Roland Wolf

Insights into drug metabolism by cytochromes P450 from modelling studies of CYP2D6-drug interactions

Marechal, J-D., Kemp, C. A., Roberts, G. C. K., Paine, M., Wolf, R. & Sutcliffe, M. J. Mar-2008 In : British Journal of Pharmacology. 153, p. S82-S89, 8 p.

Research output: Contribution to journal › Article

Metabolic activation of benzo[a]pyrene in vitro by hepatic cytochrome P450 contrasts with detoxification in vivo: experiments with hepatic cytochrome P450 reductase null mice

Arlt, V. M., Stiborova, M., Henderson, C. J., Thiemann, M., Frei, E., Aimova, D., Singh, R., da Costa, G. G., Schmitz, O. J., Farmer, P. B., Wolf, C. R. & Phillips, D. H. Mar-2008 In : Carcinogenesis. 29, 3, p. 656-665, 10 p.

Research output: Contribution to journal › Article

Role of hepatic cytochromes P450 in bioactivation of the anticancer drug ellipticine: Studies with the hepatic NADPH: Cytochrome P450 reductase null mouse

Stiborova, M., Arlt, V. M., Henderson, C. J., Wolf, C. R., Kotrbova, V., Moserova, M., Hudecek, J., Phillips, D. H. & Frei, E. 1-Feb-2008 In : Toxicology and Applied Pharmacology. 226, 3, p. 318-327, 10 p.

Research output: Contribution to journal › Article

A novel panel of double 'humanised' & knockout PXR and car mouse models

Ross, J., Scheer, N. & Wolf, R. 2008 In : Drug Metabolism Reviews. 40, p. 114-115, 2 p.

Research output: Contribution to journal › Book/Film/Article review

Recombinant yeast and bacteria that express human p450s: bioreactors for drug-discovery, -development and -biotechnology

Friedberg, T. H., Hanlon, S., Kittelmann, M., Ghisalba, O. & Wolf, C. R. 2008 In : Drug Metabolism Reviews. 40, p. 75-76, 2 p.

Research output: Contribution to journal › Book/Film/Article review

Identification of retinoic acid as an inhibitor of transcription factor Nrf2 through activation of retinoic acid receptor alpha

Wang, X. J., Hayes, J. D., Henderson, C. J. & Wolf, C. R. 4-Dec-2007 In : Proceedings of the National Academy of Sciences of the United States of America. 104, 49, p. 19589-19594, 6 p.

Research output: Contribution to journal › Article

Melanocortin 1 receptor (MC1R) genotype influences erythemal sensitivity to psoralen-ultraviolet A photochemotherapy

Smith, G., Wilkie, M. J. V., Deeni, Y. Y., Farr, P. M., Ferguson, J., Wolf, C. R. & Ibbotson, S. H. Dec-2007 In : British Journal of Dermatology. 157, 6, p. 1230-4, 5 p.

Research output: Contribution to journal › Article

Development of a liquid Chromatography-Electrospray ionization tandem mass spectrometry method for detecting Oxaliplatin-DNA intrastrand cross-links in biological samples

Le Pla, R. C., Ritchie, K. J., Henderson, C. J., Wolf, C. R., Harrington, C. F. & Farmer, P. B. Aug-2007 In : Chemical Research in Toxicology. 20, 8, p. 1177-1182, 6 p.

Research output: Contribution to journal › Article

Conditional deletion of cytochrome P450 oxidoreductase in the liver and gastrointestinal tract: A new model for studying the functions of the P450 system

Finn, R. D., McLaren, A. W., Carrie, D., Henderson, C. J. & Wolf, C. R. Jul-2007 In : Journal of Pharmacology and Experimental Therapeutics. 322, 1, p. 40-47, 8 p.

Research output: Contribution to journal › Article

A splice site polymorphism in the G-protein beta subunit influences antidepressant efficacy in depression

Wilkie, M. J. V., Smith, D., Reid, I. C., Day, R. K., Matthews, K., Wolf, R., Blackwood, D. & Smith, G. Mar-2007 In : Pharmacogenetics and Genomics. 17, 3, p. 207-215, 9 p.

Research output: Contribution to journal › Article