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A Role for Dormant Origins in Tumor Suppression

A Role for Dormant Origins in Tumor Suppression

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Original languageEnglish
Pages495-496
Number of pages2
JournalMolecular Cell
Journal publication date4 Mar 2011
Volume41
Issue5
DOIs
StatePublished

Abstract

In this issue of Molecular Cell, Kawabata et al. (2011) show that mice hypomorphic for the replication licensing protein Mcm4 show spontaneous DNA replication defects due to a lack of dormant origins, potentially explaining why these mice are cancer prone.

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