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A pivotal role for the response regulator DegU in controlling multicellular behaviour

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A pivotal role for the response regulator DegU in controlling multicellular behaviour. / Murray, Ewan J.; Kiley, Taryn B.; Stanley-Wall, Nicola R.

In: Microbiology-SGM, Vol. 155, 01.2009, p. 18.

Research output: Contribution to journalScientific review

Harvard

Murray, EJ, Kiley, TB & Stanley-Wall, NR 2009, 'A pivotal role for the response regulator DegU in controlling multicellular behaviour' Microbiology-SGM, vol 155, pp. 18.

APA

Murray, E. J., Kiley, T. B., & Stanley-Wall, N. R. (2009). A pivotal role for the response regulator DegU in controlling multicellular behaviour. Microbiology-SGM, 155, 18doi: 10.1099/mic.0.023903-0

Vancouver

Murray EJ, Kiley TB, Stanley-Wall NR. A pivotal role for the response regulator DegU in controlling multicellular behaviour. Microbiology-SGM. 2009 Jan;155:18.

Author

Murray, Ewan J.; Kiley, Taryn B.; Stanley-Wall, Nicola R. / A pivotal role for the response regulator DegU in controlling multicellular behaviour.

In: Microbiology-SGM, Vol. 155, 01.2009, p. 18.

Research output: Contribution to journalScientific review

Bibtex - Download

@article{7d9ac3b5f3c84e33b446be5d8a819e3d,
title = "A pivotal role for the response regulator DegU in controlling multicellular behaviour",
author = "Murray, {Ewan J.} and Kiley, {Taryn B.} and Stanley-Wall, {Nicola R.}",
year = "2009",
volume = "155",
pages = "18",
journal = "Microbiology-SGM",
issn = "1350-0872",

}

RIS (suitable for import to EndNote) - Download

TY - JOUR

T1 - A pivotal role for the response regulator DegU in controlling multicellular behaviour

A1 - Murray,Ewan J.

A1 - Kiley,Taryn B.

A1 - Stanley-Wall,Nicola R.

AU - Murray,Ewan J.

AU - Kiley,Taryn B.

AU - Stanley-Wall,Nicola R.

PY - 2009/1

Y1 - 2009/1

N2 - <p>Bacteria control multicellular behavioural responses, including biofilm formation and swarming motility, by integrating environmental cues through a complex regulatory network. Heterogeneous gene expression within an otherwise isogenic cell population that allows for differentiation of cell fate is an intriguing phenomenon that adds to the complexity of multicellular behaviour. This review focuses on recent data about how DegU, a pleiotropic response regulator, co-ordinates multicellular behaviour in Bacillus subtilis. We review studies that challenge the conventional understanding of the molecular mechanisms underpinning the DegU regulatory system and others that describe novel targets of DegU during activation of biofilm formation by B. subtilis. We also discuss a novel role for DegU in regulating multicellular processes in the food-borne pathogen Listeria monocytogenes.</p>

AB - <p>Bacteria control multicellular behavioural responses, including biofilm formation and swarming motility, by integrating environmental cues through a complex regulatory network. Heterogeneous gene expression within an otherwise isogenic cell population that allows for differentiation of cell fate is an intriguing phenomenon that adds to the complexity of multicellular behaviour. This review focuses on recent data about how DegU, a pleiotropic response regulator, co-ordinates multicellular behaviour in Bacillus subtilis. We review studies that challenge the conventional understanding of the molecular mechanisms underpinning the DegU regulatory system and others that describe novel targets of DegU during activation of biofilm formation by B. subtilis. We also discuss a novel role for DegU in regulating multicellular processes in the food-borne pathogen Listeria monocytogenes.</p>

KW - BACILLUS-SUBTILIS DEGU

KW - DEGRADATIVE ENZYME-SYNTHESIS

KW - GENOME-WIDE ANALYSIS

KW - LISTERIA-MONOCYTOGENES

KW - BIOFILM FORMATION

KW - GENE-EXPRESSION

KW - FLAGELLAR MOTILITY

KW - POSITIVE REGULATOR

KW - ACETYL PHOSPHATE

KW - CELL FATE

U2 - 10.1099/mic.0.023903-0

DO - 10.1099/mic.0.023903-0

M1 - Scientific review

JO - Microbiology-SGM

JF - Microbiology-SGM

SN - 1350-0872

VL - 155

SP - 18

ER -

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