Discovery - University of Dundee - Online Publications

Library & Learning Centre

Roland Wolf

1 - 50 out of 191Page size: 50
RSS feed
Sort by: Publication year

  1. Evidence that Cytochrome b5 and Cytochrome b5 Reductase Can Act as Sole Electron Donors to the Hepatic Cytochrome P450 System

    Henderson, C. J., McLaughlin, L. A. & Wolf, C. R. 2013 In : Molecular Pharmacology.

    Research output: Contribution to journal › Article

  2. Individuality in FGF1 expression significantly influences platinum resistance and progression-free survival in ovarian cancer

    Smith, G., Ng, M. T. H., Shepherd, L., Herrington, C. S., Gourley, C., Ferguson, M. & Wolf, C. R. 9-Oct-2012 In : British Journal of Cancer. 107, 8, p. 1327-1336, 10 p.

    Research output: Contribution to journal › Article

  3. Role of structural factors of antitumour anthraquinone derivatives and analogues in the ability to undergo bioreductive activation by NADPH cytochrome P450 reductase: implications for increasing the activity against sensitive and multidrug-resistant leukaemia HL60 cells

    Kostrzewa-Nowak, D., Bieg, B., Paine, M. J. I., Wolf, C. R. & Tarasiuk, J. 1-Apr-2012 In : Anti-Cancer Drugs. 23, 4, p. 393-405, 13 p.

    Research output: Contribution to journal › Article

  4. Characterization of a Human Keratinocyte HaCaT Cell Line Model to Study the Regulation of CYP2S1

    McNeilly, A. D., Woods, J. A., Ibbotson, S. H., Wolf, C. R. & Smith, G. Feb-2012 In : Drug Metabolism and Disposition. 40, 2, p. 283-289, 7 p.

    Research output: Contribution to journal › Article

  5. The role of bioreductive activation of antitumour anthracycline drugs in cytotoxic activity against sensitive and multidrug resistant leukaemia HL60 cells

    Kostrzewa-Nowak, D., Bieg, B., Paine, M. J. I., Wolf, C. R. & Tarasiuk, J. 14-Jan-2012 In : European Journal of Pharmacology. 674, 2-3, p. 112-125, 14 p.

    Research output: Contribution to journal › Article

  6. Glutathione S-transferase genotype is associated with sensitivity to psoralen-ultraviolet A photochemotherapy

    Ibbotson, S. H., Dawe, R. S., Dinkova-Kostova, A. T., Weidlich, S., Farr, P. M., Ferguson, J., Wolf, C. R. & Smith, G. 1-Jan-2012 In : British Journal of Dermatology. 166, 2, p. 380-388, 9 p.

    Research output: Contribution to journal › Article

  7. Glutathione S-Transferase pi Mediates MPTP-Induced c-Jun N-Terminal Kinase Activation in the Nigrostriatal Pathway

    Castro-Caldas, M., Carvalho, A. N., Rodrigues, E., Gama, M. J., Henderson, C. & Wolf, C. R. 1-Jan-2012 In : Molecular Neurobiology. p. 1-12, 12 p.

    Research output: Contribution to journal › Article

  8. Modeling Human Cytochrome P450 2D6 Metabolism and Drug-Drug Interaction by a Novel Panel of Knockout and Humanized Mouse Lines

    Scheer, N., Kapelyukh, Y., McEwan, J., Beuger, V., Stanley, L. A., Rode, A. & Wolf, C. R. Jan-2012 In : Molecular Pharmacology. 81, 1, p. 63-72, 10 p.

    Research output: Contribution to journal › Article

  9. Conditional expression of human PPARδ and a dominant negative variant of hPPARδ in vivo

    Higgins, L. G., Garbacz, W. G., Gustafsson, M. C. U., Sitheswaran, N., Ashby, P. R., Wolf, C. R. & Palmer, C. N. A. 2012 In : PPAR Research. 12 p., 216817

    Research output: Contribution to journal › Article

  10. Exposure to benzo[a]pyrene of hepatic cytochrome P450 reductase null (HRN) and P450 reductase conditional null (RCN) mice: detection of benzo[a]pyrene diol epoxide-DNA adducts by immunohistochemistry and P-postlabelling

    Arlt, V. M., Poirier, M. C., Sykes, S. E., John, K., Moserova, M., Stiborova, M., Wolf, C. R., Henderson, C. J. & Phillips, D. H. 2012 In : Toxicology Letters. 213, 2, p. 160-166, 7 p.

