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Roland Wolf

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  1. Evidence that Cytochrome b5 and Cytochrome b5 Reductase Can Act as Sole Electron Donors to the Hepatic Cytochrome P450 System

    Henderson, C. J., McLaughlin, L. A. & Wolf, C. R. Jun-2013 In : Molecular Pharmacology. 83, 6, p. 1209-1217, 9 p.

    Research output: Contribution to journal › Article

  2. Individuality in FGF1 expression significantly influences platinum resistance and progression-free survival in ovarian cancer

    Smith, G., Ng, M. T. H., Shepherd, L., Herrington, C. S., Gourley, C., Ferguson, M. & Wolf, C. R. 9-Oct-2012 In : British Journal of Cancer. 107, 8, p. 1327-1336, 10 p.

    Research output: Contribution to journal › Article

  3. Role of structural factors of antitumour anthraquinone derivatives and analogues in the ability to undergo bioreductive activation by NADPH cytochrome P450 reductase: implications for increasing the activity against sensitive and multidrug-resistant leukaemia HL60 cells

    Kostrzewa-Nowak, D., Bieg, B., Paine, M. J. I., Wolf, C. R. & Tarasiuk, J. 1-Apr-2012 In : Anti-Cancer Drugs. 23, 4, p. 393-405, 13 p.

    Research output: Contribution to journal › Article

  4. Characterization of a Human Keratinocyte HaCaT Cell Line Model to Study the Regulation of CYP2S1

    McNeilly, A. D., Woods, J. A., Ibbotson, S. H., Wolf, C. R. & Smith, G. Feb-2012 In : Drug Metabolism and Disposition. 40, 2, p. 283-289, 7 p.

    Research output: Contribution to journal › Article

  5. The role of bioreductive activation of antitumour anthracycline drugs in cytotoxic activity against sensitive and multidrug resistant leukaemia HL60 cells

    Kostrzewa-Nowak, D., Bieg, B., Paine, M. J. I., Wolf, C. R. & Tarasiuk, J. 14-Jan-2012 In : European Journal of Pharmacology. 674, 2-3, p. 112-125, 14 p.

    Research output: Contribution to journal › Article

  6. Glutathione S-transferase genotype is associated with sensitivity to psoralen-ultraviolet A photochemotherapy

    Ibbotson, S. H., Dawe, R. S., Dinkova-Kostova, A. T., Weidlich, S., Farr, P. M., Ferguson, J., Wolf, C. R. & Smith, G. 1-Jan-2012 In : British Journal of Dermatology. 166, 2, p. 380-388, 9 p.

    Research output: Contribution to journal › Article

  7. Glutathione S-Transferase pi Mediates MPTP-Induced c-Jun N-Terminal Kinase Activation in the Nigrostriatal Pathway

    Castro-Caldas, M., Carvalho, A. N., Rodrigues, E., Gama, M. J., Henderson, C. & Wolf, C. R. 1-Jan-2012 In : Molecular Neurobiology. p. 1-12, 12 p.

    Research output: Contribution to journal › Article

  8. Modeling Human Cytochrome P450 2D6 Metabolism and Drug-Drug Interaction by a Novel Panel of Knockout and Humanized Mouse Lines

    Scheer, N., Kapelyukh, Y., McEwan, J., Beuger, V., Stanley, L. A., Rode, A. & Wolf, C. R. Jan-2012 In : Molecular Pharmacology. 81, 1, p. 63-72, 10 p.

    Research output: Contribution to journal › Article

  9. Conditional expression of human PPARδ and a dominant negative variant of hPPARδ in vivo

    Higgins, L. G., Garbacz, W. G., Gustafsson, M. C. U., Sitheswaran, N., Ashby, P. R., Wolf, C. R. & Palmer, C. N. A. 2012 In : PPAR Research. 12 p., 216817

    Research output: Contribution to journal › Article

  10. Exposure to benzo[a]pyrene of hepatic cytochrome P450 reductase null (HRN) and P450 reductase conditional null (RCN) mice: detection of benzo[a]pyrene diol epoxide-DNA adducts by immunohistochemistry and P-postlabelling

    Arlt, V. M., Poirier, M. C., Sykes, S. E., John, K., Moserova, M., Stiborova, M., Wolf, C. R., Henderson, C. J. & Phillips, D. H. 2012 In : Toxicology Letters. 213, 2, p. 160-166, 7 p.

    Research output: Contribution to journal › Article

  11. Generation and characterization of a novel multidrug resistance protein 2 humanized mouse line

    Scheer, N., Balimane, P., Hayward, M. D., Buechel, S., Kauselmann, G. & Wolf, C. R. 2012 In : Drug Metabolism and Disposition. 40, 11, p. 2212-2218, 7 p.

    Research output: Contribution to journal › Article

  12. Tauroursodeoxycholic acid prevents MPTP-induced dopaminergic cell death in a mouse model of Parkinson's disease

    Castro-Caldas, M., Carvalho, A. N., Rodrigues, E., Henderson, C. J., Wolf, C. R., Rodrigues, C. M. P. & Gama, M. J. 2012 In : Molecular Neurobiology. 46, 2, p. 475-486, 12 p.

    Research output: Contribution to journal › Article

  13. Non-catalytic mechanisms involved in glutathione Stransferase Pi mediated cytoprotection

    McGarry, D. J., Wolf, C. R. & Henderson, C. J. 18-Dec-2011 In : Toxicology. 290, 2-3, p. 130-130, 1 p.

    Research output: Contribution to journal › Book/Film/Article review

  14. Effect of hepatic cytochrome P450 (P450) oxidoreductase deficiency on 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine-DNA Adduct Formation in P450 reductase conditional null mice

    Arlt, V. M., Singh, R., Stiborova, M., da Costa, G. G., Frei, E., Evans, J. D., Farmer, P. B., Wolf, C. R., Henderson, C. J. & Phillips, D. H. Dec-2011 In : Drug Metabolism and Disposition. 39, 12, p. 2169-2173, 5 p.

    Research output: Contribution to journal › Article

  15. Increased Skin Papilloma Formation in Mice Lacking Glutathione Transferase GSTP

    Henderson, C. J., Ritchie, K. J., McLaren, A., Chakravarty, P. & Wolf, C. R. 15-Nov-2011 In : Cancer Research. 71, 22, p. 7048-7060, 13 p.

    Research output: Contribution to journal › Article

  16. Humanizing pi-Class Glutathione S-Transferase Regulation in a Mouse Model Alters Liver Toxicity in Response to Acetaminophen Overdose

    Vaughn, M. P., Shinohara, D. B., Castagna, N., Hicks, J. L., Netto, G., De Marzo, A. M., Speed, T. J., Reichert, Z. R., Kwabi-Addo, B., Henderson, C. J., Wolf, C. R., Yegnasubramanian, S. & Nelson, W. G. 11-Oct-2011 In : PLoS ONE. 6, 10, p. -, 10 p., e25707

    Research output: Contribution to journal › Article

  17. Enzyme and protein engineering: engineering a self-sufficient human cytochrome P450 monooxygenase system

    Deeni, Y. & Wolf, R. Sep-2011 In : Current Opinion in Biotechnology. 22, p. S18-S18, 1 p.

    Research output: Contribution to journal › Book/Film/Article review

  18. Quantitative Prediction of Human Pregnane X Receptor and Cytochrome P450 3A4 Mediated Drug-Drug Interaction in a Novel Multiple Humanized Mouse Line

    Hasegawa, M., Kapelyukh, Y., Tahara, H., Seibler, J., Rode, A., Krueger, S., Lee, D. N., Wolf, C. R. & Scheer, N. Sep-2011 In : Molecular Pharmacology. 80, 3, p. 518-528, 11 p.

    Research output: Contribution to journal › Article

  19. Role of CAR and PXR in xenobiotic toxicity

    Wolf, C. R., Elcombe, C., Rode, A., Scheer, N., Bower, C. & Henderson, C. 28-Aug-2011 In : Toxicology Letters. 205, p. S13-S13, 1 p.

    Research output: Contribution to journal › Book/Film/Article review

  20. The Imidazoacridinone Antitumor Drug, C-1311, Is Metabolized by Flavin Monooxygenases but Not by Cytochrome P450s

    Potega, A., Dabrowska, E., Niemira, M., Kot-Wasik, A., Ronseaux, S., Henderson, C. J., Wolf, C. R. & Mazerska, Z. Aug-2011 In : Drug Metabolism and Disposition. 39, 8, p. 1423-1432, 10 p.

    Research output: Contribution to journal › Article

  21. Pyrosequencing-based methods reveal marked inter-individual differences in oncogene mutation burden in human colorectal tumours

    Weidlich, S., Walsh, K., Crowther, D., Burczynski, M. E., Feuerstein, G., Carey, F., Steele, R. J. C., Wolf, C. R., Miele, G. & Smith, G. 12-Jul-2011 In : British Journal of Cancer. 105, 2, p. 246-254, 9 p.

    Research output: Contribution to journal › Article

  22. Cytochrome b (5) null mouse: a new model for studying inherited skin disorders and the role of unsaturated fatty acids in normal homeostasis

    Finn, R. D., McLaughlin, L. A., Hughes, C., Song, C., Henderson, C. J. & Wolf, C. R. Jun-2011 In : Transgenic Research. 20, 3, p. 491-502, 12 p.

    Research output: Contribution to journal › Article

  23. Knockout and transgenic mice in glutathione transferase research

    Henderson, C. J. & Wolf, C. R. May-2011 In : Drug Metabolism Reviews. 43, 2, p. 152-164, 13 p.

