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Roland Wolf

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  1. Cytochrome b and epoxide hydrolase contribute to benzo[a]pyrene-DNA adduct formation catalyzed by cytochrome P450 1A1 under low NADPH:P450 oxidoreductase conditions

    Stiborová, M., Moserová, M., Černá, V., Indra, R., Dračínský, M., Šulc, M., Henderson, C. J., Wolf, C. R., Schmeiser, H. H., Phillips, D. H., Frei, E. & Arlt, V. M. 6 Apr 2014 In : Toxicology. 318, 1, p. 1-12 12 p.

    Research output: Contribution to journalArticle

  2. Epigenetic profiles as defined signatures of xenobiotic exposure

    Thomson, J. P., Moggs, J. G., Wolf, C. R. & Meehan, R. R. Apr 2014 In : Mutation Research: Genetic Toxicology and Environmental Mutagenesis. 764-765, p. 3-9 7 p.

    Research output: Contribution to journalArticle

  3. A role for cytochrome b5 in the in vivo disposition of anti-cancer and cytochrome P450 probe drugs in mice

    Henderson, C. J., McLaughlin, L. A., Finn, R. D., Ronseaux, S., Kapelyukh, Y. & Wolf, C. R. Jan 2014 In : Drug Metabolism and Disposition. 42, 1, p. 70-77 8 p.

    Research output: Contribution to journalArticle

  4. Deletion of 30 murine cytochrome p450 genes results in viable mice with compromised drug metabolism

    Scheer, N., McLaughlin, L. A., Rode, A., MacLeod, A. K., Henderson, C. J. & Wolf, C. R. 2014 In : Drug Metabolism and Disposition. 42, 6, p. 1022-1030 9 p.

    Research output: Contribution to journalArticle

  5. Glutathione S-transferase P1 (GSTP1) directly influences platinum drug chemosensitivity in ovarian tumour cell lines

    Sawers, L., Ferguson, M. J., Ihrig, B. R., Young, H. C., Chakravarty, P., Wolf, C. R. & Smith, G. 2014 In : British Journal of Cancer.

    Research output: Contribution to journalArticle

  6. In vivo regulation of human glutathione transferase GSTP by chemopreventive agents

    Henderson, C. J., McLaren, A. W. & Wolf, C. R. 2014 In : Cancer Research.

    Research output: Contribution to journalArticle

  7. Phenobarbital induces cell cycle transcriptional responses in mouse liver humanized for constitutive androstane and pregnane X receptors

    Henderson, C. J. , Wolf, C. R. & 24 others Luisier, R., Lempiäinen, H., Scherbichler, N., Braeuning, A., Geissler, M., Dubost, V., Müller, A., Scheer, N., Chibout, S-D., Hara, H., Picard, F., Theil, D., Couttet, P., Vitobello, A., Grenet, O., Grasl-Kraupp, B., Ellinger-Ziegelbauer, H., Thomson, J. P., Meehan, R. R., Elcombe, C. R., Schwarz, M., Moulin, P., Terranova, R. & Moggs, J. G. 2014 In : Toxicological Sciences. 139, 2, p. 501-511 11 p.

    Research output: Contribution to journalArticle

  8. Generation and utility of genetically humanized mouse models

    Scheer, N., Snaith, M., Wolf, C. R. & Seibler, J. Dec 2013 In : Drug Discovery Today. 18, 23-24, p. 1200-1211 12 p.

    Research output: Contribution to journalArticle

  9. Cytochrome P450 CYP1B1 Interacts with 8-Methoxypsoralen (8-MOP) and Influences Psoralen-Ultraviolet A (PUVA) Sensitivity

    Deeni, Y. Y., Ibbotson, S. H., Woods, J. A., Wolf, C. R. & Smith, G. 23 Sep 2013 In : PLoS ONE. 8, 9, e75494

    Research output: Contribution to journalArticle

  10. Cytochrome P450 CYP1B1 interacts with 8-methoxypsoralen (8-MOP) and influences psoralen-ultraviolet (PUVA) sensitivity

    Deeni, Y. Y., Ibbotson, S. H., Woods, J. A., Wolf, C. R. & Smith, G. 23 Sep 2013 In : PLoS ONE. 8, 9, e75494

    Research output: Contribution to journalArticle

  11. Ubiquitin-proteasome system impairment and MPTP-induced oxidative stress in the brain of C57BL/6 wild-type and GSTP knockout mice

    Carvalho, A. N., Marques, C., Rodrigues, E., Henderson, C. J., Wolf, C. R., Pereira, P. & Gama, M. J. Apr 2013 In : Molecular Neurobiology. 47, 2, p. 662-72 11 p.

    Research output: Contribution to journalArticle

  12. NADPH-cytochrome P450 oxidoreductase: roles in physiology, pharmacology, and toxicology

    Riddick, D. S., Ding, X., Wolf, C. R., Porter, T. D., Pandey, A. V., Zhang, Q-Y., Gu, J., Finn, R. D., Ronseaux, S., McLaughlin, L. A., Henderson, C. J., Zou, L. & Flück, C. E. Jan 2013 In : Drug Metabolism and Disposition. 41, 1, p. 12-23 12 p.

