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Roland Wolf

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  1. Evidence that Cytochrome b5 and Cytochrome b5 Reductase Can Act as Sole Electron Donors to the Hepatic Cytochrome P450 System

    Henderson, C. J., McLaughlin, L. A. & Wolf, C. R. Jun-2013 In : Molecular Pharmacology. 83, 6, p. 1209-1217, 9 p.

    Research output: Contribution to journal › Article

  2. Individuality in FGF1 expression significantly influences platinum resistance and progression-free survival in ovarian cancer

    Smith, G., Ng, M. T. H., Shepherd, L., Herrington, C. S., Gourley, C., Ferguson, M. & Wolf, C. R. 9-Oct-2012 In : British Journal of Cancer. 107, 8, p. 1327-1336, 10 p.

    Research output: Contribution to journal › Article

  3. Role of structural factors of antitumour anthraquinone derivatives and analogues in the ability to undergo bioreductive activation by NADPH cytochrome P450 reductase: implications for increasing the activity against sensitive and multidrug-resistant leukaemia HL60 cells

    Kostrzewa-Nowak, D., Bieg, B., Paine, M. J. I., Wolf, C. R. & Tarasiuk, J. 1-Apr-2012 In : Anti-Cancer Drugs. 23, 4, p. 393-405, 13 p.

    Research output: Contribution to journal › Article

  4. Characterization of a Human Keratinocyte HaCaT Cell Line Model to Study the Regulation of CYP2S1

    McNeilly, A. D., Woods, J. A., Ibbotson, S. H., Wolf, C. R. & Smith, G. Feb-2012 In : Drug Metabolism and Disposition. 40, 2, p. 283-289, 7 p.

    Research output: Contribution to journal › Article

  5. The role of bioreductive activation of antitumour anthracycline drugs in cytotoxic activity against sensitive and multidrug resistant leukaemia HL60 cells

    Kostrzewa-Nowak, D., Bieg, B., Paine, M. J. I., Wolf, C. R. & Tarasiuk, J. 14-Jan-2012 In : European Journal of Pharmacology. 674, 2-3, p. 112-125, 14 p.

    Research output: Contribution to journal › Article

  6. Glutathione S-transferase genotype is associated with sensitivity to psoralen-ultraviolet A photochemotherapy

    Ibbotson, S. H., Dawe, R. S., Dinkova-Kostova, A. T., Weidlich, S., Farr, P. M., Ferguson, J., Wolf, C. R. & Smith, G. 1-Jan-2012 In : British Journal of Dermatology. 166, 2, p. 380-388, 9 p.

    Research output: Contribution to journal › Article

  7. Glutathione S-Transferase pi Mediates MPTP-Induced c-Jun N-Terminal Kinase Activation in the Nigrostriatal Pathway

    Castro-Caldas, M., Carvalho, A. N., Rodrigues, E., Gama, M. J., Henderson, C. & Wolf, C. R. 1-Jan-2012 In : Molecular Neurobiology. p. 1-12, 12 p.

    Research output: Contribution to journal › Article

  8. Modeling Human Cytochrome P450 2D6 Metabolism and Drug-Drug Interaction by a Novel Panel of Knockout and Humanized Mouse Lines

    Scheer, N., Kapelyukh, Y., McEwan, J., Beuger, V., Stanley, L. A., Rode, A. & Wolf, C. R. Jan-2012 In : Molecular Pharmacology. 81, 1, p. 63-72, 10 p.

    Research output: Contribution to journal › Article

  9. Conditional expression of human PPARδ and a dominant negative variant of hPPARδ in vivo

    Higgins, L. G., Garbacz, W. G., Gustafsson, M. C. U., Sitheswaran, N., Ashby, P. R., Wolf, C. R. & Palmer, C. N. A. 2012 In : PPAR Research. 12 p., 216817

    Research output: Contribution to journal › Article

  10. Exposure to benzo[a]pyrene of hepatic cytochrome P450 reductase null (HRN) and P450 reductase conditional null (RCN) mice: detection of benzo[a]pyrene diol epoxide-DNA adducts by immunohistochemistry and P-postlabelling

    Arlt, V. M., Poirier, M. C., Sykes, S. E., John, K., Moserova, M., Stiborova, M., Wolf, C. R., Henderson, C. J. & Phillips, D. H. 2012 In : Toxicology Letters. 213, 2, p. 160-166, 7 p.

    Research output: Contribution to journal › Article

  11. Generation and characterization of a novel multidrug resistance protein 2 humanized mouse line

    Scheer, N., Balimane, P., Hayward, M. D., Buechel, S., Kauselmann, G. & Wolf, C. R. 2012 In : Drug Metabolism and Disposition. 40, 11, p. 2212-2218, 7 p.

    Research output: Contribution to journal › Article

  12. Tauroursodeoxycholic acid prevents MPTP-induced dopaminergic cell death in a mouse model of Parkinson's disease

    Castro-Caldas, M., Carvalho, A. N., Rodrigues, E., Henderson, C. J., Wolf, C. R., Rodrigues, C. M. P. & Gama, M. J. 2012 In : Molecular Neurobiology. 46, 2, p. 475-486, 12 p.

