Discovery - University of Dundee - Online Publications

Library & Learning Centre

Colin Henderson

  1. Application of Humanised and Other Transgenic Models to Predict Human Responses to Drugs

    Wolf, C. R., Kapelyukh, Y., Scheer, N. & Henderson, C. J. 20 Nov 2016 New Horizons in Predictive drug Metabolism and Pharmocokentics. 49 ed. Royal Society of Chemistry, Vol. 2016-January, p. 152-176 25 p. (RSC Drug Discovery Series; vol. 2016-January, no. 49)

    Research output: Chapter in Book/Report/Conference proceedingChapter

  2. The role of protein-protein and protein-membrane Interactions on P450 function

    Scott, E. E., Wolf, C. R., Otyepka, M., Humphreys, S. C., Reed, J. R., Henderson, C. J., McLaughlin, L. A., Paloncyova, M., Navratilova, V., Berka, K., Anzenbacher, P., Dahal, U. P., Barnaba, C., Brozik, J. A., Jones, J. P., Estrada, F., Laurence, J. S., Park, J. W. & Backes, W. L. 5 Feb 2016 In : Drug Metabolism and Disposition. 44, 4, p. 576-590 15 p.

    Research output: Contribution to journalArticle

  3. Activation status of the Pregnane X Receptor influences Vemurafenib availability in humanized mouse models

    MacLeod, A. K., McLaughlin, L. A., Henderson, C. J. & Wolf, C. R. 1 Nov 2015 In : Cancer Research. 75, 21, p. 4573-4581 10 p.

    Research output: Contribution to journalArticle

  4. Defining human pathways of drug metabolism in vivo through the development of a multiple humanized mouse model

    Scheer, N., Kapelyukh, Y., Rode, A., Oswald, S., Busch, D., McLaughlin, L. A., Lin, D., Henderson, C. J. & Wolf, C. R. Nov 2015 In : Drug Metabolism and Disposition. 43, 11, p. 1679-1690 12 p.

    Research output: Contribution to journalArticle

  5. Model systems for understanding mechanisms of non-genotoxic carcinogenesis: response

    Braeuning, A., Henderson, C. J., Wolf, C. R. & Schwarz, M. Oct 2015 In : Toxicological Sciences. 147, 2, p. 299-300 2 p.

    Research output: Contribution to journalLetter

  6. Pharmacokinetics and pharmacodynamics of orally administered acetylenic tricyclic bis(cyanoenone), a highly potent Nrf2 activator with a reversible covalent mode of action

    Kostov, R. V., Knatko, E., McLaughlin, L., Henderson, C., Zheng, S., Huang, J. T-J., Honda, T. & Dinkova-Kostova, A. T. 25 Sep 2015 In : Biochemical and Biophysical Research Communications. 465, 3, p. 402-407 6 p.

    Research output: Contribution to journalArticle

  7. Proteome-wide identification and quantification of S-glutathionylation targets in mouse liver

    McGarry, D. J., Chen, W., Chakravarty, P., Lamont, D. L., Wolf, C. R. & Henderson, C. J. Jun 2015 In : Biochemical Journal. 469, 1, p. 25-32 8 p.

    Research output: Contribution to journalArticle

  8. Evidence that the capacity of nongenotoxic carcinogens to induce oxidative stress is subject to marked variability

    Henderson, C. J., Cameron, A. R., Chatham, L., Stanley, L. A. & Wolf, C. R. May 2015 In : Toxicological Sciences. 145, 1, p. 138-148 11 p.

    Research output: Contribution to journalArticle

  9. Cytochrome b5 is a major determinant of human cytochrome P450 CYP2D6 and CYP3A4 activity in vivo

    Henderson, C. J., McLaughlin, L. A., Scheer, N., Stanley, L. A. & Wolf, C. R. Apr 2015 In : Molecular Pharmacology. 87, 4, p. 733-739 7 p.

    Research output: Contribution to journalArticle

  10. An enhanced in vivo stable isotope labeling by amino acids in cell culture (SILAC) model for quantification of drug metabolism enzymes

    MacLeod, A. K., Fallon, P. G., Sharp, S., Henderson, C. J., Wolf, C. R. & Huang, J. T-J. Mar 2015 In : Molecular & Cellular Proteomics. 14, 3, p. 750-760 11 p.

    Research output: Contribution to journalArticle

  11. Application of a novel regulatable Cre recombinase system to define the role of liver and gut metabolism in drug oral bioavailability

    Henderson, C. J., McLaughlin, L. A., Osuna-Cabello, M., Taylor, M., Gilbert, I., McLaren, A. W. & Wolf, C. R. 1 Feb 2015 In : Biochemical Journal. 465, 3, p. 479-488 10 p.