    Research output: Contribution to journal › Scientific review

  24. Role of Cytochromes P450 1A1/2 in Detoxication and Activation of Carcinogenic Aristolochic Acid I: Studies with the Hepatic NADPH:Cytochrome P450 Reductase Null (HRN) Mouse Model

    Levova, K., Moserova, M., Kotrbova, V., Sulc, M., Henderson, C. J., Wolf, C. R., Phillips, D. H., Frei, E., Schmeiser, H. H., Mares, J., Arlt, V. M. & Stiborova, M. May-2011 In : Toxicological Sciences. 121, 1, p. 43-56, 14 p.

    Research output: Contribution to journal › Article

  25. Spatial p21 expression profile in the mid-term mouse embryo

    Vasey, D. B., Wolf, C. R., Brown, K. & Whitelaw, C. B. A. Feb-2011 In : Transgenic Research. 20, 1, p. 23-28, 6 p.

    Research output: Contribution to journal › Article

  26. Non-catalytic mechanisms involved in glutathione S-transferase pi mediated cytoprotection

    McGarry, D. J., Wolf, C. R. & Henderson, C. J. 30-Dec-2010 In : Toxicology. 278, 3, p. 371-372, 2 p.

    Research output: Contribution to journal › Book/Film/Article review

  27. A phase I clinical trial of CXR1002 in patients (pts) with advanced cancer

    Macpherson, M., Bissett, D., Tait, B., Samuel, L. M., MacDonald, J., Barnett, A. L., Wolf, C. R., Elcombe, C. R., Jeynes-Ellis, A. & Evans, T. R. J. Nov-2010 In : EJC Supplements. 8, 7, p. 124-124, 1 p.

    Research output: Contribution to journal › Book/Film/Article review

  28. Anti-tumor activity of CXR1002, a novel anti-cancer clinical phase compound that induces ER stress and inhibits PIM kinases: Human tumor xenograft efficacy and in vitro mode of action

    Barnett, A., Ding, S., Murray, C., Chamberlain, M., Plummer, S., Evans, T. R. J., MacPherson, I., Bissett, D., Elcombe, C. R. & Wolf, C. R. Nov-2010 In : EJC Supplements. 8, 7, p. 45-46, 2 p.

    Research output: Contribution to journal › Book/Film/Article review

  29. Spatial monitoring of toxicity in HMOX-LacZ transgenic mice

    Young, R., Wolf, C. R., Brown, K., Hayes, J. D. & Whitelaw, C. B. A. Oct-2010 In : Transgenic Research. 19, 5, p. 897-902, 6 p.

    Research output: Contribution to journal › Article

  30. Activating K-Ras mutations outwith "hotspot" codons in sporadic colorectal tumours: implications for personalised cancer medicine

    Smith, G., Bounds, R., Wolf, H., Pratt, N., Carey, F., Steele, R. & Wolf, C. Sep-2010 In : Journal of Pathology. 222, S1, p. S12-S12, 1 p.

    Research output: Contribution to journal › Book/Film/Article review

  31. Deletion of Microsomal Cytochrome b(5) Profoundly Affects Hepatic and Extrahepatic Drug Metabolism

    McLaughlin, L. A., Ronseaux, S., Finn, R. D., Henderson, C. J. & Wolf, C. R. Aug-2010 In : Molecular Pharmacology. 78, 2, p. 269-278, 10 p.

    Research output: Contribution to journal › Article

  32. Human Constitutive Androstane Receptor (CAR) and Pregnane X Receptor (PXR) Support the Hypertrophic but not the Hyperplastic Response to the Murine Nongenotoxic Hepatocarcinogens Phenobarbital and Chlordane In Vivo

    Ross, J., Plummer, S. M., Rode, A., Scheer, N., Bower, C. C., Vogel, O., Henderson, C. J., Wolf, C. R. & Elcombe, C. R. Aug-2010 In : Toxicological Sciences. 116, 2, p. 452-466, 15 p.

    Research output: Contribution to journal › Article

  33. Peroxiredoxin Gene Expression Signatures in Liver Reflect Toxic Insult

    Young, R., Hayes, J. D., Brown, K., Wolf, C. R. & Whitelaw, C. B. A. Aug-2010 In : ASSAY and Drug Development Technologies. 8, 4, p. 512-517, 6 p.

    Research output: Contribution to journal › Article

  34. In Vivo Responses of the Human and Murine Pregnane X Receptor to Dexamethasone in Mice

    Scheer, N., Ross, J., Kapelyukh, Y., Rode, A. & Wolf, C. R. Jul-2010 In : Drug Metabolism and Disposition. 38, 7, p. 1046-1053, 8 p.

    Research output: Contribution to journal › Article

  35. Polymorphisms in xenobiotic metabolizing enzymes and diet influence colorectal adenoma risk

    Northwood, E. L., Elliott, F., Forman, D., Barrett, J. H., Wilkie, M. J. V., Carey, F. A., Steele, R. J. C., Wolf, R., Bishop, T. & Smith, G. May-2010 In : Pharmacogenetics and Genomics. 20, 5, p. 315-326, 12 p.

    Research output: Contribution to journal › Article

  36. Glutathione S-transferase M1 (GSTM1) genotype is associated with serum 8-MOP concentration and PUVA sensitivity

    Ibbotson, S. H., Dawe, R. S., Weidlich, S., Dinkova-Kostova, A. T., Farr, P. M., Ferguson, J., Wolf, C. R. & Smith, G. Apr-2010 In : British Journal of Dermatology. 162, 4, p. 941-941, 1 p.

    Research output: Contribution to journal › Meeting abstract

  37. The Hepatic cytochrome P450 reductase null (HRN) mouse model as a tool to study xenobiotic metabolism

    Arlt, V. M., Henderson, C. J., Wolf, C. R., Phillips, D. H. & Stiborova, M. Mar-2010 In : Naunyn-Schmiedeberg's Archives of Pharmacology. 381, p. 83-83, 1 p.

    Research output: Contribution to journal › Book/Film/Article review

  38. Activating K-Ras mutations outwith 'hotspot' codons in sporadic colorectal tumours: implications for personalised cancer medicine

    Smith, G., Bounds, R., Wolf, H., Steele, R., Carey, F. & Wolf, R. 16-Feb-2010 In : British Journal of Cancer. 102, 4, p. 693-703, 11 p.

    Research output: Contribution to journal › Article

  39. Activation of the NRF2 Signaling Pathway by Copper-Mediated Redox Cycling of Para- and Ortho-Hydroquinones

    Wang, X. J., Hayes, J. D., Higgins, L. G., Wolf', C. R. & Dinkova-Kostova, A. T. 29-Jan-2010 In : Chemistry & Biology. 17, 1, p. 75-85, 11 p.

    Research output: Contribution to journal › Article

  40. Markedly enhanced colon tumorigenesis in Apc(Min) mice lacking glutathione S-transferase Pi

    Ritchie, K. J., Walsh, S., Sansom, O. J., Henderson, C. J. & Wolf, C. R. 8-Dec-2009 In : Proceedings of the National Academy of Sciences of the United States of America. 106, 49, p. 20859-20864, 6 p.

    Research output: Contribution to journal › Article

  41. Meta-and pooled analyses of the methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism and colorectal cancer: a HuGE-GSEC Review

    Taioli, E., Garza, M. A., Ahn, Y. O., Bishop, D. T., Bost, J., Budai, B., Chen, K., Gemignani, F., Keku, T., Lima, C. S. P., Le Marchand, L., Matsuo, K., Moreno, V., Plaschke, J., Pufulete, M., Thomas, S. B., Toffoli, G., Wolf, C. R., Moore, C. G. & Little, J. 1-Nov-2009 In : American Journal of Epidemiology. 170, 10, p. 1207-1221, 15 p.

    Research output: Contribution to journal › Article

  42. Nuclear receptor (CAR/PXR) humanised mouse models to study non-genotoxic hepatocarcinogenesis

    Elcombe, C. R., Ross, J., Scheer, N., Rode, A. & Wolf, C. R. Nov-2009 In : Mutagenesis. 24, 6, p. 523-524, 2 p.

    Research output: Contribution to journal › Book/Film/Article review

  43. Biomarkers and molecular tumour classification for non-genotoxic carcinogenesis

    Wolf, R. & 23 others Moggs, J., Friedberg, T., Stewart, N., Elcombe, C., Plummer, S., Grasl-Kraupp, B., Schulte-Hermann, R., Gerner, C., Meehan, R., Schwarz, M., Zell, A., Schroeder, A., Supper, J., Pichler, B., Templin, M., Maurel, P., Daujat-Chavanieu, M., Pacquet, J-L., Kalkuhl, A., Matheis, K., Ahr, H-J., Dhalluin, S. & Ostenfeldt, N. 13-Sep-2009 In : Toxicology Letters. 189, p. S136-S136, 1 p.

    Research output: Contribution to journal › Book/Film/Article review

  44. An in vitro model for the prediction of chemical metabolism and toxicity

    Ding, S-H., Vardy, A., Elcombe, C. R. & Wolf, C. R. 28-Jul-2009 In : Toxicology. 262, 1, p. 23-23, 1 p.

    Research output: Contribution to journal › Book/Film/Article review

  45. Human constitutive androstane receptor (CAR) supports the hypertrophic but not the hyperplastic response to the murine non-genotoxic carcinogen phenobarbital (pb) in vivo

    Elcombe, C. R., Ross, J., Scheer, N., Rode, A. & Wolf, C. R. 28-Jul-2009 In : Toxicology. 262, 1, p. 11-12, 2 p.

    Research output: Contribution to journal › Book/Film/Article review

  46. Nomenclature for alleles of the cytochrome P450 oxidoreductase gene

    Sim, S. C., Miller, W. L., Zhong, X-B., Arlt, W., Ogata, T., Ding, X., Wolf, C. R., Flueck, C. E., Pandey, A. V., Henderson, C. J., Porter, T. D., Daly, A. K., Nebert, D. W. & Ingelman-Sundberg, M. Jul-2009 In : Pharmacogenetics and Genomics. 19, 7, p. 565-566, 2 p.

