Discovery - University of Dundee - Online Publications

Library & Learning Centre

6-(3,4-dichlorophenyl)-1-[(methyloxy)methyl]-3-azabicyclo[4.1.0]heptane

Standard

6-(3,4-dichlorophenyl)-1-[(methyloxy)methyl]-3-azabicyclo[4.1.0]heptane : a new potent and selective triple reuptake inhibitor. / Micheli, Fabrizio; Cavanni, Paolo; Andreotti, Daniele; Arban, Roberto; Benedetti, Roberto; Bertani, Barbara; Bettati, Michela; Bettelini, Letizia; Bonanomi, Giorgio; Braggio, Simone; Carletti, Renzo; Checchia, Anna; Corsi, Mauro; Fazzolari, Elettra; Fontana, Stefano; Marchioro, Carla; Merlo-Pich, Emilio; Negri, Michele; Oliosi, Beatrice; Ratti, Emiliangelo; Read, Kevin D.; Roscic, Maja; Sartori, Ilaria; Spada, Simone; Tedesco, Giovanna; Tarsi, Luca; Terreni, Silvia; Visentini, Filippo; Zocchi, Alessandro; Zonzini, Laura; Di Fabio, Romano.

In: Journal of Medicinal Chemistry, Vol. 53, No. 13, 08.07.2010, p. 4989-5001.

Research output: Contribution to journalArticle

Harvard

Micheli, F, Cavanni, P, Andreotti, D, Arban, R, Benedetti, R, Bertani, B, Bettati, M, Bettelini, L, Bonanomi, G, Braggio, S, Carletti, R, Checchia, A, Corsi, M, Fazzolari, E, Fontana, S, Marchioro, C, Merlo-Pich, E, Negri, M, Oliosi, B, Ratti, E, Read, KD, Roscic, M, Sartori, I, Spada, S, Tedesco, G, Tarsi, L, Terreni, S, Visentini, F, Zocchi, A, Zonzini, L & Di Fabio, R 2010, '6-(3,4-dichlorophenyl)-1-[(methyloxy)methyl]-3-azabicyclo[4.1.0]heptane: a new potent and selective triple reuptake inhibitor' Journal of Medicinal Chemistry, vol 53, no. 13, pp. 4989-5001., 10.1021/jm100481d

APA

Micheli, F., Cavanni, P., Andreotti, D., Arban, R., Benedetti, R., Bertani, B., ... Di Fabio, R. (2010). 6-(3,4-dichlorophenyl)-1-[(methyloxy)methyl]-3-azabicyclo[4.1.0]heptane: a new potent and selective triple reuptake inhibitor. Journal of Medicinal Chemistry, 53(13), 4989-5001. 10.1021/jm100481d

Vancouver

Micheli F, Cavanni P, Andreotti D, Arban R, Benedetti R, Bertani B et al. 6-(3,4-dichlorophenyl)-1-[(methyloxy)methyl]-3-azabicyclo[4.1.0]heptane: a new potent and selective triple reuptake inhibitor. Journal of Medicinal Chemistry. 2010 Jul 8;53(13):4989-5001. Available from: 10.1021/jm100481d

Author

Micheli, Fabrizio; Cavanni, Paolo; Andreotti, Daniele; Arban, Roberto; Benedetti, Roberto; Bertani, Barbara; Bettati, Michela; Bettelini, Letizia; Bonanomi, Giorgio; Braggio, Simone; Carletti, Renzo; Checchia, Anna; Corsi, Mauro; Fazzolari, Elettra; Fontana, Stefano; Marchioro, Carla; Merlo-Pich, Emilio; Negri, Michele; Oliosi, Beatrice; Ratti, Emiliangelo; Read, Kevin D.; Roscic, Maja; Sartori, Ilaria; Spada, Simone; Tedesco, Giovanna; Tarsi, Luca; Terreni, Silvia; Visentini, Filippo; Zocchi, Alessandro; Zonzini, Laura; Di Fabio, Romano / 6-(3,4-dichlorophenyl)-1-[(methyloxy)methyl]-3-azabicyclo[4.1.0]heptane : a new potent and selective triple reuptake inhibitor.

In: Journal of Medicinal Chemistry, Vol. 53, No. 13, 08.07.2010, p. 4989-5001.