    Research output: Contribution to journalArticle

  13. Cytochrome P450 CYP1B1 interacts with 8-methoxypsoralen (8-MOP) and influences psoralen-ultraviolet A (PUVA) sensitivity

    Deeni, Y. Y., Ibbotson, S. H., Woods, J. A., Wolf, C. R. & Smith, G. 2013 In : PLoS ONE. 8, 9, p. e75494

    Research output: Contribution to journalArticle

  14. The involvement of mitochondrial amidoxime reducing components 1 and 2 and mitochondrial cytochrome b5 in N-reductive metabolism in human cells

    Plitzko, B., Ott, G., Reichmann, D., Henderson, C. J., Wolf, C. R., Mendel, R., Bittner, F., Clement, B. & Havemeyer, A. 2013 In : Journal of Biological Chemistry. 288, 28, p. 20228-20237 10 p.

    Research output: Contribution to journalArticle

  15. Individuality in FGF1 expression significantly influences platinum resistance and progression-free survival in ovarian cancer

    Smith, G., Ng, M. T. H., Shepherd, L., Herrington, C. S., Gourley, C., Ferguson, M. & Wolf, C. R. 9 Oct 2012 In : British Journal of Cancer. 107, 8, p. 1327-1336 10 p.

    Research output: Contribution to journalArticle

  16. Characterization of a Human Keratinocyte HaCaT Cell Line Model to Study the Regulation of CYP2S1

    McNeilly, A. D., Woods, J. A., Ibbotson, S. H., Wolf, C. R. & Smith, G. Feb 2012 In : Drug Metabolism and Disposition. 40, 2, p. 283-289 7 p.

    Research output: Contribution to journalArticle

  17. Glutathione S-transferase genotype is associated with sensitivity to psoralen-ultraviolet A photochemotherapy

    Ibbotson, S. H., Dawe, R. S., Dinkova-Kostova, A. T., Weidlich, S., Farr, P. M., Ferguson, J., Wolf, C. R. & Smith, G. Feb 2012 In : British Journal of Dermatology. 166, 2, p. 380-388 9 p.

    Research output: Contribution to journalArticle

  18. The role of bioreductive activation of antitumour anthracycline drugs in cytotoxic activity against sensitive and multidrug resistant leukaemia HL60 cells

    Kostrzewa-Nowak, D., Bieg, B., Paine, M. J. I., Wolf, C. R. & Tarasiuk, J. 14 Jan 2012 In : European Journal of Pharmacology. 674, 2-3, p. 112-125 14 p.

    Research output: Contribution to journalArticle

  19. Glutathione S-Transferase pi Mediates MPTP-Induced c-Jun N-Terminal Kinase Activation in the Nigrostriatal Pathway

    Castro-Caldas, M., Carvalho, A. N., Rodrigues, E., Gama, M. J., Henderson, C. & Wolf, C. R. 1 Jan 2012 In : Molecular Neurobiology. p. 1-12 12 p.

    Research output: Contribution to journalArticle

  20. Modeling Human Cytochrome P450 2D6 Metabolism and Drug-Drug Interaction by a Novel Panel of Knockout and Humanized Mouse Lines

    Scheer, N., Kapelyukh, Y., McEwan, J., Beuger, V., Stanley, L. A., Rode, A. & Wolf, C. R. Jan 2012 In : Molecular Pharmacology. 81, 1, p. 63-72 10 p.

    Research output: Contribution to journalArticle

  21. Conditional expression of human PPARδ and a dominant negative variant of hPPARδ in vivo

    Higgins, L. G., Garbacz, W. G., Gustafsson, M. C. U., Sitheswaran, N., Ashby, P. R., Wolf, C. R. & Palmer, C. N. A. 2012 In : PPAR Research. 12 p.216817

    Research output: Contribution to journalArticle

  22. Exposure to benzo[a]pyrene of hepatic cytochrome P450 reductase null (HRN) and P450 reductase conditional null (RCN) mice: detection of benzo[a]pyrene diol epoxide-DNA adducts by immunohistochemistry and P-postlabelling

    Arlt, V. M., Poirier, M. C., Sykes, S. E., John, K., Moserova, M., Stiborova, M., Wolf, C. R., Henderson, C. J. & Phillips, D. H. 2012 In : Toxicology Letters. 213, 2, p. 160-166 7 p.

    Research output: Contribution to journalArticle

  23. Generation and characterization of a novel multidrug resistance protein 2 humanized mouse line

    Scheer, N., Balimane, P., Hayward, M. D., Buechel, S., Kauselmann, G. & Wolf, C. R. 2012 In : Drug Metabolism and Disposition. 40, 11, p. 2212-2218 7 p.

