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Colin Henderson

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  1. Cytochrome b and epoxide hydrolase contribute to benzo[a]pyrene-DNA adduct formation catalyzed by cytochrome P450 1A1 under low NADPH:P450 oxidoreductase conditions

    Stiborová, M., Moserová, M., Černá, V., Indra, R., Dračínský, M., Šulc, M., Henderson, C. J., Wolf, C. R., Schmeiser, H. H., Phillips, D. H., Frei, E. & Arlt, V. M. 6 Apr 2014 In : Toxicology. 318, 1, p. 1-12 12 p.

    Research output: Contribution to journalArticle

  2. A role for cytochrome b5 in the in vivo disposition of anti-cancer and cytochrome P450 probe drugs in mice

    Henderson, C. J., McLaughlin, L. A., Finn, R. D., Ronseaux, S., Kapelyukh, Y. & Wolf, C. R. Jan 2014 In : Drug Metabolism and Disposition. 42, 1, p. 70-77 8 p.

    Research output: Contribution to journalArticle

  3. Deletion of 30 murine cytochrome p450 genes results in viable mice with compromised drug metabolism

    Scheer, N., McLaughlin, L. A., Rode, A., MacLeod, A. K., Henderson, C. J. & Wolf, C. R. 2014 In : Drug Metabolism and Disposition. 42, 6, p. 1022-1030 9 p.

    Research output: Contribution to journalArticle

  4. In vivo regulation of human glutathione transferase GSTP by chemopreventive agents

    Henderson, C. J., McLaren, A. W. & Wolf, C. R. 2014 In : Cancer Research.

    Research output: Contribution to journalArticle

  5. Phenobarbital induces cell cycle transcriptional responses in mouse liver humanized for constitutive androstane and pregnane X receptors

    Henderson, C. J. , Wolf, C. R. & 24 others Luisier, R., Lempiäinen, H., Scherbichler, N., Braeuning, A., Geissler, M., Dubost, V., Müller, A., Scheer, N., Chibout, S-D., Hara, H., Picard, F., Theil, D., Couttet, P., Vitobello, A., Grenet, O., Grasl-Kraupp, B., Ellinger-Ziegelbauer, H., Thomson, J. P., Meehan, R. R., Elcombe, C. R., Schwarz, M., Moulin, P., Terranova, R. & Moggs, J. G. 2014 In : Toxicological Sciences. 139, 2, p. 501-511 11 p.

    Research output: Contribution to journalArticle

  6. Pyrethroid activity-based probes for profiling cytochrome P450 activities associated with insecticide interactions

    Ismail, H. M., O'Neill, P. M., Hong, D. W., Finn, R. D., Henderson, C. J., Wright, A. T., Cravatt, B. F., Hemingway, J. & Paine, M. J. I. 3 Dec 2013 In : Proceedings of the National Academy of Sciences of the United States of America. 110, 49, p. 19766-19771 6 p.

    Research output: Contribution to journalArticle

  7. Ubiquitin-proteasome system impairment and MPTP-induced oxidative stress in the brain of C57BL/6 wild-type and GSTP knockout mice

    Carvalho, A. N., Marques, C., Rodrigues, E., Henderson, C. J., Wolf, C. R., Pereira, P. & Gama, M. J. Apr 2013 In : Molecular Neurobiology. 47, 2, p. 662-72 11 p.

    Research output: Contribution to journalArticle

  8. NADPH-cytochrome P450 oxidoreductase: roles in physiology, pharmacology, and toxicology

    Riddick, D. S., Ding, X., Wolf, C. R., Porter, T. D., Pandey, A. V., Zhang, Q-Y., Gu, J., Finn, R. D., Ronseaux, S., McLaughlin, L. A., Henderson, C. J., Zou, L. & Flück, C. E. Jan 2013 In : Drug Metabolism and Disposition. 41, 1, p. 12-23 12 p.

