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A Hes1-based oscillator in cultured cells and its potential implications for the segmentation clock

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A Hes1-based oscillator in cultured cells and its potential implications for the segmentation clock. / Dale, J. Kim; Maroto, Miguel.

In: BioEssays, Vol. 25, No. 3, 2003, p. 200-203.

Research output: Contribution to journalArticle

Harvard

Dale, JK & Maroto, M 2003, 'A Hes1-based oscillator in cultured cells and its potential implications for the segmentation clock' BioEssays, vol 25, no. 3, pp. 200-203.

APA

Dale, J. K., & Maroto, M. (2003). A Hes1-based oscillator in cultured cells and its potential implications for the segmentation clock. BioEssays, 25(3), 200-203doi: 10.1002/bies.10253

Vancouver

Dale JK, Maroto M. A Hes1-based oscillator in cultured cells and its potential implications for the segmentation clock. BioEssays. 2003;25(3):200-203.

Author

Dale, J. Kim; Maroto, Miguel / A Hes1-based oscillator in cultured cells and its potential implications for the segmentation clock.

In: BioEssays, Vol. 25, No. 3, 2003, p. 200-203.

Research output: Contribution to journalArticle

Bibtex - Download

@article{5a57ef7d6ffd4978ae52317d183706fb,
title = "A Hes1-based oscillator in cultured cells and its potential implications for the segmentation clock",
author = "Dale, {J. Kim} and Miguel Maroto",
note = "dc.publisher: Wiley-Blackwell The definitive version is available at www3.interscience.wiley.com",
year = "2003",
volume = "25",
number = "3",
pages = "200--203",
journal = "BioEssays",
issn = "0265-9247",

}

RIS (suitable for import to EndNote) - Download

TY - JOUR

T1 - A Hes1-based oscillator in cultured cells and its potential implications for the segmentation clock

A1 - Dale,J. Kim

A1 - Maroto,Miguel

AU - Dale,J. Kim

AU - Maroto,Miguel

PY - 2003

Y1 - 2003

N2 - During somitogenesis an oscillatory mechanism termed the “segmentation” clock generates periodic waves of gene expression, which translate into the periodic spatial pattern manifest as somites. The dynamic expression of the clock genes shares the same periodicity as somitogenesis. Notch signaling is believed to play a role in the segmentation clock mechanism. The paper by Hirata et al.(1) identifies a biological clock in cultured cells that is dependent upon the Notch target gene Hes1, and which shows a periodicity similar to that of the segmentation clock. This finding opens the possibility that the same oscillator mechanism might also operate in other tissues or cell types.

AB - During somitogenesis an oscillatory mechanism termed the “segmentation” clock generates periodic waves of gene expression, which translate into the periodic spatial pattern manifest as somites. The dynamic expression of the clock genes shares the same periodicity as somitogenesis. Notch signaling is believed to play a role in the segmentation clock mechanism. The paper by Hirata et al.(1) identifies a biological clock in cultured cells that is dependent upon the Notch target gene Hes1, and which shows a periodicity similar to that of the segmentation clock. This finding opens the possibility that the same oscillator mechanism might also operate in other tissues or cell types.

U2 - 10.1002/bies.10253

DO - 10.1002/bies.10253

M1 - Article

JO - BioEssays

JF - BioEssays

SN - 0265-9247

IS - 3

VL - 25

SP - 200

EP - 203

ER -

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