mutations in Notch receptors in cutaneous and lung squamous cell carcinoma

Wang, N. J. , Sanborn, Z. , Arnett, K. L. , Bayston, L. J. , Liao, W. , Proby, C. M. , Leigh, I. M. , Collisson, E. A. , Gordon, P. B. , Jakkula, L. , Pennypacker, S. , Zou, Y. , Sharma, M. , North, J. P. , Vemula, S. S. , Mauro, T. M. , Neuhaus, I. M. , LeBoit, P. E. , Hur, J. S. , Park, K. & 13 others Huh, N., Kwok, P-Y., Arron, S. T., Massion, P. P., Bale, A. E., Haussler, D., Cleaver, J. E., Gray, J. W., Spellman, P. T., South, A. P., Aster, J. C., Blacklow, S. C. & Cho, R. J. 25-Oct-2011 In : Proceedings of the National Academy of Sciences of the United States of America. 108, 43, p. 17761-17766, 6 p.

Research output: Contribution to journal › Article

The TRAF-associated protein TANK facilitates cross-talk within the I kappa B kinase family during Toll-like receptor signaling

Clark, K., Takeuchi, O., Akira, S. & Cohen, P. 11-Oct-2011 In : Proceedings of the National Academy of Sciences of the United States of America. 108, 41, p. 17093-17098, 6 p.

Research output: Contribution to journal › Article

Genetic analysis of specific and redundant roles for p38 alpha and p38 beta MAPKs during mouse development

del Barco Barrantes, I., Manuel Coya, J., Maina, F., Arthur, J. S. C. & Nebreda, A. R. 2-Aug-2011 In : Proceedings of the National Academy of Sciences of the United States of America. 108, 31, p. 12764-12769, 6 p.

Research output: Contribution to journal › Article

Control of mTORC1 signaling by the Opitz syndrome protein MID1

Liu, E., Knutzen, C. A., Krauss, S., Schweiger, S. & Chiang, G. G. 24-May-2011 In : Proceedings of the National Academy of Sciences of the United States of America. 108, 21, p. 8680-8685, 6 p.

Research output: Contribution to journal › Article

Temperature-sensitive ipl1-2/Aurora B mutation is suppressed by mutations in TOR complex 1 via the Glc7/PP1 phosphatase

Tatchell, K., Makrantoni, V., Stark, M. J. R. & Robinson, L. C. 8-Mar-2011 In : Proceedings of the National Academy of Sciences of the United States of America. 108, 10, p. 3994-3999, 6 p.

Research output: Contribution to journal › Article

Molecular basis for ubiquitin and ISG15 cross-reactivity in viral ovarian tumor domains

Akutsu, M., Ye, Y., Virdee, S., Chin, J. W. & Komander, D. 8-Feb-2011 In : Proceedings of the National Academy of Sciences of the United States of America. 108, 6, p. 2228-2233, 6 p.

Research output: Contribution to journal › Article

Mild oxidative stress activates Nrf2 in astrocytes, which contributes to neuroprotective ischemic preconditioning

Bell, K. F., Al-Mubarak, B., Fowler, J. H., Baxter, P. S., Gupta, K., Tsujita, T., Chowdhry, S., Patani, R., Chandran, S., Horsburgh, K., Hayes, J. D. & Hardingham, G. E. 4-Jan-2011 In : Proceedings of the National Academy of Sciences of the United States of America. 108, 1, p. E1-E2, 2 p.

Research output: Contribution to journal › Letter

Functional dynamics in the voltage-dependent anion channel

Villinger, S., Briones, R., Giller, K., Zachariae, U., Lange, A., De Groot, B. L., Griesinger, C., Becker, S. & Zweckstetter, M. 28-Dec-2010 In : Proceedings of the National Academy of Sciences of the United States of America. 107, 52, p. 22546-22551, 6 p.

Research output: Contribution to journal › Article

Biguanide metformin acts on tau phosphorylation via mTOR/protein phosphatase 2A (PP2A) signaling

Kickstein, E., Krauss, S., Thornhill, P., Rutschow, D., Zeller, R., Sharkey, J., Williamson, R., Fuchs, M., Koehler, A., Glossmann, H., Schneider, R., Sutherland, C. & Schweiger, S. 14-Dec-2010 In : Proceedings of the National Academy of Sciences of the United States of America. 107, 50, p. 21830-21835, 6 p.

