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Cell-Nonautonomous Regulation of C. elegans Germ Cell Death by kri-1

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Cell-Nonautonomous Regulation of C. elegans Germ Cell Death by kri-1. / Ito, Shu; Greiss, Sebastian; Gartner, Anton; Derry, W. Brent.

In: Current Biology, Vol. 20, No. 4, 23.02.2010, p. 333-338.

Research output: Contribution to journalArticle

Harvard

Ito, S, Greiss, S, Gartner, A & Derry, WB 2010, 'Cell-Nonautonomous Regulation of C. elegans Germ Cell Death by kri-1' Current Biology, vol 20, no. 4, pp. 333-338.

APA

Ito, S., Greiss, S., Gartner, A., & Derry, W. B. (2010). Cell-Nonautonomous Regulation of C. elegans Germ Cell Death by kri-1. Current Biology, 20(4), 333-338doi: 10.1016/j.cub.2009.12.032

Vancouver

Ito S, Greiss S, Gartner A, Derry WB. Cell-Nonautonomous Regulation of C. elegans Germ Cell Death by kri-1. Current Biology. 2010 Feb 23;20(4):333-338.

Author

Ito, Shu; Greiss, Sebastian; Gartner, Anton; Derry, W. Brent / Cell-Nonautonomous Regulation of C. elegans Germ Cell Death by kri-1.

In: Current Biology, Vol. 20, No. 4, 23.02.2010, p. 333-338.

Research output: Contribution to journalArticle

Bibtex - Download

@article{a8a22e6c00e44dcba2442454e003c41b,
title = "Cell-Nonautonomous Regulation of C. elegans Germ Cell Death by kri-1",
author = "Shu Ito and Sebastian Greiss and Anton Gartner and Derry, {W. Brent}",
year = "2010",
volume = "20",
number = "4",
pages = "333--338",
journal = "Current Biology",
issn = "0960-9822",

}

RIS (suitable for import to EndNote) - Download

TY - JOUR

T1 - Cell-Nonautonomous Regulation of C. elegans Germ Cell Death by kri-1

A1 - Ito,Shu

A1 - Greiss,Sebastian

A1 - Gartner,Anton

A1 - Derry,W. Brent

AU - Ito,Shu

AU - Greiss,Sebastian

AU - Gartner,Anton

AU - Derry,W. Brent

PY - 2010/2/23

Y1 - 2010/2/23

N2 - <p>Programmed cell death (or apoptosis) is an evolutionarily conserved, genetically controlled suicide mechanism for cells that, when deregulated, can lead to developmental defects, cancers, and degenerative diseases [1, 2]. In C. elegans, DNA damage induces germ cell death by signaling through cep-1/p53, ultimately leading to the activation of CED-3/caspase [3-13]. It has been hypothesized that the major regulatory events controlling cell death occur by cell-autonomous mechanisms, that is, within the dying cell. In support of this, genetic studies in C. elegans have shown that the core apoptosis pathway genes ced-4l APAF-1 and ced-3/caspase are required in cells fated to die [9]. However, it is not known whether the upstream signals that activate apoptosis function in a cell-autonomous manner. Here we show that kri-1, an ortholog of KRIT1/CCM1, which is mutated in the human neurovascular disease cerebral cavernous malformation [14, 15], is required to activate DNA damage-dependent cell death independently of cep-1/p53. Interestingly, we find that kri-1 regulates cell death in a cell-nonautonomous manner, revealing a novel regulatory role for nondying cells in eliciting cell death in response to DNA damage.</p>

AB - <p>Programmed cell death (or apoptosis) is an evolutionarily conserved, genetically controlled suicide mechanism for cells that, when deregulated, can lead to developmental defects, cancers, and degenerative diseases [1, 2]. In C. elegans, DNA damage induces germ cell death by signaling through cep-1/p53, ultimately leading to the activation of CED-3/caspase [3-13]. It has been hypothesized that the major regulatory events controlling cell death occur by cell-autonomous mechanisms, that is, within the dying cell. In support of this, genetic studies in C. elegans have shown that the core apoptosis pathway genes ced-4l APAF-1 and ced-3/caspase are required in cells fated to die [9]. However, it is not known whether the upstream signals that activate apoptosis function in a cell-autonomous manner. Here we show that kri-1, an ortholog of KRIT1/CCM1, which is mutated in the human neurovascular disease cerebral cavernous malformation [14, 15], is required to activate DNA damage-dependent cell death independently of cep-1/p53. Interestingly, we find that kri-1 regulates cell death in a cell-nonautonomous manner, revealing a novel regulatory role for nondying cells in eliciting cell death in response to DNA damage.</p>

KW - DAMAGE-INDUCED APOPTOSIS

KW - DNA-DAMAGE

KW - CAENORHABDITIS-ELEGANS

KW - CHECKPOINT PROTEIN

KW - LIFE-SPAN

KW - TUMOR-SUPPRESSOR

KW - ENCODING KRIT1

KW - GENE

KW - CED-4

KW - P53

U2 - 10.1016/j.cub.2009.12.032

DO - 10.1016/j.cub.2009.12.032

M1 - Article

JO - Current Biology

JF - Current Biology

SN - 0960-9822

IS - 4

VL - 20

SP - 333

EP - 338

ER -

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