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Albena Dinkova-Kostova

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  1. Diffusion dynamics of the Keap1-Cullin3 interaction in single live cells

    Baird, L. & Dinkova-Kostova, A. T. 29-Mar-2013 In : Biochemical and Biophysical Research Communications. 433, 1, p. 58-65, 8 p.

    Research output: Contribution to journal › Article

  2. Synthesis, chemical reactivity as Michael acceptors, and biological potency of monocyclic cyanoenones, novel and highly potent anti-inflammatory and cytoprotective agents

    Zheng, S., Laxmi, Y. R. S., David, E., Dinkova-Kostova, A. T., Shiavoni, K. H., Ren, Y., Zheng, Y., Trevino, I., Bumeister, R., Ojima, I., Wigley, W. C., Bliska, J. B., Mierke, D. F. & Honda, T. 24-May-2012 In : Journal of Medicinal Chemistry. 55, 10, p. 4837-4846, 10 p.

    Research output: Contribution to journal › Article

  3. Arthur Neish Young Investigator Award Lecture a Novel Role for Sulfhydryl-Reactive Activators of Transcription Factor NRF2: HSF1-Dependent Upregulation of Hsp70

    Zhang, Y., Ahn, Y-H., Calabrese, V., Cole, P. A. & Dinkova-Kostova, A. T. May-2012 In : Pharmaceutical Biology. 50, 5, p. 625-625, 1 p.

    Research output: Contribution to journal › Special issue

  4. Cellular stress responses, hormetic phytochemicals and vitagenes in aging and longevity

    Calabrese, V., Cornelius, C., Dinkova-Kostova, A. T., Iavicoli, I., Di Paola, R., Koverech, A., Cuzzocrea, S., Rizzarelli, E. & Calabrese, E. J. May-2012 In : Biochimica et Biophysica Acta. Molecular Basis of Disease. 1822, 5, p. 753-783, 31 p.

    Research output: Contribution to journal › Scientific review

  5. Glutathione S-transferase genotype is associated with sensitivity to psoralen-ultraviolet A photochemotherapy

    Ibbotson, S. H., Dawe, R. S., Dinkova-Kostova, A. T., Weidlich, S., Farr, P. M., Ferguson, J., Wolf, C. R. & Smith, G. 1-Jan-2012 In : British Journal of Dermatology. 166, 2, p. 380-388, 9 p.

    Research output: Contribution to journal › Article

  6. Glucosinolates and isothiocyanates in health and disease

    Dinkova-Kostova, A. T. & Kostov, R. V. 2012 In : Trends in Molecular Medicine. 18, 6, p. 337-347, 11 p.

    Research output: Contribution to journal › Article

  7. Highly potent activation of Nrf2 by topical tricyclic bis(cyano enone): Implications for protection against UV radiation during thiopurine therapy

    Kalra, S., Knatko, E. V., Zhang, Y., Honda, T., Yamamoto, M. & Dinkova-Kostova, A. T. 2012 In : Cancer Prevention Research. 5, 7, p. 973-981, 9 p.

    Research output: Contribution to journal › Article

  8. HSF1-Dependent Upregulation of Hsp70 by Sulfhydryl-Reactive Inducers of the KEAP1/NRF2/ARE Pathway

    Zhang, Y., Ahn, Y-H., Benjamin, I. J., Honda, T., Hicks, R. J., Calabrese, V., Cole, P. A. & Dinkova-Kostova, A. T. 23-Nov-2011 In : Chemistry & Biology. 18, 11, p. 1355-1361, 7 p.

    Research output: Contribution to journal › Article

  9. Oral Azathioprine Leads to Higher Incorporation of 6-Thioguanine in DNA of Skin than Liver: The Protective Role of the Keap1/Nrf2/ARE Pathway

    Kalra, S., Zhang, Y., Knatko, E. V., Finlayson, S., Yamamoto, M. & Dinkova-Kostova, A. T. Oct-2011 In : Cancer Prevention Research. 4, 10, p. 1665-1674, 10 p.

    Research output: Contribution to journal › Article

  10. Induction of the Keapl/Nrf2/ARE pathway by oxidizable diphenols

    Dinkova-Kostova, A. T. & Wang, X. J. 30-Jun-2011 In : Chemico-Biological Interactions. 192, 1-2, p. 101-106, 6 p.

    Research output: Contribution to journal › Article

  11. Effects of chemoprotective agent HBB-2 on cell survival in SH-SY5Y neuroblastoma cells

    Scuto, M. C., Cavallaro, M. M., Luca, M., Cornelius, C., Cambria, M. T., Rizza, S., Salinaro, A. T., Dinkova-Kostova, A. & Calabrese, V. Jun-2011 In : FEBS Journal. 278, p. 268-268, 1 p.

