AMPK and autophagy get connected. / Hardie, D. Grahame.
In: EMBO Journal, Vol. 30, No. 4, 16.02.2011, p. 634-635.Research output: Contribution to journal › Editorial
}
TY - JOUR
T1 - AMPK and autophagy get connected
A1 - Hardie,D. Grahame
AU - Hardie,D. Grahame
PY - 2011/2/16
Y1 - 2011/2/16
N2 - <p>The energy sensor AMP-activated protein kinase (AMPK), which is activated by ATP depletion or glucose starvation, was previously thought to activate autophagy entirely through its ability to inactivate mTOR complex-1. Two recent papers now provide evidence that it also mediates this by direct phosphorylation of the protein kinase that initiate autophagy, ULK1. Surprisingly, however, the two groups identified different sites on ULK1.</p>
AB - <p>The energy sensor AMP-activated protein kinase (AMPK), which is activated by ATP depletion or glucose starvation, was previously thought to activate autophagy entirely through its ability to inactivate mTOR complex-1. Two recent papers now provide evidence that it also mediates this by direct phosphorylation of the protein kinase that initiate autophagy, ULK1. Surprisingly, however, the two groups identified different sites on ULK1.</p>
KW - CELLULAR-ENERGY
KW - GROWTH
U2 - 10.1038/emboj.2011.12
DO - 10.1038/emboj.2011.12
M1 - Editorial
JO - EMBO Journal
JF - EMBO Journal
SN - 0261-4189
IS - 4
VL - 30
SP - 634
EP - 635
ER -