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Michael McMahon

  1. Targeting the Ataxia Telangiectasia Mutated-null phenotype in chronic lymphocytic leukemia with pro-oxidants

    McMahon, M. , Hayes, J. D. & 19 others Agathanggelou, A., Weston, V. J., Perry, T., Davies, N. J., Skowronska, A., Payne, D. T., Fossey, J. S., Oldreive, C. E., Wei, W., Pratt, G., Parry, H., Oscier, D., Coles, S. J., Hole, P. S., Darley, R. L., Moss, P., Stewart, G., Taylor, A. M. R. & Stankovic, T. Aug 2015 In : Haematologica. 100, 8, p. 1076-1085 10 p.

    Research output: Contribution to journalArticle

  2. HDAC inhibitors increase NRF2-signaling in tumour cells and blunt the efficacy of co-adminstered cytotoxic agents

    McMahon, M., Campbell, K. H., MacLeod, A. K., McLaughlin, L. A., Henderson, C. J. & Wolf, C. R. 26 Nov 2014 In : PLoS ONE. 9, 11, e114055

    Research output: Contribution to journalArticle

  3. Nrf2 is controlled by two distinct β-TrCP recognition motifs in its Neh6 domain, one of which can be modulated by GSK-3 activity

    Chowdhry, S., Zhang, Y., McMahon, M., Sutherland, C., Cuadrado, A. & Hayes, J. D. 2012 In : Oncogene. 32, p. 3765-3781 17 p.

    Research output: Contribution to journalArticle

  4. Nrf2-mediated induction of antioxidant response element-driven gene expression by flavonoids is dependent on their chemical structure

    Xiao, H., Hourihan, J. M., Brown, L., McMahon, M., Stewart, D. & Hayes, J. D. 18 Dec 2011 In : Toxicology. 290, 2-3, p. 126-127 2 p.

    Research output: Contribution to journalBook/Film/Article review

  5. SCF/{beta}-TrCP promotes glycogen synthase kinase 3-dependent degradation of the Nrf2 transcription factor in a Keap1-independent manner

    Rada, P., Rojo, A. I., Chowdhry, S., McMahon, M., Hayes, J. D. & Cuadrado, A. Mar 2011 In : Molecular and Cellular Biology. 31, 6, p. 1121-1133 13 p.

    Research output: Contribution to journalArticle

  6. p62/SQSTM1 is a target gene for transcription factor NRF2 and creates a positive feedback loop by inducing antioxidant response element-driven gene transcription

    Jain, A., Lamark, T., Sjottem, E., Larsen, K. B., Awuh, J. A., Overvatn, A., McMahon, M., Hayes, J. D. & Johansen, T. 16 Jul 2010 In : Journal of Biological Chemistry. 285, 29, p. 22576-22591 16 p.

    Research output: Contribution to journalArticle

  7. Cancer chemoprevention mechanisms mediated through the Keap1-Nrf2 pathway

    Hayes, J. D., McMahon, M., Chowdhry, S. & Dinkova-Kostova, A. T. 2010 In : Antioxidants & Redox Signaling. 13, 11, p. 1713-1748 36 p.

    Research output: Contribution to journalArticle

  8. 1-Cyano-2,3-epithiopropane is a novel plant-derived chemopreventive agent which induces cytoprotective genes that afford resistance against the genotoxic alpha,beta-unsaturated aldehyde acrolein

    Kelleher, M. O., McMahon, M., Eggleston, I. M., Dixon, M. J., Taguchi, K., Yamamoto, M. & Hayes, J. D. Oct 2009 In : Carcinogenesis. 30, 10, p. 1754-1762 9 p.

    Research output: Contribution to journalArticle

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