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Colin Henderson

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  1. Evidence that Cytochrome b5 and Cytochrome b5 Reductase Can Act as Sole Electron Donors to the Hepatic Cytochrome P450 System

    Henderson, C. J., McLaughlin, L. A. & Wolf, C. R. Jun-2013 In : Molecular Pharmacology. 83, 6, p. 1209-1217, 9 p.

    Research output: Contribution to journal › Article

  2. Diminished toxicity of C-1748, 4-methyl-9-hydroxyethylamino-1-nitroacridine, compared with its demethyl analog, C-857, corresponds to its resistance to metabolism in HepG2 cells

    Wisniewska, A., Niemira, M., Jagiello, K., Potega, A., Swist, M., Henderson, C., Skwarska, A., Augustin, E., Konopa, J. & Mazerska, Z. 1-Jul-2012 In : Biochemical Pharmacology. 84, 1, p. 30-42, 13 p.

    Research output: Contribution to journal › Article

  3. Glutathione S-Transferase pi Mediates MPTP-Induced c-Jun N-Terminal Kinase Activation in the Nigrostriatal Pathway

    Castro-Caldas, M., Carvalho, A. N., Rodrigues, E., Gama, M. J., Henderson, C. & Wolf, C. R. 1-Jan-2012 In : Molecular Neurobiology. p. 1-12, 12 p.

    Research output: Contribution to journal › Article

  4. Exposure to benzo[a]pyrene of hepatic cytochrome P450 reductase null (HRN) and P450 reductase conditional null (RCN) mice: detection of benzo[a]pyrene diol epoxide-DNA adducts by immunohistochemistry and P-postlabelling

    Arlt, V. M., Poirier, M. C., Sykes, S. E., John, K., Moserova, M., Stiborova, M., Wolf, C. R., Henderson, C. J. & Phillips, D. H. 2012 In : Toxicology Letters. 213, 2, p. 160-166, 7 p.

    Research output: Contribution to journal › Article

  5. Tauroursodeoxycholic acid prevents MPTP-induced dopaminergic cell death in a mouse model of Parkinson's disease

    Castro-Caldas, M., Carvalho, A. N., Rodrigues, E., Henderson, C. J., Wolf, C. R., Rodrigues, C. M. P. & Gama, M. J. 2012 In : Molecular Neurobiology. 46, 2, p. 475-486, 12 p.

    Research output: Contribution to journal › Article

  6. Non-catalytic mechanisms involved in glutathione Stransferase Pi mediated cytoprotection

    McGarry, D. J., Wolf, C. R. & Henderson, C. J. 18-Dec-2011 In : Toxicology. 290, 2-3, p. 130-130, 1 p.

    Research output: Contribution to journal › Book/Film/Article review

  7. Effect of hepatic cytochrome P450 (P450) oxidoreductase deficiency on 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine-DNA Adduct Formation in P450 reductase conditional null mice

    Arlt, V. M., Singh, R., Stiborova, M., da Costa, G. G., Frei, E., Evans, J. D., Farmer, P. B., Wolf, C. R., Henderson, C. J. & Phillips, D. H. Dec-2011 In : Drug Metabolism and Disposition. 39, 12, p. 2169-2173, 5 p.

    Research output: Contribution to journal › Article

  8. Increased Skin Papilloma Formation in Mice Lacking Glutathione Transferase GSTP

    Henderson, C. J., Ritchie, K. J., McLaren, A., Chakravarty, P. & Wolf, C. R. 15-Nov-2011 In : Cancer Research. 71, 22, p. 7048-7060, 13 p.

    Research output: Contribution to journal › Article

  9. Regulation of hepatic uptake and efflux transporters in vitro

    Hawksworth, G. M., Farooq, M., Henderson, C. J. & Weaver, R. J. Nov-2011 In : Drug Metabolism Reviews. 43, p. 209-209, 1 p.

    Research output: Contribution to journal › Book/Film/Article review

  10. Humanizing pi-Class Glutathione S-Transferase Regulation in a Mouse Model Alters Liver Toxicity in Response to Acetaminophen Overdose

    Vaughn, M. P., Shinohara, D. B., Castagna, N., Hicks, J. L., Netto, G., De Marzo, A. M., Speed, T. J., Reichert, Z. R., Kwabi-Addo, B., Henderson, C. J., Wolf, C. R., Yegnasubramanian, S. & Nelson, W. G. 11-Oct-2011 In : PLoS ONE. 6, 10, p. -, 10 p., e25707

    Research output: Contribution to journal › Article

  11. Role of CAR and PXR in xenobiotic toxicity

    Wolf, C. R., Elcombe, C., Rode, A., Scheer, N., Bower, C. & Henderson, C. 28-Aug-2011 In : Toxicology Letters. 205, p. S13-S13, 1 p.