    Research output: Contribution to journal › Letter

  47. Cholesterol Metabolism: the Main Pathway Acting Downstream of Cytochrome P450 Oxidoreductase in Skeletal Development of the Limb

    Schmidt, K., Hughes, C., Chudek, J. A., Goodyear, S. R., Aspden, R. M., Talbot, R., Gundersen, T. E., Blomhoff, R., Henderson, C., Wolf, C. R. & Tickle, C. 15-May-2009 In : Molecular and Cellular Biology. 29, 10, p. 2716-2729, 14 p.

    Research output: Contribution to journal › Article

  48. A Novel CYP3A Gene Cluster Humanized Mouse Model

    Kapelyukh, Y., Ross, J., Scheer, N. & Wolf, C. R. May-2009 In : Drug Metabolism Reviews. 41, p. 42-42, 1 p.

    Research output: Contribution to journal › Book/Film/Article review

  49. GSTpi Mediates MPTP-induced JNK Activation in the Nigrostriatal Pathway

    Gama, M. J., Castro-Caldas, M., Carvalho, A. N., Rodrigues, E., Henderson, C. J. & Wolf, C. R. May-2009 In : Drug Metabolism Reviews. 41, p. 29-30, 2 p.

    Research output: Contribution to journal › Book/Film/Article review

  50. Humanized Mouse Models for PK and Safety Profiling of Compounds

    Scheer, N., Ross, J., Rode, A. & Wolf, C. R. May-2009 In : Drug Metabolism Reviews. 41, p. 56, 2 p.

    Research output: Contribution to journal › Book/Film/Article review

  51. Glutathione S-transferase M1 genotype is associated with erythemal sensitivity to narrowband ultraviolet B in patients with psoriasis

    Ibbotson, S. H., Weidlich, S., Ferguson, J., Wolf, R., Dawe, R. S. & Smith, G. Apr-2009 In : British Journal of Dermatology. 160, 4, p. 928-928, 1 p.

    Research output: Contribution to journal › Article

  52. Prespective on the application of pharmacogenomics in the treatment of cancer

    Wolf, R. Apr-2009 In : Pharmacogenomics Journal. 10, 4, p. 527-529, 3 p.

    Research output: Contribution to journal › Editorial

  53. Drug transporters: Gatekeepers controlling access of xenobiotics to the cellular interior

    Stanley, L. A., Horsburgh, B. C., Ross, J., Scheer, N. & Wolf, C. R. Feb-2009 In : Drug Metabolism Reviews. 41, 1, p. 27-65, 39 p.

    Research output: Contribution to journal › Scientific review

  54. Polymorphisms in the SLC6A4 and HTR2A genes influence treatment outcome following antidepressant therapy

    Wilkie, M. J. V., Smith, G., Day, R., Matthews, K., Smith, D., Blackwood, D., Reid, I. C. & Wolf, R. Feb-2009 In : Pharmacogenomics Journal. 9, 1, p. 61-70, 10 p.

    Research output: Contribution to journal › Article

  55. Advances in the generation of mouse models to elucidate the pathways of drug metabolism in rodents and man

    Henderson, C. J., Scheer, N. & Wolf, C. R. 1-Jan-2009 In : Expert Review of Clinical Pharmacology. 2, 2, p. 105-109, 5 p.

    Research output: Contribution to journal › Editorial

  56. Interview: Perspective on the application of pharmacogenomics in the treatment of cancer

    Wolf, R. 1-Jan-2009 In : Pharmacogenomics. 10, 4, p. 527-529, 3 p.

    Research output: Contribution to journal › Article

  57. Preclinical toxicokinetic evaluation of Phortress [2-(4-amino-3- methylphenyl)-5-fluorobenzothiazole lysylamide dihydrochloride] in two rodent species

    Bradshaw, T. D., Wren, J. E., Bruce, M., Barrett, D. A., Leong, C-O., Gaskell, M., Wright, E. K., Farmer, P. B., Henderson, C. J., Wolf, R. & Stevens, M. F. G. 1-Jan-2009 In : Pharmacology. 83, 2, p. 99-109, 11 p.

    Research output: Contribution to journal › Article

  58. Unsaturated fatty acid regulation of cytochrome P450 expression via a CAR-dependent pathway

    Finn, R. D., Henderson, C. J., Scott, C. L. & Wolf, C. R. 1-Jan-2009 In : Biochemical Journal. 417, p. 43-54, 12 p.

    Research output: Contribution to journal › Article

  59. Glutathione Transferase P1 An Endogenous Inhibitor of Allergic Responses in a Mouse Model of Asthma

    Zhou, J., Wolf, C. R., Henderson, C. J., Cai, Y., Board, P. G., Foster, P. S. & Webb, D. C. 15-Dec-2008 In : American Journal of Respiratory and Critical Care Medicine. 178, 12, p. 1202-1210, 9 p.

    Research output: Contribution to journal › Article

  60. Defining the in Vivo Role for Cytochrome b(5) in Cytochrome P450 Function through the Conditional Hepatic Deletion of Microsomal Cytochrome b(5)

    Finn, R. D., McLaughlin, L. A., Ronseaux, S., Rosewell, I., Houston, J. B., Henderson, C. J. & Wolf, C. R. 14-Nov-2008 In : Journal of Biological Chemistry. 283, 46, p. 31385-31393, 9 p.

    Research output: Contribution to journal › Article

  61. Multiple substrate binding by cytochrome P450 3A4: Estimation of the number of bound substrate molecules

    Kapelyukh, Y., Paine, M., Marechal, J-D., Sutcliffe, M. J., Wolf, C. R. & Roberts, G. C. K. Oct-2008 In : Drug Metabolism and Disposition. 36, 10, p. 2136-2144, 9 p.

    Research output: Contribution to journal › Article

  62. A novel panel of mouse models to evaluate the role of human pregnane X receptor and constitutive androstane receptor in drug response

    Scheer, N., Ross, J., Rode, A., Zevnik, B., Niehaves, S., Faust, N. & Wolf, C. R. Sep-2008 In : Journal of Clinical Investigation. 118, 9, p. 3228-3239, 12 p.

    Research output: Contribution to journal › Article

  63. Methylene tetrahydrofolate reductase genotype modifies the chemopreventive effect of folate in colorectal adenoma, but not colorectal cancer

    Lightfoot, T. J., Barrett, J. H., Bishop, T., Northwood, E. L., Smith, G., Wilkie, M. J. V., Steele, R. J. C., Carey, F. A., Key, T. J., Wolf, R. & Forman, D. Sep-2008 In : Cancer Epidemiology, Biomarkers & Prevention. 17, 9, p. 2421-2430, 10 p.

    Research output: Contribution to journal › Article

  64. Control differentiation of embryonic stem cell to specific lineages

    Zhao, D., Hay, D., Fletcher, J., Hewitt, Z., McLean, D., Black, J., Urruticoechea-Uriguen, A., Elcombe, C., Ross, J., Wolf, R. & Cui, W. Aug-2008 In : Cell Research. 18, p. -, 1 p.

    Research output: Contribution to journal › Book/Film/Article review

  65. Functional expression and comparative characterization of nine murine cytochromes P450 by fluorescent inhibition screening

    McLaughlin, L. A., Dickmann, L. J., Wolf, C. R. & Henderson, C. J. Jul-2008 In : Drug Metabolism and Disposition. 36, 7, p. 1322-1331, 10 p.

    Research output: Contribution to journal › Article

  66. Illuminating role of CYP1A1 in skin function

    Rowe, J. M., Welsh, C., Pena, R. N., Wolf, C. R., Brown, K. & Whitelaw, C. B. A. Jul-2008 In : Journal of Investigative Dermatology. 128, 7, p. 1866-1868, 4 p.

    Research output: Contribution to journal › Letter

  67. Efficient differentiation of hepatocytes from human embryonic stem cells exhibiting markers recapitulating liver development in vivo

    Hay, D. C., Zhao, D., Fletcher, J., Hewitt, Z. A., McLean, D., Urruticoechea-Uriguen, A., Black, J. R., Elcombe, C., Ross, J. A., Wolf, R. & Cui, W. Apr-2008 In : Stem Cells. 26, 4, p. 894-902, 9 p.

    Research output: Contribution to journal › Article

  68. p21-LacZ reporter mice reflect p53-dependent toxic insult

    Vasey, D. B., Wolf, C. R., MacArtney, T., Brown, K. & Whitelaw, C. B. A. 15-Mar-2008 In : Toxicology and Applied Pharmacology. 227, 3, p. 440-450, 11 p.

    Research output: Contribution to journal › Article

  69. Dusp1/mkp-1, dusp2/hpac1 and dusp8/vh5 expression in colorectal cancer

    Conlin, A., Steele, R. J. C. & Wolf, C. R. Mar-2008 In : Gut. 57, Supplement 1, p. A133-A133, 1 p., 349

    Research output: Contribution to journal › Book/Film/Article review

  70. DUSP6/MKP-3 expression and K-ras mutation in colorectal cancer

    Conlin, A., Smith, G., Steele, R. J. C. & Wolf, C. R. Mar-2008 In : Gut. 57, Supplement 1, p. A134-A134, 1 p., 350

    Research output: Contribution to journal › Book/Film/Article review

  71. Insights into drug metabolism by cytochromes P450 from modelling studies of CYP2D6-drug interactions

    Marechal, J-D., Kemp, C. A., Roberts, G. C. K., Paine, M., Wolf, R. & Sutcliffe, M. J. Mar-2008 In : British Journal of Pharmacology. 153, p. S82-S89, 8 p.

