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A Hes1-based oscillator in cultured cells and its potential implications for the segmentation clock

A Hes1-based oscillator in cultured cells and its potential implications for the segmentation clock

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Authors

  • J. Kim Dale
  • Miguel Maroto

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Info

Original languageEnglish
Pages200-203
Number of pages4
JournalBioEssays
Journal publication date2003
Journal number3
Volume25
DOIs
StatePublished

Abstract

During somitogenesis an oscillatory mechanism termed the “segmentation” clock generates periodic waves of gene expression, which translate into the periodic spatial pattern manifest as somites. The dynamic expression of the clock genes shares the same periodicity as somitogenesis. Notch signaling is believed to play a role in the segmentation clock mechanism. The paper by Hirata et al.(1) identifies a biological clock in cultured cells that is dependent upon the Notch target gene Hes1, and which shows a periodicity similar to that of the segmentation clock. This finding opens the possibility that the same oscillator mechanism might also operate in other tissues or cell types.

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