    Research output: Contribution to journal › Article

  13. Non-catalytic mechanisms involved in glutathione Stransferase Pi mediated cytoprotection

    McGarry, D. J., Wolf, C. R. & Henderson, C. J. 18-Dec-2011 In : Toxicology. 290, 2-3, p. 130-130, 1 p.

    Research output: Contribution to journal › Book/Film/Article review

  14. Effect of hepatic cytochrome P450 (P450) oxidoreductase deficiency on 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine-DNA Adduct Formation in P450 reductase conditional null mice

    Arlt, V. M., Singh, R., Stiborova, M., da Costa, G. G., Frei, E., Evans, J. D., Farmer, P. B., Wolf, C. R., Henderson, C. J. & Phillips, D. H. Dec-2011 In : Drug Metabolism and Disposition. 39, 12, p. 2169-2173, 5 p.

    Research output: Contribution to journal › Article

  15. Increased Skin Papilloma Formation in Mice Lacking Glutathione Transferase GSTP

    Henderson, C. J., Ritchie, K. J., McLaren, A., Chakravarty, P. & Wolf, C. R. 15-Nov-2011 In : Cancer Research. 71, 22, p. 7048-7060, 13 p.

    Research output: Contribution to journal › Article

  16. Humanizing pi-Class Glutathione S-Transferase Regulation in a Mouse Model Alters Liver Toxicity in Response to Acetaminophen Overdose

    Vaughn, M. P., Shinohara, D. B., Castagna, N., Hicks, J. L., Netto, G., De Marzo, A. M., Speed, T. J., Reichert, Z. R., Kwabi-Addo, B., Henderson, C. J., Wolf, C. R., Yegnasubramanian, S. & Nelson, W. G. 11-Oct-2011 In : PLoS ONE. 6, 10, p. -, 10 p., e25707

    Research output: Contribution to journal › Article

  17. Enzyme and protein engineering: engineering a self-sufficient human cytochrome P450 monooxygenase system

    Deeni, Y. & Wolf, R. Sep-2011 In : Current Opinion in Biotechnology. 22, p. S18-S18, 1 p.

    Research output: Contribution to journal › Book/Film/Article review

  18. Quantitative Prediction of Human Pregnane X Receptor and Cytochrome P450 3A4 Mediated Drug-Drug Interaction in a Novel Multiple Humanized Mouse Line

    Hasegawa, M., Kapelyukh, Y., Tahara, H., Seibler, J., Rode, A., Krueger, S., Lee, D. N., Wolf, C. R. & Scheer, N. Sep-2011 In : Molecular Pharmacology. 80, 3, p. 518-528, 11 p.

    Research output: Contribution to journal › Article

  19. Role of CAR and PXR in xenobiotic toxicity

    Wolf, C. R., Elcombe, C., Rode, A., Scheer, N., Bower, C. & Henderson, C. 28-Aug-2011 In : Toxicology Letters. 205, p. S13-S13, 1 p.

    Research output: Contribution to journal › Book/Film/Article review

  20. The Imidazoacridinone Antitumor Drug, C-1311, Is Metabolized by Flavin Monooxygenases but Not by Cytochrome P450s

    Potega, A., Dabrowska, E., Niemira, M., Kot-Wasik, A., Ronseaux, S., Henderson, C. J., Wolf, C. R. & Mazerska, Z. Aug-2011 In : Drug Metabolism and Disposition. 39, 8, p. 1423-1432, 10 p.

    Research output: Contribution to journal › Article

  21. Pyrosequencing-based methods reveal marked inter-individual differences in oncogene mutation burden in human colorectal tumours

    Weidlich, S., Walsh, K., Crowther, D., Burczynski, M. E., Feuerstein, G., Carey, F., Steele, R. J. C., Wolf, C. R., Miele, G. & Smith, G. 12-Jul-2011 In : British Journal of Cancer. 105, 2, p. 246-254, 9 p.

    Research output: Contribution to journal › Article

  22. Cytochrome b (5) null mouse: a new model for studying inherited skin disorders and the role of unsaturated fatty acids in normal homeostasis

    Finn, R. D., McLaughlin, L. A., Hughes, C., Song, C., Henderson, C. J. & Wolf, C. R. Jun-2011 In : Transgenic Research. 20, 3, p. 491-502, 12 p.

    Research output: Contribution to journal › Article

  23. Knockout and transgenic mice in glutathione transferase research

    Henderson, C. J. & Wolf, C. R. May-2011 In : Drug Metabolism Reviews. 43, 2, p. 152-164, 13 p.

    Research output: Contribution to journal › Scientific review

  24. Role of Cytochromes P450 1A1/2 in Detoxication and Activation of Carcinogenic Aristolochic Acid I: Studies with the Hepatic NADPH:Cytochrome P450 Reductase Null (HRN) Mouse Model

    Levova, K., Moserova, M., Kotrbova, V., Sulc, M., Henderson, C. J., Wolf, C. R., Phillips, D. H., Frei, E., Schmeiser, H. H., Mares, J., Arlt, V. M. & Stiborova, M. May-2011 In : Toxicological Sciences. 121, 1, p. 43-56, 14 p.

    Research output: Contribution to journal › Article

  25. Spatial p21 expression profile in the mid-term mouse embryo

    Vasey, D. B., Wolf, C. R., Brown, K. & Whitelaw, C. B. A. Feb-2011 In : Transgenic Research. 20, 1, p. 23-28, 6 p.

