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Association between age, IL-10, IFNγ, stimulated C-peptide and disease progression in children with newly diagnosed Type 1 diabetes

Association between age, IL-10, IFNγ, stimulated C-peptide and disease progression in children with newly diagnosed Type 1 diabetes

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Authors

  • A Kaas
  • C Pfleger
  • A V Kharagjitsingh
  • N C Schloot
  • L Hansen
  • K Buschard
  • B P C Koeleman
  • B O Roep
  • H B Mortensen
  • B Z Alizadeh
  • S. A. Greene
  • on behalf of the Hvidoere Study Group on Childhood Diabetes

Info

Original languageEnglish
Pages (from-to)734-741
Number of pages8
JournalDiabetic Medicine
Volume29
Issue number6
DOIs
StatePublished - 2012

Abstract

Diabet. Med. 29, 734-741 (2012) ABSTRACT: Aims The relation of disease progression and age, serum interleukin 10 (IL-10) and interferon gamma (IFN?) and their genetic correlates were studied in paediatric patients with newly diagnosed Type 1 diabetes. Methods Two hundred and twenty-seven patients from the Hvidoere Study Group were classified in four different progression groups as assessed by change in stimulated C-peptide from 1 to 6 months. CA repeat variants of the IL-10 and IFN? gene were genotyped and serum levels of IL-10 and IFN? were measured at 1, 6 and 12 months. Results IL-10 decreased (P

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