    Research output: Contribution to journal › Article

  11. Generation and characterization of a novel multidrug resistance protein 2 humanized mouse line

    Scheer, N., Balimane, P., Hayward, M. D., Buechel, S., Kauselmann, G. & Wolf, C. R. 2012 In : Drug Metabolism and Disposition. 40, 11, p. 2212-2218, 7 p.

    Research output: Contribution to journal › Article

  12. Tauroursodeoxycholic acid prevents MPTP-induced dopaminergic cell death in a mouse model of Parkinson's disease

    Castro-Caldas, M., Carvalho, A. N., Rodrigues, E., Henderson, C. J., Wolf, C. R., Rodrigues, C. M. P. & Gama, M. J. 2012 In : Molecular Neurobiology. 46, 2, p. 475-486, 12 p.

    Research output: Contribution to journal › Article

  13. Non-catalytic mechanisms involved in glutathione Stransferase Pi mediated cytoprotection

    McGarry, D. J., Wolf, C. R. & Henderson, C. J. 18-Dec-2011 In : Toxicology. 290, 2-3, p. 130-130, 1 p.

    Research output: Contribution to journal › Book/Film/Article review

  14. Effect of hepatic cytochrome P450 (P450) oxidoreductase deficiency on 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine-DNA Adduct Formation in P450 reductase conditional null mice

    Arlt, V. M., Singh, R., Stiborova, M., da Costa, G. G., Frei, E., Evans, J. D., Farmer, P. B., Wolf, C. R., Henderson, C. J. & Phillips, D. H. Dec-2011 In : Drug Metabolism and Disposition. 39, 12, p. 2169-2173, 5 p.

    Research output: Contribution to journal › Article

  15. Increased Skin Papilloma Formation in Mice Lacking Glutathione Transferase GSTP

    Henderson, C. J., Ritchie, K. J., McLaren, A., Chakravarty, P. & Wolf, C. R. 15-Nov-2011 In : Cancer Research. 71, 22, p. 7048-7060, 13 p.

    Research output: Contribution to journal › Article

  16. Humanizing pi-Class Glutathione S-Transferase Regulation in a Mouse Model Alters Liver Toxicity in Response to Acetaminophen Overdose

    Vaughn, M. P., Shinohara, D. B., Castagna, N., Hicks, J. L., Netto, G., De Marzo, A. M., Speed, T. J., Reichert, Z. R., Kwabi-Addo, B., Henderson, C. J., Wolf, C. R., Yegnasubramanian, S. & Nelson, W. G. 11-Oct-2011 In : PLoS ONE. 6, 10, p. -, 10 p., e25707

    Research output: Contribution to journal › Article

  17. Enzyme and protein engineering: engineering a self-sufficient human cytochrome P450 monooxygenase system

    Deeni, Y. & Wolf, R. Sep-2011 In : Current Opinion in Biotechnology. 22, p. S18-S18, 1 p.

    Research output: Contribution to journal › Book/Film/Article review

  18. Quantitative Prediction of Human Pregnane X Receptor and Cytochrome P450 3A4 Mediated Drug-Drug Interaction in a Novel Multiple Humanized Mouse Line

    Hasegawa, M., Kapelyukh, Y., Tahara, H., Seibler, J., Rode, A., Krueger, S., Lee, D. N., Wolf, C. R. & Scheer, N. Sep-2011 In : Molecular Pharmacology. 80, 3, p. 518-528, 11 p.

    Research output: Contribution to journal › Article

  19. Role of CAR and PXR in xenobiotic toxicity

    Wolf, C. R., Elcombe, C., Rode, A., Scheer, N., Bower, C. & Henderson, C. 28-Aug-2011 In : Toxicology Letters. 205, p. S13-S13, 1 p.

    Research output: Contribution to journal › Book/Film/Article review

  20. The Imidazoacridinone Antitumor Drug, C-1311, Is Metabolized by Flavin Monooxygenases but Not by Cytochrome P450s

    Potega, A., Dabrowska, E., Niemira, M., Kot-Wasik, A., Ronseaux, S., Henderson, C. J., Wolf, C. R. & Mazerska, Z. Aug-2011 In : Drug Metabolism and Disposition. 39, 8, p. 1423-1432, 10 p.

