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ATRX

ATRX : put me on repeat

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Authors

  • Iestyn Whitehouse
  • Tom Owen-Hughes

Research units

Info

Original languageEnglish
Pages335-336
Number of pages2
JournalCell
Journal publication date29 Oct 2010
Journal number3
Volume143
DOIs
StatePublished

Abstract

Mutations in the chromatin-remodeling protein ATRX cause alpha thalassaemia and mental retardation, but the severity of the disorder is independent of the specific mutation. In this issue of Cell, Law et al. (2010) demonstrate that ATRX alters gene expression by binding to G-rich tandem repeats, and the degree of transcriptional silencing caused by ATRX mutations correlates with the number of repeats.

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