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Abnormal neural responses to social exclusion in schizophrenia

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Abnormal neural responses to social exclusion in schizophrenia. / Gradin, Victoria B.; Waiter, Gordon; Kumar, Poornima; Stickle, Catriona; Milders, Maarten; Matthews, Keith; Reid, Ian; Hall, Jeremy; Steele, J. Douglas.

In: PLoS ONE, Vol. 7, No. 8, e42608, 16.08.2012, p. -.

Research output: Contribution to journalArticle

Harvard

Gradin, VB, Waiter, G, Kumar, P, Stickle, C, Milders, M, Matthews, K, Reid, I, Hall, J & Steele, JD 2012, 'Abnormal neural responses to social exclusion in schizophrenia' PLoS ONE, vol 7, no. 8, e42608, pp. -.

APA

Gradin, V. B., Waiter, G., Kumar, P., Stickle, C., Milders, M., Matthews, K., Reid, I., Hall, J., & Steele, J. D. (2012). Abnormal neural responses to social exclusion in schizophrenia. PLoS ONE, 7(8), -[e42608]doi: 10.1371/journal.pone.0042608

Vancouver

Gradin VB, Waiter G, Kumar P, Stickle C, Milders M, Matthews K et al. Abnormal neural responses to social exclusion in schizophrenia. PLoS ONE. 2012 Aug 16;7(8):-. e42608.

Author

Gradin, Victoria B.; Waiter, Gordon; Kumar, Poornima; Stickle, Catriona; Milders, Maarten; Matthews, Keith; Reid, Ian; Hall, Jeremy; Steele, J. Douglas / Abnormal neural responses to social exclusion in schizophrenia.

In: PLoS ONE, Vol. 7, No. 8, e42608, 16.08.2012, p. -.

Research output: Contribution to journalArticle

Bibtex - Download

@article{9ccc477564c24b6a875cac7a7358a8ad,
title = "Abnormal neural responses to social exclusion in schizophrenia",
author = "Gradin, {Victoria B.} and Gordon Waiter and Poornima Kumar and Catriona Stickle and Maarten Milders and Keith Matthews and Ian Reid and Jeremy Hall and Steele, {J. Douglas}",
year = "2012",
volume = "7",
number = "8",
pages = "--",
journal = "PLoS ONE",
issn = "1932-6203",

}

RIS (suitable for import to EndNote) - Download

TY - JOUR

T1 - Abnormal neural responses to social exclusion in schizophrenia

A1 - Gradin,Victoria B.

A1 - Waiter,Gordon

A1 - Kumar,Poornima

A1 - Stickle,Catriona

A1 - Milders,Maarten

A1 - Matthews,Keith

A1 - Reid,Ian

A1 - Hall,Jeremy

A1 - Steele,J. Douglas

AU - Gradin,Victoria B.

AU - Waiter,Gordon

AU - Kumar,Poornima

AU - Stickle,Catriona

AU - Milders,Maarten

AU - Matthews,Keith

AU - Reid,Ian

AU - Hall,Jeremy

AU - Steele,J. Douglas

PY - 2012/8/16

Y1 - 2012/8/16

N2 - <p>Social exclusion is an influential concept in politics, mental health and social psychology. Studies on healthy subjects have implicated the medial prefrontal cortex (mPFC), a region involved in emotional and social information processing, in neural responses to social exclusion. Impairments in social interactions are common in schizophrenia and are associated with reduced quality of life. Core symptoms such as delusions usually have a social content. However little is known about the neural underpinnings of social abnormalities. The aim of this study was to investigate the neural substrates of social exclusion in schizophrenia. Patients with schizophrenia and healthy controls underwent fMRI while participating in a popular social exclusion paradigm. This task involves passing a 'ball' between the participant and two cartoon representations of other subjects. The extent of social exclusion (ball not being passed to the participant) was parametrically varied throughout the task. Replicating previous findings, increasing social exclusion activated the mPFC in controls. In contrast, patients with schizophrenia failed to modulate mPFC responses with increasing exclusion. Furthermore, the blunted response to exclusion correlated with increased severity of positive symptoms. These data support the hypothesis that the neural response to social exclusion differs in schizophrenia, highlighting the mPFC as a potential substrate of impaired social interactions.</p>

AB - <p>Social exclusion is an influential concept in politics, mental health and social psychology. Studies on healthy subjects have implicated the medial prefrontal cortex (mPFC), a region involved in emotional and social information processing, in neural responses to social exclusion. Impairments in social interactions are common in schizophrenia and are associated with reduced quality of life. Core symptoms such as delusions usually have a social content. However little is known about the neural underpinnings of social abnormalities. The aim of this study was to investigate the neural substrates of social exclusion in schizophrenia. Patients with schizophrenia and healthy controls underwent fMRI while participating in a popular social exclusion paradigm. This task involves passing a 'ball' between the participant and two cartoon representations of other subjects. The extent of social exclusion (ball not being passed to the participant) was parametrically varied throughout the task. Replicating previous findings, increasing social exclusion activated the mPFC in controls. In contrast, patients with schizophrenia failed to modulate mPFC responses with increasing exclusion. Furthermore, the blunted response to exclusion correlated with increased severity of positive symptoms. These data support the hypothesis that the neural response to social exclusion differs in schizophrenia, highlighting the mPFC as a potential substrate of impaired social interactions.</p>

KW - Schizophrenia

KW - Magnetic Resonance Imaging

KW - Neurons

KW - Humans

KW - Adult

KW - Case-Control Studies

KW - Middle Aged

KW - Social Isolation

KW - Male

KW - Female

U2 - 10.1371/journal.pone.0042608

DO - 10.1371/journal.pone.0042608

M1 - Article

JO - PLoS ONE

JF - PLoS ONE

SN - 1932-6203

IS - 8

VL - 7

SP - -

ER -

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