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Albena Dinkova-Kostova

  1. Flavonolignan 2,3-dehydrosilydianin activates Nrf2 and upregulates NAD(P)H: quinone oxidoreductase 1 in Hepa1c1c7 cells

    Roubalová, L., Dinkova-Kostova, A. T., Biedermann, D., Křen, V., Ulrichová, J. & Vrba, J. Jun 2017 In : Fitoterapia. 119, p. 115-120 6 p.

    Research output: Contribution to journalArticle

  2. KEAP1-modifying small molecule reveals muted NRF2 signaling responses in neural stem cells from Huntington's disease patients

    Dinkova-Kostova, A. & 38 others Quinti, L., Dayalan Naidu, S., Träge, U., Chen, X., Kegel-Gleason, K., Lleres, D., Connolly, C., Chopra, V., Low, C., Moniot, S., Sapp, E., Tousley, A. R., Vodicka, P., Van Kanegan, M. J., Kaltenbach, L. S., Crawford, L. A., Fuszard, M., Higgins, M., Miller, J. R. C., Farmer, R. E., Potluri, V., Samajdar, S., Meisel, L., Zhang, N., Snyder, A., Stein, R., Hersch, S. M., Ellerby, L. M., Weerapana, E., Schwarzschild, M. A., Steegborn, C., Leavitt, B. R., Degterev, A., Tabrizi, S. J., Lo, D. C., DiFiglia, M., Thompson, L. M. & Kazantsev, A. G. 22 May 2017 In : Proceedings of the National Academy of Sciences of the United States of America.

    Research output: Contribution to journalArticle

  3. Pathogenic p62/SQSTM1 mutations impair energy metabolism through limitation of mitochondrial substrates

    Bartolome, F., Esteras, N., Martin-Requero, A., Boutoleau-Bretonniere, C., Vercelletto, M., Gabelle, A., Le Ber, I., Honda, T., Dinkova-Kostova, A. T., Hardy, J., Carro, E. & Abramov, A. Y. 10 May 2017 In : Scientific Reports. 7, p. 1-14 14 p., 1666

    Research output: Contribution to journalArticle

  4. Activation of Nrf2 signaling augments Vesicular Stomatitis Virus Oncolysis via Autophagy-Driven Suppression of Antiviral Immunity

    Olagnier, D., Lababidi, R. R., Bel Hadj, S., Sze, A., Liu, Y., Dayalan Naidu, S., Ferrari, M., Jiang, Y., Chiang, C., Beljanski, V., Goulet, M-L., Knatko, E. V., Dinkova-Kostova, A. T., Hiscott, J. & Lin, R. 27 Apr 2017 In : Molecular Therapy. 17 p.

    Research output: Contribution to journalArticle

  5. Activation of Nrf2 signaling as a common treatment of neurodegenerative diseases

    Dinkova-Kostova, A. T. & Kazantsev, A. G. Apr 2017 7, 2, p. 97-100 4 p.

    Research output: Contribution to journalEditorial

  6. Keap1, the cysteine-based mammalian intracellular sensor for electrophiles and oxidants

    Dinkova-Kostova, A. T., Kostov, R. V. & Canning, P. 1 Mar 2017 In : Archives of Biochemistry and Biophysics. 617, p. 84-93 10 p.

    Research output: Contribution to journalArticle

  7. KEAP1 and done? Targeting the NRF2 pathway with sulforaphane

    Dinkova-Kostova, A. T., Fahey, J. W., Kostov, R. V. & Kensler, T. W. 16 Feb 2017 In : Trends in Food Science and Technology. 13 p.

    Research output: Contribution to journalReview article

  8. NRF2 as an emerging therapeutic target

    Copple, I. M., Dinkova-Kostova, A. T., Kensler, T. W., Liby, K. T. & Wigley, W. C. 31 Jan 2017 In : Oxidative Medicine and Cellular Longevity. 2017, 2 p., 8165458

    Research output: Contribution to journalEditorial

  9. Regulation of the mammalian heat shock factor 1

    Dayalan Naidu, S. & Dinkova-Kostova, A. 4 Jan 2017 In : FEBS Journal.

