Discovery - University of Dundee - Online Publications

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Albena Dinkova-Kostova

  1. Keap1, the cysteine-based mammalian intracellular sensor for electrophiles and oxidants

    Dinkova-Kostova, A. T., Kostov, R. V. & Canning, P. 1 Mar 2017 In : Archives of Biochemistry and Biophysics. 617, p. 84-93 10 p.

    Research output: Contribution to journalArticle

  2. KEAP1 and done? Targeting the NRF2 pathway with sulforaphane

    Dinkova-Kostova, A. T., Fahey, J. W., Kostov, R. V. & Kensler, T. W. 16 Feb 2017 In : Trends in Food Science and Technology. 13 p.

    Research output: Contribution to journalReview article

  3. NRF2 as an emerging therapeutic target

    Copple, I. M., Dinkova-Kostova, A. T., Kensler, T. W., Liby, K. T. & Wigley, W. C. 31 Jan 2017 In : Oxidative Medicine and Cellular Longevity. 2017, 2 p., 8165458

    Research output: Contribution to journalEditorial

  4. Regulation of the mammalian heat shock factor 1

    Dayalan Naidu, S. & Dinkova-Kostova, A. 4 Jan 2017 In : FEBS Journal.

    Research output: Contribution to journalReview article

  5. Whole-exome sequencing validates a preclinical mouse model for the prevention and treatment of cutaneous squamous cell carcinoma

    Knatko, E. V., Praslicka, B., Higgins, M., Evans, A., Purdie, K. J., Harwood, C. A., Proby, C. M., Ooi, A. & Dinkova-Kostova, A. T. Jan 2017 In : Cancer Prevention Research. 10, 1, p. 67-75 9 p.

    Research output: Contribution to journalArticle

  6. Semisynthetic flavonoid 7-O-galloylquercetin activates Nrf2 and induces Nrf2-dependent gene expression in RAW264.7 and Hepa1c1c7 cells

    Roubalová, L., Biedermann, D., Papoušková, B., Vacek, J., Kuzma, M., Křen, V., Ulrichová, J., Dinkova-Kostova, A. T. & Vrba, J. 25 Dec 2016 In : Chemico-Biological Interactions. 260, p. 58-66 9 p.

    Research output: Contribution to journalArticle

  7. Regulation of the CNC-bZIP transcription factor Nrf2 by Keap1 and the axis between GSK-3 and β-TrCP

    Hayes, J. D., Ebisine, K., Sharma, R. S., Chowdhry, S., Dinkova-Kostova, A. T. & Sutherland, C. Dec 2016 In : Current Opinion in Toxicology. 1, p. 92-103 12 p.

    Research output: Contribution to journalReview article

  8. The multifaceted role of Nrf2 in mitochondrial function

    Holmström, K. M., Kostov, R. V. & Dinkova-Kostova, A. Dec 2016 In : Current Opinion in Toxicology. 1, p. 80-91 12 p.

    Research output: Contribution to journalArticle

  9. Nrf2-mediated neuroprotection response to recurrent hypoglycemia is insufficient to prevent cognitive impairment in a rodent model of type 1 diabetes

    McNeilly, A. D., Gallagher, J. R., Dinkova-Kostova, A. T., Hayes, J. D., Sharkey, J., Ashford, M. L. J. & McCrimmon, R. J. 1 Oct 2016 In : Diabetes. 65, 10, p. 3151-3160 10 p.

    Research output: Contribution to journalArticle

  10. Heat Shock Factor 1 is a Substrate for p38 Mitogen-Activated Protein Kinases

    Dayalan Naidu, S., Sutherland, C., Zhang, Y., Risco, A., de la Vega, L., Caunt, C. J., Hastie, C. J., Lamont, D. J., Torrente, L., Chowdhry, S., Benjamin, I. J., Keyse, S. M., Cuenda, A. & Dinkova-Kostova, A. T. 15 Sep 2016 In : Molecular and Cellular Biology. 36, 18, p. 2403-2417 15 p.

    Research output: Contribution to journalArticle

  11. Electron affinity of tricyclic, bicyclic, and monocyclic compounds containing cyanoenones correlates with their potency as inducers of a cytoprotective enzyme

    Bensasson, R. V., Dinkova-Kostova, A. T., Zheng, S., Saito, A., Li, W., Zoete, V. & Honda, T. 1 Sep 2016 In : Bioorganic & Medicinal Chemistry Letters. 26, 17, p. 4345-4349 5 p.