    Research output: Contribution to journalArticle

  24. Tauroursodeoxycholic acid prevents MPTP-induced dopaminergic cell death in a mouse model of Parkinson's disease

    Castro-Caldas, M., Carvalho, A. N., Rodrigues, E., Henderson, C. J., Wolf, C. R., Rodrigues, C. M. P. & Gama, M. J. 2012 In : Molecular Neurobiology. 46, 2, p. 475-486 12 p.

    Research output: Contribution to journalArticle

  25. Non-catalytic mechanisms involved in glutathione Stransferase Pi mediated cytoprotection

    McGarry, D. J., Wolf, C. R. & Henderson, C. J. 18 Dec 2011 In : Toxicology. 290, 2-3, p. 130-130 1 p.

    Research output: Contribution to journalBook/Film/Article review

  26. Effect of hepatic cytochrome P450 (P450) oxidoreductase deficiency on 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine-DNA Adduct Formation in P450 reductase conditional null mice

    Arlt, V. M., Singh, R., Stiborova, M., da Costa, G. G., Frei, E., Evans, J. D., Farmer, P. B., Wolf, C. R., Henderson, C. J. & Phillips, D. H. Dec 2011 In : Drug Metabolism and Disposition. 39, 12, p. 2169-2173 5 p.

    Research output: Contribution to journalArticle

  27. Increased Skin Papilloma Formation in Mice Lacking Glutathione Transferase GSTP

    Henderson, C. J., Ritchie, K. J., McLaren, A., Chakravarty, P. & Wolf, C. R. 15 Nov 2011 In : Cancer Research. 71, 22, p. 7048-7060 13 p.

    Research output: Contribution to journalArticle

  28. Enzyme and protein engineering: engineering a self-sufficient human cytochrome P450 monooxygenase system

    Deeni, Y. & Wolf, R. Sep 2011 In : Current Opinion in Biotechnology. 22, p. S18-S18 1 p.

    Research output: Contribution to journalBook/Film/Article review

  29. Quantitative Prediction of Human Pregnane X Receptor and Cytochrome P450 3A4 Mediated Drug-Drug Interaction in a Novel Multiple Humanized Mouse Line

    Hasegawa, M., Kapelyukh, Y., Tahara, H., Seibler, J., Rode, A., Krueger, S., Lee, D. N., Wolf, C. R. & Scheer, N. Sep 2011 In : Molecular Pharmacology. 80, 3, p. 518-528 11 p.

    Research output: Contribution to journalArticle

  30. The Imidazoacridinone Antitumor Drug, C-1311, Is Metabolized by Flavin Monooxygenases but Not by Cytochrome P450s

    Potega, A., Dabrowska, E., Niemira, M., Kot-Wasik, A., Ronseaux, S., Henderson, C. J., Wolf, C. R. & Mazerska, Z. Aug 2011 In : Drug Metabolism and Disposition. 39, 8, p. 1423-1432 10 p.

    Research output: Contribution to journalArticle

  31. Pyrosequencing-based methods reveal marked inter-individual differences in oncogene mutation burden in human colorectal tumours

    Weidlich, S., Walsh, K., Crowther, D., Burczynski, M. E., Feuerstein, G., Carey, F., Steele, R. J. C., Wolf, C. R., Miele, G. & Smith, G. 12 Jul 2011 In : British Journal of Cancer. 105, 2, p. 246-254 9 p.

    Research output: Contribution to journalArticle

  32. Cytochrome b (5) null mouse: a new model for studying inherited skin disorders and the role of unsaturated fatty acids in normal homeostasis

    Finn, R. D., McLaughlin, L. A., Hughes, C., Song, C., Henderson, C. J. & Wolf, C. R. Jun 2011 In : Transgenic Research. 20, 3, p. 491-502 12 p.

    Research output: Contribution to journalArticle

  33. Knockout and transgenic mice in glutathione transferase research

    Henderson, C. J. & Wolf, C. R. May 2011 In : Drug Metabolism Reviews. 43, 2, p. 152-164 13 p.

    Research output: Contribution to journalScientific review

  34. Role of cytochromes P450 1A1/2 in detoxication and activation of carcinogenic aristolochic acid I: studies with the hepatic NADPH:cytochrome P450 reductase null (HRN) mouse model

    Levova, K., Moserova, M., Kotrbova, V., Sulc, M., Henderson, C. J., Wolf, C. R., Phillips, D. H., Frei, E., Schmeiser, H. H., Mares, J., Arlt, V. M. & Stiborova, M. May 2011 In : Toxicological Sciences. 121, 1, p. 43-56 14 p.

    Research output: Contribution to journalArticle

  35. Spatial p21 expression profile in the mid-term mouse embryo

    Vasey, D. B., Wolf, C. R., Brown, K. & Whitelaw, C. B. A. Feb 2011 In : Transgenic Research. 20, 1, p. 23-28 6 p.