    Research output: Contribution to journalArticle

  9. The involvement of mitochondrial amidoxime reducing components 1 and 2 and mitochondrial cytochrome b5 in N-reductive metabolism in human cells

    Plitzko, B., Ott, G., Reichmann, D., Henderson, C. J., Wolf, C. R., Mendel, R., Bittner, F., Clement, B. & Havemeyer, A. 2013 In : Journal of Biological Chemistry. 288, 28, p. 20228-20237 10 p.

    Research output: Contribution to journalArticle

  10. Diminished toxicity of C-1748, 4-methyl-9-hydroxyethylamino-1-nitroacridine, compared with its demethyl analog, C-857, corresponds to its resistance to metabolism in HepG2 cells

    Wisniewska, A., Niemira, M., Jagiello, K., Potega, A., Swist, M., Henderson, C., Skwarska, A., Augustin, E., Konopa, J. & Mazerska, Z. 1 Jul 2012 In : Biochemical Pharmacology. 84, 1, p. 30-42 13 p.

    Research output: Contribution to journalArticle

  11. Glutathione S-Transferase pi Mediates MPTP-Induced c-Jun N-Terminal Kinase Activation in the Nigrostriatal Pathway

    Castro-Caldas, M., Carvalho, A. N., Rodrigues, E., Gama, M. J., Henderson, C. & Wolf, C. R. 1 Jan 2012 In : Molecular Neurobiology. p. 1-12 12 p.

    Research output: Contribution to journalArticle

  12. Exposure to benzo[a]pyrene of hepatic cytochrome P450 reductase null (HRN) and P450 reductase conditional null (RCN) mice: detection of benzo[a]pyrene diol epoxide-DNA adducts by immunohistochemistry and P-postlabelling

    Arlt, V. M., Poirier, M. C., Sykes, S. E., John, K., Moserova, M., Stiborova, M., Wolf, C. R., Henderson, C. J. & Phillips, D. H. 2012 In : Toxicology Letters. 213, 2, p. 160-166 7 p.

    Research output: Contribution to journalArticle

  13. Tauroursodeoxycholic acid prevents MPTP-induced dopaminergic cell death in a mouse model of Parkinson's disease

    Castro-Caldas, M., Carvalho, A. N., Rodrigues, E., Henderson, C. J., Wolf, C. R., Rodrigues, C. M. P. & Gama, M. J. 2012 In : Molecular Neurobiology. 46, 2, p. 475-486 12 p.

    Research output: Contribution to journalArticle

  14. Non-catalytic mechanisms involved in glutathione Stransferase Pi mediated cytoprotection

    McGarry, D. J., Wolf, C. R. & Henderson, C. J. 18 Dec 2011 In : Toxicology. 290, 2-3, p. 130-130 1 p.

    Research output: Contribution to journalBook/Film/Article review

  15. Effect of hepatic cytochrome P450 (P450) oxidoreductase deficiency on 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine-DNA Adduct Formation in P450 reductase conditional null mice

    Arlt, V. M., Singh, R., Stiborova, M., da Costa, G. G., Frei, E., Evans, J. D., Farmer, P. B., Wolf, C. R., Henderson, C. J. & Phillips, D. H. Dec 2011 In : Drug Metabolism and Disposition. 39, 12, p. 2169-2173 5 p.

    Research output: Contribution to journalArticle

  16. Increased Skin Papilloma Formation in Mice Lacking Glutathione Transferase GSTP

    Henderson, C. J., Ritchie, K. J., McLaren, A., Chakravarty, P. & Wolf, C. R. 15 Nov 2011 In : Cancer Research. 71, 22, p. 7048-7060 13 p.

    Research output: Contribution to journalArticle

  17. Regulation of hepatic uptake and efflux transporters in vitro

    Hawksworth, G. M., Farooq, M., Henderson, C. J. & Weaver, R. J. Nov 2011 In : Drug Metabolism Reviews. 43, p. 209-209 1 p.

