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Application of optical trapping for cavitation studies

Application of optical trapping for cavitation studies

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Original languageEnglish
Title of host publicationOptical Trapping and Optical Micromanipulation V
EditorsKishan Dholakia, Gabriel C. Spalding
Place of PublicationBellingham
PublisherSPIE-International Society for Optical Engineering
Number of pages8
ISBN (Print)9780819472588
StatePublished - 2008

Publication series

NameProceedings of SPIE


ConferenceSPIE Optics+Photonics 2008: Optical Trapping and Optical Micromanipulation V
Abbreviated title
CountryUnited States
CitySan Diego
Internet address


This study has observed microscopic level cavitation processes in shelled second generation ultrasound contrast agent microbubbles. The spatial and temporal resolutions required for this undertaking have been achieved via a unique hybridisation of optical trapping with ultra high speed microphotography. Upon insonation with ultrasound in the region of 0.5-4MPa, microjets were observed to develop within, and subsequently issue from, cavitating bubbles. Jet impact into target substrates, including monolayers of biological cells, was observed. These observations provide direct evidence for the involvement of microjetting events during ultrasound exposure on live cells, a process that may have future potential as a novel non-invasive route to drug- and gene-based therapies.



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