    Research output: Contribution to journal › Article

  26. Non-catalytic mechanisms involved in glutathione S-transferase pi mediated cytoprotection

    McGarry, D. J., Wolf, C. R. & Henderson, C. J. 30-Dec-2010 In : Toxicology. 278, 3, p. 371-372, 2 p.

    Research output: Contribution to journal › Book/Film/Article review

  27. A phase I clinical trial of CXR1002 in patients (pts) with advanced cancer

    Macpherson, M., Bissett, D., Tait, B., Samuel, L. M., MacDonald, J., Barnett, A. L., Wolf, C. R., Elcombe, C. R., Jeynes-Ellis, A. & Evans, T. R. J. Nov-2010 In : EJC Supplements. 8, 7, p. 124-124, 1 p.

    Research output: Contribution to journal › Book/Film/Article review

  28. Anti-tumor activity of CXR1002, a novel anti-cancer clinical phase compound that induces ER stress and inhibits PIM kinases: Human tumor xenograft efficacy and in vitro mode of action

    Barnett, A., Ding, S., Murray, C., Chamberlain, M., Plummer, S., Evans, T. R. J., MacPherson, I., Bissett, D., Elcombe, C. R. & Wolf, C. R. Nov-2010 In : EJC Supplements. 8, 7, p. 45-46, 2 p.

    Research output: Contribution to journal › Book/Film/Article review

  29. Spatial monitoring of toxicity in HMOX-LacZ transgenic mice

    Young, R., Wolf, C. R., Brown, K., Hayes, J. D. & Whitelaw, C. B. A. Oct-2010 In : Transgenic Research. 19, 5, p. 897-902, 6 p.

    Research output: Contribution to journal › Article

  30. Activating K-Ras mutations outwith "hotspot" codons in sporadic colorectal tumours: implications for personalised cancer medicine

    Smith, G., Bounds, R., Wolf, H., Pratt, N., Carey, F., Steele, R. & Wolf, C. Sep-2010 In : Journal of Pathology. 222, S1, p. S12-S12, 1 p.

    Research output: Contribution to journal › Book/Film/Article review

  31. Deletion of Microsomal Cytochrome b(5) Profoundly Affects Hepatic and Extrahepatic Drug Metabolism

    McLaughlin, L. A., Ronseaux, S., Finn, R. D., Henderson, C. J. & Wolf, C. R. Aug-2010 In : Molecular Pharmacology. 78, 2, p. 269-278, 10 p.

    Research output: Contribution to journal › Article

  32. Human Constitutive Androstane Receptor (CAR) and Pregnane X Receptor (PXR) Support the Hypertrophic but not the Hyperplastic Response to the Murine Nongenotoxic Hepatocarcinogens Phenobarbital and Chlordane In Vivo

    Ross, J., Plummer, S. M., Rode, A., Scheer, N., Bower, C. C., Vogel, O., Henderson, C. J., Wolf, C. R. & Elcombe, C. R. Aug-2010 In : Toxicological Sciences. 116, 2, p. 452-466, 15 p.

    Research output: Contribution to journal › Article

  33. Peroxiredoxin Gene Expression Signatures in Liver Reflect Toxic Insult

    Young, R., Hayes, J. D., Brown, K., Wolf, C. R. & Whitelaw, C. B. A. Aug-2010 In : ASSAY and Drug Development Technologies. 8, 4, p. 512-517, 6 p.

    Research output: Contribution to journal › Article

  34. In Vivo Responses of the Human and Murine Pregnane X Receptor to Dexamethasone in Mice

    Scheer, N., Ross, J., Kapelyukh, Y., Rode, A. & Wolf, C. R. Jul-2010 In : Drug Metabolism and Disposition. 38, 7, p. 1046-1053, 8 p.

    Research output: Contribution to journal › Article

  35. Polymorphisms in xenobiotic metabolizing enzymes and diet influence colorectal adenoma risk

    Northwood, E. L., Elliott, F., Forman, D., Barrett, J. H., Wilkie, M. J. V., Carey, F. A., Steele, R. J. C., Wolf, R., Bishop, T. & Smith, G. May-2010 In : Pharmacogenetics and Genomics. 20, 5, p. 315-326, 12 p.

    Research output: Contribution to journal › Article

  36. Glutathione S-transferase M1 (GSTM1) genotype is associated with serum 8-MOP concentration and PUVA sensitivity

    Ibbotson, S. H., Dawe, R. S., Weidlich, S., Dinkova-Kostova, A. T., Farr, P. M., Ferguson, J., Wolf, C. R. & Smith, G. Apr-2010 In : British Journal of Dermatology. 162, 4, p. 941-941, 1 p.

    Research output: Contribution to journal › Meeting abstract

  37. The Hepatic cytochrome P450 reductase null (HRN) mouse model as a tool to study xenobiotic metabolism

    Arlt, V. M., Henderson, C. J., Wolf, C. R., Phillips, D. H. & Stiborova, M. Mar-2010 In : Naunyn-Schmiedeberg's Archives of Pharmacology. 381, p. 83-83, 1 p.