    Research output: Contribution to journalBook/Film/Article review

  18. The Imidazoacridinone Antitumor Drug, C-1311, Is Metabolized by Flavin Monooxygenases but Not by Cytochrome P450s

    Potega, A., Dabrowska, E., Niemira, M., Kot-Wasik, A., Ronseaux, S., Henderson, C. J., Wolf, C. R. & Mazerska, Z. Aug 2011 In : Drug Metabolism and Disposition. 39, 8, p. 1423-1432 10 p.

    Research output: Contribution to journalArticle

  19. Cytochrome b (5) null mouse: a new model for studying inherited skin disorders and the role of unsaturated fatty acids in normal homeostasis

    Finn, R. D., McLaughlin, L. A., Hughes, C., Song, C., Henderson, C. J. & Wolf, C. R. Jun 2011 In : Transgenic Research. 20, 3, p. 491-502 12 p.

    Research output: Contribution to journalArticle

  20. Knockout and transgenic mice in glutathione transferase research

    Henderson, C. J. & Wolf, C. R. May 2011 In : Drug Metabolism Reviews. 43, 2, p. 152-164 13 p.

    Research output: Contribution to journalScientific review

  21. Role of cytochromes P450 1A1/2 in detoxication and activation of carcinogenic aristolochic acid I: studies with the hepatic NADPH:cytochrome P450 reductase null (HRN) mouse model

    Levova, K., Moserova, M., Kotrbova, V., Sulc, M., Henderson, C. J., Wolf, C. R., Phillips, D. H., Frei, E., Schmeiser, H. H., Mares, J., Arlt, V. M. & Stiborova, M. May 2011 In : Toxicological Sciences. 121, 1, p. 43-56 14 p.

    Research output: Contribution to journalArticle

  22. Humanizing π-class glutathione S-transferase regulation in a mouse model alters liver toxicity in response to acetaminophen overdose

    Vaughn, M. P., Shinohara, D. B., Castagna, N., Hicks, J. L., Netto, G., De Marzo, A. M., Speed, T. J., Reichert, Z. R., Kwabi-Addo, B., Henderson, C. J., Wolf, C. R., Yegnasubramanian, S. & Nelson, W. G. 2011 In : PLoS ONE. 6, 10, p. - 10 p.e25707

    Research output: Contribution to journalArticle

  23. Role of CAR and PXR in xenobiotic toxicity

    Wolf, C. R., Elcombe, C., Rode, A., Scheer, N., Bower, C. & Henderson, C. 2011 In : Toxicology Letters. 205, p. S13 1 p.

    Research output: Contribution to journalBook/Film/Article review

  24. Non-catalytic mechanisms involved in glutathione S-transferase pi mediated cytoprotection

    McGarry, D. J., Wolf, C. R. & Henderson, C. J. 30 Dec 2010 In : Toxicology. 278, 3, p. 371-372 2 p.

    Research output: Contribution to journalBook/Film/Article review

  25. Deletion of Microsomal Cytochrome b(5) Profoundly Affects Hepatic and Extrahepatic Drug Metabolism

    McLaughlin, L. A., Ronseaux, S., Finn, R. D., Henderson, C. J. & Wolf, C. R. Aug 2010 In : Molecular Pharmacology. 78, 2, p. 269-278 10 p.

    Research output: Contribution to journalArticle

  26. Human Constitutive Androstane Receptor (CAR) and Pregnane X Receptor (PXR) Support the Hypertrophic but not the Hyperplastic Response to the Murine Nongenotoxic Hepatocarcinogens Phenobarbital and Chlordane In Vivo

    Ross, J., Plummer, S. M., Rode, A., Scheer, N., Bower, C. C., Vogel, O., Henderson, C. J., Wolf, C. R. & Elcombe, C. R. Aug 2010 In : Toxicological Sciences. 116, 2, p. 452-466 15 p.

    Research output: Contribution to journalArticle

  27. The Hepatic cytochrome P450 reductase null (HRN) mouse model as a tool to study xenobiotic metabolism

    Arlt, V. M., Henderson, C. J., Wolf, C. R., Phillips, D. H. & Stiborova, M. Mar 2010 In : Naunyn-Schmiedeberg's Archives of Pharmacology. 381, p. 83-83 1 p.