    Research output: Contribution to journalArticle

  12. Glutathione transferases P1/P2 regulate the timing of signaling pathway activations and cell cycle progression during mouse liver regeneration

    Pajaud, J., Ribault, C., Ben Mosbah, I., Rauch, C., Henderson, C., Bellaud, P., Aninat, C., Loyer, P., Morel, F. & Corlu, A. 15 Jan 2015 In : Cell Death and Disease. 6, 13 p., e1598

    Research output: Contribution to journalArticle

  13. HDAC inhibitors increase NRF2-signaling in tumour cells and blunt the efficacy of co-adminstered cytotoxic agents

    McMahon, M., Campbell, K. H., MacLeod, A. K., McLaughlin, L. A., Henderson, C. J. & Wolf, C. R. 26 Nov 2014 In : PLoS ONE. 9, 11, e114055

    Research output: Contribution to journalArticle

  14. Phenobarbital-mediated tumor promotion in transgenic mice with humanized CAR and PXR

    Braeuning, A., Gavrilov, A., Brown, S., Wolf, C. R., Henderson, C. J. & Schwarz, M. 1 Aug 2014 In : Toxicological Sciences. 140, 2, p. 259-70 12 p.

    Research output: Contribution to journalArticle

  15. Cytochrome b5 and epoxide hydrolase contribute to benzo[a]pyrene-DNA adduct formation catalyzed by cytochrome P450 1A1 under low NADPH:P450 oxidoreductase conditions

    Stiborová, M., Moserová, M., Černá, V., Indra, R., Dračínský, M., Šulc, M., Henderson, C. J., Wolf, C. R., Schmeiser, H. H., Phillips, D. H., Frei, E. & Arlt, V. M. 6 Apr 2014 In : Toxicology. 318, 1, p. 1-12 12 p.

    Research output: Contribution to journalArticle

  16. A Targeted in Vivo SILAC Approach for Quantification of Drug Metabolism Enzymes: Regulation by the Constitutive Androstane Receptor

    Macleod, A. K., Zang, T., Riches, Z., Henderson, C. J., Wolf, C. R. & Huang, J. T-J. 7 Feb 2014 In : Journal of Proteome Research. 13, 2, p. 866-874 9 p.

    Research output: Contribution to journalArticle

  17. A role for cytochrome b5 in the in vivo disposition of anti-cancer and cytochrome P450 probe drugs in mice

    Henderson, C. J., McLaughlin, L. A., Finn, R. D., Ronseaux, S., Kapelyukh, Y. & Wolf, C. R. Jan 2014 In : Drug Metabolism and Disposition. 42, 1, p. 70-77 8 p.

    Research output: Contribution to journalArticle

  18. Deletion of 30 murine cytochrome p450 genes results in viable mice with compromised drug metabolism

    Scheer, N., McLaughlin, L. A., Rode, A., MacLeod, A. K., Henderson, C. J. & Wolf, C. R. 2014 In : Drug Metabolism and Disposition. 42, 6, p. 1022-1030 9 p.

    Research output: Contribution to journalArticle

  19. In vivo regulation of human glutathione transferase GSTP by chemopreventive agents

    Henderson, C. J., McLaren, A. W. & Wolf, C. R. 2014 In : Cancer Research. p. 4378 1 p.

    Research output: Contribution to journalArticle

  20. Phenobarbital induces cell cycle transcriptional responses in mouse liver humanized for constitutive androstane and pregnane X receptors

    Henderson, C. J. , Wolf, C. R. & 24 others Luisier, R., Lempiäinen, H., Scherbichler, N., Braeuning, A., Geissler, M., Dubost, V., Müller, A., Scheer, N., Chibout, S-D., Hara, H., Picard, F., Theil, D., Couttet, P., Vitobello, A., Grenet, O., Grasl-Kraupp, B., Ellinger-Ziegelbauer, H., Thomson, J. P., Meehan, R. R., Elcombe, C. R., Schwarz, M., Moulin, P., Terranova, R. & Moggs, J. G. 2014 In : Toxicological Sciences. 139, 2, p. 501-511 11 p.

    Research output: Contribution to journalArticle

  21. Pyrethroid activity-based probes for profiling cytochrome P450 activities associated with insecticide interactions

    Ismail, H. M., O'Neill, P. M., Hong, D. W., Finn, R. D., Henderson, C. J., Wright, A. T., Cravatt, B. F., Hemingway, J. & Paine, M. J. I. 3 Dec 2013 In : Proceedings of the National Academy of Sciences of the United States of America. 110, 49, p. 19766-19771 6 p.

    Research output: Contribution to journalArticle

  22. Ubiquitin-proteasome system impairment and MPTP-induced oxidative stress in the brain of C57BL/6 wild-type and GSTP knockout mice

    Carvalho, A. N., Marques, C., Rodrigues, E., Henderson, C. J., Wolf, C. R., Pereira, P. & Gama, M. J. Apr 2013 In : Molecular Neurobiology. 47, 2, p. 662-72 11 p.

