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Absolute quantitation of brain metabolites with respect to heterogeneous tissue compositions in H-1-MR spectroscopic volumes

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Absolute quantitation of brain metabolites with respect to heterogeneous tissue compositions in H-1-MR spectroscopic volumes. / Gussew, Alexander; Erdtel, Marko; Hiepe, Patrick; Rzanny, Reinhard; Reichenbach, Jurgen R.

In: Magnetic Resonance Materials in Physics Biology and Medicine, Vol. 25, No. 5, 10.2012, p. 321-333.

Research output: Contribution to journalArticle

Harvard

Gussew, A, Erdtel, M, Hiepe, P, Rzanny, R & Reichenbach, JR 2012, 'Absolute quantitation of brain metabolites with respect to heterogeneous tissue compositions in H-1-MR spectroscopic volumes' Magnetic Resonance Materials in Physics Biology and Medicine, vol 25, no. 5, pp. 321-333.

APA

Gussew, A., Erdtel, M., Hiepe, P., Rzanny, R., & Reichenbach, J. R. (2012). Absolute quantitation of brain metabolites with respect to heterogeneous tissue compositions in H-1-MR spectroscopic volumes. Magnetic Resonance Materials in Physics Biology and Medicine, 25(5), 321-333doi: 10.1007/s10334-012-0305-z

Vancouver

Gussew A, Erdtel M, Hiepe P, Rzanny R, Reichenbach JR. Absolute quantitation of brain metabolites with respect to heterogeneous tissue compositions in H-1-MR spectroscopic volumes. Magnetic Resonance Materials in Physics Biology and Medicine. 2012 Oct;25(5):321-333.

Author

Gussew, Alexander; Erdtel, Marko; Hiepe, Patrick; Rzanny, Reinhard; Reichenbach, Jurgen R. / Absolute quantitation of brain metabolites with respect to heterogeneous tissue compositions in H-1-MR spectroscopic volumes.

In: Magnetic Resonance Materials in Physics Biology and Medicine, Vol. 25, No. 5, 10.2012, p. 321-333.

Research output: Contribution to journalArticle

Bibtex - Download

@article{1e5621fb753a4c85916496f7b01199ad,
title = "Absolute quantitation of brain metabolites with respect to heterogeneous tissue compositions in H-1-MR spectroscopic volumes",
author = "Alexander Gussew and Marko Erdtel and Patrick Hiepe and Reinhard Rzanny and Reichenbach, {Jurgen R.}",
year = "2012",
volume = "25",
number = "5",
pages = "321--333",
journal = "Magnetic Resonance Materials in Physics Biology and Medicine",
issn = "0968-5243",

}

RIS (suitable for import to EndNote) - Download

TY - JOUR

T1 - Absolute quantitation of brain metabolites with respect to heterogeneous tissue compositions in H-1-MR spectroscopic volumes

A1 - Gussew,Alexander

A1 - Erdtel,Marko

A1 - Hiepe,Patrick

A1 - Rzanny,Reinhard

A1 - Reichenbach,Jurgen R.

AU - Gussew,Alexander

AU - Erdtel,Marko

AU - Hiepe,Patrick

AU - Rzanny,Reinhard

AU - Reichenbach,Jurgen R.

PY - 2012/10

Y1 - 2012/10

N2 - <p>Referencing metabolite intensities to the tissue water intensity is commonly applied to determine metabolite concentrations from in vivo H-1-MRS brain data. However, since the water concentration and relaxation properties differ between grey matter, white matter and cerebrospinal fluid (CSF), the volume fractions of these compartments have to be considered in MRS voxels.</p><p>The impact of partial volume correction was validated by phantom measurements in voxels containing mixtures of solutions with different NAA and water concentrations as well as by analyzing in vivo H-1-MRS brain data acquired with various voxel compositions.</p><p>Phantom measurements indicated substantial underestimation of NAA concentrations when assuming homogeneously composed voxels, especially for voxels containing solution, which simulated CSF (error: a parts per thousand currency sign92%). This bias was substantially reduced by taking into account voxel composition (error: a parts per thousand currency sign10%). In the in vivo study, tissue correction reduced the overall variation of quantified metabolites by up to 35% and revealed the expected metabolic differences between various brain tissues.</p><p>Tissue composition affects extraction of metabolite concentrations and may cause misinterpretations when comparing measurements performed with different voxel sizes. This variation can be reduced by considering the different tissue types by means of combined analysis of spectroscopic and imaging data.</p>

AB - <p>Referencing metabolite intensities to the tissue water intensity is commonly applied to determine metabolite concentrations from in vivo H-1-MRS brain data. However, since the water concentration and relaxation properties differ between grey matter, white matter and cerebrospinal fluid (CSF), the volume fractions of these compartments have to be considered in MRS voxels.</p><p>The impact of partial volume correction was validated by phantom measurements in voxels containing mixtures of solutions with different NAA and water concentrations as well as by analyzing in vivo H-1-MRS brain data acquired with various voxel compositions.</p><p>Phantom measurements indicated substantial underestimation of NAA concentrations when assuming homogeneously composed voxels, especially for voxels containing solution, which simulated CSF (error: a parts per thousand currency sign92%). This bias was substantially reduced by taking into account voxel composition (error: a parts per thousand currency sign10%). In the in vivo study, tissue correction reduced the overall variation of quantified metabolites by up to 35% and revealed the expected metabolic differences between various brain tissues.</p><p>Tissue composition affects extraction of metabolite concentrations and may cause misinterpretations when comparing measurements performed with different voxel sizes. This variation can be reduced by considering the different tissue types by means of combined analysis of spectroscopic and imaging data.</p>

U2 - 10.1007/s10334-012-0305-z

DO - 10.1007/s10334-012-0305-z

M1 - Article

JO - Magnetic Resonance Materials in Physics Biology and Medicine

JF - Magnetic Resonance Materials in Physics Biology and Medicine

SN - 0968-5243

IS - 5

VL - 25

SP - 321

EP - 333

ER -

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