    Research output: Contribution to journal › Book/Film/Article review

  12. The Imidazoacridinone Antitumor Drug, C-1311, Is Metabolized by Flavin Monooxygenases but Not by Cytochrome P450s

    Potega, A., Dabrowska, E., Niemira, M., Kot-Wasik, A., Ronseaux, S., Henderson, C. J., Wolf, C. R. & Mazerska, Z. Aug-2011 In : Drug Metabolism and Disposition. 39, 8, p. 1423-1432, 10 p.

    Research output: Contribution to journal › Article

  13. Cytochrome b (5) null mouse: a new model for studying inherited skin disorders and the role of unsaturated fatty acids in normal homeostasis

    Finn, R. D., McLaughlin, L. A., Hughes, C., Song, C., Henderson, C. J. & Wolf, C. R. Jun-2011 In : Transgenic Research. 20, 3, p. 491-502, 12 p.

    Research output: Contribution to journal › Article

  14. Knockout and transgenic mice in glutathione transferase research

    Henderson, C. J. & Wolf, C. R. May-2011 In : Drug Metabolism Reviews. 43, 2, p. 152-164, 13 p.

    Research output: Contribution to journal › Scientific review

  15. Role of Cytochromes P450 1A1/2 in Detoxication and Activation of Carcinogenic Aristolochic Acid I: Studies with the Hepatic NADPH:Cytochrome P450 Reductase Null (HRN) Mouse Model

    Levova, K., Moserova, M., Kotrbova, V., Sulc, M., Henderson, C. J., Wolf, C. R., Phillips, D. H., Frei, E., Schmeiser, H. H., Mares, J., Arlt, V. M. & Stiborova, M. May-2011 In : Toxicological Sciences. 121, 1, p. 43-56, 14 p.

    Research output: Contribution to journal › Article

  16. Non-catalytic mechanisms involved in glutathione S-transferase pi mediated cytoprotection

    McGarry, D. J., Wolf, C. R. & Henderson, C. J. 30-Dec-2010 In : Toxicology. 278, 3, p. 371-372, 2 p.

    Research output: Contribution to journal › Book/Film/Article review

  17. Detection and quantitation of N-(deoxyguanosin-8-yl)-2-amino-1-methyl-6-Phenylimidazo[4,5-b]pyridine adducts in DNA using online column-switching liquid chromatography tandem mass spectrometry

    Singh, R., Arlt, V. M., Henderson, C. J., Phillips, D. H., Farmer, P. B. & da Costa, G. G. 1-Aug-2010 In : Journal of Chromatography B-Analytical Technologies in the Biomedical and Life Sciences. 878, 23, p. 2155-2162, 8 p.

    Research output: Contribution to journal › Article

  18. Deletion of Microsomal Cytochrome b(5) Profoundly Affects Hepatic and Extrahepatic Drug Metabolism

    McLaughlin, L. A., Ronseaux, S., Finn, R. D., Henderson, C. J. & Wolf, C. R. Aug-2010 In : Molecular Pharmacology. 78, 2, p. 269-278, 10 p.

    Research output: Contribution to journal › Article

  19. Human Constitutive Androstane Receptor (CAR) and Pregnane X Receptor (PXR) Support the Hypertrophic but not the Hyperplastic Response to the Murine Nongenotoxic Hepatocarcinogens Phenobarbital and Chlordane In Vivo

    Ross, J., Plummer, S. M., Rode, A., Scheer, N., Bower, C. C., Vogel, O., Henderson, C. J., Wolf, C. R. & Elcombe, C. R. Aug-2010 In : Toxicological Sciences. 116, 2, p. 452-466, 15 p.

    Research output: Contribution to journal › Article

  20. The Hepatic cytochrome P450 reductase null (HRN) mouse model as a tool to study xenobiotic metabolism

    Arlt, V. M., Henderson, C. J., Wolf, C. R., Phillips, D. H. & Stiborova, M. Mar-2010 In : Naunyn-Schmiedeberg's Archives of Pharmacology. 381, p. 83-83, 1 p.

    Research output: Contribution to journal › Book/Film/Article review

  21. Markedly enhanced colon tumorigenesis in Apc(Min) mice lacking glutathione S-transferase Pi

    Ritchie, K. J., Walsh, S., Sansom, O. J., Henderson, C. J. & Wolf, C. R. 8-Dec-2009 In : Proceedings of the National Academy of Sciences of the United States of America. 106, 49, p. 20859-20864, 6 p.