    Research output: Contribution to journalArticle

  36. Humanizing π-class glutathione S-transferase regulation in a mouse model alters liver toxicity in response to acetaminophen overdose

    Vaughn, M. P., Shinohara, D. B., Castagna, N., Hicks, J. L., Netto, G., De Marzo, A. M., Speed, T. J., Reichert, Z. R., Kwabi-Addo, B., Henderson, C. J., Wolf, C. R., Yegnasubramanian, S. & Nelson, W. G. 2011 In : PLoS ONE. 6, 10, p. - 10 p.e25707

    Research output: Contribution to journalArticle

  37. Role of CAR and PXR in xenobiotic toxicity

    Wolf, C. R., Elcombe, C., Rode, A., Scheer, N., Bower, C. & Henderson, C. 2011 In : Toxicology Letters. 205, p. S13 1 p.

    Research output: Contribution to journalBook/Film/Article review

  38. Non-catalytic mechanisms involved in glutathione S-transferase pi mediated cytoprotection

    McGarry, D. J., Wolf, C. R. & Henderson, C. J. 30 Dec 2010 In : Toxicology. 278, 3, p. 371-372 2 p.

    Research output: Contribution to journalBook/Film/Article review

  39. Spatial monitoring of toxicity in HMOX-LacZ transgenic mice

    Young, R., Wolf, C. R., Brown, K., Hayes, J. D. & Whitelaw, C. B. A. Oct 2010 In : Transgenic Research. 19, 5, p. 897-902 6 p.

    Research output: Contribution to journalArticle

  40. Activating K-Ras mutations outwith "hotspot" codons in sporadic colorectal tumours: implications for personalised cancer medicine

    Smith, G., Bounds, R., Wolf, H., Pratt, N., Carey, F., Steele, R. & Wolf, C. Sep 2010 In : Journal of Pathology. 222, S1, p. S12-S12 1 p.

    Research output: Contribution to journalBook/Film/Article review

  41. Deletion of Microsomal Cytochrome b(5) Profoundly Affects Hepatic and Extrahepatic Drug Metabolism

    McLaughlin, L. A., Ronseaux, S., Finn, R. D., Henderson, C. J. & Wolf, C. R. Aug 2010 In : Molecular Pharmacology. 78, 2, p. 269-278 10 p.

    Research output: Contribution to journalArticle

  42. Human Constitutive Androstane Receptor (CAR) and Pregnane X Receptor (PXR) Support the Hypertrophic but not the Hyperplastic Response to the Murine Nongenotoxic Hepatocarcinogens Phenobarbital and Chlordane In Vivo

    Ross, J., Plummer, S. M., Rode, A., Scheer, N., Bower, C. C., Vogel, O., Henderson, C. J., Wolf, C. R. & Elcombe, C. R. Aug 2010 In : Toxicological Sciences. 116, 2, p. 452-466 15 p.

    Research output: Contribution to journalArticle

  43. Peroxiredoxin Gene Expression Signatures in Liver Reflect Toxic Insult

    Young, R., Hayes, J. D., Brown, K., Wolf, C. R. & Whitelaw, C. B. A. Aug 2010 In : ASSAY and Drug Development Technologies. 8, 4, p. 512-517 6 p.

    Research output: Contribution to journalArticle

  44. In Vivo Responses of the Human and Murine Pregnane X Receptor to Dexamethasone in Mice

    Scheer, N., Ross, J., Kapelyukh, Y., Rode, A. & Wolf, C. R. Jul 2010 In : Drug Metabolism and Disposition. 38, 7, p. 1046-1053 8 p.

    Research output: Contribution to journalArticle

  45. Glutathione S-transferase M1 (GSTM1) genotype is associated with serum 8-MOP concentration and PUVA sensitivity

    Ibbotson, S. H., Dawe, R. S., Weidlich, S., Dinkova-Kostova, A. T., Farr, P. M., Ferguson, J., Wolf, C. R. & Smith, G. Apr 2010 In : British Journal of Dermatology. 162, 4, p. 941-941 1 p.

    Research output: Contribution to journalMeeting abstract

  46. The Hepatic cytochrome P450 reductase null (HRN) mouse model as a tool to study xenobiotic metabolism

    Arlt, V. M., Henderson, C. J., Wolf, C. R., Phillips, D. H. & Stiborova, M. Mar 2010 In : Naunyn-Schmiedeberg's Archives of Pharmacology. 381, p. 83-83 1 p.

    Research output: Contribution to journalBook/Film/Article review

  47. Activating K-Ras mutations outwith 'hotspot' codons in sporadic colorectal tumours: implications for personalised cancer medicine

    Smith, G., Bounds, R., Wolf, H., Steele, R., Carey, F. & Wolf, R. 16 Feb 2010 In : British Journal of Cancer. 102, 4, p. 693-703 11 p.