    Research output: Contribution to journalReview article

  10. Whole-exome sequencing validates a preclinical mouse model for the prevention and treatment of cutaneous squamous cell carcinoma

    Knatko, E. V., Praslicka, B., Higgins, M., Evans, A., Purdie, K. J., Harwood, C. A., Proby, C. M., Ooi, A. & Dinkova-Kostova, A. T. Jan 2017 In : Cancer Prevention Research. 10, 1, p. 67-75 9 p.

    Research output: Contribution to journalArticle

  11. Semisynthetic flavonoid 7-O-galloylquercetin activates Nrf2 and induces Nrf2-dependent gene expression in RAW264.7 and Hepa1c1c7 cells

    Roubalová, L., Biedermann, D., Papoušková, B., Vacek, J., Kuzma, M., Křen, V., Ulrichová, J., Dinkova-Kostova, A. T. & Vrba, J. 25 Dec 2016 In : Chemico-Biological Interactions. 260, p. 58-66 9 p.

    Research output: Contribution to journalArticle

  12. Regulation of the CNC-bZIP transcription factor Nrf2 by Keap1 and the axis between GSK-3 and β-TrCP

    Hayes, J. D., Ebisine, K., Sharma, R. S., Chowdhry, S., Dinkova-Kostova, A. T. & Sutherland, C. Dec 2016 In : Current Opinion in Toxicology. 1, p. 92-103 12 p.

    Research output: Contribution to journalReview article

  13. The multifaceted role of Nrf2 in mitochondrial function

    Holmström, K. M., Kostov, R. V. & Dinkova-Kostova, A. T. Dec 2016 In : Current Opinion in Toxicology. 1, p. 80-91 12 p.

    Research output: Contribution to journalReview article

  14. Nrf2-mediated neuroprotection response to recurrent hypoglycemia is insufficient to prevent cognitive impairment in a rodent model of type 1 diabetes

    McNeilly, A. D., Gallagher, J. R., Dinkova-Kostova, A. T., Hayes, J. D., Sharkey, J., Ashford, M. L. J. & McCrimmon, R. J. 1 Oct 2016 In : Diabetes. 65, 10, p. 3151-3160 10 p.

    Research output: Contribution to journalArticle

  15. Heat Shock Factor 1 is a Substrate for p38 Mitogen-Activated Protein Kinases

    Dayalan Naidu, S., Sutherland, C., Zhang, Y., Risco, A., de la Vega, L., Caunt, C. J., Hastie, C. J., Lamont, D. J., Torrente, L., Chowdhry, S., Benjamin, I. J., Keyse, S. M., Cuenda, A. & Dinkova-Kostova, A. T. 15 Sep 2016 In : Molecular and Cellular Biology. 36, 18, p. 2403-2417 15 p.

    Research output: Contribution to journalArticle

  16. Electron affinity of tricyclic, bicyclic, and monocyclic compounds containing cyanoenones correlates with their potency as inducers of a cytoprotective enzyme

    Bensasson, R. V., Dinkova-Kostova, A. T., Zheng, S., Saito, A., Li, W., Zoete, V. & Honda, T. 1 Sep 2016 In : Bioorganic & Medicinal Chemistry Letters. 26, 17, p. 4345-4349 5 p.

    Research output: Contribution to journalArticle

  17. NAD(P)H: quinone oxidoreductase 1 inducer activity of some novel anilinoquinazoline derivatives

    Ghorab, M. M., Alsaid, M. S., Higgins, M., Dinkova-Kostova, A. T., Shahat, A. A., Elghazawy, N. H. & Arafa, R. K. 8 Aug 2016 In : Drug Design, Development and Therapy. 10, p. 2515-2524 10 p.

    Research output: Contribution to journalArticle

  18. Rhodiola rosea L.: from golden root to green cell factories

    Marchev, A. S., Dinkova-Kostova, A. T., György, Z., Mirmazloum, I., Aneva, I. Y. & Georgiev, M. I. Aug 2016 In : Phytochemistry Reviews. 15, 4, p. 515-536 22 p.