    Research output: Contribution to journal › Article

  22. Nomenclature for alleles of the cytochrome P450 oxidoreductase gene

    Sim, S. C., Miller, W. L., Zhong, X-B., Arlt, W., Ogata, T., Ding, X., Wolf, C. R., Flueck, C. E., Pandey, A. V., Henderson, C. J., Porter, T. D., Daly, A. K., Nebert, D. W. & Ingelman-Sundberg, M. Jul-2009 In : Pharmacogenetics and Genomics. 19, 7, p. 565-566, 2 p.

    Research output: Contribution to journal › Letter

  23. Cholesterol Metabolism: the Main Pathway Acting Downstream of Cytochrome P450 Oxidoreductase in Skeletal Development of the Limb

    Schmidt, K., Hughes, C., Chudek, J. A., Goodyear, S. R., Aspden, R. M., Talbot, R., Gundersen, T. E., Blomhoff, R., Henderson, C., Wolf, C. R. & Tickle, C. 15-May-2009 In : Molecular and Cellular Biology. 29, 10, p. 2716-2729, 14 p.

    Research output: Contribution to journal › Article

  24. GSTpi Mediates MPTP-induced JNK Activation in the Nigrostriatal Pathway

    Gama, M. J., Castro-Caldas, M., Carvalho, A. N., Rodrigues, E., Henderson, C. J. & Wolf, C. R. May-2009 In : Drug Metabolism Reviews. 41, p. 29-30, 2 p.

    Research output: Contribution to journal › Book/Film/Article review

  25. Advances in the generation of mouse models to elucidate the pathways of drug metabolism in rodents and man

    Henderson, C. J., Scheer, N. & Wolf, C. R. 1-Jan-2009 In : Expert Review of Clinical Pharmacology. 2, 2, p. 105-109, 5 p.

    Research output: Contribution to journal › Editorial

  26. Preclinical toxicokinetic evaluation of Phortress [2-(4-amino-3- methylphenyl)-5-fluorobenzothiazole lysylamide dihydrochloride] in two rodent species

    Bradshaw, T. D., Wren, J. E., Bruce, M., Barrett, D. A., Leong, C-O., Gaskell, M., Wright, E. K., Farmer, P. B., Henderson, C. J., Wolf, R. & Stevens, M. F. G. 1-Jan-2009 In : Pharmacology. 83, 2, p. 99-109, 11 p.

    Research output: Contribution to journal › Article

  27. Unsaturated fatty acid regulation of cytochrome P450 expression via a CAR-dependent pathway

    Finn, R. D., Henderson, C. J., Scott, C. L. & Wolf, C. R. 1-Jan-2009 In : Biochemical Journal. 417, p. 43-54, 12 p.

    Research output: Contribution to journal › Article

  28. Glutathione Transferase P1 An Endogenous Inhibitor of Allergic Responses in a Mouse Model of Asthma

    Zhou, J., Wolf, C. R., Henderson, C. J., Cai, Y., Board, P. G., Foster, P. S. & Webb, D. C. 15-Dec-2008 In : American Journal of Respiratory and Critical Care Medicine. 178, 12, p. 1202-1210, 9 p.

    Research output: Contribution to journal › Article

  29. Defining the in Vivo Role for Cytochrome b(5) in Cytochrome P450 Function through the Conditional Hepatic Deletion of Microsomal Cytochrome b(5)

    Finn, R. D., McLaughlin, L. A., Ronseaux, S., Rosewell, I., Houston, J. B., Henderson, C. J. & Wolf, C. R. 14-Nov-2008 In : Journal of Biological Chemistry. 283, 46, p. 31385-31393, 9 p.

    Research output: Contribution to journal › Article

  30. Functional expression and comparative characterization of nine murine cytochromes P450 by fluorescent inhibition screening

    McLaughlin, L. A., Dickmann, L. J., Wolf, C. R. & Henderson, C. J. Jul-2008 In : Drug Metabolism and Disposition. 36, 7, p. 1322-1331, 10 p.

    Research output: Contribution to journal › Article

  31. Metabolic activation of benzo[a]pyrene in vitro by hepatic cytochrome P450 contrasts with detoxification in vivo: experiments with hepatic cytochrome P450 reductase null mice

    Arlt, V. M., Stiborova, M., Henderson, C. J., Thiemann, M., Frei, E., Aimova, D., Singh, R., da Costa, G. G., Schmitz, O. J., Farmer, P. B., Wolf, C. R. & Phillips, D. H. Mar-2008 In : Carcinogenesis. 29, 3, p. 656-665, 10 p.