Research output: Contribution to journal › Article

Uncoupling the Warburg effect from cancer

Najafov, A. & Alessi, D. R. 9-Nov-2010 In : Proceedings of the National Academy of Sciences of the United States of America. 107, 45, p. 19135-19136, 2 p.

Research output: Contribution to journal › Comment/debate

Keap1 perceives stress via three sensors for the endogenous signaling molecules nitric oxide, zinc, and alkenals

McMahon, M., Lamont, D. J., Beattie, K. A. & Hayes, J. D. 2-Nov-2010 In : Proceedings of the National Academy of Sciences of the United States of America. 107, 44, p. 18838-18843, 6 p.

Research output: Contribution to journal › Article

Ancient class of translocated oomycete effectors targets the host nucleus

Schornack, S., van Damme, M., Bozkurt, T. O., Cano, L. M., Smoker, M., Thines, M., Gaulin, E., Kamoun, S. & Huitema, E. 5-Oct-2010 In : Proceedings of the National Academy of Sciences of the United States of America. 107, 40, p. 17421-17426, 6 p.

Research output: Contribution to journal › Article

Advanced hardware and software tools for fast multidimensional imaging of living cells

Swedlow, J. R. 14-Sep-2010 In : Proceedings of the National Academy of Sciences of the United States of America. 107, 37, p. 16005-16006, 2 p.

Research output: Contribution to journal › Editorial

The serine/arginine-rich protein SF2/ASF regulates protein sumoylation

Pelisch, F., Gerez, J., Druker, J., Schor, I. E., Munoz, M. J., Risso, G., Petrillo, E., Westman, B. J., Lamond, A. I., Arzt, E. & Srebrow, A. 14-Sep-2010 In : Proceedings of the National Academy of Sciences of the United States of America. 107, 37, p. 16119-16124, 6 p.

Research output: Contribution to journal › Article

DNA polymerase theta up-regulation is associated with poor survival in breast cancer, perturbs DNA replication, and promotes genetic instability

Thompson, A. & 23 others Lemee, F., Bergoglio, V., Fernandez-Vidal, A., Machado-Silva, A., Pillaire, M-J., Bieth, A., Gentil, C., Baker, L., Martin, A-L., Leduc, C., Lam, E., Magdeleine, E., Filleron, T., Oumouhou, N., Kaina, B., Seki, M., Grimal, F., Lacroix-Triki, M., Roche, H., Bourdon, J-C., Wood, R. D., Hoffmann, J-S. & Cazaux, C. 27-Jul-2010 In : Proceedings of the National Academy of Sciences of the United States of America. 107, 30, p. 13390-13395, 6 p.

Research output: Contribution to journal › Article

Nucleobase-mediated general acid-base catalysis in the Varkud satellite ribozyme

Wilson, T. J., Li, N-S., Lu, J., Frederiksen, J. K., Piccirilli, J. A. & Lilley, D. M. J. 29-Jun-2010 In : Proceedings of the National Academy of Sciences of the United States of America. 107, 26, p. 11751-11756, 6 p.

Research output: Contribution to journal › Article

Activity of any class IA PI3K isoform can sustain cell proliferation and survival

Foukas, L. C., Berenjeno, I. M., Gray, A., Khwaja, A. & Vanhaesebroeck, B. 22-Jun-2010 In : Proceedings of the National Academy of Sciences of the United States of America. 107, 25, p. 11381-11386, 6 p.

Research output: Contribution to journal › Article

Enhanced hepatitis C virus genome replication and lipid accumulation mediated by inhibition of AMP-activated protein kinase

Mankouri, J., Tedbury, P. R., Gretton, S., Hughes, M. E., Griffin, S. D. C., Dallas, M. L., Green, K. A., Hardie, D. G., Peers, C. & Harris, M. 22-Jun-2010 In : Proceedings of the National Academy of Sciences of the United States of America. 107, 25, p. 11549-11554, 6 p.