Research output: Contribution to journalArticle

Bibtex - Download

@article{b1476fe91d2f4ec4a1d0c14b60720aae,
title = "6-(3,4-dichlorophenyl)-1-[(methyloxy)methyl]-3-azabicyclo[4.1.0]heptane: a new potent and selective triple reuptake inhibitor",
author = "Fabrizio Micheli and Paolo Cavanni and Daniele Andreotti and Roberto Arban and Roberto Benedetti and Barbara Bertani and Michela Bettati and Letizia Bettelini and Giorgio Bonanomi and Simone Braggio and Renzo Carletti and Anna Checchia and Mauro Corsi and Elettra Fazzolari and Stefano Fontana and Carla Marchioro and Emilio Merlo-Pich and Michele Negri and Beatrice Oliosi and Emiliangelo Ratti and Read, {Kevin D.} and Maja Roscic and Ilaria Sartori and Simone Spada and Giovanna Tedesco and Luca Tarsi and Silvia Terreni and Filippo Visentini and Alessandro Zocchi and Laura Zonzini and {Di Fabio}, Romano",
year = "2010",
doi = "10.1021/jm100481d",
volume = "53",
number = "13",
pages = "4989--5001",
journal = "Journal of Medicinal Chemistry",
issn = "0022-2623",

}

RIS (suitable for import to EndNote) - Download

TY - JOUR

T1 - 6-(3,4-dichlorophenyl)-1-[(methyloxy)methyl]-3-azabicyclo[4.1.0]heptane

T2 - a new potent and selective triple reuptake inhibitor

A1 - Micheli,Fabrizio

A1 - Cavanni,Paolo

A1 - Andreotti,Daniele

A1 - Arban,Roberto

A1 - Benedetti,Roberto

A1 - Bertani,Barbara

A1 - Bettati,Michela

A1 - Bettelini,Letizia

A1 - Bonanomi,Giorgio

A1 - Braggio,Simone

A1 - Carletti,Renzo

A1 - Checchia,Anna

A1 - Corsi,Mauro

A1 - Fazzolari,Elettra

A1 - Fontana,Stefano

A1 - Marchioro,Carla

A1 - Merlo-Pich,Emilio

A1 - Negri,Michele

A1 - Oliosi,Beatrice

A1 - Ratti,Emiliangelo

A1 - Read,Kevin D.

A1 - Roscic,Maja

A1 - Sartori,Ilaria

A1 - Spada,Simone

A1 - Tedesco,Giovanna

A1 - Tarsi,Luca

A1 - Terreni,Silvia

A1 - Visentini,Filippo

A1 - Zocchi,Alessandro

A1 - Zonzini,Laura

A1 - Di Fabio,Romano

AU - Micheli,Fabrizio

AU - Cavanni,Paolo

AU - Andreotti,Daniele

AU - Arban,Roberto

AU - Benedetti,Roberto

AU - Bertani,Barbara

AU - Bettati,Michela

AU - Bettelini,Letizia

AU - Bonanomi,Giorgio

AU - Braggio,Simone

AU - Carletti,Renzo

AU - Checchia,Anna

AU - Corsi,Mauro

AU - Fazzolari,Elettra

AU - Fontana,Stefano

AU - Marchioro,Carla

AU - Merlo-Pich,Emilio

AU - Negri,Michele

AU - Oliosi,Beatrice

AU - Ratti,Emiliangelo

AU - Read,Kevin D.

AU - Roscic,Maja

AU - Sartori,Ilaria

AU - Spada,Simone

AU - Tedesco,Giovanna

AU - Tarsi,Luca

AU - Terreni,Silvia

AU - Visentini,Filippo

AU - Zocchi,Alessandro

AU - Zonzini,Laura

AU - Di Fabio,Romano

PY - 2010/7/8

Y1 - 2010/7/8

N2 - <p>A pharmacophore model for triple reuptake inhibitors and the new class of 1-(aryl)-6-[alkoxyalkyl]-3-azabicyclo[3.1.0]hexanes were recently reported. Further investigation in this area led to the identification of a new series of potent and selective triple reuptake inhibitors endowed with good developability characteristics. Excellent bioavailability and brain penetration are associated with this series of 6-(3,4-dichlorophenyl)-1-[(methyloxy)methyl]-3-azabicyclo[4.1.0]heptanes together with high in vitro potency and selectivity at SERT, NET, and DAT. In vivo microdialysis experiments in different animal models and receptor occupancy studies in rat confirmed that derivative 17 showed an appropriate profile to further progression of the compound.</p>

AB - <p>A pharmacophore model for triple reuptake inhibitors and the new class of 1-(aryl)-6-[alkoxyalkyl]-3-azabicyclo[3.1.0]hexanes were recently reported. Further investigation in this area led to the identification of a new series of potent and selective triple reuptake inhibitors endowed with good developability characteristics. Excellent bioavailability and brain penetration are associated with this series of 6-(3,4-dichlorophenyl)-1-[(methyloxy)methyl]-3-azabicyclo[4.1.0]heptanes together with high in vitro potency and selectivity at SERT, NET, and DAT. In vivo microdialysis experiments in different animal models and receptor occupancy studies in rat confirmed that derivative 17 showed an appropriate profile to further progression of the compound.</p>

U2 - 10.1021/jm100481d

DO - 10.1021/jm100481d

M1 - Article

JO - Journal of Medicinal Chemistry

JF - Journal of Medicinal Chemistry

SN - 0022-2623

IS - 13

VL - 53

SP - 4989

EP - 5001

ER -

Documents

Library & Learning Centre

Contact | Accessibility | Policy