Alternative polyadenylation of antisense RNAs and flowering time control

TY - JOUR

T1 - Alternative polyadenylation of antisense RNAs and flowering time control

A1 - Hornyik,Csaba

A1 - Duc,Celine

A1 - Rataj,Katarzyna

A1 - Terzi,Lionel C.

A1 - Simpson,Gordon G.

AU - Hornyik,Csaba

AU - Duc,Celine

AU - Rataj,Katarzyna

AU - Terzi,Lionel C.

AU - Simpson,Gordon G.

PY - 2010/8

Y1 - 2010/8

N2 - <p>Flowering time is controlled by precision in gene regulation mediated by different pathways. Two Arabidopsis thallium, components of the autonomous flowering pathway, FCA and FPA, function as genetically independent frons-acting regulators of alternative cleavage and polyadenylation. FCA and FPA directly associate with chromatin at the locus encoding the floral repressor FLC, but appear to control FLC transcription by mediating alternative polyadenylation of embedded non-coding antisense RNAs. These findings prompt the re-examination of how other factors control FLC expression, as it is formally possible that they function primarily to control alternative processing of antisense RNAs. As co-expressed sense and antisense gene pairs are wide spread in eukaryotes, alternative processing of antisense RNAs may represent a significant form of gene regulation.</p>

AB - <p>Flowering time is controlled by precision in gene regulation mediated by different pathways. Two Arabidopsis thallium, components of the autonomous flowering pathway, FCA and FPA, function as genetically independent frons-acting regulators of alternative cleavage and polyadenylation. FCA and FPA directly associate with chromatin at the locus encoding the floral repressor FLC, but appear to control FLC transcription by mediating alternative polyadenylation of embedded non-coding antisense RNAs. These findings prompt the re-examination of how other factors control FLC expression, as it is formally possible that they function primarily to control alternative processing of antisense RNAs. As co-expressed sense and antisense gene pairs are wide spread in eukaryotes, alternative processing of antisense RNAs may represent a significant form of gene regulation.</p>

KW - alternative polyadenylation

KW - antisense RNA

KW - chromatin

KW - flowering time control

KW - spen

KW - ARABIDOPSIS-THALIANA

KW - AUTONOMOUS PATHWAY

KW - LOCUS-C

KW - BINDING PROTEIN

KW - FLORAL TRANSITION

KW - REPEAT PROTEIN

KW - GENE

KW - FCA

KW - TRANSCRIPTION

KW - YEAST

U2 - 10.1042/BST0381077

DO - 10.1042/BST0381077

M1 - Article

JO - Biochemical Society Transactions

JF - Biochemical Society Transactions

SN - 0300-5127

VL - 38

SP - 1077

EP - 1081

ER -