    Research output: Contribution to journalArticle

  12. NAD(P)H: quinone oxidoreductase 1 inducer activity of some novel anilinoquinazoline derivatives

    Ghorab, M. M., Alsaid, M. S., Higgins, M., Dinkova-Kostova, A. T., Shahat, A. A., Elghazawy, N. H. & Arafa, R. K. 8 Aug 2016 In : Drug Design, Development and Therapy. 10, p. 2515-2524 10 p.

    Research output: Contribution to journalArticle

  13. Rhodiola rosea L.: from golden root to green cell factories

    Marchev, A. S., Dinkova-Kostova, A. T., György, Z., Mirmazloum, I., Aneva, I. Y. & Georgiev, M. I. Aug 2016 In : Phytochemistry Reviews. 15, 4, p. 515-536 22 p.

    Research output: Contribution to journalArticle

  14. SIRT2- and NRF2-Targeting Thiazole-Containing Compound with Therapeutic Activity in Huntington's Disease Models

    Dinkova-Kostova, A. T. & 23 others Quinti, L., Casale, M., Moniot, S., Pais, T. F., Van Kanegan, M. J., Kaltenbach, L. S., Pallos, J., Lim, R. G., Naidu, S. D., Runne, H., Meisel, L., Rauf, N. A., Leyfer, D., Maxwell, M. M., Saiah, E., Landers, J. E., Luthi-Carter, R., Abagyan, R., Steegborn, C., Marsh, J. L., Lo, D. C., Thompson, L. M. & Kazantsev, A. G. 21 Jul 2016 In : Cell Chemical Biology. 23, 7, p. 849-861 13 p.

    Research output: Contribution to journalArticle

  15. Potency of extracts from selected Egyptian plants as inducers of the Nrf2-dependent chemopreventive enzyme NQO1

    Hamed, A. R., Hegazy, M-E. F., Higgins, M., Mohamed, T. A., Abdel-Azim, N. S., Pare, P. W. & Dinkova-Kostova, A. T. Jul 2016 In : Journal of Natural Medicines. 70, 3, p. 683-688 6 p.

    Research output: Contribution to journalArticle

  16. Loss of Nrf2 abrogates the protective effect of Keap1 down regulation in a preclinical model of cutaneous squamous cell carcinoma

    Knatko, E. V., Higgins, M., Fahey, J. W. & Dinkova-Kostova, A. 24 May 2016 In : Scientific Reports. 6, 7 p., 25804

    Research output: Contribution to journalArticle

  17. Nrf2 activation in the treatment of neurodegenerative diseases: A focus on its role in mitochondrial bioenergetics and function

    Esteras, N., Dinkova-Kostova, A. T. & Abramov, A. Y. May 2016 In : Biological Chemistry. 397, 5, p. 383-400 18 p.

    Research output: Contribution to journalArticle

  18. Chemical constituents and NAD(P)H:Quinone oxidoreductase 1 (NQO1) inducer activity of Teucrium oliverianum Ging. ex Benth

    Shahat, A. A., Alsaid, M. S., Khan, J. A., Higgins, M. & Dinkova-Kostova, A. T. Apr 2016 In : Indian Journal of Traditional Knowledge. 15, 2, p. 232-236 5 p.

    Research output: Contribution to journalArticle

  19. Filaggrin genotype does not determine the skin's threshold to UV-induced erythema

    Forbes, D., Johnston, L., Gardner, J., MacCallum, S. F., Campbell, L. E., Dinkova-Kostova, A. T., McLean, W. H. I., Ibbotson, S. H., Dawe, R. S. & Brown, S. J. Apr 2016 In : Journal of Allergy and Clinical Immunology. 137, 4, p. 1280-1282.e3 6 p.

    Research output: Contribution to journalLetter

  20. Synthesis, molecular modeling and NAD(P)H: quinone oxidoreductase 1 inducer activity of novel 2-phenylquinazolin-4-amine derivatives

    Ghorab, M. M., Alsaid, M. S., Higgins, M., Dinkova-Kostova, A. T., Shahat, A. A., Elghazawy, N. H. & Arafa, R. K. Apr 2016 In : Journal of Enzyme Inhibition and Medicinal Chemistry. 31, 6, p. 1612-1618 7 p.

    Research output: Contribution to journalArticle

  21. Bioactive polymethoxylated flavonoids from Chiliadenus montanus

    Hamed, A. R., Mohamed, T. A., Tawfik, W. A., Hassan, E. M., Higgins, M., El-Toumy, S. A. & Dinkova-Kostova, A. T. 31 Mar 2016 In : Journal of Chemical and Pharmaceutical Research. 8, 3, p. 788-793 6 p.