    Research output: Contribution to journalArticle

  19. SIRT2- and NRF2-Targeting Thiazole-Containing Compound with Therapeutic Activity in Huntington's Disease Models

    Dinkova-Kostova, A. T. & 23 others Quinti, L., Casale, M., Moniot, S., Pais, T. F., Van Kanegan, M. J., Kaltenbach, L. S., Pallos, J., Lim, R. G., Naidu, S. D., Runne, H., Meisel, L., Rauf, N. A., Leyfer, D., Maxwell, M. M., Saiah, E., Landers, J. E., Luthi-Carter, R., Abagyan, R., Steegborn, C., Marsh, J. L., Lo, D. C., Thompson, L. M. & Kazantsev, A. G. 21 Jul 2016 In : Cell Chemical Biology. 23, 7, p. 849-861 13 p.

    Research output: Contribution to journalArticle

  20. Potency of extracts from selected Egyptian plants as inducers of the Nrf2-dependent chemopreventive enzyme NQO1

    Hamed, A. R., Hegazy, M-E. F., Higgins, M., Mohamed, T. A., Abdel-Azim, N. S., Pare, P. W. & Dinkova-Kostova, A. T. Jul 2016 In : Journal of Natural Medicines. 70, 3, p. 683-688 6 p.

    Research output: Contribution to journalArticle

  21. Loss of Nrf2 abrogates the protective effect of Keap1 down regulation in a preclinical model of cutaneous squamous cell carcinoma

    Knatko, E. V., Higgins, M., Fahey, J. W. & Dinkova-Kostova, A. 24 May 2016 In : Scientific Reports. 6, 7 p., 25804

    Research output: Contribution to journalArticle

  22. Nrf2 activation in the treatment of neurodegenerative diseases: A focus on its role in mitochondrial bioenergetics and function

    Esteras, N., Dinkova-Kostova, A. T. & Abramov, A. Y. May 2016 In : Biological Chemistry. 397, 5, p. 383-400 18 p.

    Research output: Contribution to journalArticle

  23. Chemical constituents and NAD(P)H:Quinone oxidoreductase 1 (NQO1) inducer activity of Teucrium oliverianum Ging. ex Benth

    Shahat, A. A., Alsaid, M. S., Khan, J. A., Higgins, M. & Dinkova-Kostova, A. T. Apr 2016 In : Indian Journal of Traditional Knowledge. 15, 2, p. 232-236 5 p.

    Research output: Contribution to journalArticle

  24. Filaggrin genotype does not determine the skin's threshold to UV-induced erythema

    Forbes, D., Johnston, L., Gardner, J., MacCallum, S. F., Campbell, L. E., Dinkova-Kostova, A. T., McLean, W. H. I., Ibbotson, S. H., Dawe, R. S. & Brown, S. J. Apr 2016 In : Journal of Allergy and Clinical Immunology. 137, 4, p. 1280-1282.e3 6 p.

    Research output: Contribution to journalLetter

  25. Synthesis, molecular modeling and NAD(P)H: quinone oxidoreductase 1 inducer activity of novel 2-phenylquinazolin-4-amine derivatives

    Ghorab, M. M., Alsaid, M. S., Higgins, M., Dinkova-Kostova, A. T., Shahat, A. A., Elghazawy, N. H. & Arafa, R. K. Apr 2016 In : Journal of Enzyme Inhibition and Medicinal Chemistry. 31, 6, p. 1612-1618 7 p.

    Research output: Contribution to journalArticle

  26. Bioactive polymethoxylated flavonoids from Chiliadenus montanus

    Hamed, A. R., Mohamed, T. A., Tawfik, W. A., Hassan, E. M., Higgins, M., El-Toumy, S. A. & Dinkova-Kostova, A. T. 31 Mar 2016 In : Journal of Chemical and Pharmaceutical Research. 8, 3, p. 788-793 6 p.

    Research output: Contribution to journalArticle

  27. The multifaceted role of sulforaphane in protection against uv radiation-mediated skin damage

    Benedict, A. L., Knatko, E. V., Kostov, R. V., Zhang, Y., Higgins, M., Kalra, S., Fahey, J. W., Ibbotson, S. H., Proby, C. M., Talalay, P. & Dinkova-Kostova, A. T. Jan 2016 Broccoli: Cultivation, Nutritional Properties and Effects on Health. Nova Science Publishers, Inc., p. 185-208 24 p.