    Research output: Contribution to journal › Article

  72. Metabolic activation of benzo[a]pyrene in vitro by hepatic cytochrome P450 contrasts with detoxification in vivo: experiments with hepatic cytochrome P450 reductase null mice

    Arlt, V. M., Stiborova, M., Henderson, C. J., Thiemann, M., Frei, E., Aimova, D., Singh, R., da Costa, G. G., Schmitz, O. J., Farmer, P. B., Wolf, C. R. & Phillips, D. H. Mar-2008 In : Carcinogenesis. 29, 3, p. 656-665, 10 p.

    Research output: Contribution to journal › Article

  73. Role of hepatic cytochromes P450 in bioactivation of the anticancer drug ellipticine: Studies with the hepatic NADPH: Cytochrome P450 reductase null mouse

    Stiborova, M., Arlt, V. M., Henderson, C. J., Wolf, C. R., Kotrbova, V., Moserova, M., Hudecek, J., Phillips, D. H. & Frei, E. 1-Feb-2008 In : Toxicology and Applied Pharmacology. 226, 3, p. 318-327, 10 p.

    Research output: Contribution to journal › Article

  74. A novel panel of double 'humanised' & knockout PXR and car mouse models

    Ross, J., Scheer, N. & Wolf, R. 2008 In : Drug Metabolism Reviews. 40, p. 114-115, 2 p.

    Research output: Contribution to journal › Book/Film/Article review

  75. Recombinant yeast and bacteria that express human p450s: bioreactors for drug-discovery, -development and -biotechnology

    Friedberg, T. H., Hanlon, S., Kittelmann, M., Ghisalba, O. & Wolf, C. R. 2008 In : Drug Metabolism Reviews. 40, p. 75-76, 2 p.

    Research output: Contribution to journal › Book/Film/Article review

  76. Identification of retinoic acid as an inhibitor of transcription factor Nrf2 through activation of retinoic acid receptor alpha

    Wang, X. J., Hayes, J. D., Henderson, C. J. & Wolf, C. R. 4-Dec-2007 In : Proceedings of the National Academy of Sciences of the United States of America. 104, 49, p. 19589-19594, 6 p.

    Research output: Contribution to journal › Article

  77. Melanocortin 1 receptor (MC1R) genotype influences erythemal sensitivity to psoralen-ultraviolet A photochemotherapy

    Smith, G., Wilkie, M. J. V., Deeni, Y. Y., Farr, P. M., Ferguson, J., Wolf, C. R. & Ibbotson, S. H. Dec-2007 In : British Journal of Dermatology. 157, 6, p. 1230-4, 5 p.

    Research output: Contribution to journal › Article

  78. Development of a liquid Chromatography-Electrospray ionization tandem mass spectrometry method for detecting Oxaliplatin-DNA intrastrand cross-links in biological samples

    Le Pla, R. C., Ritchie, K. J., Henderson, C. J., Wolf, C. R., Harrington, C. F. & Farmer, P. B. Aug-2007 In : Chemical Research in Toxicology. 20, 8, p. 1177-1182, 6 p.

    Research output: Contribution to journal › Article

  79. Conditional deletion of cytochrome P450 oxidoreductase in the liver and gastrointestinal tract: A new model for studying the functions of the P450 system

    Finn, R. D., McLaren, A. W., Carrie, D., Henderson, C. J. & Wolf, C. R. Jul-2007 In : Journal of Pharmacology and Experimental Therapeutics. 322, 1, p. 40-47, 8 p.

    Research output: Contribution to journal › Article

  80. A splice site polymorphism in the G-protein beta subunit influences antidepressant efficacy in depression

    Wilkie, M. J. V., Smith, D., Reid, I. C., Day, R. K., Matthews, K., Wolf, R., Blackwood, D. & Smith, G. Mar-2007 In : Pharmacogenetics and Genomics. 17, 3, p. 207-215, 9 p.

    Research output: Contribution to journal › Article

  81. Exposure to benzo[A]pyrene in the hepatic cytochrome p450 oxidoreductase null mouse: detoxification by hepatic cytochrome p450 is more important than metabolic activation

    Arlt, V. M., Stiborova, M., Henderson, C. J., Thiemann, M., Frei, E., Singh, R., da Costa, G. G., Schmitz, O. J., Farmer, P. B., Wolf, C. R. & Phillips, D. H. Mar-2007 In : Naunyn-Schmiedeberg's Archives of Pharmacology. 375, Supplement 1, p. 73-73, 1 p., 352

    Research output: Contribution to journal › Meeting abstract

  82. Activation of Nrf2 and cellular inflammatory response by hypochlorous acid

    Woods, C. G., Andersen, M. E., Zhang, Q., Thomas, R. S., Henderson, C. J., Wolf, C. R. & Pi, J. 2007 In : Free Radical Biology and Medicine. 43, p. S160-S160, 1 p.

    Research output: Contribution to journal › Book/Film/Article review

  83. Glutathione transferase π plays a critical role in the development of lung carcinogenesis following exposure to tobacco-related carcinogens and urethane

    Ritchie, K. J., Henderson, C. J., Wang, X-J., Vassieva, O., Carrie, D., Farmer, P. B., Gaskell, M., Park, K. & Wolf, C. R. 2007 In : Cancer Research. 67, 19, p. 9248-9257, 10 p.

    Research output: Contribution to journal › Article

  84. Genetic factors associated with the aetiology and treatment of colorectal cancer

    Wolf, C. R., Steele, R. J. C., Carey, F. A., Pratt, N. D., Bishop, D. T., Barrett, J. H., Forman, D. & Smith, G. 1-Sep-2006 In : Toxicology. 226, 1, p. 14-14, 1 p.

    Research output: Contribution to journal › Meeting abstract

  85. Hepatic cytochrome P-450 reductase-null mice show reduced transcriptional response to quercetin and reveal physiological homeostasis between jejunum and liver

    Mutch, D. M., Crespy, V., Clough, J., Henderson, C. J., Lariani, S., Mansourian, R., Moulin, J., Wolf, C. R. & Williamson, G. Jul-2006 In : American Journal of Physiology-Gastrointestinal and Liver Physiology. 291, 1, p. G63-G72, 10 p.

    Research output: Contribution to journal › Article

  86. Inter- and intrasubject variation in cytoprotective gene expression in patients with psoriasis

    Smith, G., Hearn, R., Wolf, C. R., Ferguson, J. & Ibbotson, S. H. Jul-2006 In : British Journal of Dermatology. 155, 1, p. 254-254, 1 p., P26

    Research output: Contribution to journal › Meeting abstract

  87. Melanocortin 1 receptor genotype influences erythemal sensitivity and treatment response in patients undergoing psoralen plus ultraviolet A treatment

    Smith, G., Wilkie, M. J. V., Deeni, Y. Y., Ferguson, J., Wolf, C. R. & Ibbotson, S. H. Jul-2006 In : British Journal of Dermatology. 155, 1, p. 240-240, 1 p., O15

    Research output: Contribution to journal › Meeting abstract

  88. Bioactivation of 3-aminobenzanthrone, a human metabolite of the environmental pollutant 3-nitrobenzanthrone: evidence for DNA adduct formation mediated by cytochrome P450 enzymes and peroxidases

    Arlt, V. M., Henderson, C. J., Wolf, C. R., Schmeiser, H. H., Phillips, D. H. & Stiborova, M. 28-Mar-2006 In : Cancer Letters. 234, 2, p. 220-231, 12 p.

    Research output: Contribution to journal › Article

  89. The hepatic cytochrome P450 reductase null mouse as a tool to identify a successful candidate entity

    Henderson, C. J., Pass, G. J. & Wolf, C. R. 15-Mar-2006 In : Toxicology Letters. 162, 1, p. 111-117, 7 p.

    Research output: Contribution to journal › Article

  90. Chromosomal changes in colorectal adenomas: relationship to gene mutations and potential for clinical utility

    Leslie, A., Stewart, A., Baty, D. U., Mechan, D., McGreavey, L., Smith, G., Wolf, C. R., Sales, M., Pratt, N. R., Steele, R. J. C. & Carey, F. A. Feb-2006 In : Genes, Chromosomes and Cancer. 45, 2, p. 126-135, 10 p.

    Research output: Contribution to journal › Article

  91. Generation of a stable antioxidant response element-driven reporter gene cell line and its use to show redox-dependent activation of Nrf2 by cancer chemotherapeutic agents

    Wang, X. J., Hayes, J. D. & Wolf, C. R. 2006 In : Cancer Research. 66, 22, p. 10983-94, 12 p.

    Research output: Contribution to journal › Article

  92. Generation Scotland: the Scottish Family Health Study; a new resource for researching genes and heritability

    Smith, B. H. , Wolf, R. & 24 others Campbell, H., Blackwood, D., Connell, J., Connor, M., Deary, I. J., Dominiczak, A. F., Fitzpatrick, B., Ford, I., Jackson, C., Haddow, G., Kerr, S., Lindsay, R., McGilchrist, M., Morton, R., Murray, G., Palmer, C. N. A., Pell, J. P., Ralston, S. H., St Clair, D., Sullivan, F., Watt, G., Wright, A., Porteous, D. & Morris, A. D. 2006 In : BMC Medical Genetics. 7, 74

    Research output: Contribution to journal › Article

  93. Identification of CYP2S1 ligands

    Dickmann, L. J., Deeni, Y., Smith, G. & Wolf, C. R. 2006 In : Drug Metabolism Reviews. 38, Suppl., p. 56-56, 1 p.