    Research output: Contribution to journalArticle

  22. The multifaceted role of sulforaphane in protection against uv radiation-mediated skin damage

    Benedict, A. L., Knatko, E. V., Kostov, R. V., Zhang, Y., Higgins, M., Kalra, S., Fahey, J. W., Ibbotson, S. H., Proby, C. M., Talalay, P. & Dinkova-Kostova, A. T. Jan 2016 Broccoli: Cultivation, Nutritional Properties and Effects on Health. Nova Science Publishers, Inc., p. 185-208 24 p.

    Research output: Chapter in Book/Report/Conference proceedingChapter

  23. NAD(P)H: Quinone oxidoreductase 1 inducer activity of novel 4-aminoquinazoline derivatives

    Ghorab, M. M., Alsaid, M. S., El-Gazzar, M. G., Higgins, M., Dinkova-Kostova, A. T. & Shahat, A. A. 2016 In : Journal of Enzyme Inhibition and Medicinal Chemistry. 31, 6, p. 1369-1374 7 p.

    Research output: Contribution to journalArticle

  24. Synthesis and NAD(P)H: Quinone oxidoreductase 1 inducer activity of acetamide and pyridine-3-carbonitrile derivatives

    Ghorab, M. M., Shahat, A. A., Alsaid, M. S., Higgins, M., Dinkova-Kostova, A. T. & Naser, A. A. 2016 In : Biomedical Research. 27, 4

    Research output: Contribution to journalArticle

  25. Mechanisms of activation of the transcription factor Nrf2 by redox stressors, nutrient cues, and energy status and the pathways through which it attenuates degenerative disease

    Tebay, L. E., Robertson, H., Durant, S. T., Vitale, S. R., Penning, T. M., Dinkova-Kostova, A. T. & Hayes, J. D. Nov 2015 In : Free Radical Biology and Medicine. 88, Part B, p. 108-146 39 p.

    Research output: Contribution to journalArticle

  26. The emerging role of Nrf2 in mitochondrial function

    Dinkova-Kostova, A. T. & Abramov, A. Y. Nov 2015 In : Free Radical Biology and Medicine. 88, Part B, p. 179-188 10 p.

    Research output: Contribution to journalArticle

  27. Pharmacokinetics and pharmacodynamics of orally administered acetylenic tricyclic bis(cyanoenone), a highly potent Nrf2 activator with a reversible covalent mode of action

    Kostov, R. V., Knatko, E. V., McLaughlin, L. A., Henderson, C. J., Zheng, S., Huang, J. T. J., Honda, T. & Dinkova-Kostova, A. T. 25 Sep 2015 In : Biochemical and Biophysical Research Communications. 465, 3, p. 402-407 6 p.

    Research output: Contribution to journalArticle

  28. Design, synthesis, and evaluation of triazole derivatives that induce Nrf2 dependent gene products and inhibit the Keap1-Nrf2 protein-protein interaction

    Bertrand, H. C., Schaap, M., Baird, L., Georgakopoulos, N. D., Fowkes, A., Thiollier, C., Kachi, H., Dinkova-Kostova, A. T. & Wells, G. 24 Sep 2015 In : Journal of Medicinal Chemistry. 58, 18, p. 7186-7194 9 p.

    Research output: Contribution to journalArticle

  29. Dual regulation of transcription factor Nrf2 by Keap1 and by the combined actions of β-TrCP and GSK-3

    Hayes, J. D., Chowdhry, S., Dinkova-Kostova, A. T. & Sutherland, C. Aug 2015 In : Biochemical Society Transactions. 43, 4, p. 611-620 10 p.

    Research output: Contribution to journalArticle

  30. The spatiotemporal regulation of the Keap1-Nrf2 pathway and its importance in cellular bioenergetics

    Dinkova-Kostova, A. T., Baird, L., Holmström, K. M., Meyer, C. J. & Abramov, A. Y. Aug 2015 In : Biochemical Society Transactions. 43, 4, p. 602-610 9 p.

    Research output: Contribution to journalArticle

  31. New monocyclic, bicyclic, and tricyclic ethynylcyanodienones as activators of the Keap1/Nrf2/ARE pathway and inhibitors of inducible nitric oxide synthase

    Li, W., Zheng, S., Higgins, M., Morra, R. P., Mendis, A. T., Chien, C-W., Ojima, I., Mierke, D. F., Dinkova-Kostova, A. T. & Honda, T. 11 Jun 2015 In : Journal of Medicinal Chemistry. 58, 11, p. 4738-4748 11 p.