    Research output: Contribution to journal › Meeting abstract

  12. Synthesis and biological evaluation of 1-[2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oyl]-4-ethynylimidazole. A novel and highly potent anti-inflammatory and cytoprotective agent

    Honda, T., Dinkova-Kostova, A. T., David, E., Padegimas, E. M., Sundararajan, C., Visnick, M., Bumeister, R. & Wigley, W. C. 15-Apr-2011 In : Bioorganic & Medicinal Chemistry Letters. 21, 8, p. 2188-2191, 4 p.

    Research output: Contribution to journal › Article

  13. The cytoprotective role of the Keap1-Nrf2 pathway

    Baird, L. & Dinkova-Kostova, A. T. Apr-2011 In : Archives of Toxicology. 85, 4, p. 241-272, 32 p.

    Research output: Contribution to journal › Scientific review

  14. Cellular Stress Responses, The Hormesis Paradigm, and Vitagenes: Novel Targets for Therapeutic Intervention in Neurodegenerative Disorders

    Calabrese, V., Cornelius, C., Dinkova-Kostova, A. T., Calabrese, E. J. & Mattson, M. P. Dec-2010 In : Antioxidants & Redox Signaling. 13, 11, p. 1763-1811, 49 p.

    Research output: Contribution to journal › Scientific review

  15. An Exceptionally Potent Inducer of Cytoprotective Enzymes elucidation of the structural features that determine inducer potency and reactivity with Keap1

    Dinkova-Kostova, A. T., Talalay, P., Sharkey, J., Zhang, Y., Holtzclaw, W. D., Wang, X. J., David, E., Schiavoni, K. H., Finlayson, S., Mierke, D. F. & Honda, T. 29-Oct-2010 In : Journal of Biological Chemistry. 285, 44, p. 33747-33755, 9 p.

    Research output: Contribution to journal › Article

  16. NAD(P)H:quinone acceptor oxidoreductase 1 (NQO1), a multifunctional antioxidant enzyme and exceptionally versatile cytoprotector

    Dinkova-Kostova, A. T. & Talalay, P. 1-Sep-2010 In : Archives of Biochemistry and Biophysics. 501, 1, p. 116-123, 8 p.

    Research output: Contribution to journal › Scientific review

  17. Potency ranking of triterpenoids as inducers of a cytoprotective enzyme and as inhibitors of a cellular inflammatory response via their electron affinity and their electrophilicity index

    Bensasson, R. V., Zoete, V., Berthier, G., Talalay, P. & Dinkova-Kostova, A. T. 30-Jul-2010 In : Chemico-Biological Interactions. 186, 2, p. 118-126, 9 p.

    Research output: Contribution to journal › Article

  18. The effectiveness of the isothiocyanate sulforaphane in chemoprotection

    Dinkova-Kostova, A. T. Jun-2010 Acta Horticulturae. Hansen, M. (ed.). Lillehammer, Norway: International Society for Horticultural Science , Vol. 867, p. 27-36 10 p.

    Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

  19. Electrophilic tuning of the chemoprotective natural product sulforaphane

    Ahn, Y-H., Hwang, Y., Liu, H., Wang, X-J., Zhang, Y., Stephenson, K. K., Boronina, T. N., Cole, R. N., Dinkova-Kostova, A. T., Talalay, P. & Cole, P. A. 25-May-2010 In : Proceedings of the National Academy of Sciences of the United States of America. 107, 21, p. 9590-9595, 6 p.

    Research output: Contribution to journal › Article

  20. Glutathione S-transferase M1 (GSTM1) genotype is associated with serum 8-MOP concentration and PUVA sensitivity

    Ibbotson, S. H., Dawe, R. S., Weidlich, S., Dinkova-Kostova, A. T., Farr, P. M., Ferguson, J., Wolf, C. R. & Smith, G. Apr-2010 In : British Journal of Dermatology. 162, 4, p. 941-941, 1 p.

    Research output: Contribution to journal › Meeting abstract

  21. Activation of the NRF2 Signaling Pathway by Copper-Mediated Redox Cycling of Para- and Ortho-Hydroquinones

    Wang, X. J., Hayes, J. D., Higgins, L. G., Wolf', C. R. & Dinkova-Kostova, A. T. 29-Jan-2010 In : Chemistry & Biology. 17, 1, p. 75-85, 11 p.

