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Can vitamin D deficiency cause diabetes and cardiovascular diseases?

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Can vitamin D deficiency cause diabetes and cardiovascular diseases? : Present evidence and future perspectives. / Muscogiuri, G.; Sorice, G. P.; Ajjan, R.; Mezza, T.; Pilz, S.; Prioletta, A.; Scragg, R.; Volpe, S. L.; Witham, M. D.; Giaccari, A.

In: Nutrition, Metabolism and Cardiovascular Diseases, Vol. 22, No. 2, 02.2012, p. 81-87.

Research output: Contribution to journalScientific review

Harvard

Muscogiuri, G, Sorice, GP, Ajjan, R, Mezza, T, Pilz, S, Prioletta, A, Scragg, R, Volpe, SL, Witham, MD & Giaccari, A 2012, 'Can vitamin D deficiency cause diabetes and cardiovascular diseases?: Present evidence and future perspectives' Nutrition, Metabolism and Cardiovascular Diseases, vol 22, no. 2, pp. 81-87., 10.1016/j.numecd.2011.11.001

APA

Muscogiuri, G., Sorice, G. P., Ajjan, R., Mezza, T., Pilz, S., Prioletta, A., ... Giaccari, A. (2012). Can vitamin D deficiency cause diabetes and cardiovascular diseases?: Present evidence and future perspectives. Nutrition, Metabolism and Cardiovascular Diseases, 22(2), 81-87. 10.1016/j.numecd.2011.11.001

Vancouver

Muscogiuri G, Sorice GP, Ajjan R, Mezza T, Pilz S, Prioletta A et al. Can vitamin D deficiency cause diabetes and cardiovascular diseases?: Present evidence and future perspectives. Nutrition, Metabolism and Cardiovascular Diseases. 2012 Feb;22(2):81-87. Available from: 10.1016/j.numecd.2011.11.001

Author

Muscogiuri, G.; Sorice, G. P.; Ajjan, R.; Mezza, T.; Pilz, S.; Prioletta, A.; Scragg, R.; Volpe, S. L.; Witham, M. D.; Giaccari, A. / Can vitamin D deficiency cause diabetes and cardiovascular diseases? : Present evidence and future perspectives.

In: Nutrition, Metabolism and Cardiovascular Diseases, Vol. 22, No. 2, 02.2012, p. 81-87.

Research output: Contribution to journalScientific review

Bibtex - Download

@article{4ca10d284adf409da116dff6d6850ab2,
title = "Can vitamin D deficiency cause diabetes and cardiovascular diseases?: Present evidence and future perspectives",
author = "G. Muscogiuri and Sorice, {G. P.} and R. Ajjan and T. Mezza and S. Pilz and A. Prioletta and R. Scragg and Volpe, {S. L.} and Witham, {M. D.} and A. Giaccari",
year = "2012",
doi = "10.1016/j.numecd.2011.11.001",
volume = "22",
number = "2",
pages = "81--87",
journal = "Nutrition, Metabolism and Cardiovascular Diseases",
issn = "0939-4753",

}

RIS (suitable for import to EndNote) - Download

TY - JOUR

T1 - Can vitamin D deficiency cause diabetes and cardiovascular diseases?

T2 - Present evidence and future perspectives

A1 - Muscogiuri,G.

A1 - Sorice,G. P.

A1 - Ajjan,R.

A1 - Mezza,T.

A1 - Pilz,S.

A1 - Prioletta,A.

A1 - Scragg,R.

A1 - Volpe,S. L.

A1 - Witham,M. D.

A1 - Giaccari,A.

AU - Muscogiuri,G.

AU - Sorice,G. P.

AU - Ajjan,R.

AU - Mezza,T.

AU - Pilz,S.

AU - Prioletta,A.

AU - Scragg,R.

AU - Volpe,S. L.

AU - Witham,M. D.

AU - Giaccari,A.

PY - 2012/2

Y1 - 2012/2

N2 - <p>Several studies have shown that vitamin D may play a role in many biochemical mechanisms in addition to bone and calcium metabolism. Recently, vitamin D has sparked widespread interest because of its involvement in the homeostasis of the cardiovascular system. Hypovitaminosis D has been associated with obesity, related to trapping in adipose tissue due to its lipophilic structure. In addition, vitamin D deficiency is associated with increased risk of cardiovascular disease (CVD) and this may be due to the relationship between low vitamin D levels and obesity, diabetes mellitus, dyslipidaemia, endothelial dysfunction and hypertension. However, although vitamin D has been identified as a potentially important marker of CVD, the mechanisms through which it might modulate cardiovascular risk are not fully understood. Given this background, in this work we summarise clinical retrospective and prospective observational studies linking vitamin D levels with cardio-metabolic risk factors and vascular outcome. Moreover, we review various randomised controlled trials (RCTs) investigating the effects of vitamin D supplementation on surrogate markers of cardiovascular risk. Considering the high prevalence of hypovitaminosis D among patients with high cardiovascular risk, vitamin D replacement therapy in this population may be warranted; however, further RCTs are urgently needed to establish when to begin vitamin D therapy, as well as to determine the dose and route and duration of administration. (C) 2011 Elsevier B.V. All rights reserved.</p>

AB - <p>Several studies have shown that vitamin D may play a role in many biochemical mechanisms in addition to bone and calcium metabolism. Recently, vitamin D has sparked widespread interest because of its involvement in the homeostasis of the cardiovascular system. Hypovitaminosis D has been associated with obesity, related to trapping in adipose tissue due to its lipophilic structure. In addition, vitamin D deficiency is associated with increased risk of cardiovascular disease (CVD) and this may be due to the relationship between low vitamin D levels and obesity, diabetes mellitus, dyslipidaemia, endothelial dysfunction and hypertension. However, although vitamin D has been identified as a potentially important marker of CVD, the mechanisms through which it might modulate cardiovascular risk are not fully understood. Given this background, in this work we summarise clinical retrospective and prospective observational studies linking vitamin D levels with cardio-metabolic risk factors and vascular outcome. Moreover, we review various randomised controlled trials (RCTs) investigating the effects of vitamin D supplementation on surrogate markers of cardiovascular risk. Considering the high prevalence of hypovitaminosis D among patients with high cardiovascular risk, vitamin D replacement therapy in this population may be warranted; however, further RCTs are urgently needed to establish when to begin vitamin D therapy, as well as to determine the dose and route and duration of administration. (C) 2011 Elsevier B.V. All rights reserved.</p>

U2 - 10.1016/j.numecd.2011.11.001

DO - 10.1016/j.numecd.2011.11.001

M1 - Scientific review

JO - Nutrition, Metabolism and Cardiovascular Diseases

JF - Nutrition, Metabolism and Cardiovascular Diseases

SN - 0939-4753

IS - 2

VL - 22

SP - 81

EP - 87

ER -

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