    Research output: Contribution to journalArticle

  48. Activation of the NRF2 Signaling Pathway by Copper-Mediated Redox Cycling of Para- and Ortho-Hydroquinones

    Wang, X. J., Hayes, J. D., Higgins, L. G., Wolf, C. R. & Dinkova-Kostova, A. T. 29 Jan 2010 In : Chemistry & Biology. 17, 1, p. 75-85 11 p.

    Research output: Contribution to journalArticle

  49. A phase I clinical trial of CXR1002 in patients (pts) with advanced cancer

    Macpherson, M., Bissett, D., Tait, B., Samuel, L. M., MacDonald, J., Barnett, A. L., Wolf, C. R., Elcombe, C. R., Jeynes-Ellis, A. & Evans, T. R. J. 2010 In : EJC Supplements. 8, 7, p. 124 1 p.

    Research output: Contribution to journalBook/Film/Article review

  50. Anti-tumor activity of CXR1002, a novel anti-cancer clinical phase compound that induces ER stress and inhibits PIM kinases: Human tumor xenograft efficacy and in vitro mode of action

    Barnett, A., Ding, S., Murray, C., Chamberlain, M., Plummer, S., Evans, T. R. J., MacPherson, I., Bissett, D., Elcombe, C. R. & Wolf, C. R. 2010 In : EJC Supplements. 8, 7, p. 45-46 2 p.

    Research output: Contribution to journalBook/Film/Article review

  51. Polymorphisms in xenobiotic metabolizing enzymes and diet influence colorectal adenoma risk

    Northwood, E. L., Elliott, F., Forman, D., Barrett, J. H., Wilkie, M. J. V., Carey, F. A., Steele, R. J. C., Wolf, R., Bishop, T. & Smith, G. 2010 In : Pharmacogenetics and Genomics. 20, 5, p. 315-326 12 p.

    Research output: Contribution to journalArticle

  52. Markedly enhanced colon tumorigenesis in Apc(Min) mice lacking glutathione S-transferase Pi

    Ritchie, K. J., Walsh, S., Sansom, O. J., Henderson, C. J. & Wolf, C. R. 8 Dec 2009 In : Proceedings of the National Academy of Sciences of the United States of America. 106, 49, p. 20859-20864 6 p.

    Research output: Contribution to journalArticle

  53. Nuclear receptor (CAR/PXR) humanised mouse models to study non-genotoxic hepatocarcinogenesis

    Elcombe, C. R., Ross, J., Scheer, N., Rode, A. & Wolf, C. R. Nov 2009 In : Mutagenesis. 24, 6, p. 523-524 2 p.

    Research output: Contribution to journalBook/Film/Article review

  54. Biomarkers and molecular tumour classification for non-genotoxic carcinogenesis

    Wolf, R. & 23 others Moggs, J., Friedberg, T., Stewart, N., Elcombe, C., Plummer, S., Grasl-Kraupp, B., Schulte-Hermann, R., Gerner, C., Meehan, R., Schwarz, M., Zell, A., Schroeder, A., Supper, J., Pichler, B., Templin, M., Maurel, P., Daujat-Chavanieu, M., Pacquet, J-L., Kalkuhl, A., Matheis, K., Ahr, H-J., Dhalluin, S. & Ostenfeldt, N. 13 Sep 2009 In : Toxicology Letters. 189, p. S136-S136 1 p.

    Research output: Contribution to journalBook/Film/Article review

  55. An in vitro model for the prediction of chemical metabolism and toxicity

    Ding, S-H., Vardy, A., Elcombe, C. R. & Wolf, C. R. 28 Jul 2009 In : Toxicology. 262, 1, p. 23-23 1 p.

    Research output: Contribution to journalBook/Film/Article review

  56. Human constitutive androstane receptor (CAR) supports the hypertrophic but not the hyperplastic response to the murine non-genotoxic carcinogen phenobarbital (pb) in vivo

    Elcombe, C. R., Ross, J., Scheer, N., Rode, A. & Wolf, C. R. 28 Jul 2009 In : Toxicology. 262, 1, p. 11-12 2 p.

    Research output: Contribution to journalBook/Film/Article review

  57. Cholesterol Metabolism: the Main Pathway Acting Downstream of Cytochrome P450 Oxidoreductase in Skeletal Development of the Limb

    Schmidt, K., Hughes, C., Chudek, J. A., Goodyear, S. R., Aspden, R. M., Talbot, R., Gundersen, T. E., Blomhoff, R., Henderson, C., Wolf, C. R. & Tickle, C. 15 May 2009 In : Molecular and Cellular Biology. 29, 10, p. 2716-2729 14 p.

    Research output: Contribution to journalArticle

  58. A Novel CYP3A Gene Cluster Humanized Mouse Model

    Kapelyukh, Y., Ross, J., Scheer, N. & Wolf, C. R. May 2009 In : Drug Metabolism Reviews. 41, p. 42-42 1 p.

    Research output: Contribution to journalBook/Film/Article review

  59. GSTpi Mediates MPTP-induced JNK Activation in the Nigrostriatal Pathway

    Gama, M. J., Castro-Caldas, M., Carvalho, A. N., Rodrigues, E., Henderson, C. J. & Wolf, C. R. May 2009 In : Drug Metabolism Reviews. 41, p. 29-30 2 p.