    Research output: Contribution to journalArticle

  23. NADPH-cytochrome P450 oxidoreductase: roles in physiology, pharmacology, and toxicology

    Riddick, D. S., Ding, X., Wolf, C. R., Porter, T. D., Pandey, A. V., Zhang, Q-Y., Gu, J., Finn, R. D., Ronseaux, S., McLaughlin, L. A., Henderson, C. J., Zou, L. & Flück, C. E. Jan 2013 In : Drug Metabolism and Disposition. 41, 1, p. 12-23 12 p.

    Research output: Contribution to journalArticle

  24. The involvement of mitochondrial amidoxime reducing components 1 and 2 and mitochondrial cytochrome b5 in N-reductive metabolism in human cells

    Plitzko, B., Ott, G., Reichmann, D., Henderson, C. J., Wolf, C. R., Mendel, R., Bittner, F., Clement, B. & Havemeyer, A. 2013 In : Journal of Biological Chemistry. 288, 28, p. 20228-20237 10 p.

    Research output: Contribution to journalArticle

  25. Diminished toxicity of C-1748, 4-methyl-9-hydroxyethylamino-1-nitroacridine, compared with its demethyl analog, C-857, corresponds to its resistance to metabolism in HepG2 cells

    Wisniewska, A., Niemira, M., Jagiello, K., Potega, A., Swist, M., Henderson, C., Skwarska, A., Augustin, E., Konopa, J. & Mazerska, Z. 1 Jul 2012 In : Biochemical Pharmacology. 84, 1, p. 30-42 13 p.

    Research output: Contribution to journalArticle

  26. Glutathione S-Transferase pi Mediates MPTP-Induced c-Jun N-Terminal Kinase Activation in the Nigrostriatal Pathway

    Castro-Caldas, M., Carvalho, A. N., Rodrigues, E., Gama, M. J., Henderson, C. & Wolf, C. R. 1 Jan 2012 In : Molecular Neurobiology. p. 1-12 12 p.

    Research output: Contribution to journalArticle

  27. Exposure to benzo[a]pyrene of hepatic cytochrome P450 reductase null (HRN) and P450 reductase conditional null (RCN) mice: detection of benzo[a]pyrene diol epoxide-DNA adducts by immunohistochemistry and P-postlabelling

    Arlt, V. M., Poirier, M. C., Sykes, S. E., John, K., Moserova, M., Stiborova, M., Wolf, C. R., Henderson, C. J. & Phillips, D. H. 2012 In : Toxicology Letters. 213, 2, p. 160-166 7 p.

    Research output: Contribution to journalArticle

  28. Tauroursodeoxycholic acid prevents MPTP-induced dopaminergic cell death in a mouse model of Parkinson's disease

    Castro-Caldas, M., Carvalho, A. N., Rodrigues, E., Henderson, C. J., Wolf, C. R., Rodrigues, C. M. P. & Gama, M. J. 2012 In : Molecular Neurobiology. 46, 2, p. 475-486 12 p.

    Research output: Contribution to journalArticle

  29. Non-catalytic mechanisms involved in glutathione Stransferase Pi mediated cytoprotection

    McGarry, D. J., Wolf, C. R. & Henderson, C. J. 18 Dec 2011 In : Toxicology. 290, 2-3, p. 130-130 1 p.

    Research output: Contribution to journalBook/Film/Article review

  30. Effect of hepatic cytochrome P450 (P450) oxidoreductase deficiency on 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine-DNA Adduct Formation in P450 reductase conditional null mice

    Arlt, V. M., Singh, R., Stiborova, M., da Costa, G. G., Frei, E., Evans, J. D., Farmer, P. B., Wolf, C. R., Henderson, C. J. & Phillips, D. H. Dec 2011 In : Drug Metabolism and Disposition. 39, 12, p. 2169-2173 5 p.

    Research output: Contribution to journalArticle

  31. Increased Skin Papilloma Formation in Mice Lacking Glutathione Transferase GSTP

    Henderson, C. J., Ritchie, K. J., McLaren, A., Chakravarty, P. & Wolf, C. R. 15 Nov 2011 In : Cancer Research. 71, 22, p. 7048-7060 13 p.

    Research output: Contribution to journalArticle

  32. Regulation of hepatic uptake and efflux transporters in vitro

    Hawksworth, G. M., Farooq, M., Henderson, C. J. & Weaver, R. J. Nov 2011 In : Drug Metabolism Reviews. 43, p. 209-209 1 p.

    Research output: Contribution to journalBook/Film/Article review

  33. The Imidazoacridinone Antitumor Drug, C-1311, Is Metabolized by Flavin Monooxygenases but Not by Cytochrome P450s

    Potega, A., Dabrowska, E., Niemira, M., Kot-Wasik, A., Ronseaux, S., Henderson, C. J., Wolf, C. R. & Mazerska, Z. Aug 2011 In : Drug Metabolism and Disposition. 39, 8, p. 1423-1432 10 p.