    Research output: Chapter in Book/Report/Conference proceedingChapter

  28. NAD(P)H: Quinone oxidoreductase 1 inducer activity of novel 4-aminoquinazoline derivatives

    Ghorab, M. M., Alsaid, M. S., El-Gazzar, M. G., Higgins, M., Dinkova-Kostova, A. T. & Shahat, A. A. 2016 In : Journal of Enzyme Inhibition and Medicinal Chemistry. 31, 6, p. 1369-1374 7 p.

    Research output: Contribution to journalArticle

  29. Synthesis and NAD(P)H: Quinone oxidoreductase 1 inducer activity of acetamide and pyridine-3-carbonitrile derivatives

    Ghorab, M. M., Shahat, A. A., Alsaid, M. S., Higgins, M., Dinkova-Kostova, A. T. & Naser, A. A. 2016 In : Biomedical Research. 27, 4

    Research output: Contribution to journalArticle

  30. Mechanisms of activation of the transcription factor Nrf2 by redox stressors, nutrient cues, and energy status and the pathways through which it attenuates degenerative disease

    Tebay, L. E., Robertson, H., Durant, S. T., Vitale, S. R., Penning, T. M., Dinkova-Kostova, A. T. & Hayes, J. D. Nov 2015 In : Free Radical Biology and Medicine. 88, Part B, p. 108-146 39 p.

    Research output: Contribution to journalArticle

  31. The emerging role of Nrf2 in mitochondrial function

    Dinkova-Kostova, A. T. & Abramov, A. Y. Nov 2015 In : Free Radical Biology and Medicine. 88, Part B, p. 179-188 10 p.

    Research output: Contribution to journalArticle

  32. Pharmacokinetics and pharmacodynamics of orally administered acetylenic tricyclic bis(cyanoenone), a highly potent Nrf2 activator with a reversible covalent mode of action

    Kostov, R. V., Knatko, E. V., McLaughlin, L. A., Henderson, C. J., Zheng, S., Huang, J. T. J., Honda, T. & Dinkova-Kostova, A. T. 25 Sep 2015 In : Biochemical and Biophysical Research Communications. 465, 3, p. 402-407 6 p.

    Research output: Contribution to journalArticle

  33. Design, synthesis, and evaluation of triazole derivatives that induce Nrf2 dependent gene products and inhibit the Keap1-Nrf2 protein-protein interaction

    Bertrand, H. C., Schaap, M., Baird, L., Georgakopoulos, N. D., Fowkes, A., Thiollier, C., Kachi, H., Dinkova-Kostova, A. T. & Wells, G. 24 Sep 2015 In : Journal of Medicinal Chemistry. 58, 18, p. 7186-7194 9 p.

    Research output: Contribution to journalArticle

  34. Dual regulation of transcription factor Nrf2 by Keap1 and by the combined actions of β-TrCP and GSK-3

    Hayes, J. D., Chowdhry, S., Dinkova-Kostova, A. T. & Sutherland, C. Aug 2015 In : Biochemical Society Transactions. 43, 4, p. 611-620 10 p.

    Research output: Contribution to journalArticle

  35. The spatiotemporal regulation of the Keap1-Nrf2 pathway and its importance in cellular bioenergetics

    Dinkova-Kostova, A. T., Baird, L., Holmström, K. M., Meyer, C. J. & Abramov, A. Y. Aug 2015 In : Biochemical Society Transactions. 43, 4, p. 602-610 9 p.

    Research output: Contribution to journalArticle

  36. New monocyclic, bicyclic, and tricyclic ethynylcyanodienones as activators of the Keap1/Nrf2/ARE pathway and inhibitors of inducible nitric oxide synthase

    Li, W., Zheng, S., Higgins, M., Morra, R. P., Mendis, A. T., Chien, C-W., Ojima, I., Mierke, D. F., Dinkova-Kostova, A. T. & Honda, T. 11 Jun 2015 In : Journal of Medicinal Chemistry. 58, 11, p. 4738-4748 11 p.

