Colin Henderson

Evidence that Cytochrome b5 and Cytochrome b5 Reductase Can Act as Sole Electron Donors to the Hepatic Cytochrome P450 System

Henderson, C. J., McLaughlin, L. A. & Wolf, C. R. Jun-2013 In : Molecular Pharmacology. 83, 6, p. 1209-1217, 9 p.

Research output: Contribution to journal › Article

Diminished toxicity of C-1748, 4-methyl-9-hydroxyethylamino-1-nitroacridine, compared with its demethyl analog, C-857, corresponds to its resistance to metabolism in HepG2 cells

Wisniewska, A., Niemira, M., Jagiello, K., Potega, A., Swist, M., Henderson, C., Skwarska, A., Augustin, E., Konopa, J. & Mazerska, Z. 1-Jul-2012 In : Biochemical Pharmacology. 84, 1, p. 30-42, 13 p.

Research output: Contribution to journal › Article

Glutathione S-Transferase pi Mediates MPTP-Induced c-Jun N-Terminal Kinase Activation in the Nigrostriatal Pathway

Castro-Caldas, M., Carvalho, A. N., Rodrigues, E., Gama, M. J., Henderson, C. & Wolf, C. R. 1-Jan-2012 In : Molecular Neurobiology. p. 1-12, 12 p.

Research output: Contribution to journal › Article

Exposure to benzo[a]pyrene of hepatic cytochrome P450 reductase null (HRN) and P450 reductase conditional null (RCN) mice: detection of benzo[a]pyrene diol epoxide-DNA adducts by immunohistochemistry and P-postlabelling

Arlt, V. M., Poirier, M. C., Sykes, S. E., John, K., Moserova, M., Stiborova, M., Wolf, C. R., Henderson, C. J. & Phillips, D. H. 2012 In : Toxicology Letters. 213, 2, p. 160-166, 7 p.

Research output: Contribution to journal › Article

Tauroursodeoxycholic acid prevents MPTP-induced dopaminergic cell death in a mouse model of Parkinson's disease

Castro-Caldas, M., Carvalho, A. N., Rodrigues, E., Henderson, C. J., Wolf, C. R., Rodrigues, C. M. P. & Gama, M. J. 2012 In : Molecular Neurobiology. 46, 2, p. 475-486, 12 p.

Research output: Contribution to journal › Article

Non-catalytic mechanisms involved in glutathione Stransferase Pi mediated cytoprotection

McGarry, D. J., Wolf, C. R. & Henderson, C. J. 18-Dec-2011 In : Toxicology. 290, 2-3, p. 130-130, 1 p.

Research output: Contribution to journal › Book/Film/Article review

Effect of hepatic cytochrome P450 (P450) oxidoreductase deficiency on 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine-DNA Adduct Formation in P450 reductase conditional null mice

Arlt, V. M., Singh, R., Stiborova, M., da Costa, G. G., Frei, E., Evans, J. D., Farmer, P. B., Wolf, C. R., Henderson, C. J. & Phillips, D. H. Dec-2011 In : Drug Metabolism and Disposition. 39, 12, p. 2169-2173, 5 p.

Research output: Contribution to journal › Article

Increased Skin Papilloma Formation in Mice Lacking Glutathione Transferase GSTP

Henderson, C. J., Ritchie, K. J., McLaren, A., Chakravarty, P. & Wolf, C. R. 15-Nov-2011 In : Cancer Research. 71, 22, p. 7048-7060, 13 p.

Research output: Contribution to journal › Article

Regulation of hepatic uptake and efflux transporters in vitro

Hawksworth, G. M., Farooq, M., Henderson, C. J. & Weaver, R. J. Nov-2011 In : Drug Metabolism Reviews. 43, p. 209-209, 1 p.

Research output: Contribution to journal › Book/Film/Article review

Humanizing pi-Class Glutathione S-Transferase Regulation in a Mouse Model Alters Liver Toxicity in Response to Acetaminophen Overdose

Vaughn, M. P., Shinohara, D. B., Castagna, N., Hicks, J. L., Netto, G., De Marzo, A. M., Speed, T. J., Reichert, Z. R., Kwabi-Addo, B., Henderson, C. J., Wolf, C. R., Yegnasubramanian, S. & Nelson, W. G. 11-Oct-2011 In : PLoS ONE. 6, 10, p. -, 10 p., e25707

Research output: Contribution to journal › Article

Role of CAR and PXR in xenobiotic toxicity

Wolf, C. R., Elcombe, C., Rode, A., Scheer, N., Bower, C. & Henderson, C. 28-Aug-2011 In : Toxicology Letters. 205, p. S13-S13, 1 p.

