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Ca2+ signalling in the control of motility and guidance in mammalian sperm

Ca2+ signalling in the control of motility and guidance in mammalian sperm

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  • Stephen John Publicover (Lead / Corresponding author)
  • Laura Cecilia Giojalas
  • Maria Eugenia Teves
  • Gisela Sofia Mendes Machado de Oliveira
  • Aduen Andres Morales Garcia
  • Christopher Lowther Robert Barratt
  • Claire Victoria Harper

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Original languageEnglish
Article number3105
Pages (from-to)5623-5637
Number of pages15
JournalFrontiers in Bioscience
StatePublished - 2008


Ca2+ signalling in the sperm plays a key role in the regulation of events preceding fertilisation. Control of motility, including hyperactivation and chemotaxis, is particularly dependent upon [Ca2+](i) signalling in the principal piece of the flagellum and the midpiece. Here we briefly review the processes that contribute to regulation of [Ca2+](i) in mammalian sperm and then examine two areas: (i) the regulation of hyperactivation by [Ca2+](i) and the pivotal roles played by CatSpers (sperm-specific, Ca2+-permeable membrane channels) and intracellular Ca2+ stores in this process and (ii) the elevation of [Ca2+](i) and consequent modulation of motility caused by progesterone including the ability of progesterone at micromolar concentrations to cause sperm hyperactivation and/or accumulation and the recent discovery that progesterone, at picomolar concentrations, acts as a chemoattractant for mammalian sperm.



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