Adaptive responses to environmental chemicals. / Wolf, C. R.; Smith, G.; Smith, A. G.; Brown, K.; Henderson, C. J.
Cellular responses to stress. ed. / C. P. Downes; C. R. Wolf; D. P. Lane. London : Portland Press Ltd, 1999. p. 129-139 (Biochemical Society symposia; 64).Research output: Chapter in Book/Report/Conference proceeding › Conference contribution
}
TY - CHAP
T1 - Adaptive responses to environmental chemicals
A1 - Wolf,C. R.
A1 - Smith,G.
A1 - Smith,A. G.
A1 - Brown,K.
A1 - Henderson,C. J.
AU - Wolf,C. R.
AU - Smith,G.
AU - Smith,A. G.
AU - Brown,K.
AU - Henderson,C. J.
PB - Portland Press Ltd
CY - London
PY - 1999
Y1 - 1999
N2 - Adaption to chemical agents in the environment is a fundamental part of the evolutionary process and a large number of genes have evolved to specifically detoxify potentially harmful chemical agents. These genes can act at various levels within cells and determine circulating chemical or toxin concentrations, and uptake and efflux rates as well as intracellular detoxification enzymes, such as the cytochrome P-450-dependent mono-oxygenases and glutathione S-transferases. These multigene families of proteins play a central role in chemical and drug detoxification and their polymorphic expression may well be a factor in disease susceptibility.
AB - Adaption to chemical agents in the environment is a fundamental part of the evolutionary process and a large number of genes have evolved to specifically detoxify potentially harmful chemical agents. These genes can act at various levels within cells and determine circulating chemical or toxin concentrations, and uptake and efflux rates as well as intracellular detoxification enzymes, such as the cytochrome P-450-dependent mono-oxygenases and glutathione S-transferases. These multigene families of proteins play a central role in chemical and drug detoxification and their polymorphic expression may well be a factor in disease susceptibility.
M1 - Conference contribution
SN - 1855781239
BT - Cellular responses to stress
T2 - Cellular responses to stress
A2 - Lane,D. P.
ED - Lane,D. P.
T3 - Biochemical Society symposia
T3 - en_GB
SP - 129
EP - 139
ER -