    Research output: Contribution to journalBook/Film/Article review

  28. Markedly enhanced colon tumorigenesis in Apc(Min) mice lacking glutathione S-transferase Pi

    Ritchie, K. J., Walsh, S., Sansom, O. J., Henderson, C. J. & Wolf, C. R. 8 Dec 2009 In : Proceedings of the National Academy of Sciences of the United States of America. 106, 49, p. 20859-20864 6 p.

    Research output: Contribution to journalArticle

  29. Cholesterol Metabolism: the Main Pathway Acting Downstream of Cytochrome P450 Oxidoreductase in Skeletal Development of the Limb

    Schmidt, K., Hughes, C., Chudek, J. A., Goodyear, S. R., Aspden, R. M., Talbot, R., Gundersen, T. E., Blomhoff, R., Henderson, C., Wolf, C. R. & Tickle, C. 15 May 2009 In : Molecular and Cellular Biology. 29, 10, p. 2716-2729 14 p.

    Research output: Contribution to journalArticle

  30. GSTpi Mediates MPTP-induced JNK Activation in the Nigrostriatal Pathway

    Gama, M. J., Castro-Caldas, M., Carvalho, A. N., Rodrigues, E., Henderson, C. J. & Wolf, C. R. May 2009 In : Drug Metabolism Reviews. 41, p. 29-30 2 p.

    Research output: Contribution to journalBook/Film/Article review

  31. Preclinical toxicokinetic evaluation of Phortress [2-(4-amino-3- methylphenyl)-5-fluorobenzothiazole lysylamide dihydrochloride] in two rodent species

    Bradshaw, T. D., Wren, J. E., Bruce, M., Barrett, D. A., Leong, C-O., Gaskell, M., Wright, E. K., Farmer, P. B., Henderson, C. J., Wolf, R. & Stevens, M. F. G. 1 Jan 2009 In : Pharmacology. 83, 2, p. 99-109 11 p.

    Research output: Contribution to journalArticle

  32. Unsaturated fatty acid regulation of cytochrome P450 expression via a CAR-dependent pathway

    Finn, R. D., Henderson, C. J., Scott, C. L. & Wolf, C. R. 1 Jan 2009 In : Biochemical Journal. 417, 1, p. 43-54 12 p.

    Research output: Contribution to journalArticle

  33. Nomenclature for alleles of the cytochrome P450 oxidoreductase gene

    Sim, S. C., Miller, W. L., Zhong, X-B., Arlt, W., Ogata, T., Ding, X., Wolf, C. R., Flueck, C. E., Pandey, A. V., Henderson, C. J., Porter, T. D., Daly, A. K., Nebert, D. W. & Ingelman-Sundberg, M. 2009 In : Pharmacogenetics and Genomics. 19, 7, p. 565-566 2 p.

    Research output: Contribution to journalLetter

  34. Glutathione Transferase P1 An Endogenous Inhibitor of Allergic Responses in a Mouse Model of Asthma

    Zhou, J., Wolf, C. R., Henderson, C. J., Cai, Y., Board, P. G., Foster, P. S. & Webb, D. C. 15 Dec 2008 In : American Journal of Respiratory and Critical Care Medicine. 178, 12, p. 1202-1210 9 p.

    Research output: Contribution to journalArticle

  35. Defining the in Vivo Role for Cytochrome b(5) in Cytochrome P450 Function through the Conditional Hepatic Deletion of Microsomal Cytochrome b(5)

    Finn, R. D., McLaughlin, L. A., Ronseaux, S., Rosewell, I., Houston, J. B., Henderson, C. J. & Wolf, C. R. 14 Nov 2008 In : Journal of Biological Chemistry. 283, 46, p. 31385-31393 9 p.

    Research output: Contribution to journalArticle

  36. Functional expression and comparative characterization of nine murine cytochromes P450 by fluorescent inhibition screening

    McLaughlin, L. A., Dickmann, L. J., Wolf, C. R. & Henderson, C. J. Jul 2008 In : Drug Metabolism and Disposition. 36, 7, p. 1322-1331 10 p.

