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Catalysis by the nucleolytic ribozymes

Catalysis by the nucleolytic ribozymes

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Authors

  • David M. J. Lilley

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Info

Original languageEnglish
Pages641-646
Number of pages6
JournalBiochemical Society Transactions
Journal publication dateApr 2011
Volume39
DOIs
StatePublished

Abstract

The nucleolytic ribozymes use general acid-base catalysis to contribute significantly to their rate enhancement. The VS (Varkud satellite) ribozyme uses a guanine and an adenine nucleobase as general base and acid respectively in the cleavage reaction. The hairpin ribozyme is probably closely similar, while the remaining nucleolytic ribozymes provide some interesting contrasts.

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