    Research output: Contribution to journal › Article

  21. Pyrosequencing-based methods reveal marked inter-individual differences in oncogene mutation burden in human colorectal tumours

    Weidlich, S., Walsh, K., Crowther, D., Burczynski, M. E., Feuerstein, G., Carey, F., Steele, R. J. C., Wolf, C. R., Miele, G. & Smith, G. 12-Jul-2011 In : British Journal of Cancer. 105, 2, p. 246-254, 9 p.

    Research output: Contribution to journal › Article

  22. Cytochrome b (5) null mouse: a new model for studying inherited skin disorders and the role of unsaturated fatty acids in normal homeostasis

    Finn, R. D., McLaughlin, L. A., Hughes, C., Song, C., Henderson, C. J. & Wolf, C. R. Jun-2011 In : Transgenic Research. 20, 3, p. 491-502, 12 p.

    Research output: Contribution to journal › Article

  23. Knockout and transgenic mice in glutathione transferase research

    Henderson, C. J. & Wolf, C. R. May-2011 In : Drug Metabolism Reviews. 43, 2, p. 152-164, 13 p.

    Research output: Contribution to journal › Scientific review

  24. Role of Cytochromes P450 1A1/2 in Detoxication and Activation of Carcinogenic Aristolochic Acid I: Studies with the Hepatic NADPH:Cytochrome P450 Reductase Null (HRN) Mouse Model

    Levova, K., Moserova, M., Kotrbova, V., Sulc, M., Henderson, C. J., Wolf, C. R., Phillips, D. H., Frei, E., Schmeiser, H. H., Mares, J., Arlt, V. M. & Stiborova, M. May-2011 In : Toxicological Sciences. 121, 1, p. 43-56, 14 p.

    Research output: Contribution to journal › Article

  25. Spatial p21 expression profile in the mid-term mouse embryo

    Vasey, D. B., Wolf, C. R., Brown, K. & Whitelaw, C. B. A. Feb-2011 In : Transgenic Research. 20, 1, p. 23-28, 6 p.

    Research output: Contribution to journal › Article

  26. Non-catalytic mechanisms involved in glutathione S-transferase pi mediated cytoprotection

    McGarry, D. J., Wolf, C. R. & Henderson, C. J. 30-Dec-2010 In : Toxicology. 278, 3, p. 371-372, 2 p.

    Research output: Contribution to journal › Book/Film/Article review

  27. A phase I clinical trial of CXR1002 in patients (pts) with advanced cancer

    Macpherson, M., Bissett, D., Tait, B., Samuel, L. M., MacDonald, J., Barnett, A. L., Wolf, C. R., Elcombe, C. R., Jeynes-Ellis, A. & Evans, T. R. J. Nov-2010 In : EJC Supplements. 8, 7, p. 124-124, 1 p.

    Research output: Contribution to journal › Book/Film/Article review

  28. Anti-tumor activity of CXR1002, a novel anti-cancer clinical phase compound that induces ER stress and inhibits PIM kinases: Human tumor xenograft efficacy and in vitro mode of action

    Barnett, A., Ding, S., Murray, C., Chamberlain, M., Plummer, S., Evans, T. R. J., MacPherson, I., Bissett, D., Elcombe, C. R. & Wolf, C. R. Nov-2010 In : EJC Supplements. 8, 7, p. 45-46, 2 p.

    Research output: Contribution to journal › Book/Film/Article review

  29. Spatial monitoring of toxicity in HMOX-LacZ transgenic mice

    Young, R., Wolf, C. R., Brown, K., Hayes, J. D. & Whitelaw, C. B. A. Oct-2010 In : Transgenic Research. 19, 5, p. 897-902, 6 p.

    Research output: Contribution to journal › Article

  30. Activating K-Ras mutations outwith "hotspot" codons in sporadic colorectal tumours: implications for personalised cancer medicine

    Smith, G., Bounds, R., Wolf, H., Pratt, N., Carey, F., Steele, R. & Wolf, C. Sep-2010 In : Journal of Pathology. 222, S1, p. S12-S12, 1 p.

    Research output: Contribution to journal › Book/Film/Article review

  31. Deletion of Microsomal Cytochrome b(5) Profoundly Affects Hepatic and Extrahepatic Drug Metabolism

    McLaughlin, L. A., Ronseaux, S., Finn, R. D., Henderson, C. J. & Wolf, C. R. Aug-2010 In : Molecular Pharmacology. 78, 2, p. 269-278, 10 p.

