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A Role for Dormant Origins in Tumor Suppression

A Role for Dormant Origins in Tumor Suppression

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Original languageEnglish
Pages495-496
Number of pages2
JournalMolecular Cell
Journal publication date4 Mar 2011
Volume41
Issue5
DOIs
StatePublished
Peer-reviewedYes

Abstract

In this issue of Molecular Cell, Kawabata et al. (2011) show that mice hypomorphic for the replication licensing protein Mcm4 show spontaneous DNA replication defects due to a lack of dormant origins, potentially explaining why these mice are cancer prone.

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