    Research output: Contribution to journalArticle

  34. Cytochrome b (5) null mouse: a new model for studying inherited skin disorders and the role of unsaturated fatty acids in normal homeostasis

    Finn, R. D., McLaughlin, L. A., Hughes, C., Song, C., Henderson, C. J. & Wolf, C. R. Jun 2011 In : Transgenic Research. 20, 3, p. 491-502 12 p.

    Research output: Contribution to journalArticle

  35. Knockout and transgenic mice in glutathione transferase research

    Henderson, C. J. & Wolf, C. R. May 2011 In : Drug Metabolism Reviews. 43, 2, p. 152-164 13 p.

    Research output: Contribution to journalScientific review

  36. Role of cytochromes P450 1A1/2 in detoxication and activation of carcinogenic aristolochic acid I: studies with the hepatic NADPH:cytochrome P450 reductase null (HRN) mouse model

    Levova, K., Moserova, M., Kotrbova, V., Sulc, M., Henderson, C. J., Wolf, C. R., Phillips, D. H., Frei, E., Schmeiser, H. H., Mares, J., Arlt, V. M. & Stiborova, M. May 2011 In : Toxicological Sciences. 121, 1, p. 43-56 14 p.

    Research output: Contribution to journalArticle

  37. Humanizing π-class glutathione S-transferase regulation in a mouse model alters liver toxicity in response to acetaminophen overdose

    Vaughn, M. P., Shinohara, D. B., Castagna, N., Hicks, J. L., Netto, G., De Marzo, A. M., Speed, T. J., Reichert, Z. R., Kwabi-Addo, B., Henderson, C. J., Wolf, C. R., Yegnasubramanian, S. & Nelson, W. G. 2011 In : PLoS ONE. 6, 10, p. - 10 p., e25707

    Research output: Contribution to journalArticle

  38. Role of CAR and PXR in xenobiotic toxicity

    Wolf, C. R., Elcombe, C., Rode, A., Scheer, N., Bower, C. & Henderson, C. 2011 In : Toxicology Letters. 205, p. S13 1 p.

    Research output: Contribution to journalBook/Film/Article review

  39. Non-catalytic mechanisms involved in glutathione S-transferase pi mediated cytoprotection

    McGarry, D. J., Wolf, C. R. & Henderson, C. J. 30 Dec 2010 In : Toxicology. 278, 3, p. 371-372 2 p.

    Research output: Contribution to journalBook/Film/Article review

  40. Deletion of Microsomal Cytochrome b(5) Profoundly Affects Hepatic and Extrahepatic Drug Metabolism

    McLaughlin, L. A., Ronseaux, S., Finn, R. D., Henderson, C. J. & Wolf, C. R. Aug 2010 In : Molecular Pharmacology. 78, 2, p. 269-278 10 p.

    Research output: Contribution to journalArticle

  41. Human Constitutive Androstane Receptor (CAR) and Pregnane X Receptor (PXR) Support the Hypertrophic but not the Hyperplastic Response to the Murine Nongenotoxic Hepatocarcinogens Phenobarbital and Chlordane In Vivo

    Ross, J., Plummer, S. M., Rode, A., Scheer, N., Bower, C. C., Vogel, O., Henderson, C. J., Wolf, C. R. & Elcombe, C. R. Aug 2010 In : Toxicological Sciences. 116, 2, p. 452-466 15 p.

    Research output: Contribution to journalArticle

  42. The Hepatic cytochrome P450 reductase null (HRN) mouse model as a tool to study xenobiotic metabolism

    Arlt, V. M., Henderson, C. J., Wolf, C. R., Phillips, D. H. & Stiborova, M. Mar 2010 In : Naunyn-Schmiedeberg's Archives of Pharmacology. 381, p. 83-83 1 p.

    Research output: Contribution to journalBook/Film/Article review

  43. Markedly enhanced colon tumorigenesis in Apc(Min) mice lacking glutathione S-transferase Pi

    Ritchie, K. J., Walsh, S., Sansom, O. J., Henderson, C. J. & Wolf, C. R. 8 Dec 2009 In : Proceedings of the National Academy of Sciences of the United States of America. 106, 49, p. 20859-20864 6 p.

    Research output: Contribution to journalArticle

  44. Cholesterol Metabolism: the Main Pathway Acting Downstream of Cytochrome P450 Oxidoreductase in Skeletal Development of the Limb

    Schmidt, K., Hughes, C., Chudek, J. A., Goodyear, S. R., Aspden, R. M., Talbot, R., Gundersen, T. E., Blomhoff, R., Henderson, C., Wolf, C. R. & Tickle, C. 15 May 2009 In : Molecular and Cellular Biology. 29, 10, p. 2716-2729 14 p.