    Research output: Contribution to journal › Book/Film/Article review

  38. Activating K-Ras mutations outwith 'hotspot' codons in sporadic colorectal tumours: implications for personalised cancer medicine

    Smith, G., Bounds, R., Wolf, H., Steele, R., Carey, F. & Wolf, R. 16-Feb-2010 In : British Journal of Cancer. 102, 4, p. 693-703, 11 p.

    Research output: Contribution to journal › Article

  39. Activation of the NRF2 Signaling Pathway by Copper-Mediated Redox Cycling of Para- and Ortho-Hydroquinones

    Wang, X. J., Hayes, J. D., Higgins, L. G., Wolf', C. R. & Dinkova-Kostova, A. T. 29-Jan-2010 In : Chemistry & Biology. 17, 1, p. 75-85, 11 p.

    Research output: Contribution to journal › Article

  40. Markedly enhanced colon tumorigenesis in Apc(Min) mice lacking glutathione S-transferase Pi

    Ritchie, K. J., Walsh, S., Sansom, O. J., Henderson, C. J. & Wolf, C. R. 8-Dec-2009 In : Proceedings of the National Academy of Sciences of the United States of America. 106, 49, p. 20859-20864, 6 p.

    Research output: Contribution to journal › Article

  41. Meta-and pooled analyses of the methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism and colorectal cancer: a HuGE-GSEC Review

    Taioli, E., Garza, M. A., Ahn, Y. O., Bishop, D. T., Bost, J., Budai, B., Chen, K., Gemignani, F., Keku, T., Lima, C. S. P., Le Marchand, L., Matsuo, K., Moreno, V., Plaschke, J., Pufulete, M., Thomas, S. B., Toffoli, G., Wolf, C. R., Moore, C. G. & Little, J. 1-Nov-2009 In : American Journal of Epidemiology. 170, 10, p. 1207-1221, 15 p.

    Research output: Contribution to journal › Article

  42. Nuclear receptor (CAR/PXR) humanised mouse models to study non-genotoxic hepatocarcinogenesis

    Elcombe, C. R., Ross, J., Scheer, N., Rode, A. & Wolf, C. R. Nov-2009 In : Mutagenesis. 24, 6, p. 523-524, 2 p.

    Research output: Contribution to journal › Book/Film/Article review

  43. Biomarkers and molecular tumour classification for non-genotoxic carcinogenesis

    Wolf, R. & 23 others Moggs, J., Friedberg, T., Stewart, N., Elcombe, C., Plummer, S., Grasl-Kraupp, B., Schulte-Hermann, R., Gerner, C., Meehan, R., Schwarz, M., Zell, A., Schroeder, A., Supper, J., Pichler, B., Templin, M., Maurel, P., Daujat-Chavanieu, M., Pacquet, J-L., Kalkuhl, A., Matheis, K., Ahr, H-J., Dhalluin, S. & Ostenfeldt, N. 13-Sep-2009 In : Toxicology Letters. 189, p. S136-S136, 1 p.

    Research output: Contribution to journal › Book/Film/Article review

  44. An in vitro model for the prediction of chemical metabolism and toxicity

    Ding, S-H., Vardy, A., Elcombe, C. R. & Wolf, C. R. 28-Jul-2009 In : Toxicology. 262, 1, p. 23-23, 1 p.

    Research output: Contribution to journal › Book/Film/Article review

  45. Human constitutive androstane receptor (CAR) supports the hypertrophic but not the hyperplastic response to the murine non-genotoxic carcinogen phenobarbital (pb) in vivo

    Elcombe, C. R., Ross, J., Scheer, N., Rode, A. & Wolf, C. R. 28-Jul-2009 In : Toxicology. 262, 1, p. 11-12, 2 p.

    Research output: Contribution to journal › Book/Film/Article review

  46. Nomenclature for alleles of the cytochrome P450 oxidoreductase gene

    Sim, S. C., Miller, W. L., Zhong, X-B., Arlt, W., Ogata, T., Ding, X., Wolf, C. R., Flueck, C. E., Pandey, A. V., Henderson, C. J., Porter, T. D., Daly, A. K., Nebert, D. W. & Ingelman-Sundberg, M. Jul-2009 In : Pharmacogenetics and Genomics. 19, 7, p. 565-566, 2 p.

    Research output: Contribution to journal › Letter

  47. Cholesterol Metabolism: the Main Pathway Acting Downstream of Cytochrome P450 Oxidoreductase in Skeletal Development of the Limb

    Schmidt, K., Hughes, C., Chudek, J. A., Goodyear, S. R., Aspden, R. M., Talbot, R., Gundersen, T. E., Blomhoff, R., Henderson, C., Wolf, C. R. & Tickle, C. 15-May-2009 In : Molecular and Cellular Biology. 29, 10, p. 2716-2729, 14 p.

    Research output: Contribution to journal › Article

  48. A Novel CYP3A Gene Cluster Humanized Mouse Model

    Kapelyukh, Y., Ross, J., Scheer, N. & Wolf, C. R. May-2009 In : Drug Metabolism Reviews. 41, p. 42-42, 1 p.

    Research output: Contribution to journal › Book/Film/Article review

  49. GSTpi Mediates MPTP-induced JNK Activation in the Nigrostriatal Pathway

    Gama, M. J., Castro-Caldas, M., Carvalho, A. N., Rodrigues, E., Henderson, C. J. & Wolf, C. R. May-2009 In : Drug Metabolism Reviews. 41, p. 29-30, 2 p.