    Research output: Contribution to journalBook/Film/Article review

  60. Humanized Mouse Models for PK and Safety Profiling of Compounds

    Scheer, N., Ross, J., Rode, A. & Wolf, C. R. May 2009 In : Drug Metabolism Reviews. 41, p. 56 2 p.

    Research output: Contribution to journalBook/Film/Article review

  61. Glutathione S-transferase M1 genotype is associated with erythemal sensitivity to narrowband ultraviolet B in patients with psoriasis

    Ibbotson, S. H., Weidlich, S., Ferguson, J., Wolf, R., Dawe, R. S. & Smith, G. Apr 2009 In : British Journal of Dermatology. 160, 4, p. 928-928 1 p.

    Research output: Contribution to journalArticle

  62. Prespective on the application of pharmacogenomics in the treatment of cancer

    Wolf, R. Apr 2009 In : Pharmacogenomics Journal. 10, 4, p. 527-529 3 p.

    Research output: Contribution to journalEditorial

  63. Drug transporters: Gatekeepers controlling access of xenobiotics to the cellular interior

    Stanley, L. A., Horsburgh, B. C., Ross, J., Scheer, N. & Wolf, C. R. Feb 2009 In : Drug Metabolism Reviews. 41, 1, p. 27-65 39 p.

    Research output: Contribution to journalScientific review

  64. Interview: Perspective on the application of pharmacogenomics in the treatment of cancer

    Wolf, R. 1 Jan 2009 In : Pharmacogenomics. 10, 4, p. 527-529 3 p.

    Research output: Contribution to journalArticle

  65. Preclinical toxicokinetic evaluation of Phortress [2-(4-amino-3- methylphenyl)-5-fluorobenzothiazole lysylamide dihydrochloride] in two rodent species

    Bradshaw, T. D., Wren, J. E., Bruce, M., Barrett, D. A., Leong, C-O., Gaskell, M., Wright, E. K., Farmer, P. B., Henderson, C. J., Wolf, R. & Stevens, M. F. G. 1 Jan 2009 In : Pharmacology. 83, 2, p. 99-109 11 p.

    Research output: Contribution to journalArticle

  66. Unsaturated fatty acid regulation of cytochrome P450 expression via a CAR-dependent pathway

    Finn, R. D., Henderson, C. J., Scott, C. L. & Wolf, C. R. 1 Jan 2009 In : Biochemical Journal. 417, 1, p. 43-54 12 p.

    Research output: Contribution to journalArticle

  67. Meta-and pooled analyses of the methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism and colorectal cancer: a HuGE-GSEC Review

    Taioli, E., Garza, M. A., Ahn, Y. O., Bishop, D. T., Bost, J., Budai, B., Chen, K., Gemignani, F., Keku, T., Lima, C. S. P., Le Marchand, L., Matsuo, K., Moreno, V., Plaschke, J., Pufulete, M., Thomas, S. B., Toffoli, G., Wolf, C. R., Moore, C. G. & Little, J. 2009 In : American Journal of Epidemiology. 170, 10, p. 1207-1221 15 p.

    Research output: Contribution to journalArticle

  68. Nomenclature for alleles of the cytochrome P450 oxidoreductase gene

    Sim, S. C., Miller, W. L., Zhong, X-B., Arlt, W., Ogata, T., Ding, X., Wolf, C. R., Flueck, C. E., Pandey, A. V., Henderson, C. J., Porter, T. D., Daly, A. K., Nebert, D. W. & Ingelman-Sundberg, M. 2009 In : Pharmacogenetics and Genomics. 19, 7, p. 565-566 2 p.

    Research output: Contribution to journalLetter

  69. Polymorphisms in the SLC6A4 and HTR2A genes influence treatment outcome following antidepressant therapy

    Wilkie, M. J. V., Smith, G., Day, R., Matthews, K., Smith, D., Blackwood, D., Reid, I. C. & Wolf, R. 2009 In : Pharmacogenomics Journal. 9, 1, p. 61-70 10 p.

    Research output: Contribution to journalArticle

  70. Glutathione Transferase P1 An Endogenous Inhibitor of Allergic Responses in a Mouse Model of Asthma

    Zhou, J., Wolf, C. R., Henderson, C. J., Cai, Y., Board, P. G., Foster, P. S. & Webb, D. C. 15 Dec 2008 In : American Journal of Respiratory and Critical Care Medicine. 178, 12, p. 1202-1210 9 p.

    Research output: Contribution to journalArticle

  71. Defining the in Vivo Role for Cytochrome b(5) in Cytochrome P450 Function through the Conditional Hepatic Deletion of Microsomal Cytochrome b(5)

    Finn, R. D., McLaughlin, L. A., Ronseaux, S., Rosewell, I., Houston, J. B., Henderson, C. J. & Wolf, C. R. 14 Nov 2008 In : Journal of Biological Chemistry. 283, 46, p. 31385-31393 9 p.