Research output: Contribution to journal › Article

Electrophilic tuning of the chemoprotective natural product sulforaphane

Ahn, Y-H., Hwang, Y., Liu, H., Wang, X-J., Zhang, Y., Stephenson, K. K., Boronina, T. N., Cole, R. N., Dinkova-Kostova, A. T., Talalay, P. & Cole, P. A. 25-May-2010 In : Proceedings of the National Academy of Sciences of the United States of America. 107, 21, p. 9590-9595, 6 p.

Research output: Contribution to journal › Article

Phytophthora infestans effector AVR3a is essential for virulence and manipulates plant immunity by stabilizing host E3 ligase CMPG1

Bos, J. I. B., Armstrong, M. R., Gilroy, E. M., Boevink, P. C., Hein, I., Taylor, R. M., Tian Zhendong, . N. V., Engelhardt, S., Vetukuri, R. R., Harrower, B., Dixelius, C., Bryan, G., Sadanandom, A., Whisson, S. C., Kamoun, S. & Birch, P. R. J. 25-May-2010 In : Proceedings of the National Academy of Sciences of the United States of America. 107, 21, p. 9909-9914, 6 p.

Research output: Contribution to journal › Article

Cell-cell signal-dependent dynamic interactions between HD-GYP and GGDEF domain proteins mediate virulence in Xanthomonas campestris

Ryan, R. P., McCarthy, Y., Andrade, M., Farah, C. S., Armitage, J. P. & Dow, J. M. 30-Mar-2010 In : Proceedings of the National Academy of Sciences of the United States of America. 107, 13, p. 5989-5994, 6 p.

Research output: Contribution to journal › Article

Protein localization and dynamics within a bacterial organelle

Hughes, H. V., Huitema, E., Pritchard, S., Keiler, K. C., Brun, Y. V. & Viollier, P. H. 23-Mar-2010 In : Proceedings of the National Academy of Sciences of the United States of America. 107, 12, p. 5599-5604, 6 p.

Research output: Contribution to journal › Article

Cocaine effects on mouse incentive-learning and human addiction are linked to alpha 2 subunit-containing GABA(A) receptors

Dixon, C. I., Morris, H. V., Breen, G., Desrivieres, S., Jugurnauth, S., Steiner, R. C., Vallada, H., Guindalini, C., Laranjeira, R., Messas, G., Rosahl, T. W., Atack, J. R., Peden, D. R., Belelli, D., Lambert, J. J., King, S. L., Schumann, G. & Stephens, D. N. 2-Feb-2010 In : Proceedings of the National Academy of Sciences of the United States of America. 107, 5, p. 2289-2294, 6 p.

Research output: Contribution to journal › Article

Structural insights into phosphoinositide 3-kinase activation by the influenza A virus NS1 protein

Hale, B. G., Kerry, P. S., Jackson, D., Precious, B. L., Gray, A., Killip, M. J., Randall, R. E. & Russell, R. J. 2-Feb-2010 In : Proceedings of the National Academy of Sciences of the United States of America. 107, 5, p. 1954-1959, 6 p.

Research output: Contribution to journal › Article

Markedly enhanced colon tumorigenesis in Apc(Min) mice lacking glutathione S-transferase Pi

Ritchie, K. J., Walsh, S., Sansom, O. J., Henderson, C. J. & Wolf, C. R. 8-Dec-2009 In : Proceedings of the National Academy of Sciences of the United States of America. 106, 49, p. 20859-20864, 6 p.

Research output: Contribution to journal › Article

Quaternary structure of the human Cdt1-Geminin complex regulates DNA replication licensing

De Marco, V., Gillespie, P. J., Li, A., Karantzelis, N., Christodoulou, E., Klompmaker, R., van Gerwen, S., Fish, A., Petoukhov, M. V., Iliou, M. S., Lygerou, Z., Medema, R. H., Blow, J. J., Svergun, D. I., Taraviras, S. & Perrakis, A. 24-Nov-2009 In : Proceedings of the National Academy of Sciences of the United States of America. 106, 47, p. 19807-19812, 6 p.