    Research output: Contribution to journal › Article

  22. Cancer chemoprevention mechanisms mediated through the Keap1-Nrf2 pathway

    Hayes, J. D., McMahon, M., Chowdhry, S. & Dinkova-Kostova, A. T. 2010 In : Antioxidants & Redox Signaling. 13, 11, p. 1713-1748, 36 p.

    Research output: Contribution to journal › Article

  23. Dietary glucoraphanin-rich broccoli sprout extracts protect against UV radiation-induced skin carcinogenesis in SKH-1 hairless mice

    Dinkova-Kostova, A. T., Fahey, J. W., Benedict, A. L., Jenkins, S. N., Ye, L., Wehage, S. L. & Talalay, P. 2010 In : Photochemical & Photobiological Sciences. 9, 4, p. 597-600, 4 p.

    Research output: Contribution to journal › Article

  24. Loss of Nrf2 markedly exacerbates nonalcoholic steatohepatitis

    Chowdhry, S., Nazmy, M. H., Meakin, P. J., Dinkova-Kostova, A. T., Walsh, S. V., Tsujita, T., Dillon, J. F., Ashford, M. L. J. & Hayes, J. D. 2010 In : Free Radical Biology and Medicine. 48, 2, p. 357-371, 15 p.

    Research output: Contribution to journal › Article

  25. Nitric Oxide in Cell Survival: A Janus Molecule

    Calabrese, V., Cornelius, C., Rizzarelli, E., Owen, J. B., Dinkova-Kostova, A. T. & Butterfield, D. A. Nov-2009 In : Antioxidants & Redox Signaling. 11, 11, p. 2717-2739, 23 p.

    Research output: Contribution to journal › Scientific review

  26. Cross-talk between Transcription Factors AhR and Nrf2: Lessons for Cancer Chemoprevention from Dioxin

    Hayes, J. D., Dinkova-Kostova, A. T. & McMahon, M. Oct-2009 In : Toxicological Sciences. 111, 2, p. 199-201, 3 p.

    Research output: Contribution to journal › Editorial

  27. Precise determination of the erythema response of human skin to ultraviolet radiation and quantification of effects of protectors

    Healy, Z. R., Dinkova-Kostova, A. T., Wehage, S. L., Thompson, R. E., Fahey, J. W. & Talalay, P. Feb-2009 In : Photodermatology, Photoimmunology & Photomedicine. 25, 1, p. 45-50, 6 p.

    Research output: Contribution to journal › Article

  28. Vitagenes, cellular stress response, and acetylcarnitine: Relevance to hormesis

    Calabrese, V., Cornelius, C., Dinkova-Kostova, A. T. & Calabrese, E. J. 2009 In : BioFactors. 35, 2, p. 146-160, 15 p.

    Research output: Contribution to journal › Scientific review

  29. Coordinate regulation of enzyme markers for inflammation and for protection against oxidants and electrophiles

    Liu, H., Dinkova-Kostova, A. T. & Talalay, P. 14-Oct-2008 In : Proceedings of the National Academy of Sciences of the United States of America. 105, 41, p. 15926-15931, 6 p.

    Research output: Contribution to journal › Article

  30. Phytochemicals as Protectors Against Ultraviolet Radiation: Versatility of Effects and Mechanisms

    Dinkova-Kostova, A. T. Oct-2008 In : Planta Medica. 74, 13, p. 1548-1559, 12 p.

    Research output: Contribution to journal › Scientific review

  31. Curcumin and the cellular stress response in free radical-related diseases

    Calabrese, V., Bates, T. E., Mancuso, C., Cornelius, C., Ventimiglia, B., Cambria, M. T., Di Renzo, L., De Lorenzo, A. & Dinkova-Kostova, A. T. Sep-2008 In : Molecular Nutrition & Food Research. 52, 9, p. 1062-1073, 12 p.

    Research output: Contribution to journal › Scientific review

  32. A novel acetylenic tricyclic bis-(cyano enone) potently induces phase 2 cytoprotective pathways and blocks liver carcinogenesis induced by aflatoxin

    Liby, K., Yore, M. M., Roebuck, B. D., Baumgartner, K. J., Honda, T., Sundararajan, C., Yoshizawa, H., Gribble, G. W., Williams, C. R., Risingsong, R., Royce, D. B., Dinkova-Kostova, A. T., Stephenson, K. K., Egner, P. A., Yates, M. S., Groopman, J. D., Kensler, T. W. & Sporn, M. B. 15-Aug-2008 In : Cancer Research. 68, 16, p. 6727-6733, 7 p.

