Association between age, IL-10, IFNγ, stimulated C-peptide and disease progression in children with newly diagnosed Type 1 diabetes
Research output: Contribution to journal › Article
- A Kaas
- C Pfleger
- A V Kharagjitsingh
- N C Schloot
- L Hansen
- K Buschard
- B P C Koeleman
- B O Roep
- H B Mortensen
- B Z Alizadeh
- S. A. Greene
- on behalf of the Hvidoere Study Group on Childhood Diabetes
| Original language | English |
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| Number of pages | 8 |
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| Pages | 734-741 |
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| Journal | Diabetic Medicine |
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| Journal publication date | 2012 |
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| Journal number | 6 |
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| Volume | 29 |
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| DOIs | |
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| State | Published |
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Diabet. Med. 29, 734-741 (2012) ABSTRACT: Aims The relation of disease progression and age, serum interleukin 10 (IL-10) and interferon gamma (IFN?) and their genetic correlates were studied in paediatric patients with newly diagnosed Type 1 diabetes. Methods Two hundred and twenty-seven patients from the Hvidoere Study Group were classified in four different progression groups as assessed by change in stimulated C-peptide from 1 to 6 months. CA repeat variants of the IL-10 and IFN? gene were genotyped and serum levels of IL-10 and IFN? were measured at 1, 6 and 12 months. Results IL-10 decreased (P