Research output: Contribution to journal › Article

Structural analysis of substrate binding by the TatBC component of the twin-arginine protein transport system

Tarry, M. J., Schaefer, E., Chen, S., Buchanan, G., Greene, N. P., Lea, S. M., Palmer, T., Saibil, H. R. & Berks, B. C. 11-Aug-2009 In : Proceedings of the National Academy of Sciences of the United States of America. 106, 32, p. 13284-13289, 6 p.

Research output: Contribution to journal › Article

Genome-wide association and meta-analysis of bipolar disorder in individuals of European ancestry

Scott, L. J. , Muglia, P. , Kong, X. Q. , Guan, W. , Flickinger, M. , Upmanyu, R. , Tozzi, F. , Li, J. Z. , Burmeisterg, M. , Absher, D. , Thompson, R. C. , Francks, C. , Meng, F. , Antoniades, A. , Southwick, A. M. , Schatzberg, A. F. , Bunney, W. E. , Barchask, J. D. , Jones, E. G. , Day, R. & 13 others Matthews, K., McGuffin, P., Strauss, J. S., Kennedy, J. L., Middleton, L., Roses, A. D., Watson, S. J., Vincent, J. B., Myers, R. M., Farmer, A. E., Akil, H., Burns, D. K. & Boehnke, M. 5-May-2009 In : Proceedings of the National Academy of Sciences of the United States of America. 106, 18, p. 7501-7506, 6 p.

Research output: Contribution to journal › Article

Activated cAMP receptors switch encystation into sporulation

Kawabe, Y., Morio, T., James, J. L., Prescott, A. R., Tanaka, Y. & Schaap, P. 28-Apr-2009 In : Proceedings of the National Academy of Sciences of the United States of America. 106, 17, p. 7089-7094, 6 p.

Research output: Contribution to journal › Article

Identification of the phosphorylation sites on the E3 ubiquitin ligase Pellino that are critical for activation by IRAK1 and IRAK4

Smith, H., Peggie, M., Campbell, D. G., Vandermoere, F., Carrick, E. & Cohen, P. 24-Mar-2009 In : Proceedings of the National Academy of Sciences of the United States of America. 106, 12, p. 4584-4590, 7 p.

Research output: Contribution to journal › Article

Angiotensin II signaling increases activity of the renal Na-Cl cotransporter through a WNK4-SPAK-dependent pathway

San-Cristobal, P., Pacheco-Alvarez, D., Richardson, C., Ring, A. M., Vazquez, N., Rafiqi, F. H., Chari, D., Kahle, K. T., Leng, Q., Bobadilla, N. A., Hebert, S. C., Alessi, D. R., Lifton, R. P. & Gamba, G. 17-Mar-2009 In : Proceedings of the National Academy of Sciences of the United States of America. 106, 11, p. 4384-4389, 6 p.

Research output: Contribution to journal › Article

Coordinate regulation of enzyme markers for inflammation and for protection against oxidants and electrophiles

Liu, H., Dinkova-Kostova, A. T. & Talalay, P. 14-Oct-2008 In : Proceedings of the National Academy of Sciences of the United States of America. 105, 41, p. 15926-15931, 6 p.

Research output: Contribution to journal › Article

Variable stoichiometry of the TatA component of the twin-arginine protein transport system observed by in vivo single-molecule imaging

Leake, M. C., Greene, N. P., Godun, R. M., Granjon, T., Buchanan, G., Chen, S., Berry, R. M., Palmer, T. & Berks, B. C. 7-Oct-2008 In : Proceedings of the National Academy of Sciences of the United States of America. 105, 40, p. 15376-15381, 6 p.

Research output: Contribution to journal › Article

Cell cycle progression requires the CDC-48(UFD-1/NPL-4) complex for efficient DNA replication

Mouysset, J., Deichsel, A., Moser, S., Hoege, C., Hyman, A. A., Gartner, A. & Hoppe, T. 2-Sep-2008 In : Proceedings of the National Academy of Sciences of the United States of America. 105, 35, p. 12879-12884, 6 p.

Research output: Contribution to journal › Article