Discovery - University of Dundee - Online Publications

Library & Learning Centre

AMPK and autophagy get connected

AMPK and autophagy get connected

Research output: Contribution to journalEditorial

View graph of relations

Authors

  • D. Grahame Hardie

Research units

Info

Original languageEnglish
Pages (from-to)634-635
Number of pages2
JournalEMBO Journal
Volume30
Issue number4
DOIs
StatePublished - 16 Feb 2011

Abstract

The energy sensor AMP-activated protein kinase (AMPK), which is activated by ATP depletion or glucose starvation, was previously thought to activate autophagy entirely through its ability to inactivate mTOR complex-1. Two recent papers now provide evidence that it also mediates this by direct phosphorylation of the protein kinase that initiate autophagy, ULK1. Surprisingly, however, the two groups identified different sites on ULK1.

Documents

DOI

Library & Learning Centre

Contact | Accessibility | Policy