    Research output: Contribution to journal › Book/Film/Article review

  50. Humanized Mouse Models for PK and Safety Profiling of Compounds

    Scheer, N., Ross, J., Rode, A. & Wolf, C. R. May-2009 In : Drug Metabolism Reviews. 41, p. 56, 2 p.

    Research output: Contribution to journal › Book/Film/Article review

  51. Glutathione S-transferase M1 genotype is associated with erythemal sensitivity to narrowband ultraviolet B in patients with psoriasis

    Ibbotson, S. H., Weidlich, S., Ferguson, J., Wolf, R., Dawe, R. S. & Smith, G. Apr-2009 In : British Journal of Dermatology. 160, 4, p. 928-928, 1 p.

    Research output: Contribution to journal › Article

  52. Prespective on the application of pharmacogenomics in the treatment of cancer

    Wolf, R. Apr-2009 In : Pharmacogenomics Journal. 10, 4, p. 527-529, 3 p.

    Research output: Contribution to journal › Editorial

  53. Drug transporters: Gatekeepers controlling access of xenobiotics to the cellular interior

    Stanley, L. A., Horsburgh, B. C., Ross, J., Scheer, N. & Wolf, C. R. Feb-2009 In : Drug Metabolism Reviews. 41, 1, p. 27-65, 39 p.

    Research output: Contribution to journal › Scientific review

  54. Polymorphisms in the SLC6A4 and HTR2A genes influence treatment outcome following antidepressant therapy

    Wilkie, M. J. V., Smith, G., Day, R., Matthews, K., Smith, D., Blackwood, D., Reid, I. C. & Wolf, R. Feb-2009 In : Pharmacogenomics Journal. 9, 1, p. 61-70, 10 p.

    Research output: Contribution to journal › Article

  55. Advances in the generation of mouse models to elucidate the pathways of drug metabolism in rodents and man

    Henderson, C. J., Scheer, N. & Wolf, C. R. 1-Jan-2009 In : Expert Review of Clinical Pharmacology. 2, 2, p. 105-109, 5 p.

    Research output: Contribution to journal › Editorial

  56. Interview: Perspective on the application of pharmacogenomics in the treatment of cancer

    Wolf, R. 1-Jan-2009 In : Pharmacogenomics. 10, 4, p. 527-529, 3 p.

    Research output: Contribution to journal › Article

  57. Preclinical toxicokinetic evaluation of Phortress [2-(4-amino-3- methylphenyl)-5-fluorobenzothiazole lysylamide dihydrochloride] in two rodent species

    Bradshaw, T. D., Wren, J. E., Bruce, M., Barrett, D. A., Leong, C-O., Gaskell, M., Wright, E. K., Farmer, P. B., Henderson, C. J., Wolf, R. & Stevens, M. F. G. 1-Jan-2009 In : Pharmacology. 83, 2, p. 99-109, 11 p.

    Research output: Contribution to journal › Article

  58. Unsaturated fatty acid regulation of cytochrome P450 expression via a CAR-dependent pathway

    Finn, R. D., Henderson, C. J., Scott, C. L. & Wolf, C. R. 1-Jan-2009 In : Biochemical Journal. 417, p. 43-54, 12 p.

    Research output: Contribution to journal › Article

  59. Glutathione Transferase P1 An Endogenous Inhibitor of Allergic Responses in a Mouse Model of Asthma

    Zhou, J., Wolf, C. R., Henderson, C. J., Cai, Y., Board, P. G., Foster, P. S. & Webb, D. C. 15-Dec-2008 In : American Journal of Respiratory and Critical Care Medicine. 178, 12, p. 1202-1210, 9 p.

    Research output: Contribution to journal › Article

  60. Defining the in Vivo Role for Cytochrome b(5) in Cytochrome P450 Function through the Conditional Hepatic Deletion of Microsomal Cytochrome b(5)

    Finn, R. D., McLaughlin, L. A., Ronseaux, S., Rosewell, I., Houston, J. B., Henderson, C. J. & Wolf, C. R. 14-Nov-2008 In : Journal of Biological Chemistry. 283, 46, p. 31385-31393, 9 p.

    Research output: Contribution to journal › Article

  61. Multiple substrate binding by cytochrome P450 3A4: Estimation of the number of bound substrate molecules

    Kapelyukh, Y., Paine, M., Marechal, J-D., Sutcliffe, M. J., Wolf, C. R. & Roberts, G. C. K. Oct-2008 In : Drug Metabolism and Disposition. 36, 10, p. 2136-2144, 9 p.

    Research output: Contribution to journal › Article

  62. A novel panel of mouse models to evaluate the role of human pregnane X receptor and constitutive androstane receptor in drug response

    Scheer, N., Ross, J., Rode, A., Zevnik, B., Niehaves, S., Faust, N. & Wolf, C. R. Sep-2008 In : Journal of Clinical Investigation. 118, 9, p. 3228-3239, 12 p.

    Research output: Contribution to journal › Article

  63. Methylene tetrahydrofolate reductase genotype modifies the chemopreventive effect of folate in colorectal adenoma, but not colorectal cancer

    Lightfoot, T. J., Barrett, J. H., Bishop, T., Northwood, E. L., Smith, G., Wilkie, M. J. V., Steele, R. J. C., Carey, F. A., Key, T. J., Wolf, R. & Forman, D. Sep-2008 In : Cancer Epidemiology, Biomarkers & Prevention. 17, 9, p. 2421-2430, 10 p.