    Research output: Contribution to journalArticle

  45. GSTpi Mediates MPTP-induced JNK Activation in the Nigrostriatal Pathway

    Gama, M. J., Castro-Caldas, M., Carvalho, A. N., Rodrigues, E., Henderson, C. J. & Wolf, C. R. May 2009 In : Drug Metabolism Reviews. 41, p. 29-30 2 p.

    Research output: Contribution to journalBook/Film/Article review

  46. Preclinical toxicokinetic evaluation of Phortress [2-(4-amino-3- methylphenyl)-5-fluorobenzothiazole lysylamide dihydrochloride] in two rodent species

    Bradshaw, T. D., Wren, J. E., Bruce, M., Barrett, D. A., Leong, C-O., Gaskell, M., Wright, E. K., Farmer, P. B., Henderson, C. J., Wolf, R. & Stevens, M. F. G. 1 Jan 2009 In : Pharmacology. 83, 2, p. 99-109 11 p.

    Research output: Contribution to journalArticle

  47. Unsaturated fatty acid regulation of cytochrome P450 expression via a CAR-dependent pathway

    Finn, R. D., Henderson, C. J., Scott, C. L. & Wolf, C. R. 1 Jan 2009 In : Biochemical Journal. 417, 1, p. 43-54 12 p.

    Research output: Contribution to journalArticle

  48. Nomenclature for alleles of the cytochrome P450 oxidoreductase gene

    Sim, S. C., Miller, W. L., Zhong, X-B., Arlt, W., Ogata, T., Ding, X., Wolf, C. R., Flueck, C. E., Pandey, A. V., Henderson, C. J., Porter, T. D., Daly, A. K., Nebert, D. W. & Ingelman-Sundberg, M. 2009 In : Pharmacogenetics and Genomics. 19, 7, p. 565-566 2 p.

    Research output: Contribution to journalLetter

  49. Glutathione Transferase P1 An Endogenous Inhibitor of Allergic Responses in a Mouse Model of Asthma

    Zhou, J., Wolf, C. R., Henderson, C. J., Cai, Y., Board, P. G., Foster, P. S. & Webb, D. C. 15 Dec 2008 In : American Journal of Respiratory and Critical Care Medicine. 178, 12, p. 1202-1210 9 p.

    Research output: Contribution to journalArticle

  50. Defining the in Vivo Role for Cytochrome b(5) in Cytochrome P450 Function through the Conditional Hepatic Deletion of Microsomal Cytochrome b(5)

    Finn, R. D., McLaughlin, L. A., Ronseaux, S., Rosewell, I., Houston, J. B., Henderson, C. J. & Wolf, C. R. 14 Nov 2008 In : Journal of Biological Chemistry. 283, 46, p. 31385-31393 9 p.

    Research output: Contribution to journalArticle

  51. Functional expression and comparative characterization of nine murine cytochromes P450 by fluorescent inhibition screening

    McLaughlin, L. A., Dickmann, L. J., Wolf, C. R. & Henderson, C. J. Jul 2008 In : Drug Metabolism and Disposition. 36, 7, p. 1322-1331 10 p.

    Research output: Contribution to journalArticle

  52. Metabolic activation of benzo[a]pyrene in vitro by hepatic cytochrome P450 contrasts with detoxification in vivo: experiments with hepatic cytochrome P450 reductase null mice

    Arlt, V. M., Stiborova, M., Henderson, C. J., Thiemann, M., Frei, E., Aimova, D., Singh, R., da Costa, G. G., Schmitz, O. J., Farmer, P. B., Wolf, C. R. & Phillips, D. H. Mar 2008 In : Carcinogenesis. 29, 3, p. 656-665 10 p.

    Research output: Contribution to journalArticle

  53. Role of hepatic cytochromes P450 in bioactivation of the anticancer drug ellipticine: Studies with the hepatic NADPH: Cytochrome P450 reductase null mouse

    Stiborova, M., Arlt, V. M., Henderson, C. J., Wolf, C. R., Kotrbova, V., Moserova, M., Hudecek, J., Phillips, D. H. & Frei, E. 1 Feb 2008 In : Toxicology and Applied Pharmacology. 226, 3, p. 318-327 10 p.

    Research output: Contribution to journalArticle

  54. THE ROLE OF HEPATIC CYTOCHROME P-450 ENZYMES IN METABOLISM OF IMIDAZOACRIDINONE ANTITUMOR AGENT, C-1311 (SYMADEX): STUDIES WITH THE HEPATIC NADPH: CYTOCHROME P450 REDUCTASE NULL MICE

    Potega, A., Ronseaux, S., Henderson, C., Konopa, J. & Mazerska, Z. 2008 In : Drug Metabolism Reviews. 40, p. 59-60 2 p.

    Research output: Contribution to journalBook/Film/Article review

  55. The disruption of hepatic cytochrome P450 reductase afters mouse lipid metabolism

    Mutch, D. M., Klocke, B., Morrison, P., Murray, C. A., Henderson, C. J., Seifert, M. & Williamson, G. Oct 2007 In : Journal of Proteome Research. 6, 10, p. 3976-3984 9 p.

