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A trimer plus a dimer-gallate reproduce the bioactivity described for an extract of grape seed procyanidins

A trimer plus a dimer-gallate reproduce the bioactivity described for an extract of grape seed procyanidins

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Authors

  • Gemma Montagut
  • Isabel Baiges
  • Josep Valls
  • Ximena Terra
  • Joseph M. del Bas
  • Xavier Vitrac
  • Tristan Richard
  • Jean-Michel Mérillon
  • Lluis Arola
  • Mayte Blay
  • Cinta Bladé
  • Juan Fernández-Larrea
  • Gerard Pujadas
  • Josepa Salvadó
  • Anna Ardévol

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Info

Original languageEnglish
Pages265-270
Number of pages6
JournalFood Chemistry
Journal publication dateSep 2009
Volume116
Issue1
DOIs
StatePublished

Abstract

The relationship between grape seed-derived procyanidin extract components and their bioactivity was explored. The monomeric and dimeric structures only acted as anti-inflammatory agents. Similarly, pure C1 trimer was highly effective on LPS-activated macrophages. To reproduce all of the bioactivities of the total extract, a fraction enriched with trimeric structures was needed. This trimeric-enriched fraction was divided into subfractions, the most bioactive of which contained two compounds with a molecular weight equal to a trimer (865) and a dimer-gallate (729), according to spectrometric analysis. Thus, it may be concluded that a mixture of both molecules reproduces the bioactivity in glucose metabolism (3T3-L1), lipid metabolism (HepG2) and macrophage functionality (RAW 264.6). © 2009 Elsevier Ltd. All rights reserved.

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