    Research output: Contribution to journalArticle

  32. Nrf2 activation protects against solar-simulated ultraviolet radiation in mice and humans

    Knatko, E. V., Ibbotson, S. H., Zhang, Y., Higgins, M., Fahey, J. W., Talalay, P., Dawe, R. S., Ferguson, J., Huang, J. T-J., Clarke, R., Zheng, S., Saito, A., Kalra, S., Benedict, A. L., Honda, T., Proby, C. M. & Dinkova-Kostova, A. T. Jun 2015 In : Cancer Prevention Research. 8, 6, p. 475-486 12 p.

    Research output: Contribution to journalArticle

  33. Nrf2 regulates ROS production by mitochondria and NADPH oxidase

    Kovac, S., Angelova, P. R., Holmström, K. M., Zhang, Y., Dinkova-Kostova, A. T. & Abramov, A. Y. Apr 2015 In : Biochimica et Biophysica Acta: General Subjects. 1850, 4, p. 794-801 8 p.

    Research output: Contribution to journalArticle

  34. Transcription factors Hsf1 and Nrf2 engage in crosstalk for cytoprotection

    Dayalan Naidu, S., Kostov, R. V. & Dinkova-Kostova, A. T. Jan 2015 In : Trends in Pharmacological Sciences. 36, 1, p. 6-14 9 p.

    Research output: Contribution to journalArticle

  35. NAD(P)H: Quinone oxidoreductase 1 inducer activity of some enaminone derivatives

    Alsaid, M. S., Ghorab, M. M., Higgins, M., Dinkova-Kostova, A. T. & Shahat, A. A. 2015 In : Biomedical Research. 26, 1, p. 7-12 6 p.

    Research output: Contribution to journalArticle

  36. Novel Thioureido Derivatives Carrying Thione and Sulfonamide Moieties Induce the Cytoprotective Enzyme NAD(P)H:Quione Oxidoreductase 1: Quinone oxidoreductase 1

    Ghorab, M. M., Higgins, M., Dinkova-Kostova, A. T., Alsaid, M. S. & Shahat, A. A. 1 Dec 2014 In : Asian Journal of Chemistry. 26, 24, p. 8501-8504 4 p.

    Research output: Contribution to journalArticle

  37. Monitoring Keap1-Nrf2 interactions in single live cells

    Baird, L., Swift, S., Llères, D. & Dinkova-Kostova, A. T. 1 Nov 2014 In : Biotechnology Advances. 32, 6, p. 1133-1144 12 p.

    Research output: Contribution to journalArticle

  38. Chemical tuning enhances both potency toward Nrf2 and in vitro therapeutic index of triterpenoids

    Copple, I. M., Shelton, L. M., Walsh, J., Kratschmar, D. V., Lister, A., Odermatt, A., Goldring, C. E., Dinkova-Kostova, A. T., Honda, T. & Park, B. K. Aug 2014 In : Toxicological Sciences. 140, 2, p. 462-469 8 p.

    Research output: Contribution to journalArticle

  39. Synthesis of 13C215N2-labeled anti-inflammatory and cytoprotective tricyclic bis(cyanoenone) ([13C215N2]-TBE-31) as an internal standard for quantification by stable isotope dilution LC-MS method

    Zheng, S., Huang, J. T. -J., Knatko, E. V., Sharp, S., Higgins, M., Ojima, I., Dinkova-Kostova, A. T. & Honda, T. Aug 2014 In : Journal of Labelled Compounds & Radiopharmaceuticals. 57, 10, p. 606-610 5 p.

    Research output: Contribution to journalArticle

  40. Nrf2 affects the efficiency of mitochondrial fatty acid oxidation

    Ludtmann, M. H. R., Angelova, P. R., Zhang, Y., Abramov, A. Y. & Dinkova-Kostova, A. T. 1 Feb 2014 In : Biochemical Journal. 457, 3, p. 415-424 10 p.

    Research output: Contribution to journalArticle

  41. Sulphoxythiocarbamates modify cysteine residues in HSP90 causing degradation of client proteins and inhibition of cancer cell proliferation

    Zhang, Y., Dayalan Naidu, S., Samarasinghe, K., Van Hecke, G. C., Pheely, A., Boronina, T. N., Cole, R. N., Benjamin, I. J., Cole, P. A., Ahn, Y-H. & Dinkova-Kostova, A. T. 7 Jan 2014 In : British Journal of Cancer. 110, 1, p. 71-82 12 p.