    Research output: Contribution to journal › Article

  64. Control differentiation of embryonic stem cell to specific lineages

    Zhao, D., Hay, D., Fletcher, J., Hewitt, Z., McLean, D., Black, J., Urruticoechea-Uriguen, A., Elcombe, C., Ross, J., Wolf, R. & Cui, W. Aug-2008 In : Cell Research. 18, p. -, 1 p.

    Research output: Contribution to journal › Book/Film/Article review

  65. Functional expression and comparative characterization of nine murine cytochromes P450 by fluorescent inhibition screening

    McLaughlin, L. A., Dickmann, L. J., Wolf, C. R. & Henderson, C. J. Jul-2008 In : Drug Metabolism and Disposition. 36, 7, p. 1322-1331, 10 p.

    Research output: Contribution to journal › Article

  66. Illuminating role of CYP1A1 in skin function

    Rowe, J. M., Welsh, C., Pena, R. N., Wolf, C. R., Brown, K. & Whitelaw, C. B. A. Jul-2008 In : Journal of Investigative Dermatology. 128, 7, p. 1866-1868, 4 p.

    Research output: Contribution to journal › Letter

  67. Efficient differentiation of hepatocytes from human embryonic stem cells exhibiting markers recapitulating liver development in vivo

    Hay, D. C., Zhao, D., Fletcher, J., Hewitt, Z. A., McLean, D., Urruticoechea-Uriguen, A., Black, J. R., Elcombe, C., Ross, J. A., Wolf, R. & Cui, W. Apr-2008 In : Stem Cells. 26, 4, p. 894-902, 9 p.

    Research output: Contribution to journal › Article

  68. p21-LacZ reporter mice reflect p53-dependent toxic insult

    Vasey, D. B., Wolf, C. R., MacArtney, T., Brown, K. & Whitelaw, C. B. A. 15-Mar-2008 In : Toxicology and Applied Pharmacology. 227, 3, p. 440-450, 11 p.

    Research output: Contribution to journal › Article

  69. Dusp1/mkp-1, dusp2/hpac1 and dusp8/vh5 expression in colorectal cancer

    Conlin, A., Steele, R. J. C. & Wolf, C. R. Mar-2008 In : Gut. 57, Supplement 1, p. A133-A133, 1 p., 349

    Research output: Contribution to journal › Book/Film/Article review

  70. DUSP6/MKP-3 expression and K-ras mutation in colorectal cancer

    Conlin, A., Smith, G., Steele, R. J. C. & Wolf, C. R. Mar-2008 In : Gut. 57, Supplement 1, p. A134-A134, 1 p., 350

    Research output: Contribution to journal › Book/Film/Article review

  71. Insights into drug metabolism by cytochromes P450 from modelling studies of CYP2D6-drug interactions

    Marechal, J-D., Kemp, C. A., Roberts, G. C. K., Paine, M., Wolf, R. & Sutcliffe, M. J. Mar-2008 In : British Journal of Pharmacology. 153, p. S82-S89, 8 p.

    Research output: Contribution to journal › Article

  72. Metabolic activation of benzo[a]pyrene in vitro by hepatic cytochrome P450 contrasts with detoxification in vivo: experiments with hepatic cytochrome P450 reductase null mice

    Arlt, V. M., Stiborova, M., Henderson, C. J., Thiemann, M., Frei, E., Aimova, D., Singh, R., da Costa, G. G., Schmitz, O. J., Farmer, P. B., Wolf, C. R. & Phillips, D. H. Mar-2008 In : Carcinogenesis. 29, 3, p. 656-665, 10 p.

    Research output: Contribution to journal › Article

  73. Role of hepatic cytochromes P450 in bioactivation of the anticancer drug ellipticine: Studies with the hepatic NADPH: Cytochrome P450 reductase null mouse

    Stiborova, M., Arlt, V. M., Henderson, C. J., Wolf, C. R., Kotrbova, V., Moserova, M., Hudecek, J., Phillips, D. H. & Frei, E. 1-Feb-2008 In : Toxicology and Applied Pharmacology. 226, 3, p. 318-327, 10 p.

    Research output: Contribution to journal › Article

  74. A novel panel of double 'humanised' & knockout PXR and car mouse models

    Ross, J., Scheer, N. & Wolf, R. 2008 In : Drug Metabolism Reviews. 40, p. 114-115, 2 p.

    Research output: Contribution to journal › Book/Film/Article review

  75. Recombinant yeast and bacteria that express human p450s: bioreactors for drug-discovery, -development and -biotechnology

    Friedberg, T. H., Hanlon, S., Kittelmann, M., Ghisalba, O. & Wolf, C. R. 2008 In : Drug Metabolism Reviews. 40, p. 75-76, 2 p.

    Research output: Contribution to journal › Book/Film/Article review

  76. Identification of retinoic acid as an inhibitor of transcription factor Nrf2 through activation of retinoic acid receptor alpha

    Wang, X. J., Hayes, J. D., Henderson, C. J. & Wolf, C. R. 4-Dec-2007 In : Proceedings of the National Academy of Sciences of the United States of America. 104, 49, p. 19589-19594, 6 p.