    Research output: Contribution to journal › Article

  32. Role of hepatic cytochromes P450 in bioactivation of the anticancer drug ellipticine: Studies with the hepatic NADPH: Cytochrome P450 reductase null mouse

    Stiborova, M., Arlt, V. M., Henderson, C. J., Wolf, C. R., Kotrbova, V., Moserova, M., Hudecek, J., Phillips, D. H. & Frei, E. 1-Feb-2008 In : Toxicology and Applied Pharmacology. 226, 3, p. 318-327, 10 p.

    Research output: Contribution to journal › Article

  33. THE ROLE OF HEPATIC CYTOCHROME P-450 ENZYMES IN METABOLISM OF IMIDAZOACRIDINONE ANTITUMOR AGENT, C-1311 (SYMADEX): STUDIES WITH THE HEPATIC NADPH: CYTOCHROME P450 REDUCTASE NULL MICE

    Potega, A., Ronseaux, S., Henderson, C., Konopa, J. & Mazerska, Z. 2008 In : Drug Metabolism Reviews. 40, p. 59-60, 2 p.

    Research output: Contribution to journal › Book/Film/Article review

  34. Identification of retinoic acid as an inhibitor of transcription factor Nrf2 through activation of retinoic acid receptor alpha

    Wang, X. J., Hayes, J. D., Henderson, C. J. & Wolf, C. R. 4-Dec-2007 In : Proceedings of the National Academy of Sciences of the United States of America. 104, 49, p. 19589-19594, 6 p.

    Research output: Contribution to journal › Article

  35. The disruption of hepatic cytochrome P450 reductase afters mouse lipid metabolism

    Mutch, D. M., Klocke, B., Morrison, P., Murray, C. A., Henderson, C. J., Seifert, M. & Williamson, G. Oct-2007 In : Journal of Proteome Research. 6, 10, p. 3976-3984, 9 p.

    Research output: Contribution to journal › Article

  36. Development of a liquid Chromatography-Electrospray ionization tandem mass spectrometry method for detecting Oxaliplatin-DNA intrastrand cross-links in biological samples

    Le Pla, R. C., Ritchie, K. J., Henderson, C. J., Wolf, C. R., Harrington, C. F. & Farmer, P. B. Aug-2007 In : Chemical Research in Toxicology. 20, 8, p. 1177-1182, 6 p.

    Research output: Contribution to journal › Article

  37. Conditional deletion of cytochrome P450 oxidoreductase in the liver and gastrointestinal tract: A new model for studying the functions of the P450 system

    Finn, R. D., McLaren, A. W., Carrie, D., Henderson, C. J. & Wolf, C. R. Jul-2007 In : Journal of Pharmacology and Experimental Therapeutics. 322, 1, p. 40-47, 8 p.

    Research output: Contribution to journal › Article

  38. Exposure to benzo[A]pyrene in the hepatic cytochrome p450 oxidoreductase null mouse: detoxification by hepatic cytochrome p450 is more important than metabolic activation

    Arlt, V. M., Stiborova, M., Henderson, C. J., Thiemann, M., Frei, E., Singh, R., da Costa, G. G., Schmitz, O. J., Farmer, P. B., Wolf, C. R. & Phillips, D. H. Mar-2007 In : Naunyn-Schmiedeberg's Archives of Pharmacology. 375, Supplement 1, p. 73-73, 1 p., 352

    Research output: Contribution to journal › Meeting abstract

  39. Activation of Nrf2 and cellular inflammatory response by hypochlorous acid

    Woods, C. G., Andersen, M. E., Zhang, Q., Thomas, R. S., Henderson, C. J., Wolf, C. R. & Pi, J. 2007 In : Free Radical Biology and Medicine. 43, p. S160-S160, 1 p.

    Research output: Contribution to journal › Book/Film/Article review

  40. Glutathione transferase π plays a critical role in the development of lung carcinogenesis following exposure to tobacco-related carcinogens and urethane

    Ritchie, K. J., Henderson, C. J., Wang, X-J., Vassieva, O., Carrie, D., Farmer, P. B., Gaskell, M., Park, K. & Wolf, C. R. 2007 In : Cancer Research. 67, 19, p. 9248-9257, 10 p.