    Research output: Contribution to journalArticle

  42. Nrf2 impacts cellular bioenergetics by controlling substrate availability for mitochondrial respiration

    Holmström, K. M., Baird, L., Zhang, Y., Hargreaves, I., Chalasani, A., Land, J. M., Stanyer, L., Yamamoto, M., Dinkova-Kostova, A. T. & Abramov, A. Y. 15 Aug 2013 In : Open Biology. 2, 8, p. 761-770 10 p.

    Research output: Contribution to journalArticle

  43. NAD(P)H: Quinone oxidoreductase 1 inducer activity of some Saudi Arabian medicinal plants

    Shahat, A. A., Alsaid, M. S., Alyahya, M. A., Higgins, M. & Dinkova-Kostova, A. T. Apr 2013 In : Planta Medica. 79, 6, p. 459-464 6 p.

    Research output: Contribution to journalArticle

  44. Chemoprotection Against Cancer by Isothiocyanates: A Focus on the Animal Models and the Protective Mechanisms

    Dinkova-Kostova, A. T. 2013 Natural Products in Cancer Prevention and Therapy. Pezzuto, J. M. & Suh, N. (eds.). Berlin: Springer , p. 179-201 23 p. (Topics in Current Chemistry; vol. 329)

    Research output: Chapter in Book/Report/Conference proceedingChapter

  45. The indirect antioxidant sulforaphane protects against thiopurine-mediated photooxidative stress

    Benedict, A. L., Knatko, E. V. & Dinkova-Kostova, A. T. Dec 2012 In : Carcinogenesis. 33, 12, p. 2457-2466 10 p.

    Research output: Contribution to journalArticle

  46. Synthesis, chemical reactivity as Michael acceptors, and biological potency of monocyclic cyanoenones, novel and highly potent anti-inflammatory and cytoprotective agents

    Zheng, S., Laxmi, Y. R. S., David, E., Dinkova-Kostova, A. T., Shiavoni, K. H., Ren, Y., Zheng, Y., Trevino, I., Bumeister, R., Ojima, I., Wigley, W. C., Bliska, J. B., Mierke, D. F. & Honda, T. 24 May 2012 In : Journal of Medicinal Chemistry. 55, 10, p. 4837-4846 10 p.

    Research output: Contribution to journalArticle

  47. Arthur Neish Young Investigator Award Lecture a Novel Role for Sulfhydryl-Reactive Activators of Transcription Factor NRF2: HSF1-Dependent Upregulation of Hsp70

    Zhang, Y., Ahn, Y-H., Calabrese, V., Cole, P. A. & Dinkova-Kostova, A. T. May 2012 In : Pharmaceutical Biology. 50, 5, p. 625-625 1 p.

    Research output: Contribution to journalSpecial issue

  48. Cellular stress responses, hormetic phytochemicals and vitagenes in aging and longevity

    Calabrese, V., Cornelius, C., Dinkova-Kostova, A. T., Iavicoli, I., Di Paola, R., Koverech, A., Cuzzocrea, S., Rizzarelli, E. & Calabrese, E. J. May 2012 In : Biochimica et Biophysica Acta. Molecular Basis of Disease. 1822, 5, p. 753-783 31 p.

    Research output: Contribution to journalReview article

  49. Glutathione S-transferase genotype is associated with sensitivity to psoralen-ultraviolet A photochemotherapy

    Ibbotson, S. H., Dawe, R. S., Dinkova-Kostova, A. T., Weidlich, S., Farr, P. M., Ferguson, J., Wolf, C. R. & Smith, G. Feb 2012 In : British Journal of Dermatology. 166, 2, p. 380-388 9 p.

    Research output: Contribution to journalArticle

  50. Glucosinolates and isothiocyanates in health and disease

    Dinkova-Kostova, A. T. & Kostov, R. V. 2012 In : Trends in Molecular Medicine. 18, 6, p. 337-347 11 p.

    Research output: Contribution to journalArticle

  51. Highly potent activation of Nrf2 by topical tricyclic bis(cyano enone): Implications for protection against UV radiation during thiopurine therapy

    Kalra, S., Knatko, E. V., Zhang, Y., Honda, T., Yamamoto, M. & Dinkova-Kostova, A. T. 2012 In : Cancer Prevention Research. 5, 7, p. 973-981 9 p.

    Research output: Contribution to journalArticle

  52. Neuroprotective effects of sulforaphane after contusive spinal cord injury

    Benedict, A. L., Mountney, A., Hurtado, A., Bryan, K. E., Schnaar, R. L., Dinkova-Kostova, A. T. & Talalay, P. 2012 In : Journal of Neurotrauma. 29, 16, p. 2576-2586 11 p.