    Research output: Contribution to journal › Article

  77. Melanocortin 1 receptor (MC1R) genotype influences erythemal sensitivity to psoralen-ultraviolet A photochemotherapy

    Smith, G., Wilkie, M. J. V., Deeni, Y. Y., Farr, P. M., Ferguson, J., Wolf, C. R. & Ibbotson, S. H. Dec-2007 In : British Journal of Dermatology. 157, 6, p. 1230-4, 5 p.

    Research output: Contribution to journal › Article

  78. Development of a liquid Chromatography-Electrospray ionization tandem mass spectrometry method for detecting Oxaliplatin-DNA intrastrand cross-links in biological samples

    Le Pla, R. C., Ritchie, K. J., Henderson, C. J., Wolf, C. R., Harrington, C. F. & Farmer, P. B. Aug-2007 In : Chemical Research in Toxicology. 20, 8, p. 1177-1182, 6 p.

    Research output: Contribution to journal › Article

  79. Conditional deletion of cytochrome P450 oxidoreductase in the liver and gastrointestinal tract: A new model for studying the functions of the P450 system

    Finn, R. D., McLaren, A. W., Carrie, D., Henderson, C. J. & Wolf, C. R. Jul-2007 In : Journal of Pharmacology and Experimental Therapeutics. 322, 1, p. 40-47, 8 p.

    Research output: Contribution to journal › Article

  80. A splice site polymorphism in the G-protein beta subunit influences antidepressant efficacy in depression

    Wilkie, M. J. V., Smith, D., Reid, I. C., Day, R. K., Matthews, K., Wolf, R., Blackwood, D. & Smith, G. Mar-2007 In : Pharmacogenetics and Genomics. 17, 3, p. 207-215, 9 p.

    Research output: Contribution to journal › Article

  81. Exposure to benzo[A]pyrene in the hepatic cytochrome p450 oxidoreductase null mouse: detoxification by hepatic cytochrome p450 is more important than metabolic activation

    Arlt, V. M., Stiborova, M., Henderson, C. J., Thiemann, M., Frei, E., Singh, R., da Costa, G. G., Schmitz, O. J., Farmer, P. B., Wolf, C. R. & Phillips, D. H. Mar-2007 In : Naunyn-Schmiedeberg's Archives of Pharmacology. 375, Supplement 1, p. 73-73, 1 p., 352

    Research output: Contribution to journal › Meeting abstract

  82. Activation of Nrf2 and cellular inflammatory response by hypochlorous acid

    Woods, C. G., Andersen, M. E., Zhang, Q., Thomas, R. S., Henderson, C. J., Wolf, C. R. & Pi, J. 2007 In : Free Radical Biology and Medicine. 43, p. S160-S160, 1 p.

    Research output: Contribution to journal › Book/Film/Article review

  83. Glutathione transferase π plays a critical role in the development of lung carcinogenesis following exposure to tobacco-related carcinogens and urethane

    Ritchie, K. J., Henderson, C. J., Wang, X-J., Vassieva, O., Carrie, D., Farmer, P. B., Gaskell, M., Park, K. & Wolf, C. R. 2007 In : Cancer Research. 67, 19, p. 9248-9257, 10 p.

    Research output: Contribution to journal › Article

  84. Genetic factors associated with the aetiology and treatment of colorectal cancer

    Wolf, C. R., Steele, R. J. C., Carey, F. A., Pratt, N. D., Bishop, D. T., Barrett, J. H., Forman, D. & Smith, G. 1-Sep-2006 In : Toxicology. 226, 1, p. 14-14, 1 p.

    Research output: Contribution to journal › Meeting abstract

  85. Hepatic cytochrome P-450 reductase-null mice show reduced transcriptional response to quercetin and reveal physiological homeostasis between jejunum and liver

    Mutch, D. M., Crespy, V., Clough, J., Henderson, C. J., Lariani, S., Mansourian, R., Moulin, J., Wolf, C. R. & Williamson, G. Jul-2006 In : American Journal of Physiology-Gastrointestinal and Liver Physiology. 291, 1, p. G63-G72, 10 p.

    Research output: Contribution to journal › Article

  86. Inter- and intrasubject variation in cytoprotective gene expression in patients with psoriasis

    Smith, G., Hearn, R., Wolf, C. R., Ferguson, J. & Ibbotson, S. H. Jul-2006 In : British Journal of Dermatology. 155, 1, p. 254-254, 1 p., P26

    Research output: Contribution to journal › Meeting abstract

  87. Melanocortin 1 receptor genotype influences erythemal sensitivity and treatment response in patients undergoing psoralen plus ultraviolet A treatment

    Smith, G., Wilkie, M. J. V., Deeni, Y. Y., Ferguson, J., Wolf, C. R. & Ibbotson, S. H. Jul-2006 In : British Journal of Dermatology. 155, 1, p. 240-240, 1 p., O15

    Research output: Contribution to journal › Meeting abstract

  88. Bioactivation of 3-aminobenzanthrone, a human metabolite of the environmental pollutant 3-nitrobenzanthrone: evidence for DNA adduct formation mediated by cytochrome P450 enzymes and peroxidases

    Arlt, V. M., Henderson, C. J., Wolf, C. R., Schmeiser, H. H., Phillips, D. H. & Stiborova, M. 28-Mar-2006 In : Cancer Letters. 234, 2, p. 220-231, 12 p.