    Research output: Contribution to journal › Article

  41. Hepatic cytochrome P-450 reductase-null mice show reduced transcriptional response to quercetin and reveal physiological homeostasis between jejunum and liver

    Mutch, D. M., Crespy, V., Clough, J., Henderson, C. J., Lariani, S., Mansourian, R., Moulin, J., Wolf, C. R. & Williamson, G. Jul-2006 In : American Journal of Physiology-Gastrointestinal and Liver Physiology. 291, 1, p. G63-G72, 10 p.

    Research output: Contribution to journal › Article

  42. Bioactivation of 3-aminobenzanthrone, a human metabolite of the environmental pollutant 3-nitrobenzanthrone: evidence for DNA adduct formation mediated by cytochrome P450 enzymes and peroxidases

    Arlt, V. M., Henderson, C. J., Wolf, C. R., Schmeiser, H. H., Phillips, D. H. & Stiborova, M. 28-Mar-2006 In : Cancer Letters. 234, 2, p. 220-231, 12 p.

    Research output: Contribution to journal › Article

  43. The hepatic cytochrome P450 reductase null mouse as a tool to identify a successful candidate entity

    Henderson, C. J., Pass, G. J. & Wolf, C. R. 15-Mar-2006 In : Toxicology Letters. 162, 1, p. 111-117, 7 p.

    Research output: Contribution to journal › Article

  44. Relationship between hepatic phenotype and changes in gene expression in cytochrome P450 reductase (POR) null mice

    Wang, X. J., Chamberlain, M., Vassieva, O., Henderson, C. J. & Wolf, C. R. 15-Jun-2005 In : Biochemical Journal. 388, 3, p. 857-867, 11 p.

    Research output: Contribution to journal › Article

  45. Role of hepatic cytochrome P450s in the pharmacokinetics and toxicity of cyclophosphamide: studies with the hepatic cytochrome P450 reductase null mouse

    Pass, G. J., Carrie, D., Boylan, M., Lorimore, S., Wright, E., Houston, B., Henderson, C. J. & Wolf, C. R. 15-May-2005 In : Cancer Research. 65, 10, p. 4211-4217, 7 p.

    Research output: Contribution to journal › Article

  46. Environmental pollutant and potent mutagen 3-nitrobenzanthrone forms DNA adducts after reduction by NAD(P)H: quinone oxidoreductase and conjugation by acetyltransferases and sulfotransferases in human hepatic cytosols

    Arlt, V. M., Stiborova, M., Henderson, C. J., Osborne, M. R., Bieler, C. A., Frei, E., Martinek, V., Sopko, B., Wolf, C. R., Schmeiser, H. H. & Phillips, D. H. 1-Apr-2005 In : Cancer Research. 65, 7, p. 2644-2652, 9 p.

    Research output: Contribution to journal › Article

  47. The murine Cyp1a1 gene is expressed in a restricted spatial and temporal pattern during embryonic development

    Campbell, S. J., Henderson, C. J., Anthony, D. C., Davidson, D., Clark, A. J. & Wolf, C. R. 18-Feb-2005 In : Journal of Biological Chemistry. 280, 7, p. 5828-5835, 8 p.

    Research output: Contribution to journal › Article

  48. Disruption of the glutathione transferase Pi class genes

    Henderson, C. J. & Wolf, C. R. 2005 Methods in enzymology: gluthione transferases and gamma-glutamyl transpeptidases. Sies, H. & Packer, L. (eds.). San Diego: Academic Press, Vol. 401, p. 116-135 20 p.

    Research output: Chapter in Book/Report/Conference proceeding › Other chapter contribution

  49. Transcription factor Nrf2 is essential for induction of NAD(P)H:quinone oxidoreductase 1, glutathione S-transferases, and glutamate cysteine ligase by broccoli seeds and isothiocyanates

    McWalter, G. K., Higgins, L. G., McLellan, L. I., Henderson, C. J., Song, L., Thornalley, P. J., Itoh, K., Yamamoto, M. & Hayes, J. D. 1-Dec-2004 In : Journal of Nutrition. 134, 12, p. 3499S-3506S

    Research output: Contribution to journal › Article

  50. Identification of novel roles of the cytochrome P450 system in early embryogenesis: effects on vasculogenesis and retinoic acid homeostasis

    Otto, D. M. E., Henderson, C. J., Carrie, D., Davey, M., Gundersen, T. E., Blomhoff, R., Adams, R. H., Tickle, C. & Wolf, C. R. Sep-2003 In : Molecular and Cellular Biology. 23, 17, p. 6103-6116, 14 p.

    Research output: Contribution to journal › Article

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