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Albena Dinkova-Kostova

  1. Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1

    Mills, E. L. , Ryan, D. G. , Prag, H. A. , Dikovskaya, D. , Menon, D. , Zaslona, Z. , Jedrychowski, M. P. , Costa, A. S. H. , Higgins, M. , Hams, E. , Szpyt, J. , Runtsch, M. C. , King, M. S. , McGouran, J. F. , Fischer, R. , Kessler, B. M. , McGettrick, A. F. , Hughes, M. M. , Carroll, R. G. , Booty, L. M. & 15 others Knatko, E. V., Meakin, P. J., Ashford, M. L. J., Modis, L. K., Brunori, G., Sévin, D. C., Fallon, P. G., Caldwell, S. T., Kunji, E. R. S., Chouchani, E. T., Frezza, C., Dinkova-Kostova, A. T., Hartley, R. C., Murphy, M. P. & O'Neill, L. A. 5 Apr 2018 In : Nature. 556, 7699, p. 113-117 5 p.

    Research output: Contribution to journalLetter

  2. Author Correction: Pathogenic p62/SQSTM1 mutations impair energy metabolism through limitation of mitochondrial substrates

    Bartolome, F., Esteras, N., Martin-Requero, A., Boutoleau-Bretonniere, C., Vercelletto, M., Gabelle, A., Ber, I. L., Honda, T., Dinkova-Kostova, A. T., Hardy, J., Carro, E. & Abramov, A. Y. 1 Mar 2018 In : Scientific Reports. 8, p. 1-2 2 p., 4064

    Research output: Contribution to journalArticle

  3. Experimental Nonalcoholic Steatohepatitis and Liver Fibrosis Are Ameliorated by Pharmacologic Activation of Nrf2 (NF-E2 p45-Related Factor 2)

    Sharma, R. S., Harrison, D. J., Kisielewski, D., Cassidy, D. M., McNeilly, A. D., Gallagher, J. R., Walsh, S. V., Honda, T., McCrimmon, R. J., Dinkova-Kostova, A. T., Ashford, M. L. J., Dillon, J. F. & Hayes, J. D. 1 Mar 2018 In : CMGH: Cellular and Molecular Gastroenterology and Hepatology. 5, 3, p. 367-398 32 p.

    Research output: Contribution to journalArticle

  4. The role of Nrf2 signaling in counteracting neurodegenerative diseases

    Dinkova-Kostova, A. T., Kostov, R. V. & Kazantsev, A. G. 11 Jan 2018 In : FEBS Journal.

    Research output: Contribution to journalReview article

  5. Targeting the CoREST complex with dual histone deacetylase and demethylase inhibitors

    Kalin, J. H. , Wu, . M. , Gomez, A. V. , Song, Y. , Das, . J. , Hayward, D. , Adejola, . N. , Wu, M. , Panova, I. , Chung, H. J. , Kim, E. , Roberts, H. J. , Roberts, J. M. , Prusevich, P. , Jeliazkov, J. R. , Burman, S. S. R. , Fairall, L. , Milano, C. , Eroglu, A. , Proby, C. & 14 others Dinkova-Kostova, A., Hancock, W. W., Gray, J. J., Bradner, J. E., Valente, S., Mai, A., Anders, N. M., Rudek, M. A., Hu, Y., Ryu, B., Schwabe, J. W. R., Mattevi, A., Alani, R. M. & Cole, P. A. 4 Jan 2018 In : Nature Communications. 9, 1, p. 1-13 13 p., 53

    Research output: Contribution to journalArticle

  6. Crosstalk between NRF2 and HIPK2 shapes cytoprotective responses

    Torrente, L., Sanchez, C., Moreno Dorta, R., Chowdhry, S., Cabello, P., Isono, K., Koseki, H., Honda, T., Hayes, J., Dinkova-Kostova, A. & de la Vega, L. 2 Nov 2017 In : Oncogene. 36, 44, p. 6204-6212 9 p.

    Research output: Contribution to journalArticle

  7. KEAP1 and done? Targeting the NRF2 pathway with sulforaphane: Targeting the NRF2 Pathway with Sulforaphane

    Dinkova-Kostova, A. T., Fahey, J. W., Kostov, R. V. & Kensler, T. W. Nov 2017 In : Trends in Food Science and Technology. 69, B, p. 257-269 13 p.

    Research output: Contribution to journalReview article

  8. Oxidative stress and chronic inflammation in osteoarthritis: can Nrf2 counteract these partners in crime?

    Marchev, A. S., Dimitrova, P. A., Burns, A. J., Kostov, R., Dinkova-Kostova, A. & Georgiev, M. I. 11 Sep 2017 In : Annals of the New York Academy of Sciences. 1401, p. 114-135 22 p.