    Research output: Contribution to journal › Meeting abstract

  94. Identification of CYP2S1 ligands

    Dickmann, L. J., Deeni, Y., Smith, G. & Wolf, C. R. 2006

    Research output: Contribution to conference › Abstract

  95. Regulation of cutaneous drug-metabolizing enzymes and cytoprotective gene expression by topical drugs in human skin in vivo

    Smith, G., Ibbotson, S. H., Comrie, M. M., Dawe, R. S., Bryden, A., Ferguson, J. & Wolf, C. R. 2006 In : British Journal of Dermatology. 155, 2, p. 275-81, 7 p.

    Research output: Contribution to journal › Article

  96. Relationship between hepatic phenotype and changes in gene expression in cytochrome P450 reductase (POR) null mice

    Wang, X. J., Chamberlain, M., Vassieva, O., Henderson, C. J. & Wolf, C. R. 15-Jun-2005 In : Biochemical Journal. 388, 3, p. 857-867, 11 p.

    Research output: Contribution to journal › Article

  97. Role of hepatic cytochrome P450s in the pharmacokinetics and toxicity of cyclophosphamide: studies with the hepatic cytochrome P450 reductase null mouse

    Pass, G. J., Carrie, D., Boylan, M., Lorimore, S., Wright, E., Houston, B., Henderson, C. J. & Wolf, C. R. 15-May-2005 In : Cancer Research. 65, 10, p. 4211-4217, 7 p.

    Research output: Contribution to journal › Article

  98. Environmental pollutant and potent mutagen 3-nitrobenzanthrone forms DNA adducts after reduction by NAD(P)H: quinone oxidoreductase and conjugation by acetyltransferases and sulfotransferases in human hepatic cytosols

    Arlt, V. M., Stiborova, M., Henderson, C. J., Osborne, M. R., Bieler, C. A., Frei, E., Martinek, V., Sopko, B., Wolf, C. R., Schmeiser, H. H. & Phillips, D. H. 1-Apr-2005 In : Cancer Research. 65, 7, p. 2644-2652, 9 p.

    Research output: Contribution to journal › Article

  99. The murine Cyp1a1 gene is expressed in a restricted spatial and temporal pattern during embryonic development

    Campbell, S. J., Henderson, C. J., Anthony, D. C., Davidson, D., Clark, A. J. & Wolf, C. R. 18-Feb-2005 In : Journal of Biological Chemistry. 280, 7, p. 5828-5835, 8 p.

    Research output: Contribution to journal › Article

  100. AMP-activated protein kinase mediates phenobarbital induction of CYP2B gene expression in hepatocytes and a newly derived human hepatoma cell line

    Rencurel, F., Stenhouse, A., Hawley, S. A., Friedberg, T., Hardie, D. G., Sutherland, C. & Wolf, C. R. 2005 In : Journal of Biological Chemistry. 280, 6, p. 4367-4373, 7 p.

    Research output: Contribution to journal › Article

  101. Disruption of the glutathione transferase Pi class genes

    Henderson, C. J. & Wolf, C. R. 2005 Methods in enzymology: gluthione transferases and gamma-glutamyl transpeptidases. Sies, H. & Packer, L. (eds.). San Diego: Academic Press, Vol. 401, p. 116-135 20 p.

    Research output: Chapter in Book/Report/Conference proceeding › Other chapter contribution

  102. Mutation and tissue microarray analysis of tumour suppressor genes and cell cycle-related proteins in colorectal cancer

    Robertson, K. E., Conlin, A., Miller, J., Smith, G., Steele, R. J. C., Wolf, C. R., Levison, D. A. & Carey, F. A. 2005 In : Journal of Pathology. 207, Suppl. 1, p. 43-43, 1 p.

    Research output: Contribution to journal › Meeting abstract

  103. Mutation and tissue microarray analysis of tumour suppressor genes and cell cycle-related proteins in colorectal cancer

    Robertson, K. E., Conlin, A., Miller, J., Smith, G., Steele, R. J. C., Wolf, C. R., Levison, D. A. & Carey, F. A. 2005

    Research output: Contribution to conference › Abstract

  104. No evidence that polymorphisms in CYP2C8, CYP2C9, UGT1A6, PPAR[delta] and PPAR[gamma] act as modifiers of the protective effect of regular NSAID use on the risk of colorectal carcinoma

    McGreavey, L. E., Turner, F., Smith, G., Boylan, K., Bishop, D. T., Forman, D., Wolf, C. R. & Barrett, J. H. 2005 In : Pharmacogenetics and Genomics. 15, 10, p. 713-721, 9 p.

    Research output: Contribution to journal › Article

  105. The prognostic significance of K-ras, p53, and APC mutations in colorectal carcinoma

    Conlin, A., Smith, G., Carey, F. A., Wolf, C. R. & Steele, R. J. C. 2005 In : Gut. 54, 9, p. 1283-1286, 4 p.

    Research output: Contribution to journal › Article

  106. Vegetable, fruit and meat consumption and potential risk modifying genes in relation to colorectal cancer

    Turner, F., Smith, G., Sachse, C., Lightfoot, T., Garner, R. C., Wolf, C. R., Forman, D., Bishop, D. T., Barrett, J. H. & Colorectal Cancer Study Group 1-Nov-2004 In : International Journal of Cancer. 112, 2, p. 259-264, 6 p.

    Research output: Contribution to journal › Article

  107. Regulation of cytochrome P450 CYP2S1 in human skin by UVR and topical drugs used to treat psoriasis

    Smith, G., Deeni, Y. Y., Dawe, R. S., Evans, A. T., Ferguson, J., Wolf, C. R. & Ibbotson, S. H. Aug-2004 In : Drug Metabolism Reviews. 36, Supplement 1, p. 181-181, 1 p., 363

    Research output: Contribution to journal › Meeting abstract

  108. Activation of peroxisome proliferator-activated receptor δ stimulates the proliferation of human breast and prostate cancer cell lines

    Stephen, R. L., Gustafsson, M. C. U., Jarvis, M., Tatoud, R., Marshall, B. R., Knight, D., Ehrenborg, E., Harris, A. L., Wolf, C. R. & Palmer, C. N. A. May-2004 In : Cancer Research. 64, 9, p. 3162-3170, 9 p.

    Research output: Contribution to journal › Article

  109. No association of polymorphisms in CYP17, CYP19, and HSD17-B1 with plasma estradiol concentrations in 1,090 British women

    Travis, R. C., Churchman, M., Edwards, S. A., Smith, G., Verkasalo, P. K., Wolf, C. R., Wolf, H. & Key, T. J. 2004 In : Cancer Epidemiology, Biomarkers & Prevention. 13, 12, p. 2282-4, 3 p.

    Research output: Contribution to journal › Article

  110. Identification of novel roles of the cytochrome P450 system in early embryogenesis: effects on vasculogenesis and retinoic acid homeostasis

    Otto, D. M. E., Henderson, C. J., Carrie, D., Davey, M., Gundersen, T. E., Blomhoff, R., Adams, R. H., Tickle, C. & Wolf, C. R. Sep-2003 In : Molecular and Cellular Biology. 23, 17, p. 6103-6116, 14 p.

    Research output: Contribution to journal › Article

  111. Mutations of APC, K-ras, and p53 are associated with specific chromosomal aberrations in colorectal adenocarcinomas

    Leslie, A., Pratt, N. R., Gillespie, K., Sales, M., Kernohan, N. M., Smith, G., Wolf, C. R., Carey, F. A. & Steele, R. J. C. Aug-2003 In : Cancer Research. 63, 15, p. 4656-4661, 6 p.

    Research output: Contribution to journal › Article

  112. Quantitative real-time reverse transcription-polymerase chain reaction analysis of drug metabolizing and cytoprotective genes in psoriasis and regulation by ultraviolet radiation

    Smith, G., Dawe, R. S., Clark, C., Evans, A. T., Comrie, M. M., Wolf, C. R., Ferguson, J. & Ibbotson, S. H. Aug-2003 In : Journal of Investigative Dermatology. 121, 2, p. 390-398, 9 p.

    Research output: Contribution to journal › Article

  113. Increased constitutive c-Jun N-terminal kinase signaling in mice lacking glutathione S-transferase Pi

    Elsby, R., Kitteringham, N. R., Goldring, C. E., Lovatt, C. A., Chamberlain, M., Henderson, C. J., Wolf, C. R. & Park, B. K. 20-Jun-2003 In : Journal of Biological Chemistry. 278, 25, p. 22243-22249, 7 p.

    Research output: Contribution to journal › Article

  114. Cytochrome P450 CYP2S1 expression in human skin: individuality in regulation by therapeutic agents for psoriasis and other skin diseases

    Smith, G., Deeni, Y. Y., Dawe, R. S., Comrie, M. M., Wolf, C. R., Ferguson, J. & Ibbotson, S. H. Apr-2003 In : British Journal of Dermatology. 148, 4, p. 853-853, 1 p., O16

    Research output: Contribution to journal › Meeting abstract

  115. Precision-cut tissue slices from transgenic mice as an in vitro toxicology system

    Catania, J. M., Parrish, A. R., Kirkpatrick, D. S., Chitkara, M., Bowden, G. T., Henderson, C. J., Wolf, C. R., Clark, A. J., Brendel, K., Fisher, R. L. & Gandolfi, A. J. Apr-2003 In : Toxicology in Vitro. 17, 2, p. 201-205, 5 p.

    Research output: Contribution to journal › Article

  116. Protein expression profiling of glutathione S-transferase pi null mice as a strategy to identify potential markers of resistance to paracetamol-induced toxicity in the liver

    Kitteringham, N. R., Powell, H., Hamlett, J., Hamlett, J., Lovatt, C., Elsby, R., Henderson, C. J., Wolf, C. R., Pennington, S. R. & Park, B. K. Feb-2003 In : Proteomics. 3, 2, p. 191-207, 17 p.