    Research output: Contribution to journal › Article

  33. Rapid body weight gain increases the risk of UV radiation-induced skin carcinogenesis in SKH-1 hairless mice

    Dinkova-Kostova, A. T., Fahey, J. W., Jenkins, S. N., Wehage, S. L. & Talalay, P. Aug-2008 In : Molecular Nutrition & Food Research. 28, 8, p. 539-543, 5 p.

    Research output: Contribution to journal › Article

  34. Direct and indirect antioxidant properties of inducers of cytoprotective proteins

    Dinkova-Kostova, A. T. & Talalay, P. Jun-2008 In : Molecular Nutrition & Food Research. 52, p. S128-S138, 11 p.

    Research output: Contribution to journal › Scientific review

  35. Two-step mechanism of induction of the gene expression of a prototypic cancer-protective enzyme by diphenols

    Bensasson, R. V., Zoete, V., Dinkova-Kostova, A. T. & Talalay, P. Apr-2008 In : Chemical Research in Toxicology. 21, 4, p. 805-812, 8 p.

    Research output: Contribution to journal › Article

  36. A dicyanotriterpenoid induces cytoprotective enzymes and reduces multiplicity of skin tumors in UV-irradiated mice

    Dinkova-Kostova, A. T., Jenkins, S. N., Wehage, S. L., Huso, D. L., Benedict, A. L., Stephenson, K. K., Fahey, J. W., Liu, H., Liby, K. T., Honda, T., Gribble, G. W., Sporn, M. B. & Talalay, P. 21-Mar-2008 In : Biochemical and Biophysical Research Communications. 367, 4, p. 859-865, 7 p.

    Research output: Contribution to journal › Article

  37. Cellular stress response: a novel target for chemoprevention and nutritional neuroprotection in aging, neurodegenerative disorders and longevity

    Calabrese, V., Cornelius, C., Mancuso, C., Pennisi, G., Calafato, S., Bellia, F., Bates, T. E., Giuffrida Stella, A. M., Schapira, T., Rizzarelli, E. & Dinkova-Kostova, A. 2008 In : Neurochemical Research. 33, 12, p. 2444-71, 28 p.

    Research output: Contribution to journal › Article

  38. Chapter 6 Practical approaches to investigate redox regulation of heat shock protein expression and intracellular glutathione redox state

    Calabrese, V., Signorile, A., Cornelius, C., Mancuso, C., Scapagnini, G., Ventimiglia, B., Ragusa, N. & Dinkova-Kostova, A. 2008 Methods in Enzymology. Sandiego: Academic Press, Vol. 441, p. 83-110 28 p.

    Research output: Chapter in Book/Report/Conference proceeding › Other chapter contribution

  39. Extremely potent triterpenoid inducers of the phase 2 response: correlations of protection against oxidant and inflammatory stress

    Dinkova-Kostova, A. T., Liby, K. T., Stephenson, K. K., Holtzclaw, W. D., Gao, X., Suh, N., Williams, C., Risingsong, R., Honda, T., Gribble, G. W., Sporn, M. B. & Talalay, P. Mar-2005 In : Proceedings of the National Academy of Sciences of the United States of America. 102, 12, p. 4584-4589, 6 p.

    Research output: Contribution to journal › Article

  40. Protection against electrophile and oxidant stress by induction of the phase 2 response: fate of cysteines of the Keap1 sensor modified by inducers

    Wakabayashi, N., Dinkova-Kostova, A. T., Holtzclaw, W. D., Kang, M-I., Kobayashi, A., Yamamoto, M., Kensler, T. W. & Talalay, P. Feb-2004 In : Proceedings of the National Academy of Sciences of the United States of America. 101, 7, p. 2040-2045, 6 p.

    Research output: Contribution to journal › Article

  41. Direct evidence that sulfhydryl groups of Keap1 are the sensors regulating induction of phase 2 enzymes that protect against carcinogens and oxidants

    Dinkova-Kostova, A. T., Holtzclaw, W. D., Cole, R. N., Itoh, K., Wakabayashi, N., Katoh, Y., Yamamoto, M. & Talalay, P. Sep-2002 In : Proceedings of the National Academy of Sciences of the United States of America. 99, 18, p. 11908-11913, 6 p.

    Research output: Contribution to journal › Article

  42. Potency of Michael reaction acceptors as inducers of enzymes that protect against carcinogenesis depends on their reactivity with sulfhydryl groups

    Dinkova-Kostova, A. T., Massiah, M. A., Bozak, R. E., Hicks, R. J. & Talalay, P. Mar-2001 In : Diabetes. 98, 6, p. 3404-3409, 6 p.

    Research output: Contribution to journal › Article

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