    Research output: Contribution to journalReview article

  9. Metabolic and Homeostatic Changes in Seizures and Acquired Epilepsy-Mitochondria, Calcium Dynamics and Reactive Oxygen Species

    Kovac, S., Dinkova Kostova, A. T., Herrmann, A. M., Melzer, N., Meuth, S. G. & Gorji, A. 8 Sep 2017 In : International Journal of Molecular Sciences. 18, 9, p. 1-19 19 p., 1935

    Research output: Contribution to journalReview article

  10. Transcription factors NRF2 and HSF1 have opposing functions in autophagy

    Dayalan Naidu, S., Dikovskaya, D., Gaurilcikaite, E., Knatko, E., Healy, Z. R., Mohan, H., Koh, . G., Laurell, A., Ball, G., Olagnier, D., de la Vega, L., Ganley, I., Talalay, P. & Dinkova-Kostova, A. 8 Sep 2017 In : Scientific Reports. 7, p. 1-12 12 p., 11023

    Research output: Contribution to journalArticle

  11. Activation of Nrf2 signaling augments Vesicular Stomatitis Virus Oncolysis via Autophagy-Driven Suppression of Antiviral Immunity

    Olagnier, D., Lababidi, R. R., Bel Hadj, S., Sze, A., Liu, Y., Dayalan Naidu, S., Ferrari, M., Jiang, Y., Chiang, C., Beljanski, V., Goulet, M-L., Knatko, E. V., Dinkova-Kostova, A. T., Hiscott, J. & Lin, R. 2 Aug 2017 In : Molecular Therapy. 25, 8, p. 1900-1916 17 p.

    Research output: Contribution to journalArticle

  12. Oxidative stress management in the hair follicle: Could targeting NRF2 counter age-related hair disorders and beyond?

    Jadkauskaite, L., Coulombe, P. A., Schäfer, M., Dinkova-Kostova, A. T., Paus, R. & Haslam, I. S. 27 Jul 2017 In : BioEssays. 39, 8, p. 1-9 9 p., 1700029

    Research output: Contribution to journalArticle

  13. KEAP1-modifying small molecule reveals muted NRF2 signaling responses in neural stem cells from Huntington's disease patients

    Quinti, L. , Dayalan Naidu, S. , Träge, U. , Chen, X. , Kegel-Gleason, K. , Lleres, D. , Connolly, C. , Chopra, V. , Low, C. , Moniot, S. , Sapp, E. , Tousley, A. R. , Vodicka, P. , Van Kanegan, M. J. , Kaltenbach, L. S. , Crawford, L. A. , Fuszard, M. , Higgins, M. , Miller, J. R. C. , Farmer, R. E. & 19 others Potluri, V., Samajdar, S., Meisel, L., Zhang, N., Snyder, A., Stein, R., Hersch, S. M., Ellerby, L. M., Weerapana, E., Schwarzschild, M. A., Steegborn, C., Leavitt, B. R., Degterev, A., Tabrizi, S. J., Lo, D. C., DiFiglia, M., Thompson, L. M., Dinkova-Kostova, A. & Kazantsev, A. G. 6 Jun 2017 In : Proceedings of the National Academy of Sciences of the United States of America. 114, 23, p. e4676-e4685 10 p.

    Research output: Contribution to journalArticle

  14. Flavonolignan 2,3-dehydrosilydianin activates Nrf2 and upregulates NAD(P)H: quinone oxidoreductase 1 in Hepa1c1c7 cells

    Roubalová, L., Dinkova-Kostova, A. T., Biedermann, D., Křen, V., Ulrichová, J. & Vrba, J. Jun 2017 In : Fitoterapia. 119, p. 115-120 6 p.

    Research output: Contribution to journalArticle

  15. Regulation of the mammalian heat shock factor 1

    Dayalan Naidu, S. & Dinkova-Kostova, A. T. Jun 2017 In : FEBS Journal. 284, 11, p. 1606-1627 22 p.

    Research output: Contribution to journalReview article

  16. Pathogenic p62/SQSTM1 mutations impair energy metabolism through limitation of mitochondrial substrates

    Bartolome, F., Esteras, N., Martin-Requero, A., Boutoleau-Bretonniere, C., Vercelletto, M., Gabelle, A., Le Ber, I., Honda, T., Dinkova-Kostova, A. T., Hardy, J., Carro, E. & Abramov, A. Y. 10 May 2017 In : Scientific Reports. 7, p. 1-14 14 p., 1666

    Research output: Contribution to journalArticle

  17. Activation of Nrf2 signaling as a common treatment of neurodegenerative diseases

    Dinkova-Kostova, A. T. & Kazantsev, A. G. Apr 2017 In : Neurodegenerative Disease Management. 7, 2, p. 97-100 4 p.

    Research output: Contribution to journalEditorial

  18. Keap1, the cysteine-based mammalian intracellular sensor for electrophiles and oxidants

    Dinkova-Kostova, A. T., Kostov, R. V. & Canning, P. 1 Mar 2017 In : Archives of Biochemistry and Biophysics. 617, p. 84-93 10 p.

    Research output: Contribution to journalArticle

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