    Research output: Contribution to journal › Article

  117. Cutaneous expression of cytochrome P450 CYP2S1: individuality in regulation by therapeutic agents for psoriasis and other skin diseases

    Smith, G., Wolf, C. R., Deeni, Y. Y., Dawe, R. S., Evans, A. T., Comrie, M. M., Ferguson, J. & Ibbotson, S. H. 2003 In : Lancet. 361, 9366, p. 1336-1343, 8 p.

    Research output: Contribution to journal › Article

  118. Inactivation of the hepatic cytochrome P450 system by conditional deletion of hepatic cytochrome P450 reductase

    Henderson, C. J., Otto, D. M. E., Carrie, D., Magnuson, M. A., McLaren, A. W., Rosewell, I. & Wolf, C. R. 2003 In : Journal of Biological Chemistry. 278, 15, p. 13480-13486, 7 p.

    Research output: Contribution to journal › Article

  119. Investigation of interaction between N-acetyltransferase 2 and heterocyclic amines as potential risk factors for colorectal cancer

    Barrett, J. H., Smith, G., Waxman, R., Gooderham, N., Lightfoot, T., Garner, R. C., Augustsson, K., Wolf, C. R., Bishop, D. T. & Forman, D. 2003 In : Carcinogenesis. 24, 2, p. 275-282, 8 p.

    Research output: Contribution to journal › Article

  120. Knockout mice in xenobiotic metabolism

    Henderson, C. J., Otto, D. M. E., McLaren, A. W., Carrie, D. & Wolf, C. R. 2003 In : Drug Metabolism Reviews. 35, 4, p. 385-392, 8 p.

    Research output: Contribution to journal › Article

  121. Polymorphisms in the cytochrome P450 CYP1A2 gene (CYP1A2) in colorectal cancer patients and controls: allele frequencies, linkage disequilibrium and influence on caffeine metabolism

    Sachse, C., Bhambra, U., Smith, G., Lightfoot, T. J., Barrett, J. H., Scollay, J., Garner, R. C., Boobis, A. R., Wolf, C. R., Gooderham, N. J. & Colorectal Cancer Study Group 2003 In : British Journal of Clinical Pharmacology. 55, 1, p. 68-76, 9 p.

    Research output: Contribution to journal › Article

  122. Topical coal tar and all-trans retinoic acid modulate drug metabolising gene expression in human skin in vivo

    Ibbotson, S. H., Smith, G., Sawe, R. S., Comrie, M. M., Bryden, A., Wolf, C. E. & Ferguson, J. 2003 In : British Journal of Dermatology. 148, 4, p. 861-861, 1 p., P15

    Research output: Contribution to journal › Meeting abstract

  123. Topical coal tar and all-trans retinoic acid modulate drug metabolising gene expression in human skin in vivo

    Ibbotson, S. H., Smith, G., Sawe, R. S., Comrie, M. M., Bryden, A., Wolf, C. E. & Ferguson, J. 2003

    Research output: Contribution to conference › Poster

  124. A pharmacogenetic study to investigate the role of dietary carcinogens in the etiology of colorectal cancer

    Sachse, C., Smith, G., Wilkie, M. J. V., Barrett, J. H., Waxman, R., Sullivan, F., Forman, D., Bishop, D. T., Wolf, C. R. & Colorectal Cancer Study Group Nov-2002 In : Carcinogenesis. 23, 11, p. 1839-49, 11 p.

    Research output: Contribution to journal › Article

  125. Expression and regulation of cytoprotective genes by ultraviolet radiation in skin of patients with psoriasis

    Smith, G., Dawe, R. S., Evans, A. T., Comrie, M. M., Ferguson, J., Wolf, C. R. & Ibbotson, S. H. Sep-2002 In : Journal of Investigative Dermatology. 119, 3, p. 740-740, 1 p., 166

    Research output: Contribution to journal › Meeting abstract

  126. Chromosomal abnormality and gene mutation in sporadic colorectal cancer

    Leslie, A., Smith, G., Pratt, N. R., Carey, F. A., Wolf, C. R. & Steele, R. J. C. 2002 In : British Journal of Surgery. 89, 5, p. 663-664, 2 p.

    Research output: Contribution to journal › Meeting abstract

  127. Endogenous drug transporters in in vitro and in vivo models for the prediction of drug disposition in man

    Goh, L-B., Spears, K. J., Yao, D., Ayrton, A., Morgan, P., Wolf, C. R. & Friedberg, T. 2002 In : Biochemical Pharmacology. 64, 11, p. 1569-1578, 10 p.

    Research output: Contribution to journal › Article

  128. Loss of the Nrf2 transcription factor causes a marked reduction in constitutive and inducible expression of the glutathione S-transferase Gsta1, Gsta2, Gstm1, Gstm2, Gstm3 and Gstm4 genes in the livers of male and female mice

    Chanas, S. A., Jiang, Q., McMahon, M., McWalter, G. K., McLellan, L. I., Elcombe, C. R., Henderson, C. J., Wolf, C. R., Moffat, G. J., Itoh, K., Yamamoto, M. & Hayes, J. D. 2002 In : Biochemical Journal. 365, Pt 2, p. 405-16, 12 p.

    Research output: Contribution to journal › Article

  129. Mutations in APC, Kirsten-ras, and p53—alternative genetic pathways to colorectal cancer

    Smith, G., Carey, F. A., Beattie, J., Wilkie, M. J. V., Lightfoot, T. J., Coxhead, J., Garner, R. C., Steele, R. J. C. & Wolf, C. R. 2002 In : Proceedings of the National Academy of Sciences of the United States of America. 99, 14, p. 9433-9438, 6 p.

    Research output: Contribution to journal › Article

  130. Relation of mismatch repair protein status with mutational and chromosomal abnormalities in colorectal cancer

    Allen, D., Smith, G., Steele, R. J. C., Wolf, C. R. & Carey, F. A. 2002 In : Journal of Pathology. 198, 1, p. 34A-34A, 1 p.

    Research output: Contribution to journal › Meeting abstract

  131. Relation of mismatch repair protein status with mutational and chromosomal abnormalities in colorectal cancer

    Allen, D., Smith, G., Steele, R. J. C., Wolf, C. R. & Carey, F. A. 2002

    Research output: Contribution to conference › Abstract

  132. The adenoma carcinoma sequence in colorectal cancer - evidence for separate pathways based on p53 and K-ras mutation and chromosomal analysis

    Leslie, A., Smith, G., Kernohan, N. M., Pratt, N., Steele, R. J. C., Wolf, C. R. & Carey, F. A. 2002 In : Journal of Pathology. 198, 1, p. 4A-4A, 1 p.

    Research output: Contribution to journal › Meeting abstract

  133. The adenoma carcinoma sequence in colorectal cancer - evidence for separate pathways based on p53 and K-ras mutation and chromosomal analysis

    Leslie, A., Smith, G., Kernohan, N. M., Pratt, N., Steele, R. J. C., Wolf, C. R. & Carey, F. A. 2002

    Research output: Contribution to conference › Paper

  134. The peroxisome proliferator-activated receptor delta promotes lipid accumulation in human macrophages

    Vosper, H., Patel, L., Graham, T. L., Khoudoli, G. A., Hill, A., Macphee, C. H., Pinto, I., Smith, S. A., Suckling, K. E., Wolf, C. R. & Palmer, C. N. A. Nov-2001 In : Journal of Biological Chemistry. 276, 47, p. 44258-44265, 8 p.

    Research output: Contribution to journal › Article

  135. Detection of cytochrome P450 mRNA transcripts in prostate samples by RT-PCR

    Finnström, N., Bjelfman, C., Söderström, T. G., Smith, G., Egevad, L., Norlén, B. J., Wolf, C. R. & Rane, A. Oct-2001 In : European Journal of Clinical Investigation. 31, 10, p. 880-6, 7 p.

    Research output: Contribution to journal › Article

  136. Pharmacologic or genetic manipulation of glutathione S-transferase P1-1 (GST ∏) influences cell proliferation pathways

    Ruscoe, J. E., Rosario, L. A., Wang, T., Gate, L., Arifoglu, P., Wolf, C. R., Henderson, C. J., Ronai, Z. & Tew, K. D. 1-Jul-2001 In : Journal of Pharmacology and Experimental Therapeutics. 298, 1, p. 339-345, 7 p.

    Research output: Contribution to journal › Article

  137. Human NADPH-P450 oxidoreductase modulates the level of cytochrome P450 CYP2D6 holoprotein via haem oxygenase-dependent and -independent pathways

    Ding, S-H., Yao, D., Deeni, Y. Y., Burchell, B., Wolf, C. R. & Friedberg, T. Jun-2001 In : Biochemical Journal. 356, 2, p. 613-619, 7 p.

    Research output: Contribution to journal › Article

  138. The cap 'n' collar basic leucine zipper transcription factor Nrf2 (NF-E2 p45-related factor 2) controls both constitutive and inducible expression of intestinal detoxification and glutathione biosynthetic enzymes

    McMahon, M., Itoh, K., Yamamoto, M., Chanas, S. A., Henderson, C. J., McLellan, L. I., Wolf, C. R., Cavin, C. & Hayes, J. D. Apr-2001 In : Cancer Research. 61, 8, p. 3299-3307, 9 p.

    Research output: Contribution to journal › Article

  139. Implication of GST-pi expression in colon carcinogenesis

    Niitsu, Y., Takayama, T., Miyanishi, K., Nobuoka, A., Hayashi, T., Nakajima, T., Miyake, S., Henderson, C. J. & Wolf, R. 28-Feb-2001 In : Chemico-Biological Interactions. 133, 1-3, p. 287-290, 4 p.