    Research output: Contribution to journalArticle

  56. Development of a liquid Chromatography-Electrospray ionization tandem mass spectrometry method for detecting Oxaliplatin-DNA intrastrand cross-links in biological samples

    Le Pla, R. C., Ritchie, K. J., Henderson, C. J., Wolf, C. R., Harrington, C. F. & Farmer, P. B. Aug 2007 In : Chemical Research in Toxicology. 20, 8, p. 1177-1182 6 p.

    Research output: Contribution to journalArticle

  57. Exposure to benzo[A]pyrene in the hepatic cytochrome p450 oxidoreductase null mouse: detoxification by hepatic cytochrome p450 is more important than metabolic activation

    Arlt, V. M., Stiborova, M., Henderson, C. J., Thiemann, M., Frei, E., Singh, R., da Costa, G. G., Schmitz, O. J., Farmer, P. B., Wolf, C. R. & Phillips, D. H. Mar 2007 In : Naunyn-Schmiedeberg's Archives of Pharmacology. 375, Supplement 1, p. 73-73 1 p., 352

    Research output: Contribution to journalMeeting abstract

  58. Activation of Nrf2 and cellular inflammatory response by hypochlorous acid

    Woods, C. G., Andersen, M. E., Zhang, Q., Thomas, R. S., Henderson, C. J., Wolf, C. R. & Pi, J. 2007 In : Free Radical Biology and Medicine. 43, p. S160-S160 1 p.

    Research output: Contribution to journalBook/Film/Article review

  59. Glutathione transferase π plays a critical role in the development of lung carcinogenesis following exposure to tobacco-related carcinogens and urethane

    Ritchie, K. J., Henderson, C. J., Wang, X-J., Vassieva, O., Carrie, D., Farmer, P. B., Gaskell, M., Park, K. & Wolf, C. R. 2007 In : Cancer Research. 67, 19, p. 9248-9257 10 p.

    Research output: Contribution to journalArticle

  60. Hepatic cytochrome P-450 reductase-null mice show reduced transcriptional response to quercetin and reveal physiological homeostasis between jejunum and liver

    Mutch, D. M., Crespy, V., Clough, J., Henderson, C. J., Lariani, S., Mansourian, R., Moulin, J., Wolf, C. R. & Williamson, G. Jul 2006 In : American Journal of Physiology-Gastrointestinal and Liver Physiology. 291, 1, p. G63-G72 10 p.

    Research output: Contribution to journalArticle

  61. Bioactivation of 3-aminobenzanthrone, a human metabolite of the environmental pollutant 3-nitrobenzanthrone: evidence for DNA adduct formation mediated by cytochrome P450 enzymes and peroxidases

    Arlt, V. M., Henderson, C. J., Wolf, C. R., Schmeiser, H. H., Phillips, D. H. & Stiborova, M. 28 Mar 2006 In : Cancer Letters. 234, 2, p. 220-231 12 p.

    Research output: Contribution to journalArticle

  62. The hepatic cytochrome P450 reductase null mouse as a tool to identify a successful candidate entity

    Henderson, C. J., Pass, G. J. & Wolf, C. R. 15 Mar 2006 In : Toxicology Letters. 162, 1, p. 111-117 7 p.

    Research output: Contribution to journalArticle

  63. Relationship between hepatic phenotype and changes in gene expression in cytochrome P450 reductase (POR) null mice

    Wang, X. J., Chamberlain, M., Vassieva, O., Henderson, C. J. & Wolf, C. R. 15 Jun 2005 In : Biochemical Journal. 388, 3, p. 857-867 11 p.

    Research output: Contribution to journalArticle

  64. Role of hepatic cytochrome P450s in the pharmacokinetics and toxicity of cyclophosphamide: studies with the hepatic cytochrome P450 reductase null mouse

    Pass, G. J., Carrie, D., Boylan, M., Lorimore, S., Wright, E., Houston, B., Henderson, C. J. & Wolf, C. R. 15 May 2005 In : Cancer Research. 65, 10, p. 4211-4217 7 p.

    Research output: Contribution to journalArticle

  65. Environmental pollutant and potent mutagen 3-nitrobenzanthrone forms DNA adducts after reduction by NAD(P)H: quinone oxidoreductase and conjugation by acetyltransferases and sulfotransferases in human hepatic cytosols

    Arlt, V. M., Stiborova, M., Henderson, C. J., Osborne, M. R., Bieler, C. A., Frei, E., Martinek, V., Sopko, B., Wolf, C. R., Schmeiser, H. H. & Phillips, D. H. 1 Apr 2005 In : Cancer Research. 65, 7, p. 2644-2652 9 p.

    Research output: Contribution to journalArticle

  66. The murine Cyp1a1 gene is expressed in a restricted spatial and temporal pattern during embryonic development

    Campbell, S. J., Henderson, C. J., Anthony, D. C., Davidson, D., Clark, A. J. & Wolf, C. R. 18 Feb 2005 In : Journal of Biological Chemistry. 280, 7, p. 5828-5835 8 p.