    Research output: Contribution to journal › Article

  89. The hepatic cytochrome P450 reductase null mouse as a tool to identify a successful candidate entity

    Henderson, C. J., Pass, G. J. & Wolf, C. R. 15-Mar-2006 In : Toxicology Letters. 162, 1, p. 111-117, 7 p.

    Research output: Contribution to journal › Article

  90. Chromosomal changes in colorectal adenomas: relationship to gene mutations and potential for clinical utility

    Leslie, A., Stewart, A., Baty, D. U., Mechan, D., McGreavey, L., Smith, G., Wolf, C. R., Sales, M., Pratt, N. R., Steele, R. J. C. & Carey, F. A. Feb-2006 In : Genes, Chromosomes and Cancer. 45, 2, p. 126-135, 10 p.

    Research output: Contribution to journal › Article

  91. Generation of a stable antioxidant response element-driven reporter gene cell line and its use to show redox-dependent activation of Nrf2 by cancer chemotherapeutic agents

    Wang, X. J., Hayes, J. D. & Wolf, C. R. 2006 In : Cancer Research. 66, 22, p. 10983-94, 12 p.

    Research output: Contribution to journal › Article

  92. Generation Scotland: the Scottish Family Health Study; a new resource for researching genes and heritability

    Smith, B. H. , Wolf, R. & 24 others Campbell, H., Blackwood, D., Connell, J., Connor, M., Deary, I. J., Dominiczak, A. F., Fitzpatrick, B., Ford, I., Jackson, C., Haddow, G., Kerr, S., Lindsay, R., McGilchrist, M., Morton, R., Murray, G., Palmer, C. N. A., Pell, J. P., Ralston, S. H., St Clair, D., Sullivan, F., Watt, G., Wright, A., Porteous, D. & Morris, A. D. 2006 In : BMC Medical Genetics. 7, 74

    Research output: Contribution to journal › Article

  93. Identification of CYP2S1 ligands

    Dickmann, L. J., Deeni, Y., Smith, G. & Wolf, C. R. 2006 In : Drug Metabolism Reviews. 38, Suppl., p. 56-56, 1 p.

    Research output: Contribution to journal › Meeting abstract

  94. Identification of CYP2S1 ligands

    Dickmann, L. J., Deeni, Y., Smith, G. & Wolf, C. R. 2006

    Research output: Contribution to conference › Abstract

  95. Regulation of cutaneous drug-metabolizing enzymes and cytoprotective gene expression by topical drugs in human skin in vivo

    Smith, G., Ibbotson, S. H., Comrie, M. M., Dawe, R. S., Bryden, A., Ferguson, J. & Wolf, C. R. 2006 In : British Journal of Dermatology. 155, 2, p. 275-81, 7 p.

    Research output: Contribution to journal › Article

  96. Relationship between hepatic phenotype and changes in gene expression in cytochrome P450 reductase (POR) null mice

    Wang, X. J., Chamberlain, M., Vassieva, O., Henderson, C. J. & Wolf, C. R. 15-Jun-2005 In : Biochemical Journal. 388, 3, p. 857-867, 11 p.

    Research output: Contribution to journal › Article

  97. Role of hepatic cytochrome P450s in the pharmacokinetics and toxicity of cyclophosphamide: studies with the hepatic cytochrome P450 reductase null mouse

    Pass, G. J., Carrie, D., Boylan, M., Lorimore, S., Wright, E., Houston, B., Henderson, C. J. & Wolf, C. R. 15-May-2005 In : Cancer Research. 65, 10, p. 4211-4217, 7 p.

    Research output: Contribution to journal › Article

  98. Environmental pollutant and potent mutagen 3-nitrobenzanthrone forms DNA adducts after reduction by NAD(P)H: quinone oxidoreductase and conjugation by acetyltransferases and sulfotransferases in human hepatic cytosols

    Arlt, V. M., Stiborova, M., Henderson, C. J., Osborne, M. R., Bieler, C. A., Frei, E., Martinek, V., Sopko, B., Wolf, C. R., Schmeiser, H. H. & Phillips, D. H. 1-Apr-2005 In : Cancer Research. 65, 7, p. 2644-2652, 9 p.

    Research output: Contribution to journal › Article

  99. The murine Cyp1a1 gene is expressed in a restricted spatial and temporal pattern during embryonic development

    Campbell, S. J., Henderson, C. J., Anthony, D. C., Davidson, D., Clark, A. J. & Wolf, C. R. 18-Feb-2005 In : Journal of Biological Chemistry. 280, 7, p. 5828-5835, 8 p.

    Research output: Contribution to journal › Article

  100. AMP-activated protein kinase mediates phenobarbital induction of CYP2B gene expression in hepatocytes and a newly derived human hepatoma cell line

    Rencurel, F., Stenhouse, A., Hawley, S. A., Friedberg, T., Hardie, D. G., Sutherland, C. & Wolf, C. R. 2005 In : Journal of Biological Chemistry. 280, 6, p. 4367-4373, 7 p.

    Research output: Contribution to journal › Article

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