Discovery - University of Dundee - Online Publications

Library & Learning Centre

Association analyses based on false discovery rate implicate new loci for coronary artery disease

Association analyses based on false discovery rate implicate new loci for coronary artery disease

Research output: Contribution to journalLetter

View graph of relations

Authors

  • Christopher P. Nelson
  • Anuj Goel
  • Adam S. Butterworth
  • Stavroula Kanoni
  • Tom R Webb
  • Eirini Marouli
  • Lingyao Zeng
  • Ioanna Ntalla
  • Florence Y Lai
  • Jemma C. Hopewell
  • Olga Giannakopoulou
  • Tao Jiang
  • Stephen E. Hamby
  • Emanuele Di Angelantonio
  • Themistocles L. Assimes
  • Erwin P. Bottinger
  • John C. Chambers
  • Robert Clarke
  • Colin N A Palmer
  • Richard M. Cubbon
  • Patrick T. Ellinor
  • Raili Ermel
  • Evangelos Evangelou
  • Paul W. Franks
  • Christopher Grace
  • Dongfeng Gu
  • Aroon D. Hingorani
  • Joanna M. M. Howson
  • Erik Ingelsson
  • Adnan Kastrati
  • Thorsten Kessler
  • Theodosios Kyriakou
  • Terho Lehtimäki
  • Xiangfeng Lu
  • Yingchang Lu
  • Winfried März
  • Ruth McPherson
  • Andres Metspalu
  • Mar Pujades-Rodriguez
  • Arno Ruusalepp
  • Eric E. Schadt
  • Amand F Schmidt
  • Michael J Sweeting
  • Pierre A. Zalloua
  • Kamal AlGhalayini
  • Bernard D. Keavney
  • Jaspal S. Kooner
  • Ruth J. F. Loos
  • Riyaz S Patel
  • Martin K Rutter
  • Maciej Tomaszewski
  • Ioanna Tzoulaki
  • Eleftheria Zeggini
  • Jeanette Erdmann
  • George Dedoussis
  • Johan L. M. Björkegren
  • Heribert Schunkert
  • Martin Farrall
  • John Danesh
  • Nilesh J. Samani
  • Hugh Watkins (Lead / Corresponding author)
  • Panos Deloukas
  • EPIC-CVD Consortium, CARDIoGRAMplusC4D, The UK Biobank CardioMetabolic Consortium CHD working group

Research units

Info

Original languageEnglish
Pages (from-to)1385-1391
Number of pages6
JournalNature Genetics
Volume49
Issue number9
Early online date17 Jul 2017
DOIs
StatePublished - Sep 2017

Abstract

Genome-wide association studies (GWAS) in coronary artery disease (CAD) had identified 66 loci at 'genome-wide significance' (P < 5 × 10(-8)) at the time of this analysis, but a much larger number of putative loci at a false discovery rate (FDR) of 5% (refs. 1,2,3,4). Here we leverage an interim release of UK Biobank (UKBB) data to evaluate the validity of the FDR approach. We tested a CAD phenotype inclusive of angina (SOFT; ncases = 10,801) as well as a stricter definition without angina (HARD; ncases = 6,482) and selected cases with the former phenotype to conduct a meta-analysis using the two most recent CAD GWAS. This approach identified 13 new loci at genome-wide significance, 12 of which were on our previous list of loci meeting the 5% FDR threshold, thus providing strong support that the remaining loci identified by FDR represent genuine signals. The 304 independent variants associated at 5% FDR in this study explain 21.2% of CAD heritability and identify 243 loci that implicate pathways in blood vessel morphogenesis as well as lipid metabolism, nitric oxide signaling and inflammation.

Documents

DOI

Library & Learning Centre

Contact | Accessibility | Policy