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Adaptive responses to environmental chemicals

Adaptive responses to environmental chemicals

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Original languageEnglish
Title of host publicationCellular responses to stress
EditorsC. P. Downes, C. R. Wolf, D. P. Lane
Place of publicationLondon
PublisherPortland Press Ltd
Publication date1999
Pages129-139
Number of pages11
ISBN (Print)1855781239
StatePublished

Publication series

NameBiochemical Society symposia
PublisherPortland Press
Number64
ISSN (Print)0067-8964

Abstract

Adaption to chemical agents in the environment is a fundamental part of the evolutionary process and a large number of genes have evolved to specifically detoxify potentially harmful chemical agents. These genes can act at various levels within cells and determine circulating chemical or toxin concentrations, and uptake and efflux rates as well as intracellular detoxification enzymes, such as the cytochrome P-450-dependent mono-oxygenases and glutathione S-transferases. These multigene families of proteins play a central role in chemical and drug detoxification and their polymorphic expression may well be a factor in disease susceptibility.

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