    Research output: Contribution to journalArticle

  37. Metabolic activation of benzo[a]pyrene in vitro by hepatic cytochrome P450 contrasts with detoxification in vivo: experiments with hepatic cytochrome P450 reductase null mice

    Arlt, V. M., Stiborova, M., Henderson, C. J., Thiemann, M., Frei, E., Aimova, D., Singh, R., da Costa, G. G., Schmitz, O. J., Farmer, P. B., Wolf, C. R. & Phillips, D. H. Mar 2008 In : Carcinogenesis. 29, 3, p. 656-665 10 p.

    Research output: Contribution to journalArticle

  38. Role of hepatic cytochromes P450 in bioactivation of the anticancer drug ellipticine: Studies with the hepatic NADPH: Cytochrome P450 reductase null mouse

    Stiborova, M., Arlt, V. M., Henderson, C. J., Wolf, C. R., Kotrbova, V., Moserova, M., Hudecek, J., Phillips, D. H. & Frei, E. 1 Feb 2008 In : Toxicology and Applied Pharmacology. 226, 3, p. 318-327 10 p.

    Research output: Contribution to journalArticle

  39. THE ROLE OF HEPATIC CYTOCHROME P-450 ENZYMES IN METABOLISM OF IMIDAZOACRIDINONE ANTITUMOR AGENT, C-1311 (SYMADEX): STUDIES WITH THE HEPATIC NADPH: CYTOCHROME P450 REDUCTASE NULL MICE

    Potega, A., Ronseaux, S., Henderson, C., Konopa, J. & Mazerska, Z. 2008 In : Drug Metabolism Reviews. 40, p. 59-60 2 p.

    Research output: Contribution to journalBook/Film/Article review

  40. The disruption of hepatic cytochrome P450 reductase afters mouse lipid metabolism

    Mutch, D. M., Klocke, B., Morrison, P., Murray, C. A., Henderson, C. J., Seifert, M. & Williamson, G. Oct 2007 In : Journal of Proteome Research. 6, 10, p. 3976-3984 9 p.

    Research output: Contribution to journalArticle

  41. Development of a liquid Chromatography-Electrospray ionization tandem mass spectrometry method for detecting Oxaliplatin-DNA intrastrand cross-links in biological samples

    Le Pla, R. C., Ritchie, K. J., Henderson, C. J., Wolf, C. R., Harrington, C. F. & Farmer, P. B. Aug 2007 In : Chemical Research in Toxicology. 20, 8, p. 1177-1182 6 p.

    Research output: Contribution to journalArticle

  42. Exposure to benzo[A]pyrene in the hepatic cytochrome p450 oxidoreductase null mouse: detoxification by hepatic cytochrome p450 is more important than metabolic activation

    Arlt, V. M., Stiborova, M., Henderson, C. J., Thiemann, M., Frei, E., Singh, R., da Costa, G. G., Schmitz, O. J., Farmer, P. B., Wolf, C. R. & Phillips, D. H. Mar 2007 In : Naunyn-Schmiedeberg's Archives of Pharmacology. 375, Supplement 1, p. 73-73 1 p.352

    Research output: Contribution to journalMeeting abstract

  43. Activation of Nrf2 and cellular inflammatory response by hypochlorous acid

    Woods, C. G., Andersen, M. E., Zhang, Q., Thomas, R. S., Henderson, C. J., Wolf, C. R. & Pi, J. 2007 In : Free Radical Biology and Medicine. 43, p. S160-S160 1 p.

    Research output: Contribution to journalBook/Film/Article review

  44. Glutathione transferase π plays a critical role in the development of lung carcinogenesis following exposure to tobacco-related carcinogens and urethane

    Ritchie, K. J., Henderson, C. J., Wang, X-J., Vassieva, O., Carrie, D., Farmer, P. B., Gaskell, M., Park, K. & Wolf, C. R. 2007 In : Cancer Research. 67, 19, p. 9248-9257 10 p.

    Research output: Contribution to journalArticle

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