    Research output: Contribution to journalArticle

  53. HSF1-Dependent Upregulation of Hsp70 by Sulfhydryl-Reactive Inducers of the KEAP1/NRF2/ARE Pathway

    Zhang, Y., Ahn, Y-H., Benjamin, I. J., Honda, T., Hicks, R. J., Calabrese, V., Cole, P. A. & Dinkova-Kostova, A. T. 23 Nov 2011 In : Chemistry & Biology. 18, 11, p. 1355-1361 7 p.

    Research output: Contribution to journalArticle

  54. Oral Azathioprine Leads to Higher Incorporation of 6-Thioguanine in DNA of Skin than Liver: The Protective Role of the Keap1/Nrf2/ARE Pathway

    Kalra, S., Zhang, Y., Knatko, E. V., Finlayson, S., Yamamoto, M. & Dinkova-Kostova, A. T. Oct 2011 In : Cancer Prevention Research. 4, 10, p. 1665-1674 10 p.

    Research output: Contribution to journalArticle

  55. Induction of the Keapl/Nrf2/ARE pathway by oxidizable diphenols

    Dinkova-Kostova, A. T. & Wang, X. J. 30 Jun 2011 In : Chemico-Biological Interactions. 192, 1-2, p. 101-106 6 p.

    Research output: Contribution to journalArticle

  56. Synthesis and biological evaluation of 1-[2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oyl]-4-ethynylimidazole. A novel and highly potent anti-inflammatory and cytoprotective agent

    Honda, T., Dinkova-Kostova, A. T., David, E., Padegimas, E. M., Sundararajan, C., Visnick, M., Bumeister, R. & Wigley, W. C. 15 Apr 2011 In : Bioorganic & Medicinal Chemistry Letters. 21, 8, p. 2188-2191 4 p.

    Research output: Contribution to journalArticle

  57. The cytoprotective role of the Keap1-Nrf2 pathway

    Baird, L. & Dinkova-Kostova, A. T. Apr 2011 In : Archives of Toxicology. 85, 4, p. 241-272 32 p.

    Research output: Contribution to journalReview article

  58. Effects of chemoprotective agent HBB-2 on cell survival in SH-SY5Y neuroblastoma cells

    Scuto, M. C., Cavallaro, M. M., Luca, M., Cornelius, C., Cambria, M. T., Rizza, S., Salinaro, A. T., Dinkova-Kostova, A. & Calabrese, V. 2011 In : FEBS Journal. 278, S1, p. 268 1 p., P14.37

    Research output: Contribution to journalMeeting abstract

  59. Cellular Stress Responses, The Hormesis Paradigm, and Vitagenes: Novel Targets for Therapeutic Intervention in Neurodegenerative Disorders

    Calabrese, V., Cornelius, C., Dinkova-Kostova, A. T., Calabrese, E. J. & Mattson, M. P. Dec 2010 In : Antioxidants & Redox Signaling. 13, 11, p. 1763-1811 49 p.

    Research output: Contribution to journalReview article

  60. An Exceptionally Potent Inducer of Cytoprotective Enzymes elucidation of the structural features that determine inducer potency and reactivity with Keap1

    Dinkova-Kostova, A. T., Talalay, P., Sharkey, J., Zhang, Y., Holtzclaw, W. D., Wang, X. J., David, E., Schiavoni, K. H., Finlayson, S., Mierke, D. F. & Honda, T. 29 Oct 2010 In : Journal of Biological Chemistry. 285, 44, p. 33747-33755 9 p.

    Research output: Contribution to journalArticle

  61. The effectiveness of the isothiocyanate sulforaphane in chemoprotection

    Dinkova-Kostova, A. T. Jun 2010 Proceedings of the Vth international symposium on brassicas, and XVIth crucifer genetics workshop . Hansen, M. (ed.). Lillehammer, Norway: International Society for Horticultural Science , Vol. 867, p. 27-36 10 p. (Acta Horticulturae; vol. 867)

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

  62. Electrophilic tuning of the chemoprotective natural product sulforaphane

    Ahn, Y-H., Hwang, Y., Liu, H., Wang, X-J., Zhang, Y., Stephenson, K. K., Boronina, T. N., Cole, R. N., Dinkova-Kostova, A. T., Talalay, P. & Cole, P. A. 25 May 2010 In : Proceedings of the National Academy of Sciences of the United States of America. 107, 21, p. 9590-9595 6 p.

    Research output: Contribution to journalArticle

  63. Glutathione S-transferase M1 (GSTM1) genotype is associated with serum 8-MOP concentration and PUVA sensitivity

    Ibbotson, S. H., Dawe, R. S., Weidlich, S., Dinkova-Kostova, A. T., Farr, P. M., Ferguson, J., Wolf, C. R. & Smith, G. Apr 2010 In : British Journal of Dermatology. 162, 4, p. 941-941 1 p.

