Discovery - University of Dundee - Online Publications

Library & Learning Centre

Association between GDF-15 levels and changes in vascular and physical function in older patients with hypertension

Association between GDF-15 levels and changes in vascular and physical function in older patients with hypertension

Research output: Contribution to journalArticle

View graph of relations

Info

Original languageEnglish
Number of pages5
JournalAging Clinical and Experimental Research
Early online date12 Oct 2016
DOIs
StatePublished - 2016

Abstract

Background: Growth Differentiation Factor-15 (GDF-15) may be a biomarker of disease, protective response and/or prognosis, in older people with hypertension.
Aims: To correlate baseline GDF-15 levels with physical and vascular health data in this population.

Methods: Baseline blood samples were analysed using a GDF-15 ELISA assay kit. Correlations with baseline and 12-month outcome data, including measures of physical and vascular function, were performed.

Results: 147 individuals, mean age 76.8±4.7 years, were included. 77(52%) were male. Baseline logGDF15 showed significant correlations with age (r=0.37, p<0.001), total cholesterol (r=-0.33, p<0.001) and six-minute walking distance (r=-0.37, p<0.001). Age remained significantly associated with logGDF15 in multivariable analysis (beta=-0.29, p=0.001). Baseline logGDF15 was significantly associated with decline in sixminute walk distance over 12 months (beta=-0.27, p=0.01) in multivariable models. No significant correlations were seen with changes in vascular function over 12 months.

Conclusion: Baseline GDF-15 predicts declining physical, but not vascular, function in our population.

Download statistics

No data available

Documents

Open Access permissions

Open

Documents

  • Final Published Version

    Final published version, 384 KB, PDF-document

    ©The Author(s) 2016. This article is published with open access at Springerlink.com. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

DOI

Library & Learning Centre

Contact | Accessibility | Policy