    Research output: Contribution to journal › Article

  32. Human Constitutive Androstane Receptor (CAR) and Pregnane X Receptor (PXR) Support the Hypertrophic but not the Hyperplastic Response to the Murine Nongenotoxic Hepatocarcinogens Phenobarbital and Chlordane In Vivo

    Ross, J., Plummer, S. M., Rode, A., Scheer, N., Bower, C. C., Vogel, O., Henderson, C. J., Wolf, C. R. & Elcombe, C. R. Aug-2010 In : Toxicological Sciences. 116, 2, p. 452-466, 15 p.

    Research output: Contribution to journal › Article

  33. Peroxiredoxin Gene Expression Signatures in Liver Reflect Toxic Insult

    Young, R., Hayes, J. D., Brown, K., Wolf, C. R. & Whitelaw, C. B. A. Aug-2010 In : ASSAY and Drug Development Technologies. 8, 4, p. 512-517, 6 p.

    Research output: Contribution to journal › Article

  34. In Vivo Responses of the Human and Murine Pregnane X Receptor to Dexamethasone in Mice

    Scheer, N., Ross, J., Kapelyukh, Y., Rode, A. & Wolf, C. R. Jul-2010 In : Drug Metabolism and Disposition. 38, 7, p. 1046-1053, 8 p.

    Research output: Contribution to journal › Article

  35. Polymorphisms in xenobiotic metabolizing enzymes and diet influence colorectal adenoma risk

    Northwood, E. L., Elliott, F., Forman, D., Barrett, J. H., Wilkie, M. J. V., Carey, F. A., Steele, R. J. C., Wolf, R., Bishop, T. & Smith, G. May-2010 In : Pharmacogenetics and Genomics. 20, 5, p. 315-326, 12 p.

    Research output: Contribution to journal › Article

  36. Glutathione S-transferase M1 (GSTM1) genotype is associated with serum 8-MOP concentration and PUVA sensitivity

    Ibbotson, S. H., Dawe, R. S., Weidlich, S., Dinkova-Kostova, A. T., Farr, P. M., Ferguson, J., Wolf, C. R. & Smith, G. Apr-2010 In : British Journal of Dermatology. 162, 4, p. 941-941, 1 p.

    Research output: Contribution to journal › Meeting abstract

  37. The Hepatic cytochrome P450 reductase null (HRN) mouse model as a tool to study xenobiotic metabolism

    Arlt, V. M., Henderson, C. J., Wolf, C. R., Phillips, D. H. & Stiborova, M. Mar-2010 In : Naunyn-Schmiedeberg's Archives of Pharmacology. 381, p. 83-83, 1 p.

    Research output: Contribution to journal › Book/Film/Article review

  38. Activating K-Ras mutations outwith 'hotspot' codons in sporadic colorectal tumours: implications for personalised cancer medicine

    Smith, G., Bounds, R., Wolf, H., Steele, R., Carey, F. & Wolf, R. 16-Feb-2010 In : British Journal of Cancer. 102, 4, p. 693-703, 11 p.

    Research output: Contribution to journal › Article

  39. Activation of the NRF2 Signaling Pathway by Copper-Mediated Redox Cycling of Para- and Ortho-Hydroquinones

    Wang, X. J., Hayes, J. D., Higgins, L. G., Wolf', C. R. & Dinkova-Kostova, A. T. 29-Jan-2010 In : Chemistry & Biology. 17, 1, p. 75-85, 11 p.

    Research output: Contribution to journal › Article

  40. Markedly enhanced colon tumorigenesis in Apc(Min) mice lacking glutathione S-transferase Pi

    Ritchie, K. J., Walsh, S., Sansom, O. J., Henderson, C. J. & Wolf, C. R. 8-Dec-2009 In : Proceedings of the National Academy of Sciences of the United States of America. 106, 49, p. 20859-20864, 6 p.

    Research output: Contribution to journal › Article

  41. Meta-and pooled analyses of the methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism and colorectal cancer: a HuGE-GSEC Review

    Taioli, E., Garza, M. A., Ahn, Y. O., Bishop, D. T., Bost, J., Budai, B., Chen, K., Gemignani, F., Keku, T., Lima, C. S. P., Le Marchand, L., Matsuo, K., Moreno, V., Plaschke, J., Pufulete, M., Thomas, S. B., Toffoli, G., Wolf, C. R., Moore, C. G. & Little, J. 1-Nov-2009 In : American Journal of Epidemiology. 170, 10, p. 1207-1221, 15 p.