Research output: Contribution to journal › Book/Film/Article review

The Imidazoacridinone Antitumor Drug, C-1311, Is Metabolized by Flavin Monooxygenases but Not by Cytochrome P450s

Potega, A., Dabrowska, E., Niemira, M., Kot-Wasik, A., Ronseaux, S., Henderson, C. J., Wolf, C. R. & Mazerska, Z. Aug-2011 In : Drug Metabolism and Disposition. 39, 8, p. 1423-1432, 10 p.

Research output: Contribution to journal › Article

Cytochrome b (5) null mouse: a new model for studying inherited skin disorders and the role of unsaturated fatty acids in normal homeostasis

Finn, R. D., McLaughlin, L. A., Hughes, C., Song, C., Henderson, C. J. & Wolf, C. R. Jun-2011 In : Transgenic Research. 20, 3, p. 491-502, 12 p.

Research output: Contribution to journal › Article

Knockout and transgenic mice in glutathione transferase research

Henderson, C. J. & Wolf, C. R. May-2011 In : Drug Metabolism Reviews. 43, 2, p. 152-164, 13 p.

Research output: Contribution to journal › Scientific review

Role of Cytochromes P450 1A1/2 in Detoxication and Activation of Carcinogenic Aristolochic Acid I: Studies with the Hepatic NADPH:Cytochrome P450 Reductase Null (HRN) Mouse Model

Levova, K., Moserova, M., Kotrbova, V., Sulc, M., Henderson, C. J., Wolf, C. R., Phillips, D. H., Frei, E., Schmeiser, H. H., Mares, J., Arlt, V. M. & Stiborova, M. May-2011 In : Toxicological Sciences. 121, 1, p. 43-56, 14 p.

Research output: Contribution to journal › Article

Non-catalytic mechanisms involved in glutathione S-transferase pi mediated cytoprotection

McGarry, D. J., Wolf, C. R. & Henderson, C. J. 30-Dec-2010 In : Toxicology. 278, 3, p. 371-372, 2 p.

Research output: Contribution to journal › Book/Film/Article review

Detection and quantitation of N-(deoxyguanosin-8-yl)-2-amino-1-methyl-6-Phenylimidazo[4,5-b]pyridine adducts in DNA using online column-switching liquid chromatography tandem mass spectrometry

Singh, R., Arlt, V. M., Henderson, C. J., Phillips, D. H., Farmer, P. B. & da Costa, G. G. 1-Aug-2010 In : Journal of Chromatography B-Analytical Technologies in the Biomedical and Life Sciences. 878, 23, p. 2155-2162, 8 p.

Research output: Contribution to journal › Article

Deletion of Microsomal Cytochrome b(5) Profoundly Affects Hepatic and Extrahepatic Drug Metabolism

McLaughlin, L. A., Ronseaux, S., Finn, R. D., Henderson, C. J. & Wolf, C. R. Aug-2010 In : Molecular Pharmacology. 78, 2, p. 269-278, 10 p.

Research output: Contribution to journal › Article

Human Constitutive Androstane Receptor (CAR) and Pregnane X Receptor (PXR) Support the Hypertrophic but not the Hyperplastic Response to the Murine Nongenotoxic Hepatocarcinogens Phenobarbital and Chlordane In Vivo

Ross, J., Plummer, S. M., Rode, A., Scheer, N., Bower, C. C., Vogel, O., Henderson, C. J., Wolf, C. R. & Elcombe, C. R. Aug-2010 In : Toxicological Sciences. 116, 2, p. 452-466, 15 p.

Research output: Contribution to journal › Article

The Hepatic cytochrome P450 reductase null (HRN) mouse model as a tool to study xenobiotic metabolism

Arlt, V. M., Henderson, C. J., Wolf, C. R., Phillips, D. H. & Stiborova, M. Mar-2010 In : Naunyn-Schmiedeberg's Archives of Pharmacology. 381, p. 83-83, 1 p.

Research output: Contribution to journal › Book/Film/Article review