    Research output: Contribution to journalMeeting abstract

  64. Activation of the NRF2 Signaling Pathway by Copper-Mediated Redox Cycling of Para- and Ortho-Hydroquinones

    Wang, X. J., Hayes, J. D., Higgins, L. G., Wolf, C. R. & Dinkova-Kostova, A. T. 29 Jan 2010 In : Chemistry & Biology. 17, 1, p. 75-85 11 p.

    Research output: Contribution to journalArticle

  65. Cancer chemoprevention mechanisms mediated through the Keap1-Nrf2 pathway

    Hayes, J. D., McMahon, M., Chowdhry, S. & Dinkova-Kostova, A. T. 2010 In : Antioxidants & Redox Signaling. 13, 11, p. 1713-1748 36 p.

    Research output: Contribution to journalArticle

  66. Dietary glucoraphanin-rich broccoli sprout extracts protect against UV radiation-induced skin carcinogenesis in SKH-1 hairless mice

    Dinkova-Kostova, A. T., Fahey, J. W., Benedict, A. L., Jenkins, S. N., Ye, L., Wehage, S. L. & Talalay, P. 2010 In : Photochemical & Photobiological Sciences. 9, 4, p. 597-600 4 p.

    Research output: Contribution to journalArticle

  67. Loss of Nrf2 markedly exacerbates nonalcoholic steatohepatitis

    Chowdhry, S., Nazmy, M. H., Meakin, P. J., Dinkova-Kostova, A. T., Walsh, S. V., Tsujita, T., Dillon, J. F., Ashford, M. L. J. & Hayes, J. D. 2010 In : Free Radical Biology and Medicine. 48, 2, p. 357-371 15 p.

    Research output: Contribution to journalArticle

  68. Nitric Oxide in Cell Survival: A Janus Molecule

    Calabrese, V., Cornelius, C., Rizzarelli, E., Owen, J. B., Dinkova-Kostova, A. T. & Butterfield, D. A. Nov 2009 In : Antioxidants & Redox Signaling. 11, 11, p. 2717-2739 23 p.

    Research output: Contribution to journalReview article

  69. Precise determination of the erythema response of human skin to ultraviolet radiation and quantification of effects of protectors

    Healy, Z. R., Dinkova-Kostova, A. T., Wehage, S. L., Thompson, R. E., Fahey, J. W. & Talalay, P. Feb 2009 In : Photodermatology, Photoimmunology & Photomedicine. 25, 1, p. 45-50 6 p.

    Research output: Contribution to journalArticle

  70. Vitagenes, cellular stress response, and acetylcarnitine: Relevance to hormesis

    Calabrese, V., Cornelius, C., Dinkova-Kostova, A. T. & Calabrese, E. J. 2009 In : BioFactors. 35, 2, p. 146-160 15 p.

    Research output: Contribution to journalReview article

  71. Phytochemicals as Protectors Against Ultraviolet Radiation: Versatility of Effects and Mechanisms

    Dinkova-Kostova, A. T. Oct 2008 In : Planta Medica. 74, 13, p. 1548-1559 12 p.

    Research output: Contribution to journalReview article

  72. Curcumin and the cellular stress response in free radical-related diseases

    Calabrese, V., Bates, T. E., Mancuso, C., Cornelius, C., Ventimiglia, B., Cambria, M. T., Di Renzo, L., De Lorenzo, A. & Dinkova-Kostova, A. T. Sep 2008 In : Molecular Nutrition & Food Research. 52, 9, p. 1062-1073 12 p.

    Research output: Contribution to journalReview article

  73. A novel acetylenic tricyclic bis-(cyano enone) potently induces phase 2 cytoprotective pathways and blocks liver carcinogenesis induced by aflatoxin

    Liby, K., Yore, M. M., Roebuck, B. D., Baumgartner, K. J., Honda, T., Sundararajan, C., Yoshizawa, H., Gribble, G. W., Williams, C. R., Risingsong, R., Royce, D. B., Dinkova-Kostova, A. T., Stephenson, K. K., Egner, P. A., Yates, M. S., Groopman, J. D., Kensler, T. W. & Sporn, M. B. 15 Aug 2008 In : Cancer Research. 68, 16, p. 6727-6733 7 p.