    Research output: Contribution to journalArticle

  67. Disruption of the glutathione transferase Pi class genes

    Henderson, C. J. & Wolf, C. R. 2005 Gluthione transferases and gamma-glutamyl transpeptidases. Sies, H. & Packer, L. (eds.). San Diego: Academic Press, p. 116-135 20 p. (Methods in Enzymology; vol. 401)

    Research output: Chapter in Book/Report/Conference proceedingOther chapter contribution

  68. Transcription factor Nrf2 is essential for induction of NAD(P)H:quinone oxidoreductase 1, glutathione S-transferases, and glutamate cysteine ligase by broccoli seeds and isothiocyanates

    McWalter, G. K., Higgins, L. G., McLellan, L. I., Henderson, C. J., Song, L., Thornalley, P. J., Itoh, K., Yamamoto, M. & Hayes, J. D. 1 Dec 2004 In : Journal of Nutrition. 134, 12, p. 3499S-3506S

    Research output: Contribution to journalArticle

  69. Identification of novel roles of the cytochrome P450 system in early embryogenesis: effects on vasculogenesis and retinoic acid homeostasis

    Otto, D. M. E., Henderson, C. J., Carrie, D., Davey, M., Gundersen, T. E., Blomhoff, R., Adams, R. H., Tickle, C. & Wolf, C. R. Sep 2003 In : Molecular and Cellular Biology. 23, 17, p. 6103-6116 14 p.

    Research output: Contribution to journalArticle

  70. Increased constitutive c-Jun N-terminal kinase signaling in mice lacking glutathione S-transferase Pi

    Elsby, R., Kitteringham, N. R., Goldring, C. E., Lovatt, C. A., Chamberlain, M., Henderson, C. J., Wolf, C. R. & Park, B. K. 20 Jun 2003 In : Journal of Biological Chemistry. 278, 25, p. 22243-22249 7 p.

    Research output: Contribution to journalArticle

  71. Protein expression profiling of glutathione S-transferase pi null mice as a strategy to identify potential markers of resistance to paracetamol-induced toxicity in the liver

    Kitteringham, N. R., Powell, H., Hamlett, J., Hamlett, J., Lovatt, C., Elsby, R., Henderson, C. J., Wolf, C. R., Pennington, S. R. & Park, B. K. Feb 2003 In : Proteomics. 3, 2, p. 191-207 17 p.

    Research output: Contribution to journalArticle

  72. Inactivation of the hepatic cytochrome P450 system by conditional deletion of hepatic cytochrome P450 reductase

    Henderson, C. J., Otto, D. M. E., Carrie, D., Magnuson, M. A., McLaren, A. W., Rosewell, I. & Wolf, C. R. 2003 In : Journal of Biological Chemistry. 278, 15, p. 13480-13486 7 p.

    Research output: Contribution to journalArticle

  73. Knockout mice in xenobiotic metabolism

    Henderson, C. J., Otto, D. M. E., McLaren, A. W., Carrie, D. & Wolf, C. R. 2003 In : Drug Metabolism Reviews. 35, 4, p. 385-392 8 p.

    Research output: Contribution to journalArticle

  74. Precision-cut tissue slices from transgenic mice as an in vitro toxicology system

    Catania, J. M., Parrish, A. R., Kirkpatrick, D. S., Chitkara, M., Bowden, G. T., Henderson, C. J., Wolf, C. R., Clark, A. J., Brendel, K., Fisher, R. L. & Gandolfi, A. J. 2003 In : Toxicology in Vitro. 17, 2, p. 201-205 5 p.

    Research output: Contribution to journalArticle

  75. Loss of the Nrf2 transcription factor causes a marked reduction in constitutive and inducible expression of the glutathione S-transferase Gsta1, Gsta2, Gstm1, Gstm2, Gstm3 and Gstm4 genes in the livers of male and female mice

    Chanas, S. A., Jiang, Q., McMahon, M., McWalter, G. K., McLellan, L. I., Elcombe, C. R., Henderson, C. J., Wolf, C. R., Moffat, G. J., Itoh, K., Yamamoto, M. & Hayes, J. D. 2002 In : Biochemical Journal. 365, Pt 2, p. 405-16 12 p.

    Research output: Contribution to journalArticle

  76. Pharmacologic or genetic manipulation of glutathione S-transferase P1-1 (GST ∏) influences cell proliferation pathways

    Ruscoe, J. E., Rosario, L. A., Wang, T., Gate, L., Arifoglu, P., Wolf, C. R., Henderson, C. J., Ronai, Z. & Tew, K. D. 1 Jul 2001 In : Journal of Pharmacology and Experimental Therapeutics. 298, 1, p. 339-345 7 p.