    Research output: Contribution to journalArticle

  72. Multiple substrate binding by cytochrome P450 3A4: Estimation of the number of bound substrate molecules

    Kapelyukh, Y., Paine, M., Marechal, J-D., Sutcliffe, M. J., Wolf, C. R. & Roberts, G. C. K. Oct 2008 In : Drug Metabolism and Disposition. 36, 10, p. 2136-2144 9 p.

    Research output: Contribution to journalArticle

  73. A novel panel of mouse models to evaluate the role of human pregnane X receptor and constitutive androstane receptor in drug response

    Scheer, N., Ross, J., Rode, A., Zevnik, B., Niehaves, S., Faust, N. & Wolf, C. R. Sep 2008 In : Journal of Clinical Investigation. 118, 9, p. 3228-3239 12 p.

    Research output: Contribution to journalArticle

  74. Methylene tetrahydrofolate reductase genotype modifies the chemopreventive effect of folate in colorectal adenoma, but not colorectal cancer

    Lightfoot, T. J., Barrett, J. H., Bishop, T., Northwood, E. L., Smith, G., Wilkie, M. J. V., Steele, R. J. C., Carey, F. A., Key, T. J., Wolf, R. & Forman, D. Sep 2008 In : Cancer Epidemiology, Biomarkers & Prevention. 17, 9, p. 2421-2430 10 p.

    Research output: Contribution to journalArticle

  75. Control differentiation of embryonic stem cell to specific lineages

    Zhao, D., Hay, D., Fletcher, J., Hewitt, Z., McLean, D., Black, J., Urruticoechea-Uriguen, A., Elcombe, C., Ross, J., Wolf, R. & Cui, W. Aug 2008 In : Cell Research. 18, p. - 1 p.

    Research output: Contribution to journalBook/Film/Article review

  76. Functional expression and comparative characterization of nine murine cytochromes P450 by fluorescent inhibition screening

    McLaughlin, L. A., Dickmann, L. J., Wolf, C. R. & Henderson, C. J. Jul 2008 In : Drug Metabolism and Disposition. 36, 7, p. 1322-1331 10 p.

    Research output: Contribution to journalArticle

  77. Illuminating role of CYP1A1 in skin function

    Rowe, J. M., Welsh, C., Pena, R. N., Wolf, C. R., Brown, K. & Whitelaw, C. B. A. Jul 2008 In : Journal of Investigative Dermatology. 128, 7, p. 1866-1868 4 p.

    Research output: Contribution to journalLetter

  78. Efficient differentiation of hepatocytes from human embryonic stem cells exhibiting markers recapitulating liver development in vivo

    Hay, D. C., Zhao, D., Fletcher, J., Hewitt, Z. A., McLean, D., Urruticoechea-Uriguen, A., Black, J. R., Elcombe, C., Ross, J. A., Wolf, R. & Cui, W. Apr 2008 In : Stem Cells. 26, 4, p. 894-902 9 p.

    Research output: Contribution to journalArticle

  79. p21-LacZ reporter mice reflect p53-dependent toxic insult

    Vasey, D. B., Wolf, C. R., MacArtney, T., Brown, K. & Whitelaw, C. B. A. 15 Mar 2008 In : Toxicology and Applied Pharmacology. 227, 3, p. 440-450 11 p.

    Research output: Contribution to journalArticle

  80. Dusp1/mkp-1, dusp2/hpac1 and dusp8/vh5 expression in colorectal cancer

    Conlin, A., Steele, R. J. C. & Wolf, C. R. Mar 2008 In : Gut. 57, Supplement 1, p. A133-A133 1 p.349

    Research output: Contribution to journalBook/Film/Article review

  81. DUSP6/MKP-3 expression and K-ras mutation in colorectal cancer

    Conlin, A., Smith, G., Steele, R. J. C. & Wolf, C. R. Mar 2008 In : Gut. 57, Supplement 1, p. A134-A134 1 p.350

    Research output: Contribution to journalBook/Film/Article review

  82. Insights into drug metabolism by cytochromes P450 from modelling studies of CYP2D6-drug interactions

    Marechal, J-D., Kemp, C. A., Roberts, G. C. K., Paine, M., Wolf, R. & Sutcliffe, M. J. Mar 2008 In : British Journal of Pharmacology. 153, p. S82-S89 8 p.

    Research output: Contribution to journalArticle

  83. Metabolic activation of benzo[a]pyrene in vitro by hepatic cytochrome P450 contrasts with detoxification in vivo: experiments with hepatic cytochrome P450 reductase null mice

    Arlt, V. M., Stiborova, M., Henderson, C. J., Thiemann, M., Frei, E., Aimova, D., Singh, R., da Costa, G. G., Schmitz, O. J., Farmer, P. B., Wolf, C. R. & Phillips, D. H. Mar 2008 In : Carcinogenesis. 29, 3, p. 656-665 10 p.