    Research output: Contribution to journalArticle

  37. Nrf2 activation protects against solar-simulated ultraviolet radiation in mice and humans

    Knatko, E. V., Ibbotson, S. H., Zhang, Y., Higgins, M., Fahey, J. W., Talalay, P., Dawe, R. S., Ferguson, J., Huang, J. T-J., Clarke, R., Zheng, S., Saito, A., Kalra, S., Benedict, A. L., Honda, T., Proby, C. M. & Dinkova-Kostova, A. T. Jun 2015 In : Cancer Prevention Research. 8, 6, p. 475-486 12 p.

    Research output: Contribution to journalArticle

  38. Nrf2 regulates ROS production by mitochondria and NADPH oxidase

    Kovac, S., Angelova, P. R., Holmström, K. M., Zhang, Y., Dinkova-Kostova, A. T. & Abramov, A. Y. Apr 2015 In : Biochimica et Biophysica Acta: General Subjects. 1850, 4, p. 794-801 8 p.

    Research output: Contribution to journalArticle

  39. Transcription factors Hsf1 and Nrf2 engage in crosstalk for cytoprotection

    Dayalan Naidu, S., Kostov, R. V. & Dinkova-Kostova, A. T. Jan 2015 In : Trends in Pharmacological Sciences. 36, 1, p. 6-14 9 p.

    Research output: Contribution to journalArticle

  40. NAD(P)H: Quinone oxidoreductase 1 inducer activity of some enaminone derivatives

    Alsaid, M. S., Ghorab, M. M., Higgins, M., Dinkova-Kostova, A. T. & Shahat, A. A. 2015 In : Biomedical Research. 26, 1, p. 7-12 6 p.

    Research output: Contribution to journalArticle

  41. Novel Thioureido Derivatives Carrying Thione and Sulfonamide Moieties Induce the Cytoprotective Enzyme NAD(P)H:Quione Oxidoreductase 1: Quinone oxidoreductase 1

    Ghorab, M. M., Higgins, M., Dinkova-Kostova, A. T., Alsaid, M. S. & Shahat, A. A. 1 Dec 2014 In : Asian Journal of Chemistry. 26, 24, p. 8501-8504 4 p.

    Research output: Contribution to journalArticle

  42. Monitoring Keap1-Nrf2 interactions in single live cells

    Baird, L., Swift, S., Llères, D. & Dinkova-Kostova, A. T. 1 Nov 2014 In : Biotechnology Advances. 32, 6, p. 1133-1144 12 p.

    Research output: Contribution to journalArticle

  43. Chemical tuning enhances both potency toward Nrf2 and in vitro therapeutic index of triterpenoids

    Copple, I. M., Shelton, L. M., Walsh, J., Kratschmar, D. V., Lister, A., Odermatt, A., Goldring, C. E., Dinkova-Kostova, A. T., Honda, T. & Park, B. K. Aug 2014 In : Toxicological Sciences. 140, 2, p. 462-469 8 p.

    Research output: Contribution to journalArticle

  44. Synthesis of 13C215N2-labeled anti-inflammatory and cytoprotective tricyclic bis(cyanoenone) ([13C215N2]-TBE-31) as an internal standard for quantification by stable isotope dilution LC-MS method

    Zheng, S., Huang, J. T. -J., Knatko, E. V., Sharp, S., Higgins, M., Ojima, I., Dinkova-Kostova, A. T. & Honda, T. Aug 2014 In : Journal of Labelled Compounds & Radiopharmaceuticals. 57, 10, p. 606-610 5 p.

    Research output: Contribution to journalArticle

  45. Nrf2 affects the efficiency of mitochondrial fatty acid oxidation

    Ludtmann, M. H. R., Angelova, P. R., Zhang, Y., Abramov, A. Y. & Dinkova-Kostova, A. T. 1 Feb 2014 In : Biochemical Journal. 457, 3, p. 415-424 10 p.

    Research output: Contribution to journalArticle

  46. Sulphoxythiocarbamates modify cysteine residues in HSP90 causing degradation of client proteins and inhibition of cancer cell proliferation

    Zhang, Y., Dayalan Naidu, S., Samarasinghe, K., Van Hecke, G. C., Pheely, A., Boronina, T. N., Cole, R. N., Benjamin, I. J., Cole, P. A., Ahn, Y-H. & Dinkova-Kostova, A. T. 7 Jan 2014 In : British Journal of Cancer. 110, 1, p. 71-82 12 p.

    Research output: Contribution to journalArticle

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