    Research output: Contribution to journalArticle

  74. Rapid body weight gain increases the risk of UV radiation-induced skin carcinogenesis in SKH-1 hairless mice

    Dinkova-Kostova, A. T., Fahey, J. W., Jenkins, S. N., Wehage, S. L. & Talalay, P. Aug 2008 In : Molecular Nutrition & Food Research. 28, 8, p. 539-543 5 p.

    Research output: Contribution to journalArticle

  75. Direct and indirect antioxidant properties of inducers of cytoprotective proteins

    Dinkova-Kostova, A. T. & Talalay, P. Jun 2008 In : Molecular Nutrition & Food Research. 52, p. S128-S138 11 p.

    Research output: Contribution to journalReview article

  76. Two-step mechanism of induction of the gene expression of a prototypic cancer-protective enzyme by diphenols

    Bensasson, R. V., Zoete, V., Dinkova-Kostova, A. T. & Talalay, P. Apr 2008 In : Chemical Research in Toxicology. 21, 4, p. 805-812 8 p.

    Research output: Contribution to journalArticle

  77. A dicyanotriterpenoid induces cytoprotective enzymes and reduces multiplicity of skin tumors in UV-irradiated mice

    Dinkova-Kostova, A. T., Jenkins, S. N., Wehage, S. L., Huso, D. L., Benedict, A. L., Stephenson, K. K., Fahey, J. W., Liu, H., Liby, K. T., Honda, T., Gribble, G. W., Sporn, M. B. & Talalay, P. 21 Mar 2008 In : Biochemical and Biophysical Research Communications. 367, 4, p. 859-865 7 p.

    Research output: Contribution to journalArticle

  78. Cellular stress response: a novel target for chemoprevention and nutritional neuroprotection in aging, neurodegenerative disorders and longevity

    Calabrese, V., Cornelius, C., Mancuso, C., Pennisi, G., Calafato, S., Bellia, F., Bates, T. E., Giuffrida Stella, A. M., Schapira, T., Rizzarelli, E. & Dinkova-Kostova, A. 2008 In : Neurochemical Research. 33, 12, p. 2444-71 28 p.

    Research output: Contribution to journalArticle

  79. Practical approaches to investigate redox regulation of heat shock protein expression and intracellular glutathione redox state

    Calabrese, V., Signorile, A., Cornelius, C., Mancuso, C., Scapagnini, G., Ventimiglia, B., Ragusa, N. & Dinkova-Kostova, A. 2008 Nitric oxide, Part G oxidative and nitrosative stress in redox regulation of cell signaling. Cadenas, E. & Packer, L. (eds.). San Diego: Academic Press, p. 83-110 28 p. (Methods in Enzymology; vol. 441)

    Research output: Chapter in Book/Report/Conference proceedingOther chapter contribution

  80. Extremely potent triterpenoid inducers of the phase 2 response: correlations of protection against oxidant and inflammatory stress

    Dinkova-Kostova, A. T., Liby, K. T., Stephenson, K. K., Holtzclaw, W. D., Gao, X., Suh, N., Williams, C., Risingsong, R., Honda, T., Gribble, G. W., Sporn, M. B. & Talalay, P. Mar 2005 In : Proceedings of the National Academy of Sciences of the United States of America. 102, 12, p. 4584-4589 6 p.

    Research output: Contribution to journalArticle

  81. Protection against electrophile and oxidant stress by induction of the phase 2 response: fate of cysteines of the Keap1 sensor modified by inducers

    Wakabayashi, N., Dinkova-Kostova, A. T., Holtzclaw, W. D., Kang, M-I., Kobayashi, A., Yamamoto, M., Kensler, T. W. & Talalay, P. Feb 2004 In : Proceedings of the National Academy of Sciences of the United States of America. 101, 7, p. 2040-2045 6 p.

    Research output: Contribution to journalArticle

  82. Direct evidence that sulfhydryl groups of Keap1 are the sensors regulating induction of phase 2 enzymes that protect against carcinogens and oxidants

    Dinkova-Kostova, A. T., Holtzclaw, W. D., Cole, R. N., Itoh, K., Wakabayashi, N., Katoh, Y., Yamamoto, M. & Talalay, P. Sep 2002 In : Proceedings of the National Academy of Sciences of the United States of America. 99, 18, p. 11908-11913 6 p.

    Research output: Contribution to journalArticle

  83. Potency of Michael reaction acceptors as inducers of enzymes that protect against carcinogenesis depends on their reactivity with sulfhydryl groups

    Dinkova-Kostova, A. T., Massiah, M. A., Bozak, R. E., Hicks, R. J. & Talalay, P. Mar 2001 In : Diabetes. 98, 6, p. 3404-3409 6 p.

    Research output: Contribution to journalArticle

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