    Research output: Contribution to journal › Meeting abstract

  140. The Nrf2 transcription factor regulates basal expression of class Alpha and class Mu glutathione S-transferases in the mouse, but not necessarily their induction by cancer chemopreventive agents

    McMaghon, M., Chanas, S. A., Henderson, C. J., Wolf, C. R., Yamamoto, M. & Hayes, J. D. 28-Feb-2001 In : Chemico-Biological Interactions. 133, 1-3, p. 291-294, 4 p.

    Research output: Contribution to journal › Article

  141. Engineering of a functional human NADH-dependent cytochrome P450 system

    Dohr, O., Paine, M. J. I., Friedberg, T., Roberts, G. C. K. & Wolf, C. R. 2001 In : Proceedings of the National Academy of Sciences USA. 98, 1, p. 81-86, 6 p.

    Research output: Contribution to journal › Article

  142. Investigation of interaction between N-acetyltransferase 2 (NAT2) phenotype and heterocyclic amines as potential risk factors for colorectal cancer

    Barrett, J. H., Bishop, D. T., Waxman, R., Forman, D., Lightfoot, T., Garner, C., Smith, G. & Wolf, R. 2001 In : American Journal of Human Genetics. 69, 4 Suppl., p. 263-263, 1 p., 469

    Research output: Contribution to journal › Meeting abstract

  143. Investigation of interaction between N-acetyltransferase 2 (NAT2) phenotype and heterocyclic amines as potential risk factors for colorectal cancer

    Barrett, J. H., Bishop, D. T., Waxman, R., Forman, D., Lightfoot, T., Garner, C., Smith, G. & Wolf, R. 2001

    Research output: Contribution to conference › Paper

  144. Modulation of P450CYP3A4-dependent metabolism by P-glycoprotein: implications for P450 phenotyping

    Baron, J. M., Goh, L. B., Yao, D., Wolf, C. R. & Friedberg, T. 2001 In : Journal of Pharmacology and Experimental Therapeutics. 296, 2, p. 351-358, 8 p.

    Research output: Contribution to journal › Article

  145. Increased resistance to acetaminophen hepatotoxicity in mice lacking glutathione S-transferase Pi

    Henderson, C. J., Wolf, C. R., Kitteringham, N., Powell, H., Otto, D. & Park, B. K. 7-Nov-2000 In : Proceedings of the National Academy of Sciences of the United States of America. 97, 23, p. 12741-12745, 5 p.

    Research output: Contribution to journal › Article

  146. Preclinical studies with a glutathione S-transferase P1-1 (GSTP1-1) activated prodrug.

    Rosario, L. A., O'Brien, M. L., Schow, S. R., Henderson, C. J., Wolf, C. R. & Tew, K. D. Nov-2000 In : Clinical Cancer Research. 6, Supplement, p. 4489S-4489S, 1 p., 114

    Research output: Contribution to journal › Meeting abstract

  147. Cytochrome P450s and chemoprevention

    Henderson, C. J., Sahraouei, A. & Wolf, C. R. Feb-2000 In : Biochemical Society Transactions. 28, 2, p. 42-46, 5 p.

    Research output: Contribution to journal › Article

  148. The Nrf2 transcription factor contributes both to the basal expression of glutathione S-transferases in mouse liver and to their induction by the chemopreventive synthetic antioxidants, butylated hydroxyanisole and ethoxyquin

    Hayes, J. D., Chanas, S. A., Henderson, C. J., McMahon, M., Sun, C., Moffat, G. J., Wolf, C. R. & Yamamoto, M. Feb-2000 In : Biochemical Society Transactions. 28, 2, p. 33-41, 9 p.

    Research output: Contribution to journal › Article

  149. Evidence that serine 304 is not a key ligand-binding residue in the active site of cytochrome P450 2D6

    Ellis, S. W., Hayhurst, G. P., Lightfoot, T., Smith, G., Harlow, J., Rowland-Yeo, K., Larsson, C., Mahling, J., Lim, C. K., Wolf, C. R., Blackburn, M. G., Lennard, M. S. & Tucker, G. T. 2000 In : Biochemical Journal. 345 , 3, p. 565-571, 7 p.

    Research output: Contribution to journal › Article

  150. Pharmacogenetics

    Wolf, C. R., Smith, G. & Smith, R. L. 2000 In : British Medical Journal. 320, 7240, p. 987-90, 4 p.

    Research output: Contribution to journal › Article

  151. Regulation of JNK signaling by GSTp

    Adler, V., Yin, Z., Fuchs, S. Y., Benezra, M., Rosario, L., Tew, K. D., Pincus, M. R., Sardana, M., Henderson, C. J., Wolf, C. R., Davis, R. J. & Ronai, Z. 1-Mar-1999 In : EMBO Journal. 18, 5, p. 1321-1334, 14 p.

    Research output: Contribution to journal › Article

  152. Adaptive responses to environmental chemicals

    Wolf, C. R., Smith, G., Smith, A. G., Brown, K. & Henderson, C. J. 1999 Cellular responses to stress. Downes, C. P., Wolf, C. R. & Lane, D. P. (eds.). London: Portland Press Ltd, p. 129-139 11 p. (Biochemical Society symposia; 64).

    Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

  153. Cellular responses to stress

    Downes, C. P. (ed.), Wolf, C. R. (ed.) & Lane, D. P. (ed.) 1999 Portland Press Ltd. (Biochemical Society symposia; 64).

    Research output: Book/Report › Book

  154. Cytochrome P450 CYP2D6

    Wolf, C. R. & Smith, G. 1999 In : IARC Scientific Publications. 148, p. 209-29, 21 p.

    Research output: Contribution to journal › Article

  155. Pharmacogenetics

    Wolf, C. R. & Smith, G. 1999 In : British Medical Bulletin. 55, 2, p. 366-86, 21 p.

    Research output: Contribution to journal › Article

  156. Use of transgenic animals in understanding molecular mechanisms of toxicity

    Wolf, C. R. & Henderson, C. J. Jun-1998 In : Journal of Pharmacy and Pharmacology. 50, 6, p. 567-574, 8 p.

    Research output: Contribution to journal › Article

  157. Increased skin tumorigenesis in mice lacking pi class glutathione S-transferases

    Henderson, C. J., Smith, A. G., Ure, J., Brown, K., Bacon, E. J. & Wolf, C. R. 28-Apr-1998 In : Proceedings of the National Academy of Sciences of the United States of America. 95, 9, p. 5275-5280, 6 p.

    Research output: Contribution to journal › Article

  158. Pi-class glutathione S-transferase: regulation and function

    Henderson, C. J., McLaren, A. W., Moffat, G. J., Bacon, E. J. & Wolf, C. R. 24-Apr-1998 In : Chemico-Biological Interactions. 111-112, p. 69-82, 14 p.

    Research output: Contribution to journal › Article

  159. Determinants of the substrate specificity of human cytochrome P-450 CYP2D6: design and construction of a mutant with testosterone hydroxylase activity

    Smith, G., Modi, S., Pillai, I., Lian, L-Y., Sutcliffe, M. J., Pritchard, M. P., Friedberg, T., Roberts, G. C. K. & Wolf, C. R. 1998 In : Biochemical Journal. 331 , 3, p. 783-792, 10 p.

    Research output: Contribution to journal › Article

  160. Molecular genetics of the human cytochrome P450 monooxygenase superfamily

    Smith, G., Stubbins, M. J., Harries, L. W. & Wolf, C. R. 1998 In : Xenobiotica. 28, 12, p. 1129-1165, 37 p.

    Research output: Contribution to journal › Article

  161. A general strategy for the expression of recombinant human cytochrome P450s in Escherichia coli using bacterial signal peptides: expression of CYP3A4, CYP2A6, and CYP2E1

    Pritchard, M. P., Ossetian, R., Li, D. N., Henderson, C. J., Burchell, B., Wolf, C. R. & Friedberg, T. 15-Sep-1997 In : Archives of Biochemistry and Biophysics. 345, 2, p. 342-354, 13 p.

    Research output: Contribution to journal › Article

  162. Genetic structural and functional analysis of cytochrome P450s in the CYP2D gene family

    Wolf, C. R., Modi, S., Lian, L. Y., Paine, M., Smith, G. & Roberts, G. C. K. 31-Jul-1997 In : FASEB Journal. 11, 9, p. A773-A773, 1 p., P25

    Research output: Contribution to journal › Meeting abstract

  163. Active site models of human cytochrome P450s based on NMR relaxation measurements

    Modi, S., Paine, M. J., Oliver, C. F., Smith, G., Sutcliffe, M. J., Gilham, D. E., Shaw, A. N. J., Lian, L. Y., Primrose, W. U., Wolf, C. R. & Roberts, G. C. K. 1997 In : FASEB Journal. 11, 9, p. A771-A771, 1 p.

    Research output: Contribution to journal › Meeting abstract

  164. Coexpression of a human P450 (CYP3A4) and P450 reductase generates a highly functional monooxygenase system in Escherichia coli

    Blake, J. A. R., Pritchard, M., Ding, S., Smith, G. C. M., Burchell, B., Wolf, C. R. & Friedberg, T. 18-Nov-1996 In : FEBS Letters. 397, 2-3, p. 210-214, 5 p.

    Research output: Contribution to journal › Article

  165. Transfer of PCBs via lactation simultaneously induces the expression of P450 isoenzymes and the protooncogenes c-Ha-ras and c-raf in neonates

    Borlak, J. T., Scott, A., Henderson, C. J., Jenke, H. J. & Wolf, C. R. 23-Feb-1996 In : Biochemical Pharmacology. 51, 4, p. 517-529, 13 p.