    Research output: Contribution to journalArticle

  77. Implication of GST-pi expression in colon carcinogenesis

    Niitsu, Y., Takayama, T., Miyanishi, K., Nobuoka, A., Hayashi, T., Nakajima, T., Miyake, S., Henderson, C. J. & Wolf, R. 28 Feb 2001 In : Chemico-Biological Interactions. 133, 1-3, p. 287-290 4 p.

    Research output: Contribution to journalMeeting abstract

  78. Increased resistance to acetaminophen hepatotoxicity in mice lacking glutathione S-transferase Pi

    Henderson, C. J., Wolf, C. R., Kitteringham, N., Powell, H., Otto, D. & Park, B. K. 7 Nov 2000 In : Proceedings of the National Academy of Sciences of the United States of America. 97, 23, p. 12741-12745 5 p.

    Research output: Contribution to journalArticle

  79. Preclinical studies with a glutathione S-transferase P1-1 (GSTP1-1) activated prodrug.

    Rosario, L. A., O'Brien, M. L., Schow, S. R., Henderson, C. J., Wolf, C. R. & Tew, K. D. Nov 2000 In : Clinical Cancer Research. 6, Supplement, p. 4489S-4489S 1 p., 114

    Research output: Contribution to journalMeeting abstract

  80. Cytochrome P450s and chemoprevention

    Henderson, C. J., Sahraouei, A. & Wolf, C. R. Feb 2000 In : Biochemical Society Transactions. 28, 2, p. 42-46 5 p.

    Research output: Contribution to journalArticle

  81. Regulation of JNK signaling by GSTp

    Adler, V., Yin, Z., Fuchs, S. Y., Benezra, M., Rosario, L., Tew, K. D., Pincus, M. R., Sardana, M., Henderson, C. J., Wolf, C. R., Davis, R. J. & Ronai, Z. 1 Mar 1999 In : EMBO Journal. 18, 5, p. 1321-1334 14 p.

    Research output: Contribution to journalArticle

  82. Adaptive responses to environmental chemicals

    Wolf, C. R., Smith, G., Smith, A. G., Brown, K. & Henderson, C. J. 1999 Cellular responses to stress. Downes, C. P., Wolf, C. R. & Lane, D. P. (eds.). London: Portland Press Ltd, p. 129-139 11 p. (Biochemical Society symposia; no. 64)

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

  83. Use of transgenic animals in understanding molecular mechanisms of toxicity

    Wolf, C. R. & Henderson, C. J. Jun 1998 In : Journal of Pharmacy and Pharmacology. 50, 6, p. 567-574 8 p.

    Research output: Contribution to journalArticle

  84. Increased skin tumorigenesis in mice lacking pi class glutathione S-transferases

    Henderson, C. J., Smith, A. G., Ure, J., Brown, K., Bacon, E. J. & Wolf, C. R. 28 Apr 1998 In : Proceedings of the National Academy of Sciences of the United States of America. 95, 9, p. 5275-5280 6 p.

    Research output: Contribution to journalArticle

  85. Pi-class glutathione S-transferase: regulation and function

    Henderson, C. J., McLaren, A. W., Moffat, G. J., Bacon, E. J. & Wolf, C. R. 24 Apr 1998 In : Chemico-Biological Interactions. 111-112, p. 69-82 14 p.

    Research output: Contribution to journalArticle

  86. A general strategy for the expression of recombinant human cytochrome P450s in Escherichia coli using bacterial signal peptides: expression of CYP3A4, CYP2A6, and CYP2E1

    Pritchard, M. P., Ossetian, R., Li, D. N., Henderson, C. J., Burchell, B., Wolf, C. R. & Friedberg, T. 15 Sep 1997 In : Archives of Biochemistry and Biophysics. 345, 2, p. 342-354 13 p.

    Research output: Contribution to journalArticle

  87. Transfer of PCBs via lactation simultaneously induces the expression of P450 isoenzymes and the protooncogenes c-Ha-ras and c-raf in neonates

    Borlak, J. T., Scott, A., Henderson, C. J., Jenke, H. J. & Wolf, C. R. 23 Feb 1996 In : Biochemical Pharmacology. 51, 4, p. 517-529 13 p.

    Research output: Contribution to journalArticle

  88. Divergent regulation of cytochrome P450 enzymes by morphine and pethidine: a neuroendocrine mechanism?

    Rane, A., Liu, Z., Henderson, C. J. & Wolf, C. R. Jan 1995 In : Molecular Pharmacology. 47, 1, p. 57-64 8 p.

    Research output: Contribution to journalArticle

  89. Metabolism of [3-14C] coumarin by human liver microsomes

    van Iersel, M. L. P. S., Henderson, C. J., Walters, D. G., Price, R. J., Wolf, C. R. & Lake, B. G. Aug 1994 In : Xenobiotica. 24, 8, p. 795-803 9 p.

    Research output: Contribution to journalArticle

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