A trimer plus a dimer-gallate reproduce the bioactivity described for an extract of grape seed procyanidins
Research output: Contribution to journal › Article
- Gemma Montagut
- Isabel Baiges
- Josep Valls
- Ximena Terra
- Joseph M. del Bas
- Xavier Vitrac
- Tristan Richard
- Jean-Michel Mérillon
- Lluis Arola
- Mayte Blay
- Cinta Bladé
- Juan Fernández-Larrea
- Gerard Pujadas
- Josepa Salvadó
- Anna Ardévol
| Original language | English |
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| Number of pages | 6 |
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| Pages | 265-270 |
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| Journal | Food Chemistry |
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| Journal publication date | Sep-2009 |
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| Journal number | 1 |
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| Volume | 116 |
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| DOIs | |
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| State | Published |
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The relationship between grape seed-derived procyanidin extract components and their bioactivity was explored. The monomeric and dimeric structures only acted as anti-inflammatory agents. Similarly, pure C1 trimer was highly effective on LPS-activated macrophages. To reproduce all of the bioactivities of the total extract, a fraction enriched with trimeric structures was needed. This trimeric-enriched fraction was divided into subfractions, the most bioactive of which contained two compounds with a molecular weight equal to a trimer (865) and a dimer-gallate (729), according to spectrometric analysis. Thus, it may be concluded that a mixture of both molecules reproduces the bioactivity in glucose metabolism (3T3-L1), lipid metabolism (HepG2) and macrophage functionality (RAW 264.6). © 2009 Elsevier Ltd. All rights reserved.