    Research output: Contribution to journal › Article

  42. Nuclear receptor (CAR/PXR) humanised mouse models to study non-genotoxic hepatocarcinogenesis

    Elcombe, C. R., Ross, J., Scheer, N., Rode, A. & Wolf, C. R. Nov-2009 In : Mutagenesis. 24, 6, p. 523-524, 2 p.

    Research output: Contribution to journal › Book/Film/Article review

  43. Biomarkers and molecular tumour classification for non-genotoxic carcinogenesis

    Wolf, R. & 23 others Moggs, J., Friedberg, T., Stewart, N., Elcombe, C., Plummer, S., Grasl-Kraupp, B., Schulte-Hermann, R., Gerner, C., Meehan, R., Schwarz, M., Zell, A., Schroeder, A., Supper, J., Pichler, B., Templin, M., Maurel, P., Daujat-Chavanieu, M., Pacquet, J-L., Kalkuhl, A., Matheis, K., Ahr, H-J., Dhalluin, S. & Ostenfeldt, N. 13-Sep-2009 In : Toxicology Letters. 189, p. S136-S136, 1 p.

    Research output: Contribution to journal › Book/Film/Article review

  44. An in vitro model for the prediction of chemical metabolism and toxicity

    Ding, S-H., Vardy, A., Elcombe, C. R. & Wolf, C. R. 28-Jul-2009 In : Toxicology. 262, 1, p. 23-23, 1 p.

    Research output: Contribution to journal › Book/Film/Article review

  45. Human constitutive androstane receptor (CAR) supports the hypertrophic but not the hyperplastic response to the murine non-genotoxic carcinogen phenobarbital (pb) in vivo

    Elcombe, C. R., Ross, J., Scheer, N., Rode, A. & Wolf, C. R. 28-Jul-2009 In : Toxicology. 262, 1, p. 11-12, 2 p.

    Research output: Contribution to journal › Book/Film/Article review

  46. Nomenclature for alleles of the cytochrome P450 oxidoreductase gene

    Sim, S. C., Miller, W. L., Zhong, X-B., Arlt, W., Ogata, T., Ding, X., Wolf, C. R., Flueck, C. E., Pandey, A. V., Henderson, C. J., Porter, T. D., Daly, A. K., Nebert, D. W. & Ingelman-Sundberg, M. Jul-2009 In : Pharmacogenetics and Genomics. 19, 7, p. 565-566, 2 p.

    Research output: Contribution to journal › Letter

  47. Cholesterol Metabolism: the Main Pathway Acting Downstream of Cytochrome P450 Oxidoreductase in Skeletal Development of the Limb

    Schmidt, K., Hughes, C., Chudek, J. A., Goodyear, S. R., Aspden, R. M., Talbot, R., Gundersen, T. E., Blomhoff, R., Henderson, C., Wolf, C. R. & Tickle, C. 15-May-2009 In : Molecular and Cellular Biology. 29, 10, p. 2716-2729, 14 p.

    Research output: Contribution to journal › Article

  48. A Novel CYP3A Gene Cluster Humanized Mouse Model

    Kapelyukh, Y., Ross, J., Scheer, N. & Wolf, C. R. May-2009 In : Drug Metabolism Reviews. 41, p. 42-42, 1 p.

    Research output: Contribution to journal › Book/Film/Article review

  49. GSTpi Mediates MPTP-induced JNK Activation in the Nigrostriatal Pathway

    Gama, M. J., Castro-Caldas, M., Carvalho, A. N., Rodrigues, E., Henderson, C. J. & Wolf, C. R. May-2009 In : Drug Metabolism Reviews. 41, p. 29-30, 2 p.

    Research output: Contribution to journal › Book/Film/Article review

  50. Humanized Mouse Models for PK and Safety Profiling of Compounds

    Scheer, N., Ross, J., Rode, A. & Wolf, C. R. May-2009 In : Drug Metabolism Reviews. 41, p. 56, 2 p.

    Research output: Contribution to journal › Book/Film/Article review

Previous 1 2 3 4 Next

Find Researchers in Discovery

Reset

Recently Published

Library & Learning Centre

Contact | Accessibility | Policy