    Research output: Contribution to journal › Article

  166. Active-site topologies of human CYP2D6 and its aspartate-301 → glutamate, asparagine, and glycine mutants

    Mackman, R., Tschirret-Guth, R. A., Smith, G., Hayhurst, G. P., Ellis, S. W., Lennard, M. S., Tucker, G. T., Wolf, C. R. & Ortiz de Montellano, P. R. 1996 In : Archives of Biochemistry and Biophysics. 331, 1, p. 134-140, 7 p.

    Research output: Contribution to journal › Article

  167. Genetic analysis of the human cytochrome P450 CYP2C9 locus

    Stubbins, M. J., Harries, L. W., Smith, G., Tarbit, M. H. & Wolf, C. R. 1996 In : Pharmacogenetics. 6, 5, p. 429-39, 11 p.

    Research output: Contribution to journal › Article

  168. Characterization of anti-LKM-antibody targets in patients with autoimmune hepatitis typ2 and hepatitis-C

    Thalhammer, T., Smith, G., Wolf, H., Wolf, R., Boltznitulescu, G., Dopplinger, C. & Penner, E. 9-Mar-1995 In : FASEB Journal. 9, 3, p. A146-A146, 1 p., 851

    Research output: Contribution to journal › Meeting abstract

  169. Divergent regulation of cytochrome P450 enzymes by morphine and pethidine: a neuroendocrine mechanism?

    Rane, A., Liu, Z., Henderson, C. J. & Wolf, C. R. Jan-1995 In : Molecular Pharmacology. 47, 1, p. 57-64, 8 p.

    Research output: Contribution to journal › Article

  170. Evidence that aspartic acid 301 is a critical substrate-contact residue in the active site of cytochrome P450 2D6

    Ellis, S. W., Hayhurst, G. P., Smith, G., Lightfoot, T., Wong, M. M. S., Simula, A. P., Ackland, M. J., Sternberg, M. J. E., Lennard, M. S., Tucker, G. T. & Wolf, C. R. 1995 In : Journal of Biological Chemistry. 270, 49, p. 29055-29058, 4 p.

    Research output: Contribution to journal › Comment/debate

  171. Metabolic polymorphisms and cancer susceptibility

    Smith, G., Stanley, L. A., Sim, E., Strange, R. C. & Wolf, C. R. 1995 In : Cancer Surveys. 25, p. 27-65, 39 p.

    Research output: Contribution to journal › Article

  172. Suppression of multi-drug resistance gene expression in the mouse liver by 1,4-bis[2,(3,5-dichloropyridyloxy)]benzene

    Russell, A. L., Henderson, C. J., Smith, G. & Wolf, C. R. 15-Aug-1994 In : International Journal of Cancer. 58, 4, p. 550-554, 5 p.

    Research output: Contribution to journal › Article

  173. Metabolism of [3-14C] coumarin by human liver microsomes

    van Iersel, M. L. P. S., Henderson, C. J., Walters, D. G., Price, R. J., Wolf, C. R. & Lake, B. G. Aug-1994 In : Xenobiotica. 24, 8, p. 795-803, 9 p.

    Research output: Contribution to journal › Article

  174. Deduced amino acid sequence of a murine cytochrome P-450 Cyp4a protein: developmental and hornonal regulation in liver and kidney

    Henderson, C. J., Bammler, T. & Wolf, C. R. 6-Jul-1994 In : Biochimica et Biophysica Acta: General Subjects. 1200, 2, p. 182-190, 9 p.

    Research output: Contribution to journal › Article

  175. Genetic polymorphisms in xenobiotic metabolism

    Smith, C. A. D., Smith, G. & Wolf, C. R. 1994 In : European Journal of Cancer. 30, 13, p. 1921-35, 15 p.

    Research output: Contribution to journal › Article

  176. In vitro metabolism of aflatoxin B1 by normal and tumorous liver tissue from Thailand

    Kirby, G. M., Wolf, C. R., Neal, G. E., Judah, D. J., Henderson, C. J., Srivatanakul, P. & Wild, C. P. Dec-1993 In : Carcinogenesis. 14, 12, p. 2613-2620, 8 p.

    Research output: Contribution to journal › Article

  177. Expression of P450 isoenzymes during rat-liver organogenesis

    Borlakoglu, J. T., Scott, A., Henderson, C. J. & Wolf, C. R. Nov-1993 In : International Journal of Biochemistry & Cell Biology. 25, 11, p. 1659-1668, 10 p.

    Research output: Contribution to journal › Article

  178. Alterations in rat hepatic drug metabolism during pregnancy and lactation

    Borlakoglu, J. T., Scott, A., Henderson, C. J. & Wolf, C. R. 6-Jul-1993 In : Biochemical Pharmacology. 46, 1, p. 29-36, 8 p.

    Research output: Contribution to journal › Article

  179. Transplacental transfer of polychlorinated biphenyls induces simultaneously the expression of P450 isoenzymes and the protooncogenes c-Ha-ras and c-raf

    Borlakoglu, J. T., Scott, A., Henderson, C. J., Jenke, H. J. & Wolf, C. R. 6-Apr-1993 In : Biochemical Pharmacology. 45, 7, p. 1373-1386, 14 p.

    Research output: Contribution to journal › Article

  180. Lactational transfer of 2,4,5,2′,4′,5′-hexachlorobiphenyl but not 3,4,3,4′-tetrachlorobiphenyl, induces neonatal CYP4A1

    Borlakoglu, J. T., Henderson, C. J. & Wolf, C. R. 9-Feb-1993 In : Biochemical Pharmacology. 45, 3, p. 769-771, 3 p.

    Research output: Contribution to journal › Comment/debate

  181. 1,4-Bis[2-(3,5-dichloropyridyloxy)]benzene, an extremely potent modulator of mouse hepatic cytochrome P-450 gene expression.

    Smith, G., Henderson, C. J., WHITE, R., Parker, M. G., Bars, R. G. & Wolf, C. R. 1-Feb-1993 In : Biochemical Journal. 289, 3, p. 807-813, 7 p.

    Research output: Contribution to journal › Article

  182. Autoantibodies to hepatic microsomal carboxylesterase in halothane hepatitis

    Smith, G. C. M., Wolf, C. R., Kenna, J. G., Harrison, D. J. & Tew, D. 1993 In : Lancet. 342, 8877, p. 963-4, 2 p.

    Research output: Contribution to journal › Article

  183. High variability of nitrosamine metabolism among individual: role of cytochromes P450 2A6 and 2E1 in the dealkylation of N-nitrosodimethylamine and N-nitrosodiethylamine in mice and humans

    Camus, A-M., Geneste, O., Honkakoski, P., Bereziat, J-C., Henderson, C. J., Wolf, R. C., Bartsch, H. & Lang, M. A. 1993 In : Molecular Carcinogenesis. 7, 4, p. 268-275, 8 p.

    Research output: Contribution to journal › Article

  184. Human anti-endoplasmic reticulum autoantibodies produced in aromatic anticonvulsant hypersensitivity reactions recognise rodent CYP3A proteins and a similarly regulated human P450 enzyme(s)

    Riley, R. J., Smith, G., Wolf, C. R., Cook, V. A. & Leeder, J. S. 1993 In : Biochemical and Biophysical Research Communications. 191, 1, p. 32-40, 9 p.

    Research output: Contribution to journal › Article

  185. Regulation of cytochrome P450 gene expression in human colon and breast tumour xenografts

    Smith, G., Harrison, D. J., East, N., Rae, F., Wolf, H. & Wolf, C. R. 1993 In : British Journal of Cancer. 68, 1, p. 57-63, 7 p.

    Research output: Contribution to journal › Article

  186. Relative expression of cytochrome P450 isoenzymes in human liver and association with the metabolism of drugs and xenobiotics

    Forrester, L. M., Henderson, C., Glancey, M. J., Back, D. J., Park, B. K., Ball, S. E., Kitteringham, N. R., McLaren, A. W., Miles, J. S., Skett, P. & Wolf, C. R. 15-Jan-1992 In : Biochemical Journal. 281, 2, p. 359-368, 10 p.

    Research output: Contribution to journal › Article

  187. Sexual differentiation and regulation of cytochrome P-450 CYP2C7

    Henderson, C. J., Russell, A. L., Allan, J. A. & Wolf, C. R. 9-Jan-1992 In : Biochimica et Biophysica Acta: General Subjects. 1118, 2, p. 99-106, 8 p.

    Research output: Contribution to journal › Article

  188. Production of cytochrome P450 reductase yeast-rat hybrid proteins in Saccharomyces cerevisiae

    Bligh, H. F. J., Wolf, C. R., Smith, G. & Beggs, J. D. 2-Jan-1992 In : Gene. 110, 1, p. 33-9, 7 p.

    Research output: Contribution to journal › Article

  189. Molecular genetics of the human cytochrome P450-dependent monooxygenases

    Wolf, C. R., Smith, C. A. D., Smith, G., Gough, A. C., Bryant, S., Spurr, N. K. & Harrison, D. J. 1992 In : The Tohoku Journal of Experimental Medicine. 168, 2, p. 73-81, 9 p.

    Research output: Contribution to journal › Article

  190. Evidence that the androgen receptor mediates sexual differentiation of mouse renal cytochrome P450 expression

    Henderson, C. & Wolf, C. R. 1-Sep-1991 In : Biochemical Journal. 278, 2, p. 499-503, 5 p.

    Research output: Contribution to journal › Article

  191. Testosterone-mediated regulation of mouse renal cytochrome P-450 isoenzymes

    Henderson, C., Scott, A. R., Yang, C. S. & Wolf, C. R. 15-Mar-1990 In : Biochemical Journal. 266, 3, p. 675-681, 7 p.

    Research output: Contribution to journal › Article

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