    Research output: Contribution to journalArticle

  84. Role of hepatic cytochromes P450 in bioactivation of the anticancer drug ellipticine: Studies with the hepatic NADPH: Cytochrome P450 reductase null mouse

    Stiborova, M., Arlt, V. M., Henderson, C. J., Wolf, C. R., Kotrbova, V., Moserova, M., Hudecek, J., Phillips, D. H. & Frei, E. 1 Feb 2008 In : Toxicology and Applied Pharmacology. 226, 3, p. 318-327 10 p.

    Research output: Contribution to journalArticle

  85. A novel panel of double 'humanised' & knockout PXR and car mouse models

    Ross, J., Scheer, N. & Wolf, R. 2008 In : Drug Metabolism Reviews. 40, p. 114-115 2 p.

    Research output: Contribution to journalBook/Film/Article review

  86. Recombinant yeast and bacteria that express human p450s: bioreactors for drug-discovery, -development and -biotechnology

    Friedberg, T. H., Hanlon, S., Kittelmann, M., Ghisalba, O. & Wolf, C. R. 2008 In : Drug Metabolism Reviews. 40, p. 75-76 2 p.

    Research output: Contribution to journalBook/Film/Article review

  87. Melanocortin 1 receptor (MC1R) genotype influences erythemal sensitivity to psoralen-ultraviolet A photochemotherapy

    Smith, G., Wilkie, M. J. V., Deeni, Y. Y., Farr, P. M., Ferguson, J., Wolf, C. R. & Ibbotson, S. H. Dec 2007 In : British Journal of Dermatology. 157, 6, p. 1230-4 5 p.

    Research output: Contribution to journalArticle

  88. Development of a liquid Chromatography-Electrospray ionization tandem mass spectrometry method for detecting Oxaliplatin-DNA intrastrand cross-links in biological samples

    Le Pla, R. C., Ritchie, K. J., Henderson, C. J., Wolf, C. R., Harrington, C. F. & Farmer, P. B. Aug 2007 In : Chemical Research in Toxicology. 20, 8, p. 1177-1182 6 p.

    Research output: Contribution to journalArticle

  89. A splice site polymorphism in the G-protein beta subunit influences antidepressant efficacy in depression

    Wilkie, M. J. V., Smith, D., Reid, I. C., Day, R. K., Matthews, K., Wolf, R., Blackwood, D. & Smith, G. Mar 2007 In : Pharmacogenetics and Genomics. 17, 3, p. 207-215 9 p.

    Research output: Contribution to journalArticle

  90. Exposure to benzo[A]pyrene in the hepatic cytochrome p450 oxidoreductase null mouse: detoxification by hepatic cytochrome p450 is more important than metabolic activation

    Arlt, V. M., Stiborova, M., Henderson, C. J., Thiemann, M., Frei, E., Singh, R., da Costa, G. G., Schmitz, O. J., Farmer, P. B., Wolf, C. R. & Phillips, D. H. Mar 2007 In : Naunyn-Schmiedeberg's Archives of Pharmacology. 375, Supplement 1, p. 73-73 1 p.352

    Research output: Contribution to journalMeeting abstract

  91. Activation of Nrf2 and cellular inflammatory response by hypochlorous acid

    Woods, C. G., Andersen, M. E., Zhang, Q., Thomas, R. S., Henderson, C. J., Wolf, C. R. & Pi, J. 2007 In : Free Radical Biology and Medicine. 43, p. S160-S160 1 p.

    Research output: Contribution to journalBook/Film/Article review

  92. Glutathione transferase π plays a critical role in the development of lung carcinogenesis following exposure to tobacco-related carcinogens and urethane

    Ritchie, K. J., Henderson, C. J., Wang, X-J., Vassieva, O., Carrie, D., Farmer, P. B., Gaskell, M., Park, K. & Wolf, C. R. 2007 In : Cancer Research. 67, 19, p. 9248-9257 10 p.

    Research output: Contribution to journalArticle

  93. Genetic factors associated with the aetiology and treatment of colorectal cancer

    Wolf, C. R., Steele, R. J. C., Carey, F. A., Pratt, N. D., Bishop, D. T., Barrett, J. H., Forman, D. & Smith, G. 1 Sep 2006 In : Toxicology. 226, 1, p. 14-14 1 p.

    Research output: Contribution to journalMeeting abstract

  94. Hepatic cytochrome P-450 reductase-null mice show reduced transcriptional response to quercetin and reveal physiological homeostasis between jejunum and liver

    Mutch, D. M., Crespy, V., Clough, J., Henderson, C. J., Lariani, S., Mansourian, R., Moulin, J., Wolf, C. R. & Williamson, G. Jul 2006 In : American Journal of Physiology-Gastrointestinal and Liver Physiology. 291, 1, p. G63-G72 10 p.

    Research output: Contribution to journalArticle

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